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Protein
Submitted name:

Calpain 7

Gene

CAPN7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BRENDAi3.4.22.B27. 2681.

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain 7Imported
Gene namesi
Name:CAPN7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26064.

PTM / Processingi

Proteomic databases

PaxDbiQ7Z479.
PeptideAtlasiQ7Z479.
PRIDEiQ7Z479.

Expressioni

Gene expression databases

GenevisibleiQ7Z479. HS.

Interactioni

Protein-protein interaction databases

IntActiQ7Z479. 6 interactors.
STRINGi9606.ENSP00000253693.

Structurei

3D structure databases

ProteinModelPortaliQ7Z479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 540Calpain catalyticInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG036832.
KOiK08576.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.20.58.280. 2 hits.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL
60 70 80 90 100
ENIQEKITEY LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE
110 120 130 140 150
DEKENVEDAI ELYTEAVDLC LKTSYETADK VLQNKLKQLA RQALDRAEAL
160 170 180 190 200
GEPLTKPVGK ISSTSVKPKP PPERAHFPLG ANPFLERPQS FISPQSCDAQ
210 220 230 240 250
GQRYTAEEIE VLRTTSKING IEYVPFMNVD LRERFAYPMP FCDRWGKLPL
260 270 280 290 300
SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
310 320 330 340 350
AYERRFNKKL ITGIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ
360 370 380 390 400
LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL
410 420 430 440 450
TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGMMTEAEGE
460 470 480 490 500
KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVENWTPE
510 520 530 540 550
LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVIYLSWNP GLFKESTCIH
560 570 580 590 600
STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
610 620 630 640 650
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH
660 670 680 690 700
TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS
710 720 730 740 750
AGGCGNFQET HKNNPIYQFH IEKTGPLLIE LRGPRQYSVG FEVVTVSTLG
760 770 780 790 800
DPGPHGFLRK SSGDYRCGFC YLELENIPSG IFNIIPSTFL PKQEGPFFLD
810
FNSIIPIKIT QLQ
Length:813
Mass (Da):92,653
Last modified:October 1, 2003 - v1
Checksum:i5C17344D508B0AB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056202 mRNA. Translation: AAH56202.1.
RefSeqiNP_055111.1. NM_014296.2.
UniGeneiHs.595234.

Genome annotation databases

GeneIDi23473.
KEGGihsa:23473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056202 mRNA. Translation: AAH56202.1.
RefSeqiNP_055111.1. NM_014296.2.
UniGeneiHs.595234.

3D structure databases

ProteinModelPortaliQ7Z479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z479. 6 interactors.
STRINGi9606.ENSP00000253693.

Proteomic databases

PaxDbiQ7Z479.
PeptideAtlasiQ7Z479.
PRIDEiQ7Z479.

Protocols and materials databases

DNASUi23473.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23473.
KEGGihsa:23473.

Organism-specific databases

CTDi23473.
PharmGKBiPA26064.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOVERGENiHBG036832.
KOiK08576.

Enzyme and pathway databases

BRENDAi3.4.22.B27. 2681.

Miscellaneous databases

ChiTaRSiCAPN7. human.
GenomeRNAii23473.

Gene expression databases

GenevisibleiQ7Z479. HS.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.20.58.280. 2 hits.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7Z479_HUMAN
AccessioniPrimary (citable) accession number: Q7Z479
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.