Q7Z465 (BNIPL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

Gene names

Name:

BNIPL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death. Ref.2
Subunit structure	Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER. Ref.2 Ref.5
Tissue specificity	Isoform 2 is expressed in placenta and lung. Ref.5
Sequence similarities	Contains 1 CRAL-TRIO domain.

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from direct assay Ref.1Ref.2. Source: UniProtKB induction of apoptosis Inferred from direct assay Ref.1. Source: MGI negative regulation of cell proliferation Inferred from direct assay Ref.5. Source: UniProtKB regulation of growth rate Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	cytosol Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z465-1)

Also known as: BNIPL-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z465-2)

Also known as: BNIPL-1; BNIP-Salpha;

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Isoform 3 (identifier: Q7Z465-3)

Also known as: BNIP-Sbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     285-357: LRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT → VL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein		PRO_0000210770
Regions
	Domain	191 – 352	162	CRAL-TRIO
Natural variations
	Alternative sequence	1 – 82	82	Missing in isoform 2 and isoform 3.		VSP_012448
	Alternative sequence	285 – 357	73	LRKNL…GSGGT → VL in isoform 3.		VSP_012449
	Natural variant	65	1	S → N. Corresponds to variant rs12068365 [ dbSNP | Ensembl ].		VAR_051917
	Natural variant	226	1	S → N. Corresponds to variant rs12068365 [ dbSNP | Ensembl ].		VAR_051918

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (BNIPL-2) [UniParc]. Last modified October 1, 2003. Version 1. Checksum: C0BCF92BACE9DE4F	FASTA	357	39,713
	10 20 30 40 50 60 MGTIQEAGKK TDVGVREIAE APELGAALRH GELELKEEWQ DEEFPRLLPE EAGTSEDPED 70 80 90 100 110 120 PKGDSQAAAG TPSTLALCGQ RPMRKRLSAP ELRLSLTKGP GNDGASPTQS APSSPDGSSD 130 140 150 160 170 180 LEIDELETPS DSEQLDSGHE FEWEDELPRA EGLGTSETAE RLGRGCMWDV TGEDGHHWRV 190 200 210 220 230 240 FRMGPREQRV DMTVIEPYKK VLSHGGYHGD GLNAVILFAS CYLPRSSIPN YTYVMEHLFR 250 260 270 280 290 300 YMVGTLELLV AENYLLVHLS GGTSRAQVPP LSWIRQCYRT LDRRLRKNLR ALVVVHATWY 310 320 330 340 350 VKAFLALLRP FISSKFTRKI RFLDSLGELA QLISLDQVHI PEAVRQLDRD LHGSGGT
	Isoform 2 (BNIPL-1) (BNIP-Salpha) [UniParc]. Checksum: C4C63FDB0EA356CE	FASTA	275	30,974
	10 20 30 40 50 60 MRKRLSAPEL RLSLTKGPGN DGASPTQSAP SSPDGSSDLE IDELETPSDS EQLDSGHEFE 70 80 90 100 110 120 WEDELPRAEG LGTSETAERL GRGCMWDVTG EDGHHWRVFR MGPREQRVDM TVIEPYKKVL 130 140 150 160 170 180 SHGGYHGDGL NAVILFASCY LPRSSIPNYT YVMEHLFRYM VGTLELLVAE NYLLVHLSGG 190 200 210 220 230 240 TSRAQVPPLS WIRQCYRTLD RRLRKNLRAL VVVHATWYVK AFLALLRPFI SSKFTRKIRF 250 260 270 LDSLGELAQL ISLDQVHIPE AVRQLDRDLH GSGGT
	Isoform 3 (BNIP-Sbeta) [UniParc]. Checksum: E771FBD9F1B2E2AB	FASTA	204	22,908
	10 20 30 40 50 60 MRKRLSAPEL RLSLTKGPGN DGASPTQSAP SSPDGSSDLE IDELETPSDS EQLDSGHEFE 70 80 90 100 110 120 WEDELPRAEG LGTSETAERL GRGCMWDVTG EDGHHWRVFR MGPREQRVDM TVIEPYKKVL 130 140 150 160 170 180 SHGGYHGDGL NAVILFASCY LPRSSIPNYT YVMEHLFRYM VGTLELLVAE NYLLVHLSGG 190 200 TSRAQVPPLS WIRQCYRTLD RRVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence." Zhou Y.T., Soh U.J.K., Shang X., Guy G.R., Low B.C. J. Biol. Chem. 277:7483-7492(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[2]	"BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis." Qin W., Hu J., Guo M., Xu J., Li J., Yao G., Zhou X., Jiang H., Zhang P., Shen L., Wan D., Gu J. Biochem. Biophys. Res. Commun. 308:379-385(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH BCL2 AND ARHGAP1, FUNCTION. Tissue: Placenta.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[5]	"The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER." Shen L., Hu J., Lu H., Wu M., Qin W., Wan D., Li Y.-Y., Gu J. FEBS Lett. 540:86-90(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GIF AND GFER, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF193056 mRNA. Translation: AAG22484.1. AY078983 mRNA. Translation: AAL85483.1. AY078984 mRNA. Translation: AAL85484.1. AY033000 mRNA. Translation: AAK54348.1. AL590133 Genomic DNA. Translation: CAI13344.1. AL590133 Genomic DNA. Translation: CAI13347.1. BC027868 mRNA. Translation: AAH27868.2. BC074779 mRNA. Translation: AAH74779.3. BC074780 mRNA. Translation: AAH74780.3.
IPI	IPI00107433. IPI00412103. IPI00513690.
RefSeq	NP_001153114.1. NM_001159642.1. NP_612122.2. NM_138278.3.
UniGene	Hs.591473.
3D structure databases
ProteinModelPortal	Q7Z465.
SMR	Q7Z465. Positions 196-338.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z465. 8 interactions.
STRING	9606.ENSP00000357927.
PTM databases
PhosphoSite	Q7Z465.
Polymorphism databases
DMDM	57012595.
Proteomic databases
PaxDb	Q7Z465.
PRIDE	Q7Z465.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295294; ENSP00000295294; ENSG00000163141. ENST00000368931; ENSP00000357927; ENSG00000163141. ENST00000485855; ENSP00000435072; ENSG00000163141.
GeneID	149428.
KEGG	hsa:149428.
UCSC	uc001ewl.2. human.
Organism-specific databases
CTD	149428.
GeneCards	GC01P151009.
HGNC	HGNC:16976. BNIPL.
HPA	HPA019946. HPA023464.
MIM	611275. gene.
neXtProt	NX_Q7Z465.
PharmGKB	PA38196.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146834.
HOGENOM	HOG000230952.
HOVERGEN	HBG054692.
InParanoid	Q7Z465.
OMA	TYVMEHL.
OrthoDB	EOG4001JH.
Gene expression databases
ArrayExpress	Q7Z465.
Bgee	Q7Z465.
CleanEx	HS_BNIPL.
Genevestigator	Q7Z465.
GermOnline	ENSG00000163141. Homo sapiens.
Family and domain databases
Gene3D	3.40.525.10. 1 hit.
InterPro	IPR022181. Bcl2-/adenovirus-E1B. IPR001251. CRAL-TRIO_dom. [Graphical view]
Pfam	PF12496. BNIP2. 1 hit. [Graphical view]
SMART	SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	149428.
NextBio	86145.
SOURCE	Search...

Entry information

Entry name

BNIPL_HUMAN

Accession

Primary (citable) accession number: Q7Z465
Secondary accession number(s): Q6DK43, Q8TCY7, Q8WYG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.