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Protein

Low-density lipoprotein receptor-related protein 10

Gene

LRP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-HSA-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 10
Short name:
LRP-10
Gene namesi
Name:LRP10
ORF Names:MSTP087, SP220, UNQ389/PRO724
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000197324.8
HGNCiHGNC:14553 LRP10
MIMi609921 gene
neXtProtiNX_Q7Z4F1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 440ExtracellularSequence analysisAdd BLAST424
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 713CytoplasmicSequence analysisAdd BLAST252

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26020
OpenTargetsiENSG00000197324
PharmGKBiPA38383

Polymorphism and mutation databases

BioMutaiLRP10
DMDMi46396347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001733517 – 713Low-density lipoprotein receptor-related protein 10Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 57By similarity
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 98By similarity
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 152By similarity
Disulfide bondi147 ↔ 165By similarity
Disulfide bondi159 ↔ 174By similarity
Disulfide bondi192 ↔ 220By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi308 ↔ 331By similarity
Disulfide bondi315 ↔ 344By similarity
Disulfide bondi338 ↔ 353By similarity
Disulfide bondi356 ↔ 374By similarity
Disulfide bondi363 ↔ 387By similarity
Disulfide bondi381 ↔ 396By similarity
Disulfide bondi399 ↔ 411By similarity
Disulfide bondi406 ↔ 424By similarity
Disulfide bondi418 ↔ 433By similarity
Modified residuei596PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z4F1
MaxQBiQ7Z4F1
PaxDbiQ7Z4F1
PeptideAtlasiQ7Z4F1
PRIDEiQ7Z4F1

PTM databases

iPTMnetiQ7Z4F1
PhosphoSitePlusiQ7Z4F1
SwissPalmiQ7Z4F1

Expressioni

Tissue specificityi

Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000197324
CleanExiHS_LRP10
ExpressionAtlasiQ7Z4F1 baseline and differential
GenevisibleiQ7Z4F1 HS

Organism-specific databases

HPAiHPA000932

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM237Q96Q45-24EBI-2830349,EBI-10982110

Protein-protein interaction databases

BioGridi117491, 40 interactors
IntActiQ7Z4F1, 13 interactors
MINTiQ7Z4F1
STRINGi9606.ENSP00000352601

Structurei

3D structure databases

ProteinModelPortaliQ7Z4F1
SMRiQ7Z4F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 136CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini139 – 175LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini192 – 305CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini307 – 354LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST48
Domaini355 – 397LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST43
Domaini398 – 434LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi545 – 579Arg-richAdd BLAST35
Compositional biasi614 – 678Pro-richAdd BLAST65

Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT0 Eukaryota
ENOG410XV08 LUCA
GeneTreeiENSGT00810000125405
HOVERGENiHBG049162
InParanoidiQ7Z4F1
KOiK20050
OMAiWDCADGT
OrthoDBiEOG091G04LP
PhylomeDBiQ7Z4F1
TreeFamiTF332149

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00112 LDLa, 3 hits
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF00057 Ldl_recept_a, 2 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00192 LDLa, 4 hits
SUPFAMiSSF49854 SSF49854, 2 hits
SSF57424 SSF57424, 2 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 4 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z4F1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS
60 70 80 90 100
RTSPANCTWL ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA
110 120 130 140 150
PPSPLQLPGG NVTITYSYAG ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH
160 170 180 190 200
RCVSAVQRCD GVDACGDGSD EAGCSSDPFP GLTPRPVPSL PCNVTLEDFY
210 220 230 240 250
GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD LGFGDAVHVY
260 270 280 290 300
DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA
310 320 330 340 350
TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE
360 370 380 390 400
EDCPGCPPGH FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ
410 420 430 440 450
PGNFRCRDEK CVYETWVCDG QPDCADGSDE WDCSYVLPRK VITAAVIGSL
460 470 480 490 500
VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL SRMEAEIVQQ QAPPSYGQLI
510 520 530 540 550
AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG GPGARRRQRG
560 570 580 590 600
RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR
610 620 630 640 650
EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL
660 670 680 690 700
LSGVVQALRG RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG
710
VWVAEAEDEP LLT
Length:713
Mass (Da):76,193
Last modified:April 13, 2004 - v2
Checksum:iA463FB5584322220
GO
Isoform 2 (identifier: Q7Z4F1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-713: Missing.

Note: No experimental confirmation available.
Show »
Length:556
Mass (Da):60,213
Checksum:i1CCA7CAEA16A0AB1
GO

Sequence cautioni

The sequence AAD20037 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG17980 differs from that shown. Reason: Frameshift at positions 370 and 700.Curated
The sequence AAQ13610 differs from that shown. Reason: Frameshift at positions 312, 337, 496, 502 and 512.Curated
The sequence CAD39174 differs from that shown. Chimera.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti365A → T (PubMed:15498874).Curated1
Sequence conflicti434S → C (PubMed:15498874).Curated1
Sequence conflicti558R → H in CAB45753 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01817248R → W. Corresponds to variant dbSNP:rs2273837Ensembl.1
Natural variantiVAR_034097139M → V. Corresponds to variant dbSNP:rs28534929Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009820557 – 713Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358399 mRNA Translation: AAQ88765.1
BX161500 mRNA Translation: CAD61944.1
AK291030 mRNA Translation: BAF83719.1
AL080164 mRNA Translation: CAB45753.1
AL834518 mRNA Translation: CAD39174.2 Sequence problems.
CH471078 Genomic DNA Translation: EAW66232.1
CH471078 Genomic DNA Translation: EAW66235.1
BC064901 mRNA Translation: AAH64901.1
BC113714 mRNA Translation: AAI13715.1
BC113716 mRNA Translation: AAI13717.1
AF172816 mRNA Translation: AAQ13610.1 Frameshift.
AF177336 mRNA Translation: AAG17980.1 Frameshift.
AF131760 mRNA Translation: AAD20037.1 Different initiation.
CCDSiCCDS9578.1 [Q7Z4F1-1]
PIRiT12469
RefSeqiNP_001316155.1, NM_001329226.1 [Q7Z4F1-2]
NP_054764.2, NM_014045.4 [Q7Z4F1-1]
UniGeneiHs.525232
Hs.657588

Genome annotation databases

EnsembliENST00000359591; ENSP00000352601; ENSG00000197324 [Q7Z4F1-1]
ENST00000546834; ENSP00000447559; ENSG00000197324 [Q7Z4F1-2]
GeneIDi26020
KEGGihsa:26020
UCSCiuc001whd.4 human [Q7Z4F1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRP10_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4F1
Secondary accession number(s): A8K4R5
, D3DS31, O95882, Q14CK7, Q86T02, Q8NCZ4, Q9HC42, Q9UG33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: April 25, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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