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Protein

CLIP-associating protein 1

Gene

CLASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.6 Publications

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
  • kinetochore binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • microtubule plus-end binding Source: UniProtKB

GO - Biological processi

  • astral microtubule organization Source: UniProtKB
  • cell division Source: MGI
  • establishment of epithelial cell polarity Source: UniProtKB
  • establishment of mitotic spindle localization Source: UniProtKB
  • establishment of spindle orientation Source: MGI
  • establishment or maintenance of cell polarity Source: UniProtKB
  • exit from mitosis Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Reactome
  • Golgi organization Source: UniProtKB
  • microtubule anchoring Source: UniProtKB
  • microtubule bundle formation Source: UniProtKB
  • microtubule cytoskeleton organization Source: UniProtKB
  • microtubule nucleation Source: UniProtKB
  • microtubule organizing center organization Source: UniProtKB
  • mitotic spindle assembly Source: UniProtKB
  • mitotic spindle organization Source: UniProtKB
  • negative regulation of microtubule depolymerization Source: UniProtKB
  • negative regulation of microtubule polymerization or depolymerization Source: UniProtKB
  • negative regulation of stress fiber assembly Source: UniProtKB
  • negative regulation of wound healing, spreading of epidermal cells Source: UniProtKB
  • positive regulation of basement membrane assembly involved in embryonic body morphogenesis Source: UniProtKB
  • positive regulation of epithelial cell migration Source: UniProtKB
  • positive regulation of exocytosis Source: UniProtKB
  • positive regulation of extracellular matrix disassembly Source: UniProtKB
  • positive regulation of microtubule polymerization Source: UniProtKB
  • regulation of epithelial to mesenchymal transition Source: UniProtKB
  • regulation of focal adhesion assembly Source: UniProtKB
  • regulation of gastrulation Source: UniProtKB
  • regulation of microtubule cytoskeleton organization Source: UniProtKB
  • sister chromatid cohesion Source: Reactome
  • vesicle targeting Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-428890. Role of Abl in Robo-Slit signaling.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
CLIP-associating protein 1
Alternative name(s):
Cytoplasmic linker-associated protein 1
Multiple asters homolog 1
Protein Orbit homolog 1
Short name:
hOrbit1
Gene namesi
Name:CLASP1
Synonyms:KIAA0622, MAST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17088. CLASP1.

Subcellular locationi

GO - Cellular componenti

  • basal cortex Source: UniProtKB
  • cell cortex Source: MGI
  • centrosomal corona Source: UniProtKB
  • centrosome Source: UniProtKB
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cortical microtubule cytoskeleton Source: UniProtKB
  • cytoplasmic microtubule Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • kinetochore Source: UniProtKB
  • kinetochore microtubule Source: UniProtKB
  • membrane Source: UniProtKB
  • microtubule plus-end Source: UniProtKB
  • spindle microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi23332.
OpenTargetsiENSG00000074054.
PharmGKBiPA38436.

Polymorphism and mutation databases

BioMutaiCLASP1.
DMDMi74723323.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898471 – 1538CLIP-associating protein 1Add BLAST1538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei246PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei548PhosphoserineBy similarity1
Modified residuei558PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei647PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei656PhosphothreonineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei695PhosphoserineCombined sources1
Modified residuei705PhosphoserineCombined sources1
Modified residuei711PhosphothreonineCombined sources1
Modified residuei714PhosphoserineCombined sources1
Modified residuei787PhosphoserineCombined sources1
Modified residuei797PhosphoserineCombined sources1
Modified residuei823PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1095PhosphothreonineBy similarity1
Modified residuei1099PhosphothreonineCombined sources1
Modified residuei1113PhosphoserineBy similarity1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1223PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z460.
MaxQBiQ7Z460.
PaxDbiQ7Z460.
PeptideAtlasiQ7Z460.
PRIDEiQ7Z460.

PTM databases

iPTMnetiQ7Z460.
PhosphoSitePlusiQ7Z460.
SwissPalmiQ7Z460.

Miscellaneous databases

PMAP-CutDBQ7Z460.

Expressioni

Gene expression databases

BgeeiENSG00000074054.
CleanExiHS_CLASP1.
HS_MAST1.
ExpressionAtlasiQ7Z460. baseline and differential.
GenevisibleiQ7Z460. HS.

Organism-specific databases

HPAiHPA062664.
HPA065219.

Interactioni

Subunit structurei

Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. Interacts with GCC2; recruits CLASP1 to Golgi membranes. Interacts with MACF1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Clip1Q9JK252EBI-913476,EBI-908338From a different organism.
Clip2O551563EBI-913476,EBI-349416From a different organism.
JAKMIP2Q96AA83EBI-10257534,EBI-752007
KIF1BO603333EBI-913476,EBI-465633
SPAG5Q96R063EBI-913476,EBI-413317

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
  • kinetochore binding Source: UniProtKB
  • microtubule binding Source: UniProtKB
  • microtubule plus-end binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116919. 35 interactors.
IntActiQ7Z460. 35 interactors.
MINTiMINT-1683081.
STRINGi9606.ENSP00000263710.

Structurei

Secondary structure

11538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi297 – 306Combined sources10
Helixi317 – 331Combined sources15
Helixi338 – 353Combined sources16
Helixi356 – 358Combined sources3
Helixi362 – 367Combined sources6
Helixi370 – 377Combined sources8
Helixi382 – 399Combined sources18
Helixi400 – 403Combined sources4
Helixi404 – 415Combined sources12
Turni416 – 419Combined sources4
Helixi423 – 439Combined sources17
Helixi445 – 451Combined sources7
Helixi452 – 454Combined sources3
Helixi458 – 474Combined sources17
Helixi477 – 479Combined sources3
Turni480 – 482Combined sources3
Helixi484 – 495Combined sources12
Helixi500 – 516Combined sources17
Helixi518 – 527Combined sources10
Helixi530 – 537Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K92X-ray2.00A/B284-552[»]
ProteinModelPortaliQ7Z460.
SMRiQ7Z460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 124HEAT 1Add BLAST38
Repeati163 – 200HEAT 2Add BLAST38
Repeati405 – 440HEAT 3Add BLAST36
Repeati441 – 477HEAT 4Add BLAST37
Repeati974 – 1011HEAT 5Add BLAST38
Repeati1342 – 1379HEAT 6Add BLAST38
Repeati1460 – 1497HEAT 7Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni662 – 785Interaction with microtubules, MAPRE1 and MAPRE31 PublicationAdd BLAST124
Regioni1254 – 1538Interaction with CLIP2By similarityAdd BLAST285
Regioni1254 – 1538Interaction with PHLDB2 and RSN1 PublicationAdd BLAST285
Regioni1256 – 1538Localization to kinetochoresAdd BLAST283

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1299 – 1330Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 765Ser-richAdd BLAST236
Compositional biasi1526 – 1532Poly-Ser7

Sequence similaritiesi

Belongs to the CLASP family.Curated
Contains 7 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2956. Eukaryota.
ENOG410ZMY0. LUCA.
GeneTreeiENSGT00390000001762.
HOGENOMiHOG000236347.
HOVERGENiHBG079692.
InParanoidiQ7Z460.
KOiK16578.
OMAiRDYNPYP.
OrthoDBiEOG091G0GTV.
PhylomeDBiQ7Z460.
TreeFamiTF101155.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR028399. CLASP_metazoan.
IPR024395. CLASP_N_dom.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERiPTHR21567:SF28. PTHR21567:SF28. 2 hits.
PfamiPF12348. CLASP_N. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTMLDKL
60 70 80 90 100
VDGLATSWVN SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL
110 120 130 140 150
GDAKDSVREQ DQTLLLKIMD QAANPQYVWD RMLGGFKHKN FRTREGICLC
160 170 180 190 200
LIATLNASGA QTLTLSKIVP HICNLLGDPN SQVRDAAINS LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANDKN FDDEDSVDGN
260 270 280 290 300
RPSSASSTSS KAPPSSRRNV GMGTTRRLGS STLGSKSSAA KEGAGAVDEE
310 320 330 340 350
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKIRS
360 370 380 390 400
LLLAGAAEYD NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG
410 420 430 440 450
NKFDHGAEAI MPTIFNLIPN SAKIMATSGV VAVRLIIRHT HIPRLIPVIT
460 470 480 490 500
SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL ERHISVLAET IKKGIHDADS
510 520 530 540 550
EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL KNSDSIVSLP
560 570 580 590 600
QSDRSSSSSQ ESLNRPLSAK RSPTGSTTSR ASTVSTKSVS TTGSLQRSRS
610 620 630 640 650
DIDVNAAASA KSKVSSSSGT TPFSSAAALP PGSYASLGRI RTRRQSSGSA
660 670 680 690 700
TNVASTPDNR GRSRAKVVSQ SQRSRSANPA GAGSRSSSPG KLLGSGYGGL
710 720 730 740 750
TGGSSRGPPV TPSSEKRSKI PRSQGCSRET SPNRIGLARS SRIPRPSMSQ
760 770 780 790 800
GCSRDTSRES SRDTSPARGF PPLDRFGLGQ PGRIPGSVNA MRVLSTSTDL
810 820 830 840 850
EAAVADALKK PVRRRYEPYG MYSDDDANSD ASSVCSERSY GSRNGGIPHY
860 870 880 890 900
LRQTEDVAEV LNHCASSNWS ERKEGLLGLQ NLLKSQRTLS RVELKRLCEI
910 920 930 940 950
FTRMFADPHS KRVFSMFLET LVDFIIIHKD DLQDWLFVLL TQLLKKMGAD
960 970 980 990 1000
LLGSVQAKVQ KALDVTRDSF PFDQQFNILM RFIVDQTQTP NLKVKVAILK
1010 1020 1030 1040 1050
YIESLARQMD PTDFVNSSET RLAVSRIITW TTEPKSSDVR KAAQIVLISL
1060 1070 1080 1090 1100
FELNTPEFTM LLGALPKTFQ DGATKLLHNH LKNSSNTSVG SPSNTIGRTP
1110 1120 1130 1140 1150
SRHTSSRTSP LTSPTNCSHG GLSPSRLWGW SADGLAKHPP PFSQPNSIPT
1160 1170 1180 1190 1200
APSHKALRRS YSPSMLDYDT ENLNSEEIYS SLRGVTEAIE KFSFRSQEDL
1210 1220 1230 1240 1250
NEPIKRDGKK ECDIVSRDGG AASPATEGRG GSEVEGGRTA LDNKTSLLNT
1260 1270 1280 1290 1300
QPPRAFPGPR ARDYNPYPYS DAINTYDKTA LKEAVFDDDM EQLRDVPIDH
1310 1320 1330 1340 1350
SDLVADLLKE LSNHNERVEE RKGALLELLK ITREDSLGVW EEHFKTILLL
1360 1370 1380 1390 1400
LLETLGDKDH SIRALALRVL REILRNQPAR FKNYAELTIM KTLEAHKDSH
1410 1420 1430 1440 1450
KEVVRAAEEA ASTLASSIHP EQCIKVLCPI IQTADYPINL AAIKMQTKVV
1460 1470 1480 1490 1500
ERIAKESLLQ LLVDIIPGLL QGYDNTESSV RKASVFCLVA IYSVIGEDLK
1510 1520 1530
PHLAQLTGSK MKLLNLYIKR AQTTNSNSSS SSDVSTHS
Length:1,538
Mass (Da):169,451
Last modified:October 1, 2003 - v1
Checksum:i6E03BD948C227F8D
GO
Isoform 2 (identifier: Q7Z460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-772: Missing.
     808-808: L → LLLGDSRSK
     1123-1161: Missing.

Show »
Length:1,471
Mass (Da):162,110
Checksum:iF027A39E35F82BA2
GO
Isoform 3 (identifier: Q7Z460-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     737-772: Missing.
     808-808: L → LLLGDSRSK
     911-911: K → KIADSEAECEDKEGNLFPSEVSCT
     1123-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,494
Mass (Da):164,566
Checksum:i0B69865E7CD5A48F
GO
Isoform 4 (identifier: Q7Z460-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: L → LESRHMREDMEYIGLDS
     673-682: RSRSANPAGA → P
     737-772: Missing.
     808-808: L → LLLGDSRS
     1123-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,477
Mass (Da):163,061
Checksum:i7C56388FDF06760C
GO
Isoform 5 (identifier: Q7Z460-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: L → LDGTTTKAE
     737-772: Missing.
     808-808: L → LLLGDSRSK
     1123-1161: Missing.

Note: No experimental confirmation available.
Show »
Length:1,479
Mass (Da):162,914
Checksum:iEC0A6357FB967AC4
GO

Sequence cautioni

The sequence AAH32563 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAX88872 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251R → G in CAI46251 (PubMed:17974005).Curated1
Sequence conflicti556S → F in CAI46251 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053818233I → T.Corresponds to variant rs17761055dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054412637L → LESRHMREDMEYIGLDS in isoform 4. 1 Publication1
Alternative sequenceiVSP_057272637L → LDGTTTKAE in isoform 5. 1 Publication1
Alternative sequenceiVSP_054413673 – 682RSRSANPAGA → P in isoform 4. 1 Publication10
Alternative sequenceiVSP_022386737 – 772Missing in isoform 2, isoform 3 and isoform 4, isoform 5. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_022387808L → LLLGDSRSK in isoform 2, isoform 3 and isoform 5. 2 Publications1
Alternative sequenceiVSP_054414808L → LLLGDSRS in isoform 4. 1 Publication1
Alternative sequenceiVSP_022388911K → KIADSEAECEDKEGNLFPSE VSCT in isoform 3. 1 Publication1
Alternative sequenceiVSP_0223891123 – 1161Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 2 PublicationsAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347693 mRNA. Translation: AAQ15051.1.
AC012447 Genomic DNA. No translation available.
AC013399 Genomic DNA. Translation: AAX88872.1. Sequence problems.
AC018737 Genomic DNA. No translation available.
AC079449 Genomic DNA. No translation available.
BC032563 mRNA. Translation: AAH32563.1. Different initiation.
BC112940 mRNA. Translation: AAI12941.1.
BC132723 mRNA. Translation: AAI32724.1.
BC144107 mRNA. Translation: AAI44108.1.
AJ288057 mRNA. Translation: CAC35156.1.
CR933722 mRNA. Translation: CAI46251.1.
AB014522 mRNA. Translation: BAA31597.1.
PIRiT00387.
RefSeqiNP_001135745.1. NM_001142273.1. [Q7Z460-5]
NP_001135746.1. NM_001142274.1. [Q7Z460-2]
NP_001193980.1. NM_001207051.1. [Q7Z460-4]
NP_056097.1. NM_015282.2. [Q7Z460-1]
XP_011509150.1. XM_011510848.1. [Q7Z460-3]
UniGeneiHs.469840.
Hs.708183.

Genome annotation databases

EnsembliENST00000263710; ENSP00000263710; ENSG00000074054. [Q7Z460-1]
ENST00000397587; ENSP00000380717; ENSG00000074054. [Q7Z460-5]
ENST00000409078; ENSP00000386442; ENSG00000074054. [Q7Z460-2]
ENST00000541377; ENSP00000441625; ENSG00000074054. [Q7Z460-4]
GeneIDi23332.
KEGGihsa:23332.
UCSCiuc061nlf.1. human. [Q7Z460-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF347693 mRNA. Translation: AAQ15051.1.
AC012447 Genomic DNA. No translation available.
AC013399 Genomic DNA. Translation: AAX88872.1. Sequence problems.
AC018737 Genomic DNA. No translation available.
AC079449 Genomic DNA. No translation available.
BC032563 mRNA. Translation: AAH32563.1. Different initiation.
BC112940 mRNA. Translation: AAI12941.1.
BC132723 mRNA. Translation: AAI32724.1.
BC144107 mRNA. Translation: AAI44108.1.
AJ288057 mRNA. Translation: CAC35156.1.
CR933722 mRNA. Translation: CAI46251.1.
AB014522 mRNA. Translation: BAA31597.1.
PIRiT00387.
RefSeqiNP_001135745.1. NM_001142273.1. [Q7Z460-5]
NP_001135746.1. NM_001142274.1. [Q7Z460-2]
NP_001193980.1. NM_001207051.1. [Q7Z460-4]
NP_056097.1. NM_015282.2. [Q7Z460-1]
XP_011509150.1. XM_011510848.1. [Q7Z460-3]
UniGeneiHs.469840.
Hs.708183.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K92X-ray2.00A/B284-552[»]
ProteinModelPortaliQ7Z460.
SMRiQ7Z460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116919. 35 interactors.
IntActiQ7Z460. 35 interactors.
MINTiMINT-1683081.
STRINGi9606.ENSP00000263710.

PTM databases

iPTMnetiQ7Z460.
PhosphoSitePlusiQ7Z460.
SwissPalmiQ7Z460.

Polymorphism and mutation databases

BioMutaiCLASP1.
DMDMi74723323.

Proteomic databases

EPDiQ7Z460.
MaxQBiQ7Z460.
PaxDbiQ7Z460.
PeptideAtlasiQ7Z460.
PRIDEiQ7Z460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263710; ENSP00000263710; ENSG00000074054. [Q7Z460-1]
ENST00000397587; ENSP00000380717; ENSG00000074054. [Q7Z460-5]
ENST00000409078; ENSP00000386442; ENSG00000074054. [Q7Z460-2]
ENST00000541377; ENSP00000441625; ENSG00000074054. [Q7Z460-4]
GeneIDi23332.
KEGGihsa:23332.
UCSCiuc061nlf.1. human. [Q7Z460-1]

Organism-specific databases

CTDi23332.
DisGeNETi23332.
GeneCardsiCLASP1.
HGNCiHGNC:17088. CLASP1.
HPAiHPA062664.
HPA065219.
MIMi605852. gene.
neXtProtiNX_Q7Z460.
OpenTargetsiENSG00000074054.
PharmGKBiPA38436.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2956. Eukaryota.
ENOG410ZMY0. LUCA.
GeneTreeiENSGT00390000001762.
HOGENOMiHOG000236347.
HOVERGENiHBG079692.
InParanoidiQ7Z460.
KOiK16578.
OMAiRDYNPYP.
OrthoDBiEOG091G0GTV.
PhylomeDBiQ7Z460.
TreeFamiTF101155.

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-428890. Role of Abl in Robo-Slit signaling.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiCLASP1. human.
GeneWikiiCLASP1.
GenomeRNAii23332.
PMAP-CutDBQ7Z460.
PROiQ7Z460.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074054.
CleanExiHS_CLASP1.
HS_MAST1.
ExpressionAtlasiQ7Z460. baseline and differential.
GenevisibleiQ7Z460. HS.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR028399. CLASP_metazoan.
IPR024395. CLASP_N_dom.
IPR021133. HEAT_type_2.
[Graphical view]
PANTHERiPTHR21567:SF28. PTHR21567:SF28. 2 hits.
PfamiPF12348. CLASP_N. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLAP1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z460
Secondary accession number(s): A2RU21
, B7ZLX3, F5GWS0, O75118, Q2KHQ9, Q5H9P0, Q8N5B8, Q9BQT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.