Q7Z4H3 (HDDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HD domain-containing protein 2

Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 2
Short name=HCV NS5A-transactivated protein 2

Gene names

Name:	HDDC2
Synonyms:	C6orf74, NS5ATP2
ORF Names:	CGI-130

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the HDDC2 family. Contains 1 HD domain.
Sequence caution	The sequence AAH03357.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoric diester hydrolase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q76353	2	EBI-6163836,EBI-6248077	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4H3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4H3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     70-103: Missing.

Isoform 3 (identifier: Q7Z4H3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     70-71: CV → KL
     72-204: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 204

204

HD domain-containing protein 2

PRO_0000311389

Regions

Domain

46 – 148

103

HD

Natural variations

Alternative sequence

70 – 103

34

Missing in isoform 2.

VSP_029556

Alternative sequence

70 – 71

2

CV → KL in isoform 3.

VSP_029557

Alternative sequence

72 – 204

133

Missing in isoform 3.

VSP_029558

Natural variant

64

1

R → C.
Corresponds to variant rs12213371 [ dbSNP | Ensembl ].

VAR_037238

Experimental info

Sequence conflict

69

1

R → P in AAD34125. Ref.2

Sequence conflict

131

1

Q → R in AAH66332. Ref.5

Secondary structure

1

.

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.

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.

.

.

.

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204

Helix Strand Turn

Details...

Helix

14 – 26

13

Helix

33 – 37

5

Helix

46 – 59

14

Helix

67 – 76

10

Turn

77 – 80

4

Helix

81 – 84

4

Helix

89 – 91

3

Helix

95 – 110

16

Helix

115 – 130

16

Helix

134 – 158

25

Turn

161 – 164

4

Helix

165 – 170

6

Turn

171 – 173

3

Helix

178 – 199

22

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: E59D03224F8D6A16	FASTA	204	23,390
	10 20 30 40 50 60 MASVSSATFS GHGARSLLQF LRLVGQLKRV PRTGWVYRNV QRPESVSDHM YRMAVMAMVI 70 80 90 100 110 120 KDDRLNKDRC VRLALVHDMA ECIVGDIAPA DNIPKEEKHR REEEAMKQIT QLLPEDLRKE 130 140 150 160 170 180 LYELWEEYET QSSAEAKFVK QLDQCEMILQ ASEYEDLEHK PGRLQDFYDS TAGKFNHPEI 190 200 VQLVSELEAE RSTNIAAAAS EPHS
	Isoform 2 [UniParc]. Checksum: 9A9D8CC4BC1D9880	FASTA	170	19,550
	10 20 30 40 50 60 MASVSSATFS GHGARSLLQF LRLVGQLKRV PRTGWVYRNV QRPESVSDHM YRMAVMAMVI 70 80 90 100 110 120 KDDRLNKDRE AMKQITQLLP EDLRKELYEL WEEYETQSSA EAKFVKQLDQ CEMILQASEY 130 140 150 160 170 EDLEHKPGRL QDFYDSTAGK FNHPEIVQLV SELEAERSTN IAAAASEPHS
	Isoform 3 [UniParc]. Checksum: 98C8E6489460CB43	FASTA	71	8,164
	10 20 30 40 50 60 MASVSSATFS GHGARSLLQF LRLVGQLKRV PRTGWVYRNV QRPESVSDHM YRMAVMAMVI 70 KDDRLNKDRK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and identification of NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A." Yang Q., Cheng J., Liu Y., Hong Y., Wang J.-J., Zhang S.-L. World J. Gastroenterol. 10:1735-1739(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hepatoma.
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Lung and Placenta.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"Northeast structural genomics consortium target HR6723." Northeast structural genomics consortium (NESG) Submitted (APR-2012) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF529363 mRNA. Translation: AAQ09597.1.
AF151888 mRNA. Translation: AAD34125.1.
AL121938 Genomic DNA. Translation: CAI19646.1.
CH471051 Genomic DNA. Translation: EAW48138.1.
BC001671 mRNA. Translation: AAH01671.1.
BC003357 mRNA. Translation: AAH03357.2. Different initiation.
BC066332 mRNA. Translation: AAH66332.1.

IPI

IPI00386751.
IPI00783518.
IPI00872352.

RefSeq

NP_057147.2. NM_016063.2.

UniGene

Hs.32826.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DMB	X-ray	1.90	A/B	1-204	[»]

ProteinModelPortal

Q7Z4H3.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q7Z4H3. 1 interaction.

STRING

9606.ENSP00000381220.

PTM databases

PhosphoSite

Q7Z4H3.

Polymorphism databases

DMDM

74713511.

2D gel databases

REPRODUCTION-2DPAGE

IPI00386751.

Proteomic databases

PaxDb

Q7Z4H3.

PRIDE

Q7Z4H3.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000318787; ENSP00000316242; ENSG00000111906.
ENST00000368377; ENSP00000357361; ENSG00000111906.
ENST00000398153; ENSP00000381220; ENSG00000111906.

GeneID

51020.

KEGG

hsa:51020.

UCSC

uc003qaa.1. human.

Organism-specific databases

CTD

51020.

GeneCards

GC06M125596.

HGNC

HGNC:21078. HDDC2.

HPA

HPA035677.

neXtProt

NX_Q7Z4H3.

PharmGKB

PA134943525.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1896.

HOGENOM

HOG000216981.

HOVERGEN

HBG097476.

InParanoid

Q7Z4H3.

KO

K07023.

OMA

VHDIGEA.

PhylomeDB

Q7Z4H3.

Gene expression databases

ArrayExpress

Q7Z4H3.

Bgee

Q7Z4H3.

CleanEx

HS_HDDC2.

Genevestigator

Q7Z4H3.

Family and domain databases

Gene3D

1.10.3210.10. 1 hit.

InterPro

IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]

Pfam

PF13023. HD_3. 1 hit.
[Graphical view]

SMART

SM00471. HDc. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HDDC2. human.

GenomeRNAi

51020.

NextBio

53540.

Entry information

Entry name

HDDC2_HUMAN

Accession

Primary (citable) accession number: Q7Z4H3
Secondary accession number(s): Q5TDQ4 , Q6NZ49, Q9BTT2, Q9BV31, Q9Y3D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.