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Protein

HD domain-containing protein 2

Gene

HDDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
HD domain-containing protein 2
Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 2
Short name:
HCV NS5A-transactivated protein 2
Gene namesi
Name:HDDC2
Synonyms:C6orf74, NS5ATP2
ORF Names:CGI-130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21078. HDDC2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111906.
PharmGKBiPA134943525.

Polymorphism and mutation databases

BioMutaiHDDC2.
DMDMi74713511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003113892 – 204HD domain-containing protein 2Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z4H3.
MaxQBiQ7Z4H3.
PaxDbiQ7Z4H3.
PeptideAtlasiQ7Z4H3.
PRIDEiQ7Z4H3.

2D gel databases

REPRODUCTION-2DPAGEIPI00386751.

PTM databases

iPTMnetiQ7Z4H3.
PhosphoSitePlusiQ7Z4H3.

Expressioni

Gene expression databases

BgeeiENSG00000111906.
CleanExiHS_HDDC2.
ExpressionAtlasiQ7Z4H3. baseline and differential.
GenevisibleiQ7Z4H3. HS.

Organism-specific databases

HPAiHPA035677.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q763532EBI-6163836,EBI-6248077From a different organism.

Protein-protein interaction databases

BioGridi119226. 2 interactors.
IntActiQ7Z4H3. 2 interactors.
STRINGi9606.ENSP00000381220.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 25Combined sources12
Helixi26 – 29Combined sources4
Helixi33 – 36Combined sources4
Turni37 – 39Combined sources3
Helixi46 – 59Combined sources14
Helixi67 – 76Combined sources10
Turni77 – 80Combined sources4
Helixi81 – 84Combined sources4
Helixi89 – 91Combined sources3
Helixi95 – 110Combined sources16
Helixi115 – 130Combined sources16
Helixi134 – 158Combined sources25
Turni161 – 164Combined sources4
Helixi165 – 171Combined sources7
Helixi178 – 199Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DMBX-ray1.90A/B1-204[»]
4L1JX-ray1.82A/B1-204[»]
4L7EX-ray2.23A/B1-204[»]
4L7WX-ray2.30A1-204[»]
ProteinModelPortaliQ7Z4H3.
SMRiQ7Z4H3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 148HDAdd BLAST103

Sequence similaritiesi

Belongs to the HDDC2 family.Curated
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiKOG3197. Eukaryota.
COG1896. LUCA.
GeneTreeiENSGT00390000009937.
HOGENOMiHOG000216981.
HOVERGENiHBG097476.
InParanoidiQ7Z4H3.
KOiK07023.
OMAiSTAGRFH.
OrthoDBiEOG091G0N2F.
PhylomeDBiQ7Z4H3.
TreeFamiTF313855.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF13023. HD_3. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4H3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVSSATFS GHGARSLLQF LRLVGQLKRV PRTGWVYRNV QRPESVSDHM
60 70 80 90 100
YRMAVMAMVI KDDRLNKDRC VRLALVHDMA ECIVGDIAPA DNIPKEEKHR
110 120 130 140 150
REEEAMKQIT QLLPEDLRKE LYELWEEYET QSSAEAKFVK QLDQCEMILQ
160 170 180 190 200
ASEYEDLEHK PGRLQDFYDS TAGKFNHPEI VQLVSELEAE RSTNIAAAAS

EPHS
Length:204
Mass (Da):23,390
Last modified:October 1, 2003 - v1
Checksum:iE59D03224F8D6A16
GO
Isoform 2 (identifier: Q7Z4H3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-103: Missing.

Show »
Length:170
Mass (Da):19,550
Checksum:i9A9D8CC4BC1D9880
GO
Isoform 3 (identifier: Q7Z4H3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-71: CV → KL
     72-204: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:71
Mass (Da):8,164
Checksum:i98C8E6489460CB43
GO

Sequence cautioni

The sequence AAD34125 differs from that shown. Correction of a non-canonical splice junction.Curated
The sequence AAH03357 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69R → P in AAD34125 (PubMed:10810093).Curated1
Sequence conflicti131Q → R in AAH66332 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03723864R → C.Corresponds to variant rs12213371dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02955670 – 103Missing in isoform 2. CuratedAdd BLAST34
Alternative sequenceiVSP_02955770 – 71CV → KL in isoform 3. 2 Publications2
Alternative sequenceiVSP_02955872 – 204Missing in isoform 3. 2 PublicationsAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529363 mRNA. Translation: AAQ09597.1.
AF151888 mRNA. Translation: AAD34125.1. Sequence problems.
AL121938 Genomic DNA. Translation: CAI19646.1.
CH471051 Genomic DNA. Translation: EAW48138.1.
BC001671 mRNA. Translation: AAH01671.1.
BC003357 mRNA. Translation: AAH03357.2. Different initiation.
BC066332 mRNA. Translation: AAH66332.1.
CCDSiCCDS43503.1. [Q7Z4H3-1]
RefSeqiNP_057147.2. NM_016063.2. [Q7Z4H3-1]
UniGeneiHs.32826.

Genome annotation databases

EnsembliENST00000318787; ENSP00000316242; ENSG00000111906. [Q7Z4H3-3]
ENST00000398153; ENSP00000381220; ENSG00000111906. [Q7Z4H3-1]
ENST00000609477; ENSP00000476969; ENSG00000111906. [Q7Z4H3-3]
GeneIDi51020.
KEGGihsa:51020.
UCSCiuc003qaa.2. human. [Q7Z4H3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF529363 mRNA. Translation: AAQ09597.1.
AF151888 mRNA. Translation: AAD34125.1. Sequence problems.
AL121938 Genomic DNA. Translation: CAI19646.1.
CH471051 Genomic DNA. Translation: EAW48138.1.
BC001671 mRNA. Translation: AAH01671.1.
BC003357 mRNA. Translation: AAH03357.2. Different initiation.
BC066332 mRNA. Translation: AAH66332.1.
CCDSiCCDS43503.1. [Q7Z4H3-1]
RefSeqiNP_057147.2. NM_016063.2. [Q7Z4H3-1]
UniGeneiHs.32826.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DMBX-ray1.90A/B1-204[»]
4L1JX-ray1.82A/B1-204[»]
4L7EX-ray2.23A/B1-204[»]
4L7WX-ray2.30A1-204[»]
ProteinModelPortaliQ7Z4H3.
SMRiQ7Z4H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119226. 2 interactors.
IntActiQ7Z4H3. 2 interactors.
STRINGi9606.ENSP00000381220.

PTM databases

iPTMnetiQ7Z4H3.
PhosphoSitePlusiQ7Z4H3.

Polymorphism and mutation databases

BioMutaiHDDC2.
DMDMi74713511.

2D gel databases

REPRODUCTION-2DPAGEIPI00386751.

Proteomic databases

EPDiQ7Z4H3.
MaxQBiQ7Z4H3.
PaxDbiQ7Z4H3.
PeptideAtlasiQ7Z4H3.
PRIDEiQ7Z4H3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318787; ENSP00000316242; ENSG00000111906. [Q7Z4H3-3]
ENST00000398153; ENSP00000381220; ENSG00000111906. [Q7Z4H3-1]
ENST00000609477; ENSP00000476969; ENSG00000111906. [Q7Z4H3-3]
GeneIDi51020.
KEGGihsa:51020.
UCSCiuc003qaa.2. human. [Q7Z4H3-1]

Organism-specific databases

CTDi51020.
GeneCardsiHDDC2.
HGNCiHGNC:21078. HDDC2.
HPAiHPA035677.
neXtProtiNX_Q7Z4H3.
OpenTargetsiENSG00000111906.
PharmGKBiPA134943525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3197. Eukaryota.
COG1896. LUCA.
GeneTreeiENSGT00390000009937.
HOGENOMiHOG000216981.
HOVERGENiHBG097476.
InParanoidiQ7Z4H3.
KOiK07023.
OMAiSTAGRFH.
OrthoDBiEOG091G0N2F.
PhylomeDBiQ7Z4H3.
TreeFamiTF313855.

Miscellaneous databases

ChiTaRSiHDDC2. human.
GenomeRNAii51020.
PROiQ7Z4H3.

Gene expression databases

BgeeiENSG00000111906.
CleanExiHS_HDDC2.
ExpressionAtlasiQ7Z4H3. baseline and differential.
GenevisibleiQ7Z4H3. HS.

Family and domain databases

Gene3Di1.10.3210.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
[Graphical view]
PfamiPF13023. HD_3. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDDC2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4H3
Secondary accession number(s): Q5TDQ4
, Q6NZ49, Q9BTT2, Q9BV31, Q9Y3D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.