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Protein

Protein FAM220A

Gene

FAM220A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May negatively regulate STAT3.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM220A
Alternative name(s):
STAT3-interacting protein as a repressor
Gene namesi
Name:FAM220A
Synonyms:C7orf70, SIPAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22422. FAM220A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84792.
OpenTargetsiENSG00000178397.
PharmGKBiPA165617654.

Polymorphism and mutation databases

BioMutaiFAM220A.
DMDMi74713515.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219231 – 259Protein FAM220AAdd BLAST259

Proteomic databases

PaxDbiQ7Z4H9.
PRIDEiQ7Z4H9.

PTM databases

iPTMnetiQ7Z4H9.
PhosphoSitePlusiQ7Z4H9.

Expressioni

Gene expression databases

BgeeiENSG00000178397.
ExpressionAtlasiQ7Z4H9. baseline and differential.
GenevisibleiQ7Z4H9. HS.

Organism-specific databases

HPAiHPA055050.

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000317289.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZT7. Eukaryota.
ENOG4111MFX. LUCA.
GeneTreeiENSGT00390000014156.
HOGENOMiHOG000111641.
HOVERGENiHBG106751.
InParanoidiQ7Z4H9.
OrthoDBiEOG091G0LYI.
PhylomeDBiQ7Z4H9.
TreeFamiTF336869.

Family and domain databases

InterProiIPR029155. SIPAR.
[Graphical view]
PfamiPF15487. FAM220. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z4H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDRRGPLGT CLAQVQQAGG GDSDKLSCSL KKRMPEGPWP ADAPSWMNKP
60 70 80 90 100
VVDGNSQSEA LSLEMRKDPS GAGLWLHSGG PVLPYVRESV RRNPASAATP
110 120 130 140 150
STAVGLFPAP TECFARVSCS GVEALGRRDW LGGGPRATDG HRGQCPKGEP
160 170 180 190 200
RVSRLPRHQK VPEMGSFQDD PPSAFPKGLG SELEPACLHS ILSATLHVYP
210 220 230 240 250
EVLLSEETKR IFLDRLKPMF SKQTIEFKKM LKSTSDGLQI TLGLLALQPF

ELANTLCHS
Length:259
Mass (Da):28,021
Last modified:October 1, 2003 - v1
Checksum:iF649BE355ADBF5E9
GO

Sequence cautioni

The sequence AAS07509 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAG34819 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03937571G → R.Corresponds to variant rs3750041dbSNPEnsembl.1
Natural variantiVAR_039376127R → Q.2 PublicationsCorresponds to variant rs3750040dbSNPEnsembl.1
Natural variantiVAR_039377161V → L.2 PublicationsCorresponds to variant rs3750039dbSNPEnsembl.1
Natural variantiVAR_039378198V → M.2 PublicationsCorresponds to variant rs6952125dbSNPEnsembl.1
Natural variantiVAR_039379237G → S.Corresponds to variant rs2241445dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533707 mRNA. Translation: AAQ09020.1.
AK093156 mRNA. Translation: BAC04076.1.
AK311878 mRNA. Translation: BAG34819.1. Sequence problems.
AC009412 Genomic DNA. Translation: AAS07509.1. Sequence problems.
CH878731 Genomic DNA. Translation: EAW55045.1.
BC006110 mRNA. Translation: AAH06110.2.
BC142977 mRNA. Translation: AAI42978.1.
CCDSiCCDS34599.1.
RefSeqiNP_001032240.1. NM_001037163.1.
UniGeneiHs.696146.

Genome annotation databases

EnsembliENST00000313324; ENSP00000317289; ENSG00000178397.
ENST00000616824; ENSP00000483140; ENSG00000178397.
GeneIDi84792.
KEGGihsa:84792.
UCSCiuc003spu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533707 mRNA. Translation: AAQ09020.1.
AK093156 mRNA. Translation: BAC04076.1.
AK311878 mRNA. Translation: BAG34819.1. Sequence problems.
AC009412 Genomic DNA. Translation: AAS07509.1. Sequence problems.
CH878731 Genomic DNA. Translation: EAW55045.1.
BC006110 mRNA. Translation: AAH06110.2.
BC142977 mRNA. Translation: AAI42978.1.
CCDSiCCDS34599.1.
RefSeqiNP_001032240.1. NM_001037163.1.
UniGeneiHs.696146.

3D structure databases

ProteinModelPortaliQ7Z4H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317289.

PTM databases

iPTMnetiQ7Z4H9.
PhosphoSitePlusiQ7Z4H9.

Polymorphism and mutation databases

BioMutaiFAM220A.
DMDMi74713515.

Proteomic databases

PaxDbiQ7Z4H9.
PRIDEiQ7Z4H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313324; ENSP00000317289; ENSG00000178397.
ENST00000616824; ENSP00000483140; ENSG00000178397.
GeneIDi84792.
KEGGihsa:84792.
UCSCiuc003spu.3. human.

Organism-specific databases

CTDi84792.
DisGeNETi84792.
GeneCardsiFAM220A.
HGNCiHGNC:22422. FAM220A.
HPAiHPA055050.
MIMi616628. gene.
neXtProtiNX_Q7Z4H9.
OpenTargetsiENSG00000178397.
PharmGKBiPA165617654.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZT7. Eukaryota.
ENOG4111MFX. LUCA.
GeneTreeiENSGT00390000014156.
HOGENOMiHOG000111641.
HOVERGENiHBG106751.
InParanoidiQ7Z4H9.
OrthoDBiEOG091G0LYI.
PhylomeDBiQ7Z4H9.
TreeFamiTF336869.

Miscellaneous databases

GenomeRNAii84792.
PROiQ7Z4H9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178397.
ExpressionAtlasiQ7Z4H9. baseline and differential.
GenevisibleiQ7Z4H9. HS.

Family and domain databases

InterProiIPR029155. SIPAR.
[Graphical view]
PfamiPF15487. FAM220. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF220A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4H9
Secondary accession number(s): Q75ML2, Q8NA52, Q9BRR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.