Reviewed,
UniProtKB/Swiss-Prot Q7Z478 (DHX29_HUMAN)
Last modified
November 25, 2008.
Version 48.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative ATP-dependent RNA helicase DHX29 EC=3.6.1.- Alternative name(s): DEAH box protein 29 Nucleic acid helicase DDXx | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1369 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the DEAD box helicase family. DEAH subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Domain | Coiled coil |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Helicase Hydrolase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro ATP-dependent helicase activityInferred from electronic annotation. Source: InterPro nucleic acid bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1369 | 1369 | Putative ATP-dependent RNA helicase DHX29 | PRO_0000245535 | |||||
Regions | |||||||||
| Domain | 582 – 755 | 174 | Helicase ATP-binding | ||||||
| Domain | 849 – 1026 | 178 | Helicase C-terminal | ||||||
| Nucleotide binding | 595 – 602 | 8 | ATP By similarity | ||||||
| Coiled coil | 221 – 311 | 91 | Potential | ||||||
| Coiled coil | 492 – 519 | 28 | Potential | ||||||
| Motif | 702 – 705 | 4 | DEAH box | ||||||
| Compositional bias | 10 – 53 | 44 | Ala-rich | ||||||
| Compositional bias | 789 – 793 | 5 | Poly-Glu | ||||||
Amino acid modifications | |||||||||
| Modified residue | 192 | 1 | Phosphoserine | ||||||
| Modified residue | 200 | 1 | Phosphoserine | ||||||
Natural variations | |||||||||
| Natural variant | 630 | 1 | P → H: dbSNP rs17854904. | VAR_026985 | |||||
Experimental info | |||||||||
| Sequence conflict | 121 | 1 | A → D in CAH56172. Ref.3 | ||||||
| Sequence conflict | 185 | 1 | K → E in CAH56153. Ref.3 | ||||||
| Sequence conflict | 356 | 1 | D → G in AAK64516. Ref.1 | ||||||
| Sequence conflict | 885 | 1 | D → G in CAH56172. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a new member of the DDx subfamily of helicases." Abdelhaleem M.M. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-630. Tissue: Brain. |
| [3] | The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-1369. Tissue: Amygdala, Fetal kidney and Testis. |
| [4] | Bassi M.T., Banfi S., Riboni M., Ballabio A., Borsani G. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 561-1369. |
| [5] | Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1119-1369. Tissue: Brain. |
| [6] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, MASS SPECTROMETRY. Tissue: Epithelium. |
| [7] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192 AND SER-200, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192 AND SER-200, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AY036974 mRNA. Translation: AAK64516.1. BC056219 mRNA. Translation: AAH56219.1. AL834496 mRNA. Translation: CAD39154.1. BX648101 mRNA. Translation: CAH56172.1. BX648269 mRNA. Translation: CAH56153.1. AL079292 mRNA. Translation: CAB45191.1. AF070639 mRNA. Translation: AAC25394.1. | |
| RefSeq | NP_061903.2. |
| UniGene | Hs.696182 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q7Z478. |
PTM databases | |
| PhosphoSite | Q7Z478. |
Proteomic databases | |
| PeptideAtlas | Q7Z478. |
Genome annotation databases | |
| Ensembl | ENSG00000067248. Homo sapiens. [Contig view] |
| GeneID | 54505. |
| KEGG | hsa:54505. |
Organism-specific databases | |
| HGNC | HGNC:15815. DHX29. |
| PharmGKB | PA27215. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | Q7Z478. |
Gene expression databases | |
| ArrayExpress | Q7Z478. |
| CleanEx | HS_DHX29. |
| GermOnline | ENSG00000067248. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR011709. DUF1605. IPR007502. Helicase-assoc_reg. IPR014021. Helicase_SF1/SF2_ATP-bd. [Graphical view] |
| Pfam | PF00270. DEAD. 1 hit. PF07717. DUF1605. 1 hit. PF04408. HA2. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view] |
| SMART | SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view] |
| PROSITE | PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 56869. |
Entry information
| Entry name | DHX29_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q7Z478 Secondary accession number(s): O75549  Q9UMH2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |
