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Q7Z444 (RASE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase ERas

Short name=E-Ras
Alternative name(s):
Embryonic stem cell-expressed Ras
Gene names
Name:ERAS
Synonyms:HRAS2, HRASP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells By similarity.

Enzyme regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Subunit structure

Interacts with PIK3CD By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Ras family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 230230GTPase ERas
PRO_0000247538
Propeptide231 – 2333Removed in mature form By similarity
PRO_0000247539

Regions

Nucleotide binding48 – 558GTP By similarity
Nucleotide binding95 – 995GTP By similarity
Nucleotide binding151 – 1544GTP By similarity
Motif70 – 789Effector region

Amino acid modifications

Modified residue2301Cysteine methyl ester By similarity
Lipidation2261S-palmitoyl cysteine By similarity
Lipidation2281S-palmitoyl cysteine By similarity
Lipidation2301S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7Z444 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D5451F95978E7823

FASTA23325,287
        10         20         30         40         50         60 
MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS GVGKSALTIQ 

        70         80         90        100        110        120 
LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA IHRALRDQCL AVCDGVLGVF 

       130        140        150        160        170        180 
ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG NKCDLVTTAG DAHAAAAALA HSWGAHFVET 

       190        200        210        220        230 
SAKTRQGVEE AFSLLVHEIQ RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA 

« Hide

References

« Hide 'large scale' references
[1]"Role of Eras in promoting tumor-like properties in mouse embryonic stem cells."
Takahashi K., Mitsui K., Yamanaka S.
Nature 423:541-545(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB093575 mRNA. Translation: BAC76997.1.
BC101642 mRNA. Translation: AAI01643.1.
BC101644 mRNA. Translation: AAI01645.1.
CCDSCCDS35246.1.
RefSeqNP_853510.1. NM_181532.3.
UniGeneHs.447330.

3D structure databases

ProteinModelPortalQ7Z444.
SMRQ7Z444. Positions 39-201.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109502. 2 interactions.
STRING9606.ENSP00000339136.

PTM databases

PhosphoSiteQ7Z444.

Polymorphism databases

DMDM74723320.

Proteomic databases

PaxDbQ7Z444.
PRIDEQ7Z444.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338270; ENSP00000339136; ENSG00000187682.
ENST00000598069; ENSP00000470632; ENSG00000268426.
GeneID3266.
KEGGhsa:3266.
UCSCuc004dky.2. human.

Organism-specific databases

CTD3266.
GeneCardsGC0XP048687.
HGNCHGNC:5174. ERAS.
MIM300437. gene.
neXtProtNX_Q7Z444.
PharmGKBPA29448.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233973.
HOVERGENHBG009351.
InParanoidQ7Z444.
KOK17196.
OMARATWGPH.
OrthoDBEOG7BS4BJ.
PhylomeDBQ7Z444.
TreeFamTF312796.

Gene expression databases

BgeeQ7Z444.
GenevestigatorQ7Z444.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi3266.
NextBio12967.
PROQ7Z444.
SOURCESearch...

Entry information

Entry nameRASE_HUMAN
AccessionPrimary (citable) accession number: Q7Z444
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM