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Protein

COMM domain-containing protein 6

Gene

COMMD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.1 Publication2 Publications

GO - Molecular functioni

  • NF-kappaB binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:G66-31333-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 6
Gene namesi
Name:COMMD6
ORF Names:MSTP076
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:24015. COMMD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi24W → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-41. 1 Publication1
Mutagenesisi41P → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-24. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000188243.
PharmGKBiPA134906013.

Polymorphism and mutation databases

DMDMi51315937.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773981 – 85COMM domain-containing protein 6Add BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z4G1.
MaxQBiQ7Z4G1.
PeptideAtlasiQ7Z4G1.
PRIDEiQ7Z4G1.

PTM databases

iPTMnetiQ7Z4G1.
PhosphoSitePlusiQ7Z4G1.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta.2 Publications

Gene expression databases

BgeeiENSG00000188243.
CleanExiHS_COMMD6.
ExpressionAtlasiQ7Z4G1. baseline and differential.
GenevisibleiQ7Z4G1. HS.

Organism-specific databases

HPAiHPA060266.

Interactioni

Subunit structurei

Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22, CCDC93, SCNN1B, CUL4A.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC22O608267EBI-1550081,EBI-3943153
COMMD1Q8N66816EBI-1550081,EBI-1550112

GO - Molecular functioni

  • NF-kappaB binding Source: MGI

Protein-protein interaction databases

BioGridi128071. 30 interactors.
IntActiQ7Z4G1. 12 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ7Z4G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 85COMMPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018369.
HOGENOMiHOG000038017.
HOVERGENiHBG051071.
InParanoidiQ7Z4G1.
OMAiKSQVTNQ.
PhylomeDBiQ7Z4G1.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. COMM_domain. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4G1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEASSEPPLD AKSDVTNQLV DFQWKLGMAV SSDTCRSLKY PYVAVMLKVA
60 70 80
DHSGQVKTKC FEMTIPQFQN FYRQFKEIAA VIETV
Length:85
Mass (Da):9,638
Last modified:October 1, 2003 - v1
Checksum:iFBF29F240EA8756B
GO
Isoform 2 (identifier: Q7Z4G1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: Q → QPQLLATSSLLSAS

Show »
Length:98
Mass (Da):10,908
Checksum:iBADF400B61D3C3FB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04881352H → N.Corresponds to variant rs1063485dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02659369Q → QPQLLATSSLLSAS in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542161 mRNA. Translation: AAS22243.1.
AF169971 mRNA. Translation: AAQ13599.1.
AL137244 Genomic DNA. Translation: CAI12417.1.
AL137244 Genomic DNA. Translation: CAQ09795.1.
BC117391 mRNA. Translation: AAI17392.1.
BC143912 mRNA. Translation: AAI43913.1.
BC171758 mRNA. Translation: AAI71758.1.
CCDSiCCDS9451.1. [Q7Z4G1-1]
CCDS9452.1. [Q7Z4G1-2]
RefSeqiNP_987091.1. NM_203495.3. [Q7Z4G1-1]
NP_987093.1. NM_203497.3. [Q7Z4G1-2]
UniGeneiHs.508266.
Hs.713055.

Genome annotation databases

EnsembliENST00000355801; ENSP00000348054; ENSG00000188243. [Q7Z4G1-2]
ENST00000377615; ENSP00000366841; ENSG00000188243. [Q7Z4G1-1]
ENST00000406936; ENSP00000385660; ENSG00000188243. [Q7Z4G1-1]
GeneIDi170622.
KEGGihsa:170622.
UCSCiuc001vjn.3. human. [Q7Z4G1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542161 mRNA. Translation: AAS22243.1.
AF169971 mRNA. Translation: AAQ13599.1.
AL137244 Genomic DNA. Translation: CAI12417.1.
AL137244 Genomic DNA. Translation: CAQ09795.1.
BC117391 mRNA. Translation: AAI17392.1.
BC143912 mRNA. Translation: AAI43913.1.
BC171758 mRNA. Translation: AAI71758.1.
CCDSiCCDS9451.1. [Q7Z4G1-1]
CCDS9452.1. [Q7Z4G1-2]
RefSeqiNP_987091.1. NM_203495.3. [Q7Z4G1-1]
NP_987093.1. NM_203497.3. [Q7Z4G1-2]
UniGeneiHs.508266.
Hs.713055.

3D structure databases

ProteinModelPortaliQ7Z4G1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128071. 30 interactors.
IntActiQ7Z4G1. 12 interactors.

PTM databases

iPTMnetiQ7Z4G1.
PhosphoSitePlusiQ7Z4G1.

Polymorphism and mutation databases

DMDMi51315937.

Proteomic databases

EPDiQ7Z4G1.
MaxQBiQ7Z4G1.
PeptideAtlasiQ7Z4G1.
PRIDEiQ7Z4G1.

Protocols and materials databases

DNASUi170622.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355801; ENSP00000348054; ENSG00000188243. [Q7Z4G1-2]
ENST00000377615; ENSP00000366841; ENSG00000188243. [Q7Z4G1-1]
ENST00000406936; ENSP00000385660; ENSG00000188243. [Q7Z4G1-1]
GeneIDi170622.
KEGGihsa:170622.
UCSCiuc001vjn.3. human. [Q7Z4G1-1]

Organism-specific databases

CTDi170622.
GeneCardsiCOMMD6.
HGNCiHGNC:24015. COMMD6.
HPAiHPA060266.
MIMi612377. gene.
neXtProtiNX_Q7Z4G1.
OpenTargetsiENSG00000188243.
PharmGKBiPA134906013.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000018369.
HOGENOMiHOG000038017.
HOVERGENiHBG051071.
InParanoidiQ7Z4G1.
OMAiKSQVTNQ.
PhylomeDBiQ7Z4G1.

Enzyme and pathway databases

BioCyciZFISH:G66-31333-MONOMER.

Miscellaneous databases

ChiTaRSiCOMMD6. human.
GenomeRNAii170622.
PROiQ7Z4G1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188243.
CleanExiHS_COMMD6.
ExpressionAtlasiQ7Z4G1. baseline and differential.
GenevisibleiQ7Z4G1. HS.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. COMM_domain. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD6_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4G1
Secondary accession number(s): A6NF28, B7ZLN0, Q5TBK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.