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Q7Z4I7

- LIMS2_HUMAN

UniProt

Q7Z4I7 - LIMS2_HUMAN

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Protein

LIM and senescent cell antigen-like-containing domain protein 2

Gene

LIMS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.1 Publication

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell-cell junction organization Source: Ensembl
  2. cell junction assembly Source: Reactome
  3. negative regulation of apoptotic process Source: Ensembl
  4. negative regulation of hepatocyte proliferation Source: Ensembl
  5. negative regulation of neural precursor cell proliferation Source: Ensembl
  6. positive regulation of integrin-mediated signaling pathway Source: Ensembl
  7. single organismal cell-cell adhesion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_20649. Cell-extracellular matrix interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain protein 2
Alternative name(s):
LIM-like protein 2
Particularly interesting new Cys-His protein 2
Short name:
PINCH-2
Gene namesi
Name:LIMS2
Synonyms:PINCH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:16084. LIMS2.

Subcellular locationi

Nucleus Curated. Cell junctionfocal adhesion 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. focal adhesion Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341LIM and senescent cell antigen-like-containing domain protein 2PRO_0000266011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei327 – 3271Phosphothreonine1 Publication
Modified residuei328 – 3281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z4I7.
PaxDbiQ7Z4I7.
PRIDEiQ7Z4I7.

PTM databases

PhosphoSiteiQ7Z4I7.

Expressioni

Gene expression databases

BgeeiQ7Z4I7.
CleanExiHS_LIMS2.
ExpressionAtlasiQ7Z4I7. baseline and differential.
GenevestigatoriQ7Z4I7.

Organism-specific databases

HPAiHPA058340.

Interactioni

Subunit structurei

Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.By similarity2 Publications

Protein-protein interaction databases

BioGridi120808. 4 interactions.
IntActiQ7Z4I7. 4 interactions.
MINTiMINT-1194006.
STRINGi9606.ENSP00000326888.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni16 – 183
Beta strandi29 – 313
Beta strandi34 – 363
Turni38 – 403
Turni44 – 463
Helixi51 – 533
Beta strandi56 – 583
Beta strandi61 – 633
Helixi65 – 717

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IXEX-ray1.90B11-73[»]
ProteinModelPortaliQ7Z4I7.
SMRiQ7Z4I7. Positions 11-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z4I7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 7462LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini76 – 13358LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 19558LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST
Domaini196 – 25560LIM zinc-binding 4PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 31560LIM zinc-binding 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG263350.
GeneTreeiENSGT00760000118910.
HOVERGENiHBG000053.
InParanoidiQ7Z4I7.
OMAiECFRCEL.
PhylomeDBiQ7Z4I7.
TreeFamiTF314113.

Family and domain databases

Gene3Di2.10.110.10. 5 hits.
InterProiIPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24210. PTHR24210. 1 hit.
PfamiPF00412. LIM. 5 hits.
[Graphical view]
PIRSFiPIRSF038003. PINCH. 1 hit.
SMARTiSM00132. LIM. 5 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z4I7-1) [UniParc]FASTAAdd to Basket

Also known as: LIM-like protein 2B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGSNMSDAL ANAVCQRCQA RFSPAERIVN SNGELYHEHC FVCAQCFRPF
60 70 80 90 100
PEGLFYEFEG RKYCEHDFQM LFAPCCGSCG EFIIGRVIKA MNNNWHPGCF
110 120 130 140 150
RCELCDVELA DLGFVKNAGR HLCRPCHNRE KAKGLGKYIC QRCHLVIDEQ
160 170 180 190 200
PLMFRSDAYH PDHFNCTHCG KELTAEAREL KGELYCLPCH DKMGVPICGA
210 220 230 240 250
CRRPIEGRVV NALGKQWHVE HFVCAKCEKP FLGHRHYEKK GLAYCETHYN
260 270 280 290 300
QLFGDVCYNC SHVIEGDVVS ALNKAWCVSC FSCSTCNSKL TLKNKFVEFD
310 320 330 340
MKPVCKRCYE KFPLELKKRL KKLSELTSRK AQPKATDLNS A
Length:341
Mass (Da):38,916
Last modified:October 1, 2003 - v1
Checksum:iEEA8D74C309D9C8A
GO
Isoform 2 (identifier: Q7Z4I7-2) [UniParc]FASTAAdd to Basket

Also known as: LIM-like protein 2A

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MTGS → MAARLGALAASGLYRRRQHRQSPPPATG

Show »
Length:365
Mass (Da):41,512
Checksum:i3B8E1C98AFB2B698
GO
Isoform 3 (identifier: Q7Z4I7-3) [UniParc]FASTAAdd to Basket

Also known as: LIM-like protein 2C

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Show »
Length:336
Mass (Da):38,426
Checksum:i27F7EA97B557804D
GO
Isoform 4 (identifier: Q7Z4I7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Show »
Length:189
Mass (Da):21,615
Checksum:i896862131C240B5B
GO
Isoform 5 (identifier: Q7Z4I7-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-3: G → GRKRKWGETGTGSGAAPAAALRW

Note: No experimental confirmation available.

Show »
Length:363
Mass (Da):41,226
Checksum:iD0F6B8B3618F20FF
GO

Sequence cautioni

The sequence AAM77350.1 differs from that shown. Reason: Frameshift at position 331.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111D → G in BAG60013. (PubMed:14702039)Curated
Sequence conflicti294 – 2941N → D in AAM97589. (PubMed:12167643)Curated
Sequence conflicti294 – 2941N → D in BAB14047. (PubMed:15815621)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 152152Missing in isoform 4. 2 PublicationsVSP_045539Add
BLAST
Alternative sequencei1 – 55Missing in isoform 3. 2 PublicationsVSP_021916
Alternative sequencei1 – 44MTGS → MAARLGALAASGLYRRRQHR QSPPPATG in isoform 2. 1 PublicationVSP_021917
Alternative sequencei3 – 31G → GRKRKWGETGTGSGAAPAAA LRW in isoform 5. 1 PublicationVSP_046078

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484961 mRNA. Translation: AAM97589.1.
AF520987 mRNA. Translation: AAM77350.1. Frameshift.
AF527764 mRNA. Translation: AAQ09011.1.
AF527765 mRNA. Translation: AAQ09012.1.
AF527766 mRNA. Translation: AAQ09013.1.
AF527770 mRNA. Translation: AAQ09017.1.
AK022470 mRNA. Translation: BAB14047.1.
AK297645 mRNA. Translation: BAG60013.1.
BX458594 mRNA. No translation available.
AC010976 Genomic DNA. No translation available.
AC074114 Genomic DNA. No translation available.
BC065816 mRNA. Translation: AAH65816.1.
CCDSiCCDS2147.1. [Q7Z4I7-2]
CCDS54394.1. [Q7Z4I7-3]
CCDS54395.1. [Q7Z4I7-1]
CCDS54396.1. [Q7Z4I7-5]
CCDS58725.1. [Q7Z4I7-4]
RefSeqiNP_001129509.2. NM_001136037.2. [Q7Z4I7-5]
NP_001154875.1. NM_001161403.1. [Q7Z4I7-1]
NP_001154876.1. NM_001161404.1. [Q7Z4I7-3]
NP_001243471.1. NM_001256542.1. [Q7Z4I7-4]
NP_060450.2. NM_017980.4. [Q7Z4I7-2]
XP_005263766.1. XM_005263709.1. [Q7Z4I7-3]
UniGeneiHs.469881.

Genome annotation databases

EnsembliENST00000324938; ENSP00000326888; ENSG00000072163. [Q7Z4I7-2]
ENST00000355119; ENSP00000347240; ENSG00000072163. [Q7Z4I7-1]
ENST00000409254; ENSP00000386907; ENSG00000072163. [Q7Z4I7-4]
ENST00000409286; ENSP00000386252; ENSG00000072163. [Q7Z4I7-4]
ENST00000409455; ENSP00000386383; ENSG00000072163. [Q7Z4I7-3]
ENST00000409754; ENSP00000386345; ENSG00000072163. [Q7Z4I7-4]
ENST00000409808; ENSP00000386637; ENSG00000072163. [Q7Z4I7-3]
ENST00000410011; ENSP00000387002; ENSG00000072163. [Q7Z4I7-3]
ENST00000410038; ENSP00000386570; ENSG00000072163. [Q7Z4I7-4]
ENST00000545738; ENSP00000443794; ENSG00000072163. [Q7Z4I7-5]
GeneIDi55679.
KEGGihsa:55679.
UCSCiuc002tov.3. human. [Q7Z4I7-1]
uc002tox.3. human. [Q7Z4I7-2]
uc010yzm.2. human.

Polymorphism databases

DMDMi74750091.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF484961 mRNA. Translation: AAM97589.1 .
AF520987 mRNA. Translation: AAM77350.1 . Frameshift.
AF527764 mRNA. Translation: AAQ09011.1 .
AF527765 mRNA. Translation: AAQ09012.1 .
AF527766 mRNA. Translation: AAQ09013.1 .
AF527770 mRNA. Translation: AAQ09017.1 .
AK022470 mRNA. Translation: BAB14047.1 .
AK297645 mRNA. Translation: BAG60013.1 .
BX458594 mRNA. No translation available.
AC010976 Genomic DNA. No translation available.
AC074114 Genomic DNA. No translation available.
BC065816 mRNA. Translation: AAH65816.1 .
CCDSi CCDS2147.1. [Q7Z4I7-2 ]
CCDS54394.1. [Q7Z4I7-3 ]
CCDS54395.1. [Q7Z4I7-1 ]
CCDS54396.1. [Q7Z4I7-5 ]
CCDS58725.1. [Q7Z4I7-4 ]
RefSeqi NP_001129509.2. NM_001136037.2. [Q7Z4I7-5 ]
NP_001154875.1. NM_001161403.1. [Q7Z4I7-1 ]
NP_001154876.1. NM_001161404.1. [Q7Z4I7-3 ]
NP_001243471.1. NM_001256542.1. [Q7Z4I7-4 ]
NP_060450.2. NM_017980.4. [Q7Z4I7-2 ]
XP_005263766.1. XM_005263709.1. [Q7Z4I7-3 ]
UniGenei Hs.469881.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IXE X-ray 1.90 B 11-73 [» ]
ProteinModelPortali Q7Z4I7.
SMRi Q7Z4I7. Positions 11-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120808. 4 interactions.
IntActi Q7Z4I7. 4 interactions.
MINTi MINT-1194006.
STRINGi 9606.ENSP00000326888.

PTM databases

PhosphoSitei Q7Z4I7.

Polymorphism databases

DMDMi 74750091.

Proteomic databases

MaxQBi Q7Z4I7.
PaxDbi Q7Z4I7.
PRIDEi Q7Z4I7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000324938 ; ENSP00000326888 ; ENSG00000072163 . [Q7Z4I7-2 ]
ENST00000355119 ; ENSP00000347240 ; ENSG00000072163 . [Q7Z4I7-1 ]
ENST00000409254 ; ENSP00000386907 ; ENSG00000072163 . [Q7Z4I7-4 ]
ENST00000409286 ; ENSP00000386252 ; ENSG00000072163 . [Q7Z4I7-4 ]
ENST00000409455 ; ENSP00000386383 ; ENSG00000072163 . [Q7Z4I7-3 ]
ENST00000409754 ; ENSP00000386345 ; ENSG00000072163 . [Q7Z4I7-4 ]
ENST00000409808 ; ENSP00000386637 ; ENSG00000072163 . [Q7Z4I7-3 ]
ENST00000410011 ; ENSP00000387002 ; ENSG00000072163 . [Q7Z4I7-3 ]
ENST00000410038 ; ENSP00000386570 ; ENSG00000072163 . [Q7Z4I7-4 ]
ENST00000545738 ; ENSP00000443794 ; ENSG00000072163 . [Q7Z4I7-5 ]
GeneIDi 55679.
KEGGi hsa:55679.
UCSCi uc002tov.3. human. [Q7Z4I7-1 ]
uc002tox.3. human. [Q7Z4I7-2 ]
uc010yzm.2. human.

Organism-specific databases

CTDi 55679.
GeneCardsi GC02M128395.
HGNCi HGNC:16084. LIMS2.
HPAi HPA058340.
MIMi 607908. gene.
neXtProti NX_Q7Z4I7.
PharmGKBi PA30390.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263350.
GeneTreei ENSGT00760000118910.
HOVERGENi HBG000053.
InParanoidi Q7Z4I7.
OMAi ECFRCEL.
PhylomeDBi Q7Z4I7.
TreeFami TF314113.

Enzyme and pathway databases

Reactomei REACT_20649. Cell-extracellular matrix interactions.

Miscellaneous databases

EvolutionaryTracei Q7Z4I7.
GenomeRNAii 55679.
NextBioi 35473432.
PROi Q7Z4I7.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z4I7.
CleanExi HS_LIMS2.
ExpressionAtlasi Q7Z4I7. baseline and differential.
Genevestigatori Q7Z4I7.

Family and domain databases

Gene3Di 2.10.110.10. 5 hits.
InterProi IPR017351. PINCH.
IPR001781. Znf_LIM.
[Graphical view ]
PANTHERi PTHR24210. PTHR24210. 1 hit.
Pfami PF00412. LIM. 5 hits.
[Graphical view ]
PIRSFi PIRSF038003. PINCH. 1 hit.
SMARTi SM00132. LIM. 5 hits.
[Graphical view ]
PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration."
    Zhang Y., Chen K., Guo L., Wu C.
    J. Biol. Chem. 277:38328-38338(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ILK.
  2. "Cloning and characterization a novel human gene LIMS2."
    Zeng W., Zhu Y., Jiao W., Yuan W., Wu X.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. Ding P., Han W., Cheng Y., Qiu X., Song Q., Zhang Y., Ma D.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Tissue: Brain and Lung.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Placenta.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
    Tissue: Brain and Mammary gland.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: PNS.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-327 AND SER-328, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase."
    Chiswell B.P., Stiegler A.L., Razinia Z., Nalibotski E., Boggon T.J., Calderwood D.A.
    J. Struct. Biol. 170:157-163(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 11-73 IN COMPLEX WITH ILK, SUBUNIT.

Entry informationi

Entry nameiLIMS2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4I7
Secondary accession number(s): A6NLH0
, B4DMV1, F5H6E6, Q7Z4I2, Q7Z4I6, Q7Z4I8, Q8NFE7, Q9HA13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3