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Q7Z444

- RASE_HUMAN

UniProt

Q7Z444 - RASE_HUMAN

Protein

GTPase ERas

Gene

ERAS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells By similarity.By similarity

    Enzyme regulationi

    Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi48 – 558GTPBy similarity
    Nucleotide bindingi95 – 995GTPBy similarity
    Nucleotide bindingi151 – 1544GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. GTP catabolic process Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase ERas
    Short name:
    E-Ras
    Alternative name(s):
    Embryonic stem cell-expressed Ras
    Gene namesi
    Name:ERAS
    Synonyms:HRAS2, HRASP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:5174. ERAS.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29448.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 230230GTPase ERasPRO_0000247538Add
    BLAST
    Propeptidei231 – 2333Removed in mature formBy similarityPRO_0000247539

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi226 – 2261S-palmitoyl cysteineBy similarity
    Lipidationi228 – 2281S-palmitoyl cysteineBy similarity
    Modified residuei230 – 2301Cysteine methyl esterBy similarity
    Lipidationi230 – 2301S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    PaxDbiQ7Z444.
    PRIDEiQ7Z444.

    PTM databases

    PhosphoSiteiQ7Z444.

    Expressioni

    Gene expression databases

    BgeeiQ7Z444.
    GenevestigatoriQ7Z444.

    Interactioni

    Subunit structurei

    Interacts with PIK3CD.By similarity

    Protein-protein interaction databases

    BioGridi109502. 2 interactions.
    STRINGi9606.ENSP00000339136.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z444.
    SMRiQ7Z444. Positions 39-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi70 – 789Effector region

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Ras family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233973.
    HOVERGENiHBG009351.
    InParanoidiQ7Z444.
    KOiK17196.
    OMAiRATWGPH.
    OrthoDBiEOG7BS4BJ.
    PhylomeDBiQ7Z444.
    TreeFamiTF312796.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view]
    PANTHERiPTHR24070. PTHR24070. 1 hit.
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00173. RAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51421. RAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z444-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS    50
    GVGKSALTIQ LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA 100
    IHRALRDQCL AVCDGVLGVF ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG 150
    NKCDLVTTAG DAHAAAAALA HSWGAHFVET SAKTRQGVEE AFSLLVHEIQ 200
    RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA 233
    Length:233
    Mass (Da):25,287
    Last modified:October 1, 2003 - v1
    Checksum:iD5451F95978E7823
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093575 mRNA. Translation: BAC76997.1.
    BC101642 mRNA. Translation: AAI01643.1.
    BC101644 mRNA. Translation: AAI01645.1.
    CCDSiCCDS35246.1.
    RefSeqiNP_853510.1. NM_181532.3.
    UniGeneiHs.447330.

    Genome annotation databases

    EnsembliENST00000338270; ENSP00000339136; ENSG00000187682.
    GeneIDi3266.
    KEGGihsa:3266.
    UCSCiuc004dky.2. human.

    Polymorphism databases

    DMDMi74723320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093575 mRNA. Translation: BAC76997.1 .
    BC101642 mRNA. Translation: AAI01643.1 .
    BC101644 mRNA. Translation: AAI01645.1 .
    CCDSi CCDS35246.1.
    RefSeqi NP_853510.1. NM_181532.3.
    UniGenei Hs.447330.

    3D structure databases

    ProteinModelPortali Q7Z444.
    SMRi Q7Z444. Positions 39-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109502. 2 interactions.
    STRINGi 9606.ENSP00000339136.

    PTM databases

    PhosphoSitei Q7Z444.

    Polymorphism databases

    DMDMi 74723320.

    Proteomic databases

    PaxDbi Q7Z444.
    PRIDEi Q7Z444.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338270 ; ENSP00000339136 ; ENSG00000187682 .
    GeneIDi 3266.
    KEGGi hsa:3266.
    UCSCi uc004dky.2. human.

    Organism-specific databases

    CTDi 3266.
    GeneCardsi GC0XP048687.
    HGNCi HGNC:5174. ERAS.
    MIMi 300437. gene.
    neXtProti NX_Q7Z444.
    PharmGKBi PA29448.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233973.
    HOVERGENi HBG009351.
    InParanoidi Q7Z444.
    KOi K17196.
    OMAi RATWGPH.
    OrthoDBi EOG7BS4BJ.
    PhylomeDBi Q7Z444.
    TreeFami TF312796.

    Miscellaneous databases

    GenomeRNAii 3266.
    NextBioi 12967.
    PROi Q7Z444.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7Z444.
    Genevestigatori Q7Z444.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR020849. Small_GTPase_Ras.
    [Graphical view ]
    PANTHERi PTHR24070. PTHR24070. 1 hit.
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00173. RAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51421. RAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of Eras in promoting tumor-like properties in mouse embryonic stem cells."
      Takahashi K., Mitsui K., Yamanaka S.
      Nature 423:541-545(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRASE_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z444
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3