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Q7Z4I7

- LIMS2_HUMAN

UniProt

Q7Z4I7 - LIMS2_HUMAN

Protein

LIM and senescent cell antigen-like-containing domain protein 2

Gene

LIMS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.1 Publication

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell-cell junction organization Source: Ensembl
    2. cell junction assembly Source: Reactome
    3. positive regulation of integrin-mediated signaling pathway Source: Ensembl
    4. single organismal cell-cell adhesion Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20649. Cell-extracellular matrix interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM and senescent cell antigen-like-containing domain protein 2
    Alternative name(s):
    LIM-like protein 2
    Particularly interesting new Cys-His protein 2
    Short name:
    PINCH-2
    Gene namesi
    Name:LIMS2
    Synonyms:PINCH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16084. LIMS2.

    Subcellular locationi

    Nucleus Curated. Cell junctionfocal adhesion 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. focal adhesion Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30390.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341LIM and senescent cell antigen-like-containing domain protein 2PRO_0000266011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei327 – 3271Phosphothreonine1 Publication
    Modified residuei328 – 3281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z4I7.
    PaxDbiQ7Z4I7.
    PRIDEiQ7Z4I7.

    PTM databases

    PhosphoSiteiQ7Z4I7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z4I7.
    BgeeiQ7Z4I7.
    CleanExiHS_LIMS2.
    GenevestigatoriQ7Z4I7.

    Organism-specific databases

    HPAiHPA058340.

    Interactioni

    Subunit structurei

    Interacts with TGFB1I1 By similarity. Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi120808. 3 interactions.
    IntActiQ7Z4I7. 4 interactions.
    MINTiMINT-1194006.
    STRINGi9606.ENSP00000326888.

    Structurei

    Secondary structure

    1
    341
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni16 – 183
    Beta strandi29 – 313
    Beta strandi34 – 363
    Turni38 – 403
    Turni44 – 463
    Helixi51 – 533
    Beta strandi56 – 583
    Beta strandi61 – 633
    Helixi65 – 717

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IXEX-ray1.90B11-73[»]
    ProteinModelPortaliQ7Z4I7.
    SMRiQ7Z4I7. Positions 11-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7Z4I7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 7462LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini76 – 13358LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 19558LIM zinc-binding 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 25560LIM zinc-binding 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini256 – 31560LIM zinc-binding 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG263350.
    HOVERGENiHBG000053.
    OMAiECFRCEL.
    PhylomeDBiQ7Z4I7.
    TreeFamiTF314113.

    Family and domain databases

    Gene3Di2.10.110.10. 5 hits.
    InterProiIPR017351. PINCH.
    IPR001781. Znf_LIM.
    [Graphical view]
    PANTHERiPTHR24210. PTHR24210. 1 hit.
    PfamiPF00412. LIM. 5 hits.
    [Graphical view]
    PIRSFiPIRSF038003. PINCH. 1 hit.
    SMARTiSM00132. LIM. 5 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 5 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z4I7-1) [UniParc]FASTAAdd to Basket

    Also known as: LIM-like protein 2B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTGSNMSDAL ANAVCQRCQA RFSPAERIVN SNGELYHEHC FVCAQCFRPF    50
    PEGLFYEFEG RKYCEHDFQM LFAPCCGSCG EFIIGRVIKA MNNNWHPGCF 100
    RCELCDVELA DLGFVKNAGR HLCRPCHNRE KAKGLGKYIC QRCHLVIDEQ 150
    PLMFRSDAYH PDHFNCTHCG KELTAEAREL KGELYCLPCH DKMGVPICGA 200
    CRRPIEGRVV NALGKQWHVE HFVCAKCEKP FLGHRHYEKK GLAYCETHYN 250
    QLFGDVCYNC SHVIEGDVVS ALNKAWCVSC FSCSTCNSKL TLKNKFVEFD 300
    MKPVCKRCYE KFPLELKKRL KKLSELTSRK AQPKATDLNS A 341
    Length:341
    Mass (Da):38,916
    Last modified:October 1, 2003 - v1
    Checksum:iEEA8D74C309D9C8A
    GO
    Isoform 2 (identifier: Q7Z4I7-2) [UniParc]FASTAAdd to Basket

    Also known as: LIM-like protein 2A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MTGS → MAARLGALAASGLYRRRQHRQSPPPATG

    Show »
    Length:365
    Mass (Da):41,512
    Checksum:i3B8E1C98AFB2B698
    GO
    Isoform 3 (identifier: Q7Z4I7-3) [UniParc]FASTAAdd to Basket

    Also known as: LIM-like protein 2C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: Missing.

    Show »
    Length:336
    Mass (Da):38,426
    Checksum:i27F7EA97B557804D
    GO
    Isoform 4 (identifier: Q7Z4I7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-152: Missing.

    Show »
    Length:189
    Mass (Da):21,615
    Checksum:i896862131C240B5B
    GO
    Isoform 5 (identifier: Q7Z4I7-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3-3: G → GRKRKWGETGTGSGAAPAAALRW

    Note: No experimental confirmation available.

