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Reviewed, UniProtKB/Swiss-Prot Q7Z4G1 (COMD6_HUMAN)

Last modified November 24, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    COMM domain-containing protein 6
Gene names
Name: COMMD6
ORF Names: MSTP076
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length85 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Inhibits TNF-induced NFKB1 activation. Ref.5

Subunit structure

Homodimer. Can only homodimerize with isoform 1. Interact directly with COMMD1. Does not interact with NFKBIB. Ref.5

Subcellular location

Nucleus. Cytoplasm.

Tissue specificity

Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta. Ref.5

Sequence similarities

Contains 1 COMM domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein binding Ref.1

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

COMMD1Q8N6681EBI-1550081,EBI-1550112

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z4G1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z4G1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: Q → QPQLLATSSLLSAS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8585COMM domain-containing protein 6
PRO_0000077398

Regions

Domain18 – 8568COMM

Amino acid modifications

Modified residue11N-acetylmethionine

Natural variations

Alternative sequence691Q → QPQLLATSSLLSAS in isoform 2.
VSP_026593
Natural variant521H → N: dbSNP rs1063485.
VAR_048813

Experimental info

Mutagenesis241W → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-41. Ref.5
Mutagenesis411P → A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-24. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: FBF29F240EA8756B

FASTA859,638
        10         20         30         40         50         60 
MEASSEPPLD AKSDVTNQLV DFQWKLGMAV SSDTCRSLKY PYVAVMLKVA DHSGQVKTKC 

        70         80 
FEMTIPQFQN FYRQFKEIAA VIETV 

« Hide

Isoform 2.

Checksum: BADF400B61D3C3FB
Show »

FASTA9810,908

References

« Hide 'large scale' references
[1]"COMMD proteins, a novel family of structural and functional homologs of MURR1."
Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.
J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Qin B.M., Sheng H., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Zhang Q., Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Xu H.S., Chen J.Z., Cai M.Q., Zheng W.Y. expand/collapse author list , Teng C.Y., Liu Q., Yu L.T., Lin J., Gong Q., Zhang A.M., Gao R.L., Hui R.T.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Aorta.
[3]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed: 15057823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"Characterization of COMMD protein-protein interactions in NF-kappaB signalling."
de Bie P., van de Sluis B., Burstein E., Duran K.J., Berger R., Duckett C.S., Wijmenga C., Klomp L.W.
Biochem. J. 398:63-71(2006) [PubMed: 16573520] [Abstract]
Cited for: FUNCTION, INTERACTION WITH COMMD1, SUBUNIT, MUTAGENESIS OF TRP-24 AND PRO-41, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORM 2).
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, MASS SPECTROMETRY.

Cross-references

Sequence databases

AY542161 mRNA. Translation: AAS22243.1.
AF169971 mRNA. Translation: AAQ13599.1.
AL137244 Genomic DNA. Translation: CAI12417.1.
AL137244 Genomic DNA. Translation: CAQ09795.1.
BC117391 mRNA. Translation: AAI17392.1.
BC143912 mRNA. Translation: AAI43913.1.
BC171758 mRNA. Translation: AAI71758.1.
IPIIPI00375957.
IPI00409561.
RefSeqNP_987091.1.
NP_987093.1.
UniGeneHs.508266

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ7Z4G1. 3 interactions.
STRINGQ7Z4G1.

Proteomic databases

PRIDEQ7Z4G1.

Genome annotation databases

EnsemblENST00000377615; ENSP00000366841; ENSG00000188243; Homo sapiens. [Genome view]
ENST00000406936; ENSP00000385660; ENSG00000188243; Homo sapiens. [Genome view]
GeneID170622.
KEGGhsa:170622.
UCSCuc001vjn.1. human.
uc001vjo.1. human.

Organism-specific databases

CTD170622.
GeneCardsGC13M074998.
HGNCHGNC:24015. COMMD6.
MIM612377. gene.
PharmGKBPA134906013.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ7Z4G1.
OMANQLIDFQ
OrthoDBEOG9FXTSR

Gene expression databases

ArrayExpressQ7Z4G1.
BgeeQ7Z4G1.
CleanExHS_COMMD6.
GenevestigatorQ7Z4G1.
GermOnlineENSG00000188243. Homo sapiens.

Family and domain databases

InterProIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio89064.
SOURCESearch...

Entry information

Entry nameCOMD6_HUMAN
AccessionPrimary (citable) accession number: Q7Z4G1
Secondary accession number(s): A6NF28, B7ZLN0, Q5TBK4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents