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Protein

tRNA (guanine(10)-N2)-methyltransferase homolog

Gene

TRMT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine(10)-N2)-methyltransferase homolog (EC:2.1.1.-)
Alternative name(s):
tRNA guanosine-2'-O-methyltransferase TRM11 homolog
Gene namesi
Name:TRMT11
Synonyms:C6orf75
ORF Names:MDS024
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21080. TRMT11.

Pathology & Biotechi

Organism-specific databases

DisGeNETi60487.
OpenTargetsiENSG00000066651.
PharmGKBiPA162407032.

Polymorphism and mutation databases

BioMutaiTRMT11.
DMDMi74723330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002302882 – 463tRNA (guanine(10)-N2)-methyltransferase homologAdd BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z4G4.
MaxQBiQ7Z4G4.
PaxDbiQ7Z4G4.
PeptideAtlasiQ7Z4G4.
PRIDEiQ7Z4G4.

PTM databases

iPTMnetiQ7Z4G4.
PhosphoSitePlusiQ7Z4G4.

Expressioni

Gene expression databases

BgeeiENSG00000066651.
CleanExiHS_TRMT11.
ExpressionAtlasiQ7Z4G4. baseline and differential.
GenevisibleiQ7Z4G4. HS.

Interactioni

Protein-protein interaction databases

BioGridi121918. 10 interactors.
IntActiQ7Z4G4. 1 interactor.
STRINGi9606.ENSP00000333934.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4G4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2671. Eukaryota.
COG1041. LUCA.
GeneTreeiENSGT00390000018131.
HOGENOMiHOG000191866.
HOVERGENiHBG097974.
InParanoidiQ7Z4G4.
KOiK15430.
OMAiIDYNTIH.
OrthoDBiEOG091G0JCZ.
PhylomeDBiQ7Z4G4.
TreeFamiTF106161.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR016691. tRNA_mtfrase_TRM11.
[Graphical view]
PfamiPF01170. UPF0020. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
PS51627. SAM_MT_TRM11. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSCTLNRY LLLMAQEHLE FRLPEIKSLL LLFGGQFASS QETYGKSPFW
60 70 80 90 100
ILSIPSEDIA RNLMKRTVCA KSIFELWGHG QSPEELYSSL KNYPVEKMVP
110 120 130 140 150
FLHSDSTYKI KIHTFNKTLT QEEKIKRIDA LEFLPFEGKV NLKKPQHVFS
160 170 180 190 200
VLEDYGLDPN CIPENPHNIY FGRWIADGQR ELIESYSVKK RHFIGNTSMD
210 220 230 240 250
AGLSFIMANH GKVKENDIVF DPFVGTGGLL IACAHFGAYV YGTDIDYNTV
260 270 280 290 300
HGLGKATRKN QKWRGPDENI RANLRQYGLE KYYLDVLVSD ASKPSWRKGT
310 320 330 340 350
YFDAIITDPP YGIRESTRRT GSQKEIPKGI EKWEKCPESH VPVSLSYHLS
360 370 380 390 400
DMFLDLLNFA AETLVLGGRL VYWLPVYTPE YTEEMVPWHP CLELVSNCEQ
410 420 430 440 450
KLSSHTSRRL ITMEKVKKFE NRDQYSHLLS DHFLPYQGHN SFREKYFSGV
460
TKRIAKEEKS TQE
Length:463
Mass (Da):53,421
Last modified:October 1, 2003 - v1
Checksum:iD3DE2AB403F0A84C
GO
Isoform 2 (identifier: Q7Z4G4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     416-420: Missing.

Note: No experimental confirmation available.
Show »
Length:458
Mass (Da):52,789
Checksum:i71FBE63A1B8EA7CF
GO
Isoform 3 (identifier: Q7Z4G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-257: GKAT → ACST
     258-463: Missing.