    Show »
    Length:363
    Mass (Da):41,226
    Checksum:iD0F6B8B3618F20FF
    GO

    Sequence cautioni

    The sequence AAM77350.1 differs from that shown. Reason: Frameshift at position 331.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1111D → G in BAG60013. (PubMed:14702039)Curated
    Sequence conflicti294 – 2941N → D in AAM97589. (PubMed:12167643)Curated
    Sequence conflicti294 – 2941N → D in BAB14047. (PubMed:15815621)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 152152Missing in isoform 4. 2 PublicationsVSP_045539Add
    BLAST
    Alternative sequencei1 – 55Missing in isoform 3. 2 PublicationsVSP_021916
    Alternative sequencei1 – 44MTGS → MAARLGALAASGLYRRRQHR QSPPPATG in isoform 2. 1 PublicationVSP_021917
    Alternative sequencei3 – 31G → GRKRKWGETGTGSGAAPAAA LRW in isoform 5. 1 PublicationVSP_046078

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484961 mRNA. Translation: AAM97589.1.
    AF520987 mRNA. Translation: AAM77350.1. Frameshift.
    AF527764 mRNA. Translation: AAQ09011.1.
    AF527765 mRNA. Translation: AAQ09012.1.
    AF527766 mRNA. Translation: AAQ09013.1.
    AF527770 mRNA. Translation: AAQ09017.1.
    AK022470 mRNA. Translation: BAB14047.1.
    AK297645 mRNA. Translation: BAG60013.1.
    BX458594 mRNA. No translation available.
    AC010976 Genomic DNA. No translation available.
    AC074114 Genomic DNA. No translation available.
    BC065816 mRNA. Translation: AAH65816.1.
    CCDSiCCDS2147.1. [Q7Z4I7-2]
    CCDS54394.1. [Q7Z4I7-3]
    CCDS54395.1. [Q7Z4I7-1]
    CCDS54396.1. [Q7Z4I7-5]
    CCDS58725.1. [Q7Z4I7-4]
    RefSeqiNP_001129509.2. NM_001136037.2. [Q7Z4I7-5]
    NP_001154875.1. NM_001161403.1. [Q7Z4I7-1]
    NP_001154876.1. NM_001161404.1. [Q7Z4I7-3]
    NP_001243471.1. NM_001256542.1. [Q7Z4I7-4]
    NP_060450.2. NM_017980.4. [Q7Z4I7-2]
    XP_005263766.1. XM_005263709.1. [Q7Z4I7-3]
    UniGeneiHs.469881.

    Genome annotation databases

    EnsembliENST00000324938; ENSP00000326888; ENSG00000072163. [Q7Z4I7-2]
    ENST00000355119; ENSP00000347240; ENSG00000072163. [Q7Z4I7-1]
    ENST00000409254; ENSP00000386907; ENSG00000072163. [Q7Z4I7-4]
    ENST00000409286; ENSP00000386252; ENSG00000072163. [Q7Z4I7-4]
    ENST00000409455; ENSP00000386383; ENSG00000072163. [Q7Z4I7-3]
    ENST00000409754; ENSP00000386345; ENSG00000072163. [Q7Z4I7-4]
    ENST00000409808; ENSP00000386637; ENSG00000072163. [Q7Z4I7-3]
    ENST00000410011; ENSP00000387002; ENSG00000072163. [Q7Z4I7-3]
    ENST00000410038; ENSP00000386570; ENSG00000072163. [Q7Z4I7-4]
    ENST00000545738; ENSP00000443794; ENSG00000072163. [Q7Z4I7-5]
    GeneIDi55679.
    KEGGihsa:55679.
    UCSCiuc002tov.3. human. [Q7Z4I7-1]
    uc002tox.3. human. [Q7Z4I7-2]
    uc010yzm.2. human.

    Polymorphism databases

    DMDMi74750091.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF484961 mRNA. Translation: AAM97589.1 .
    AF520987 mRNA. Translation: AAM77350.1 . Frameshift.
    AF527764 mRNA. Translation: AAQ09011.1 .
    AF527765 mRNA. Translation: AAQ09012.1 .
    AF527766 mRNA. Translation: AAQ09013.1 .
    AF527770 mRNA. Translation: AAQ09017.1 .
    AK022470 mRNA. Translation: BAB14047.1 .
    AK297645 mRNA. Translation: BAG60013.1 .
    BX458594 mRNA. No translation available.
    AC010976 Genomic DNA. No translation available.
    AC074114 Genomic DNA. No translation available.
    BC065816 mRNA. Translation: AAH65816.1 .
    CCDSi CCDS2147.1. [Q7Z4I7-2 ]
    CCDS54394.1. [Q7Z4I7-3 ]
    CCDS54395.1. [Q7Z4I7-1 ]
    CCDS54396.1. [Q7Z4I7-5 ]
    CCDS58725.1. [Q7Z4I7-4 ]
    RefSeqi NP_001129509.2. NM_001136037.2. [Q7Z4I7-5 ]
    NP_001154875.1. NM_001161403.1. [Q7Z4I7-1 ]
    NP_001154876.1. NM_001161404.1. [Q7Z4I7-3 ]
    NP_001243471.1. NM_001256542.1. [Q7Z4I7-4 ]
    NP_060450.2. NM_017980.4. [Q7Z4I7-2 ]
    XP_005263766.1. XM_005263709.1. [Q7Z4I7-3 ]
    UniGenei Hs.469881.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IXE X-ray 1.90 B 11-73 [» ]
    ProteinModelPortali Q7Z4I7.
    SMRi Q7Z4I7. Positions 11-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120808. 3 interactions.
    IntActi Q7Z4I7. 4 interactions.
    MINTi MINT-1194006.
    STRINGi 9606.ENSP00000326888.

    PTM databases

    PhosphoSitei Q7Z4I7.

    Polymorphism databases

    DMDMi 74750091.

    Proteomic databases

    MaxQBi Q7Z4I7.
    PaxDbi Q7Z4I7.
    PRIDEi Q7Z4I7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324938 ; ENSP00000326888 ; ENSG00000072163 . [Q7Z4I7-2 ]
    ENST00000355119 ; ENSP00000347240 ; ENSG00000072163 . [Q7Z4I7-1 ]
    ENST00000409254 ; ENSP00000386907 ; ENSG00000072163 . [Q7Z4I7-4 ]
    ENST00000409286 ; ENSP00000386252 ; ENSG00000072163 . [Q7Z4I7-4 ]
    ENST00000409455 ; ENSP00000386383 ; ENSG00000072163 . [Q7Z4I7-3 ]
    ENST00000409754 ; ENSP00000386345 ; ENSG00000072163 . [Q7Z4I7-4 ]
    ENST00000409808 ; ENSP00000386637 ; ENSG00000072163 . [Q7Z4I7-3 ]
    ENST00000410011 ; ENSP00000387002 ; ENSG00000072163 . [Q7Z4I7-3 ]
    ENST00000410038 ; ENSP00000386570 ; ENSG00000072163 . [Q7Z4I7-4 ]
    ENST00000545738 ; ENSP00000443794 ; ENSG00000072163 . [Q7Z4I7-5 ]
    GeneIDi 55679.
    KEGGi hsa:55679.
    UCSCi uc002tov.3. human. [Q7Z4I7-1 ]
    uc002tox.3. human. [Q7Z4I7-2 ]
    uc010yzm.2. human.

    Organism-specific databases

    CTDi 55679.
    GeneCardsi GC02M128395.
    HGNCi HGNC:16084. LIMS2.
    HPAi HPA058340.
    MIMi 607908. gene.
    neXtProti NX_Q7Z4I7.
    PharmGKBi PA30390.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263350.
    HOVERGENi HBG000053.
    OMAi ECFRCEL.
    PhylomeDBi Q7Z4I7.
    TreeFami TF314113.

    Enzyme and pathway databases

    Reactomei REACT_20649. Cell-extracellular matrix interactions.

    Miscellaneous databases

    EvolutionaryTracei Q7Z4I7.
    GenomeRNAii 55679.
    NextBioi 35473432.
    PROi Q7Z4I7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z4I7.
    Bgeei Q7Z4I7.
    CleanExi HS_LIMS2.
    Genevestigatori Q7Z4I7.

    Family and domain databases

    Gene3Di 2.10.110.10. 5 hits.
    InterProi IPR017351. PINCH.
    IPR001781. Znf_LIM.
    [Graphical view ]
    PANTHERi PTHR24210. PTHR24210. 1 hit.
    Pfami PF00412. LIM. 5 hits.
    [Graphical view ]
    PIRSFi PIRSF038003. PINCH. 1 hit.
    SMARTi SM00132. LIM. 5 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 4 hits.
    PS50023. LIM_DOMAIN_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration."
      Zhang Y., Chen K., Guo L., Wu C.
      J. Biol. Chem. 277:38328-38338(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ILK.
    2. "Cloning and characterization a novel human gene LIMS2."
      Zeng W., Zhu Y., Jiao W., Yuan W., Wu X.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. Ding P., Han W., Cheng Y., Qiu X., Song Q., Zhang Y., Ma D.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
      Tissue: Brain and Lung.
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
      Tissue: Brain and Mammary gland.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: PNS.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-327 AND SER-328, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase."
      Chiswell B.P., Stiegler A.L., Razinia Z., Nalibotski E., Boggon T.J., Calderwood D.A.
      J. Struct. Biol. 170:157-163(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 11-73 IN COMPLEX WITH ILK, SUBUNIT.

    Entry informationi

    Entry nameiLIMS2_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z4I7
    Secondary accession number(s): A6NLH0
    , B4DMV1, F5H6E6, Q7Z4I2, Q7Z4I6, Q7Z4I8, Q8NFE7, Q9HA13
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3