Q7Z4F3 (Q7Z4F3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Caveolin RuleBase RU000680
Organism	Homo sapiens (Human) EMBL AAQ13608.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. RuleBase RU000680
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane › caveola; Peripheral membrane protein By similarity RuleBase RU000680.
Sequence similarities	Belongs to the caveolin family. RuleBase RU000680

Ontologies

Keywords
Cellular component	Cell membrane RuleBase RU000680 SAAS SAAS001612 Golgi apparatus SAAS SAAS001612 RuleBase RU000680 Membrane
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell caveola Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7Z4F3 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 1A7D908D1C072A47	FASTA	147	17,011
	10 20 30 40 50 60 MADELSEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF DGIWKASFTT 70 80 90 100 110 120 FTVTKYWFYR LLSALFGIPM ALIWGIYFAI LSFLHIWAVV PCIKSFLIEI QCTSRVYSIY 130 140 VHTVCDPLFE AVGKIFSNVR INLQKEI

References

[1]	Sheng H., Qin B.M., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Zhang Q., Song L., Gao Y., Zhang C.L., Ye J., Ji X.J., Liu B.H., Lu H., Xu H.S., Chen J.Z., Cai M.Q., Zheng W.Y. , Teng C.Y., Liu Q., Yu L.T., Lin J., Gong Q., Zhang A.M., Gao R.L., Hui R.T. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta EMBL AAQ13608.1.
[2]	"Transcriptional regulation of caveolin-1 beta protein isoform in human cells." Vaz M., Padhy L.C. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF172085 mRNA. Translation: AAQ13608.1. EF649774 mRNA. Translation: ABW22626.1.
IPI	IPI00853146.
RefSeq	NP_001166367.1. NM_001172896.1.
UniGene	Hs.74034.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q7Z4F3.
Proteomic databases
PRIDE	Q7Z4F3.
Protocols and materials databases
DNASU	857.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	857.
KEGG	hsa:857.
Organism-specific databases
CTD	857.
PharmGKB	PA26107.
Phylogenomic databases
HOGENOM	HOG000036550.
HOVERGEN	HBG003422.
KO	K06278.
Gene expression databases
ArrayExpress	Q7Z4F3.
Family and domain databases
InterPro	IPR001612. Caveolin. IPR015504. Caveolin_1. IPR018361. Caveolin_CS. [Graphical view]
PANTHER	PTHR10844. PTHR10844. 1 hit. PTHR10844:SF5. PTHR10844:SF5. 1 hit.
Pfam	PF01146. Caveolin. 1 hit. [Graphical view]
PROSITE	PS01210. CAVEOLIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	857.
NextBio	3556.

Entry information

Entry name

Q7Z4F3_HUMAN

Accession

Primary (citable) accession number: Q7Z4F3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	October 3, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.