Q7Z4G1 (COMD6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
COMM domain-containing protein 6

Gene names

Name:	COMMD6
ORF Names:	MSTP076

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation. Ref.1 Ref.5
Subunit structure	Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Does not interact with NFKBIB. Ref.1 Ref.5
Subcellular location	Nucleus. Cytoplasm Ref.5.
Tissue specificity	Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. Ref.1 Ref.5
Sequence similarities	Contains 1 COMM domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COMMD1	Q8N668	2	EBI-1550081,EBI-1550112

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4G1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4G1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: Q → QPQLLATSSLLSAS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 85	85	COMM domain-containing protein 6		PRO_0000077398
Regions
	Domain	18 – 85	68	COMM
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.6
Natural variations
	Alternative sequence	69	1	Q → QPQLLATSSLLSAS in isoform 2.		VSP_026593
	Natural variant	52	1	H → N. Corresponds to variant rs1063485 [ dbSNP | Ensembl ].		VAR_048813
Experimental info
	Mutagenesis	24	1	W → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-41. Ref.5
	Mutagenesis	41	1	P → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-24. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: FBF29F240EA8756B	FASTA	85	9,638
	10 20 30 40 50 60 MEASSEPPLD AKSDVTNQLV DFQWKLGMAV SSDTCRSLKY PYVAVMLKVA DHSGQVKTKC 70 80 FEMTIPQFQN FYRQFKEIAA VIETV
	Isoform 2 [UniParc]. Checksum: BADF400B61D3C3FB	FASTA	98	10,908
	10 20 30 40 50 60 MEASSEPPLD AKSDVTNQLV DFQWKLGMAV SSDTCRSLKY PYVAVMLKVA DHSGQVKTKC 70 80 90 FEMTIPQFQP QLLATSSLLS ASNFYRQFKE IAAVIETV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
[2]	Qin B.M., Sheng H., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Zhang Q., Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Xu H.S., Chen J.Z., Cai M.Q., Zheng W.Y. , Teng C.Y., Liu Q., Yu L.T., Lin J., Gong Q., Zhang A.M., Gao R.L., Hui R.T. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Aorta.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Characterization of COMMD protein-protein interactions in NF-kappaB signalling." de Bie P., van de Sluis B., Burstein E., Duran K.J., Berger R., Duckett C.S., Wijmenga C., Klomp L.W. Biochem. J. 398:63-71(2006) [PubMed: 16573520] [Abstract] Cited for: FUNCTION, INTERACTION WITH COMMD1, SUBUNIT, MUTAGENESIS OF TRP-24 AND PRO-41, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORM 2).
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY542161 mRNA. Translation: AAS22243.1. AF169971 mRNA. Translation: AAQ13599.1. AL137244 Genomic DNA. Translation: CAI12417.1. AL137244 Genomic DNA. Translation: CAQ09795.1. BC117391 mRNA. Translation: AAI17392.1. BC143912 mRNA. Translation: AAI43913.1. BC171758 mRNA. Translation: AAI71758.1.
IPI	IPI00375957. IPI00409561.
RefSeq	NP_987091.1. NM_203495.2. NP_987093.1. NM_203497.2.
UniGene	Hs.508266.
3D structure databases
ProteinModelPortal	Q7Z4G1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z4G1. 4 interactions.
STRING	Q7Z4G1.
PTM databases
PhosphoSite	Q7Z4G1.
Polymorphism databases
DMDM	51315937.
Proteomic databases
PRIDE	Q7Z4G1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377615; ENSP00000366841; ENSG00000188243. ENST00000406936; ENSP00000385660; ENSG00000188243.
GeneID	170622.
KEGG	hsa:170622.
UCSC	uc001vjn.1. human. uc001vjo.1. human.
Organism-specific databases
CTD	170622.
GeneCards	GC13M076099.
H-InvDB	HIX0011375.
HGNC	HGNC:24015. COMMD6.
MIM	612377. gene.
neXtProt	NX_Q7Z4G1.
PharmGKB	PA134906013.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21080.
GeneTree	ENSGT00390000018369.
HOVERGEN	HBG051071.
InParanoid	Q7Z4G1.
OMA	KSEVTNQ.
OrthoDB	EOG4THVVG.
Gene expression databases
ArrayExpress	Q7Z4G1.
Bgee	Q7Z4G1.
CleanEx	HS_COMMD6.
Genevestigator	Q7Z4G1.
GermOnline	ENSG00000188243. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	89064.
SOURCE	Search...

Entry information

Entry name

COMD6_HUMAN

Accession

Primary (citable) accession number: Q7Z4G1
Secondary accession number(s): A6NF28, B7ZLN0, Q5TBK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.