Q7Z4G1 (COMD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: COMM domain-containing protein 6 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 85 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. Ref.1 Ref.5 |
| Subunit structure | Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Does not interact with NFKBIB. Ref.1 Ref.5 |
| Subcellular location | |
| Tissue specificity | Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. Ref.1 Ref.5 |
| Sequence similarities | Contains 1 COMM domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Alternative splicing Polymorphism |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from physical interaction Ref.1. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| COMMD1 | Q8N668 | 2 | EBI-1550081,EBI-1550112 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q7Z4G1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q7Z4G1-2) The sequence of this isoform differs from the canonical sequence as follows: 69-69: Q → QPQLLATSSLLSAS |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 85 | 85 | COMM domain-containing protein 6 | PRO_0000077398 | |||||
Regions | |||||||||
| Domain | 18 – 85 | 68 | COMM | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1 | 1 | N-acetylmethionine Ref.6 | ||||||
Natural variations | |||||||||
| Alternative sequence | 69 | 1 | Q → QPQLLATSSLLSAS in isoform 2. | VSP_026593 | |||||
| Natural variant | 52 | 1 | H → N. Corresponds to variant rs1063485 [ dbSNP | Ensembl ]. | VAR_048813 | |||||
Experimental info | |||||||||
| Mutagenesis | 24 | 1 | W → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-41. Ref.5 | ||||||
| Mutagenesis | 41 | 1 | P → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-24. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY. |
| [2] | Qin B.M., Sheng H., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Zhang Q., Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Xu H.S., Chen J.Z., Cai M.Q., Zheng W.Y. Hui R.T.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Aorta. |
| [3] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [5] | "Characterization of COMMD protein-protein interactions in NF-kappaB signalling." de Bie P., van de Sluis B., Burstein E., Duran K.J., Berger R., Duckett C.S., Wijmenga C., Klomp L.W. Biochem. J. 398:63-71(2006) [PubMed: 16573520] [Abstract] Cited for: FUNCTION, INTERACTION WITH COMMD1, SUBUNIT, MUTAGENESIS OF TRP-24 AND PRO-41, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORM 2). |
| [6] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. Tissue: Embryonic kidney. |
| [7] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY542161 mRNA. Translation: AAS22243.1. AF169971 mRNA. Translation: AAQ13599.1. AL137244 Genomic DNA. Translation: CAI12417.1. AL137244 Genomic DNA. Translation: CAQ09795.1. BC117391 mRNA. Translation: AAI17392.1. BC143912 mRNA. Translation: AAI43913.1. BC171758 mRNA. Translation: AAI71758.1. |
| IPI | IPI00375957. IPI00409561. |
| RefSeq | NP_987091.1. NM_203495.2. NP_987093.1. NM_203497.2. |
| UniGene | Hs.508266. |
3D structure databases | |
| ProteinModelPortal | Q7Z4G1. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q7Z4G1. 4 interactions. |
| STRING | Q7Z4G1. |
PTM databases | |
| PhosphoSite | Q7Z4G1. |
Polymorphism databases | |
| DMDM | 51315937. |
Proteomic databases | |
| PRIDE | Q7Z4G1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000377615; ENSP00000366841; ENSG00000188243. ENST00000406936; ENSP00000385660; ENSG00000188243. |
| GeneID | 170622. |
| KEGG | hsa:170622. |
| UCSC | uc001vjn.1. human. uc001vjo.1. human. |
Organism-specific databases | |
| CTD | 170622. |
| GeneCards | GC13M076099. |
| H-InvDB | HIX0011375. |
| HGNC | HGNC:24015. COMMD6. |
| MIM | 612377. gene. |
| neXtProt | NX_Q7Z4G1. |
| PharmGKB | PA134906013. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG21080. |
| GeneTree | ENSGT00390000018369. |
| HOVERGEN | HBG051071. |
| InParanoid | Q7Z4G1. |
| OMA | KSEVTNQ. |
| OrthoDB | EOG4THVVG. |
Gene expression databases | |
| ArrayExpress | Q7Z4G1. |
| Bgee | Q7Z4G1. |
| CleanEx | HS_COMMD6. |
| Genevestigator | Q7Z4G1. |
| GermOnline | ENSG00000188243. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR017920. COMM. IPR009886. HCaRG. [Graphical view] |
| Pfam | PF07258. HCaRG. 1 hit. [Graphical view] |
| PROSITE | PS51269. COMM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 89064. |
| SOURCE | Search... |
Entry information
| Entry name | COMD6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q7Z4G1 Secondary accession number(s): A6NF28, B7ZLN0, Q5TBK4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with