Show »
Length:257
Mass (Da):29,193
Checksum:i0F896BC89EFE9B59
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025786230L → Q.1 PublicationCorresponds to variant rs17854915dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017816254 – 257GKAT → ACST in isoform 3. 1 Publication4
Alternative sequenceiVSP_017817258 – 463Missing in isoform 3. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_017818416 – 420Missing in isoform 2. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532977 mRNA. Translation: AAQ10284.1.
AF182423 mRNA. Translation: AAG14959.1.
AL035689 Genomic DNA. Translation: CAI42394.1.
CH471051 Genomic DNA. Translation: EAW48125.1.
CH471051 Genomic DNA. Translation: EAW48126.1.
BC056878 mRNA. Translation: AAH56878.1.
CCDSiCCDS35496.1. [Q7Z4G4-1]
RefSeqiNP_001026882.2. NM_001031712.2. [Q7Z4G4-1]
UniGeneiHs.404186.

Genome annotation databases

EnsembliENST00000334379; ENSP00000333934; ENSG00000066651. [Q7Z4G4-1]
ENST00000368332; ENSP00000357316; ENSG00000066651. [Q7Z4G4-2]
ENST00000479748; ENSP00000433724; ENSG00000066651. [Q7Z4G4-3]
GeneIDi60487.
KEGGihsa:60487.
UCSCiuc003qam.4. human. [Q7Z4G4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532977 mRNA. Translation: AAQ10284.1.
AF182423 mRNA. Translation: AAG14959.1.
AL035689 Genomic DNA. Translation: CAI42394.1.
CH471051 Genomic DNA. Translation: EAW48125.1.
CH471051 Genomic DNA. Translation: EAW48126.1.
BC056878 mRNA. Translation: AAH56878.1.
CCDSiCCDS35496.1. [Q7Z4G4-1]
RefSeqiNP_001026882.2. NM_001031712.2. [Q7Z4G4-1]
UniGeneiHs.404186.

3D structure databases

ProteinModelPortaliQ7Z4G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121918. 10 interactors.
IntActiQ7Z4G4. 1 interactor.
STRINGi9606.ENSP00000333934.

PTM databases

iPTMnetiQ7Z4G4.
PhosphoSitePlusiQ7Z4G4.

Polymorphism and mutation databases

BioMutaiTRMT11.
DMDMi74723330.

Proteomic databases

EPDiQ7Z4G4.
MaxQBiQ7Z4G4.
PaxDbiQ7Z4G4.
PeptideAtlasiQ7Z4G4.
PRIDEiQ7Z4G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334379; ENSP00000333934; ENSG00000066651. [Q7Z4G4-1]
ENST00000368332; ENSP00000357316; ENSG00000066651. [Q7Z4G4-2]
ENST00000479748; ENSP00000433724; ENSG00000066651. [Q7Z4G4-3]
GeneIDi60487.
KEGGihsa:60487.
UCSCiuc003qam.4. human. [Q7Z4G4-1]

Organism-specific databases

CTDi60487.
DisGeNETi60487.
GeneCardsiTRMT11.
HGNCiHGNC:21080. TRMT11.
neXtProtiNX_Q7Z4G4.
OpenTargetsiENSG00000066651.
PharmGKBiPA162407032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2671. Eukaryota.
COG1041. LUCA.
GeneTreeiENSGT00390000018131.
HOGENOMiHOG000191866.
HOVERGENiHBG097974.
InParanoidiQ7Z4G4.
KOiK15430.
OMAiIDYNTIH.
OrthoDBiEOG091G0JCZ.
PhylomeDBiQ7Z4G4.
TreeFamiTF106161.

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Miscellaneous databases

GenomeRNAii60487.
PROiQ7Z4G4.

Gene expression databases

BgeeiENSG00000066651.
CleanExiHS_TRMT11.
ExpressionAtlasiQ7Z4G4. baseline and differential.
GenevisibleiQ7Z4G4. HS.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR016691. tRNA_mtfrase_TRM11.
[Graphical view]
PfamiPF01170. UPF0020. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
PS51627. SAM_MT_TRM11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM11_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4G4
Secondary accession number(s): E1P570
, Q5JY11, Q6PGQ5, Q9HC13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.