Q7Z4B0 (CR020_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein encoded by LINC00305

Gene names

Name:	LINC00305
Synonyms:	C18orf20, NCRNA00305

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Subcellular location	Secreted Potential.
Caution	Product of a dubious CDS prediction. May be a non-coding RNA.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z4B0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q7Z4B0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     12-26: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 112	83	Putative uncharacterized protein encoded by LINC00305		PRO_0000019560
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	12 – 26	15	Missing in isoform 2.		VSP_014651

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 0566D1566892356D	FASTA	112	12,600
	10 20 30 40 50 60 MINLHRLCII HVVATLLSTL LSLISVAISA TCKDEKGKQE METGQQPSGL SATLTKVKCA 70 80 90 100 110 KRQKTVVRVR FYMLSMKNKA CRKNLSKGYN QRPEGSKEES HMVVKEKRKG DH
	Isoform 2 [UniParc]. Checksum: B7615B0ACE8CABD2	FASTA	97	11,089
	10 20 30 40 50 60 MINLHRLCII HAISATCKDE KGKQEMETGQ QPSGLSATLT KVKCAKRQKT VVRVRFYMLS 70 80 90 MKNKACRKNL SKGYNQRPEG SKEESHMVVK EKRKGDH

References

[1]	Shen C., Ke R., Li H., Zhou G., Zheng G., Zhong G., Yu R., Lin L., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY336744 mRNA. Translation: AAQ16114.1. AC021607 Genomic DNA. No translation available. BC029565 mRNA. No translation available.
IPI	IPI00169301. IPI00607736.
UniGene	Hs.567778.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q7Z4B0.
Polymorphism databases
DMDM	71153216.
Proteomic databases
PRIDE	Q7Z4B0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010dqk.1. human.
Organism-specific databases
HGNC	HGNC:28597. LINC00305.
neXtProt	NX_Q7Z4B0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21398.
InParanoid	Q7Z4B0.
OrthoDB	EOG4DJJZ3.
Gene expression databases
CleanEx	HS_C18orf20.
Genevestigator	Q7Z4B0.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CR020_HUMAN

Accession

Primary (citable) accession number: Q7Z4B0
Secondary accession number(s): Q8NHR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.