Q7Z4F1 (LRP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low-density lipoprotein receptor-related protein 10
Short name=LRP-10

Gene names

Name:	LRP10
ORF Names:	MSTP087, SP220, UNQ389/PRO724

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	713 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential. Membrane › coated pit By similarity.
Tissue specificity	Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart. Ref.10
Sequence similarities	Belongs to the LDLR family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains.
Sequence caution	The sequence AAD20037.1 differs from that shown. Reason: Erroneous initiation. The sequence AAG17980.1 differs from that shown. Reason: Frameshift at positions 370 and 700. The sequence AAQ13610.1 differs from that shown. Reason: Frameshift at positions 312, 337, 496, 502 and 512. The sequence CAD39174.2 differs from that shown. Reason: Chimera.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Coated pit Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inner ear development Inferred from electronic annotation. Source: Compara lipid metabolic process Inferred from electronic annotation. Source: Compara lipid transport Inferred from electronic annotation. Source: Compara
Cellular_component	coated pit Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	low-density lipoprotein receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4F1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z4F1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     557-713: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 713	697	Low-density lipoprotein receptor-related protein 10		PRO_0000017335
Regions
	Topological domain	17 – 440	424	Extracellular Potential
	Transmembrane	441 – 461	21	Helical; Potential
	Topological domain	462 – 713	252	Cytoplasmic Potential
	Domain	28 – 136	109	CUB 1
	Domain	139 – 175	37	LDL-receptor class A 1
	Domain	192 – 305	114	CUB 2
	Domain	307 – 354	48	LDL-receptor class A 2
	Domain	355 – 397	43	LDL-receptor class A 3
	Domain	398 – 434	37	LDL-receptor class A 4
	Compositional bias	545 – 579	35	Arg-rich
	Compositional bias	614 – 678	65	Pro-rich
Amino acid modifications
	Modified residue	596	1	Phosphothreonine Ref.12
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Glycosylation	299	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 57		By similarity
	Disulfide bond	80 ↔ 98		By similarity
	Disulfide bond	140 ↔ 152		By similarity
	Disulfide bond	147 ↔ 165		By similarity
	Disulfide bond	159 ↔ 174		By similarity
	Disulfide bond	192 ↔ 220		By similarity
	Disulfide bond	308 ↔ 331		By similarity
	Disulfide bond	315 ↔ 344		By similarity
	Disulfide bond	338 ↔ 353		By similarity
	Disulfide bond	356 ↔ 374		By similarity
	Disulfide bond	363 ↔ 387		By similarity
	Disulfide bond	381 ↔ 396		By similarity
	Disulfide bond	399 ↔ 411		By similarity
	Disulfide bond	406 ↔ 424		By similarity
	Disulfide bond	418 ↔ 433		By similarity
Natural variations
	Alternative sequence	557 – 713	157	Missing in isoform 2.		VSP_009820
	Natural variant	48	1	R → W. Corresponds to variant rs2273837 [ dbSNP | Ensembl ].		VAR_018172
	Natural variant	139	1	M → V. Corresponds to variant rs28534929 [ dbSNP | Ensembl ].		VAR_034097
Experimental info
	Sequence conflict	365	1	A → T Ref.8
	Sequence conflict	434	1	S → C Ref.8
	Sequence conflict	558	1	R → H in CAB45753. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: A463FB5584322220	FASTA	713	76,193
	10 20 30 40 50 60 MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS RTSPANCTWL 70 80 90 100 110 120 ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA PPSPLQLPGG NVTITYSYAG 130 140 150 160 170 180 ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH RCVSAVQRCD GVDACGDGSD EAGCSSDPFP 190 200 210 220 230 240 GLTPRPVPSL PCNVTLEDFY GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD 250 260 270 280 290 300 LGFGDAVHVY DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA 310 320 330 340 350 360 TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE EDCPGCPPGH 370 380 390 400 410 420 FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ PGNFRCRDEK CVYETWVCDG 430 440 450 460 470 480 QPDCADGSDE WDCSYVLPRK VITAAVIGSL VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL 490 500 510 520 530 540 SRMEAEIVQQ QAPPSYGQLI AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG 550 560 570 580 590 600 GPGARRRQRG RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR 610 620 630 640 650 660 EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL LSGVVQALRG 670 680 690 700 710 RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG VWVAEAEDEP LLT
	Isoform 2 [UniParc]. Checksum: 1CCA7CAEA16A0AB1	FASTA	556	60,213
	10 20 30 40 50 60 MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS RTSPANCTWL 70 80 90 100 110 120 ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA PPSPLQLPGG NVTITYSYAG 130 140 150 160 170 180 ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH RCVSAVQRCD GVDACGDGSD EAGCSSDPFP 190 200 210 220 230 240 GLTPRPVPSL PCNVTLEDFY GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD 250 260 270 280 290 300 LGFGDAVHVY DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA 310 320 330 340 350 360 TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE EDCPGCPPGH 370 380 390 400 410 420 FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ PGNFRCRDEK CVYETWVCDG 430 440 450 460 470 480 QPDCADGSDE WDCSYVLPRK VITAAVIGSL VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL 490 500 510 520 530 540 SRMEAEIVQQ QAPPSYGQLI AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG 550 GPGARRRQRG RLMRRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Cervix carcinoma.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-713 (ISOFORM 2). Tissue: Lung.
[7]	Lu H., Liu B.H., Qin B.M., Sheng H., Zhang Q., Liu Y.Q., Zhao B., Liu B., Wang X.Y., Song L., Ji X.J., Xu H.S., Chen J.Z., Zheng W.Y., Teng C.Y., Liu Q., Yu L.T., Lin J. , Gong J., Gao R.L., Hui R.T. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 136-713 (ISOFORM 1). Tissue: Aorta.
[8]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 329-713 (ISOFORM 1).
[9]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 359-713 (ISOFORM 1). Tissue: Brain.
[10]	"A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro." Sugiyama T., Kumagai H., Morikawa Y., Wada Y., Sugiyama A., Yasuda K., Yokoi N., Tamura S., Kojima T., Nosaka T., Senba E., Kimura S., Kadowaki T., Kodama T., Kitamura T. Biochemistry 39:15817-15825(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-596, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358399 mRNA. Translation: AAQ88765.1. BX161500 mRNA. Translation: CAD61944.1. AK291030 mRNA. Translation: BAF83719.1. AL080164 mRNA. Translation: CAB45753.1. AL834518 mRNA. Translation: CAD39174.2. Sequence problems. CH471078 Genomic DNA. Translation: EAW66232.1. CH471078 Genomic DNA. Translation: EAW66235.1. BC064901 mRNA. Translation: AAH64901.1. BC113714 mRNA. Translation: AAI13715.1. BC113716 mRNA. Translation: AAI13717.1. AF172816 mRNA. Translation: AAQ13610.1. Frameshift. AF177336 mRNA. Translation: AAG17980.1. Frameshift. AF131760 mRNA. Translation: AAD20037.1. Different initiation.
IPI	IPI00414231. IPI00472951.
PIR	T12469.
RefSeq	NP_054764.2. NM_014045.3.
UniGene	Hs.525232.
3D structure databases
ProteinModelPortal	Q7Z4F1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z4F1. 1 interaction.
STRING	9606.ENSP00000352601.
PTM databases
PhosphoSite	Q7Z4F1.
Polymorphism databases
DMDM	46396347.
Proteomic databases
PaxDb	Q7Z4F1.
PRIDE	Q7Z4F1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359591; ENSP00000352601; ENSG00000197324. ENST00000546834; ENSP00000447559; ENSG00000197324.
GeneID	26020.
KEGG	hsa:26020.
UCSC	uc001whd.3. human.
Organism-specific databases
CTD	26020.
GeneCards	GC14P023340.
HGNC	HGNC:14553. LRP10.
HPA	HPA000932.
MIM	609921. gene.
neXtProt	NX_Q7Z4F1.
PharmGKB	PA38383.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG312857.
HOVERGEN	HBG049162.
InParanoid	Q7Z4F1.
OMA	QEYSIFA.
OrthoDB	EOG4PNXGJ.
PhylomeDB	Q7Z4F1.
Gene expression databases
ArrayExpress	Q7Z4F1.
Bgee	Q7Z4F1.
CleanEx	HS_LRP10.
Genevestigator	Q7Z4F1.
GermOnline	ENSG00000197324. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.290. 2 hits. 4.10.400.10. 4 hits.
InterPro	IPR000859. CUB_dom. IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Pfam	PF00431. CUB. 1 hit. PF00057. Ldl_recept_a. 2 hits. [Graphical view]
SMART	SM00042. CUB. 2 hits. SM00192. LDLa. 4 hits. [Graphical view]
SUPFAM	SSF49854. CUB. 2 hits. SSF57424. LDL_rcpt_classA_cys-rich. 2 hits.
PROSITE	PS01180. CUB. 1 hit. PS01209. LDLRA_1. 1 hit. PS50068. LDLRA_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LRP10. human.
GenomeRNAi	26020.
NextBio	47794.
SOURCE	Search...

Entry information

Entry name

LRP10_HUMAN

Accession

Primary (citable) accession number: Q7Z4F1
Secondary accession number(s): A8K4R5 , D3DS31, O95882, Q14CK7, Q86T02, Q8NCZ4, Q9HC42, Q9UG33

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.