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Q7Z444

- RASE_HUMAN

UniProt

Q7Z444 - RASE_HUMAN

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Protein
GTPase ERas
Gene
ERAS, HRAS2, HRASP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells By similarity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi48 – 558GTP By similarity
Nucleotide bindingi95 – 995GTP By similarity
Nucleotide bindingi151 – 1544GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. GTP catabolic process Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase ERas
Short name:
E-Ras
Alternative name(s):
Embryonic stem cell-expressed Ras
Gene namesi
Name:ERAS
Synonyms:HRAS2, HRASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:5174. ERAS.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230GTPase ERas
PRO_0000247538Add
BLAST
Propeptidei231 – 2333Removed in mature form By similarity
PRO_0000247539

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi226 – 2261S-palmitoyl cysteine By similarity
Lipidationi228 – 2281S-palmitoyl cysteine By similarity
Modified residuei230 – 2301Cysteine methyl ester By similarity
Lipidationi230 – 2301S-farnesyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ7Z444.
PRIDEiQ7Z444.

PTM databases

PhosphoSiteiQ7Z444.

Expressioni

Gene expression databases

BgeeiQ7Z444.
GenevestigatoriQ7Z444.

Interactioni

Subunit structurei

Interacts with PIK3CD By similarity.

Protein-protein interaction databases

BioGridi109502. 2 interactions.
STRINGi9606.ENSP00000339136.

Structurei

3D structure databases

ProteinModelPortaliQ7Z444.
SMRiQ7Z444. Positions 39-201.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi70 – 789Effector region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ7Z444.
KOiK17196.
OMAiRATWGPH.
OrthoDBiEOG7BS4BJ.
PhylomeDBiQ7Z444.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z444-1 [UniParc]FASTAAdd to Basket

« Hide

MELPTKPGTF DLGLATWSPS FQGETHRAQA RRRDVGRQLP EYKAVVVGAS    50
GVGKSALTIQ LNHQCFVEDH DPTIQDSYWK ELTLDSGDCI LNVLDTAGQA 100
IHRALRDQCL AVCDGVLGVF ALDDPSSLIQ LQQIWATWGP HPAQPLVLVG 150
NKCDLVTTAG DAHAAAAALA HSWGAHFVET SAKTRQGVEE AFSLLVHEIQ 200
RVQEAMAKEP MARSCREKTR HQKATCHCGC SVA 233
Length:233
Mass (Da):25,287
Last modified:October 1, 2003 - v1
Checksum:iD5451F95978E7823
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093575 mRNA. Translation: BAC76997.1.
BC101642 mRNA. Translation: AAI01643.1.
BC101644 mRNA. Translation: AAI01645.1.
CCDSiCCDS35246.1.
RefSeqiNP_853510.1. NM_181532.3.
UniGeneiHs.447330.

Genome annotation databases

EnsembliENST00000338270; ENSP00000339136; ENSG00000187682.
ENST00000598069; ENSP00000470632; ENSG00000268426.
GeneIDi3266.
KEGGihsa:3266.
UCSCiuc004dky.2. human.

Polymorphism databases

DMDMi74723320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093575 mRNA. Translation: BAC76997.1 .
BC101642 mRNA. Translation: AAI01643.1 .
BC101644 mRNA. Translation: AAI01645.1 .
CCDSi CCDS35246.1.
RefSeqi NP_853510.1. NM_181532.3.
UniGenei Hs.447330.

3D structure databases

ProteinModelPortali Q7Z444.
SMRi Q7Z444. Positions 39-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109502. 2 interactions.
STRINGi 9606.ENSP00000339136.

PTM databases

PhosphoSitei Q7Z444.

Polymorphism databases

DMDMi 74723320.

Proteomic databases

PaxDbi Q7Z444.
PRIDEi Q7Z444.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338270 ; ENSP00000339136 ; ENSG00000187682 .
ENST00000598069 ; ENSP00000470632 ; ENSG00000268426 .
GeneIDi 3266.
KEGGi hsa:3266.
UCSCi uc004dky.2. human.

Organism-specific databases

CTDi 3266.
GeneCardsi GC0XP048687.
HGNCi HGNC:5174. ERAS.
MIMi 300437. gene.
neXtProti NX_Q7Z444.
PharmGKBi PA29448.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233973.
HOVERGENi HBG009351.
InParanoidi Q7Z444.
KOi K17196.
OMAi RATWGPH.
OrthoDBi EOG7BS4BJ.
PhylomeDBi Q7Z444.
TreeFami TF312796.

Miscellaneous databases

GenomeRNAii 3266.
NextBioi 12967.
PROi Q7Z444.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z444.
Genevestigatori Q7Z444.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view ]
PANTHERi PTHR24070. PTHR24070. 1 hit.
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00173. RAS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51421. RAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of Eras in promoting tumor-like properties in mouse embryonic stem cells."
    Takahashi K., Mitsui K., Yamanaka S.
    Nature 423:541-545(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRASE_HUMAN
AccessioniPrimary (citable) accession number: Q7Z444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi