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Protein

Polycystic kidney disease protein 1-like 3

Gene

PKD1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.3 Publications

Enzyme regulationi

The calcium channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-32457-MONOMER.

Protein family/group databases

TCDBi1.A.5.1.2. the polycystin cation channel (pcc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycystic kidney disease protein 1-like 3
Alternative name(s):
PC1-like 3 protein
Polycystin-1L3
Gene namesi
Name:PKD1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:21716. PKD1L3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 697ExtracellularSequence analysisAdd BLAST674
Transmembranei698 – 718HelicalSequence analysisAdd BLAST21
Topological domaini719 – 905CytoplasmicSequence analysisAdd BLAST187
Transmembranei906 – 926HelicalSequence analysisAdd BLAST21
Topological domaini927 – 939ExtracellularSequence analysisAdd BLAST13
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 1154CytoplasmicSequence analysisAdd BLAST194
Transmembranei1155 – 1175HelicalSequence analysisAdd BLAST21
Topological domaini1176 – 1198ExtracellularSequence analysisAdd BLAST23
Transmembranei1199 – 1219HelicalSequence analysisAdd BLAST21
Topological domaini1220 – 1280CytoplasmicSequence analysisAdd BLAST61
Transmembranei1281 – 1301HelicalSequence analysisAdd BLAST21
Topological domaini1302 – 1462ExtracellularSequence analysisAdd BLAST161
Transmembranei1463 – 1483HelicalSequence analysisAdd BLAST21
Topological domaini1484 – 1501CytoplasmicSequence analysisAdd BLAST18
Transmembranei1502 – 1522HelicalSequence analysisAdd BLAST21
Topological domaini1523 – 1550ExtracellularSequence analysisAdd BLAST28
Transmembranei1551 – 1571HelicalSequence analysisAdd BLAST21
Topological domaini1572 – 1592CytoplasmicSequence analysisAdd BLAST21
Transmembranei1593 – 1613HelicalSequence analysisAdd BLAST21
Topological domaini1614 – 1625ExtracellularSequence analysisAdd BLAST12
Transmembranei1626 – 1646HelicalSequence analysisAdd BLAST21
Topological domaini1647 – 1658CytoplasmicSequence analysisAdd BLAST12
Transmembranei1659 – 1679HelicalSequence analysisAdd BLAST21
Topological domaini1680 – 1732ExtracellularSequence analysisAdd BLAST53

GO - Cellular componenti

  • cation channel complex Source: BHF-UCL
  • cell surface Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi342372.
OpenTargetsiENSG00000277481.

Polymorphism and mutation databases

BioMutaiPKD1L3.
DMDMi74713456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000032257824 – 1732Polycystic kidney disease protein 1-like 3Add BLAST1709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 137PROSITE-ProRule annotation
Disulfide bondi112 ↔ 129PROSITE-ProRule annotation
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi537N-linked (GlcNAc...)Sequence analysis1
Glycosylationi575N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ7Z443.
MaxQBiQ7Z443.
PeptideAtlasiQ7Z443.
PRIDEiQ7Z443.

PTM databases

iPTMnetiQ7Z443.
PhosphoSitePlusiQ7Z443.

Expressioni

Tissue specificityi

Highly expressed in placenta, weakly in heart and lung.1 Publication

Gene expression databases

CleanExiHS_PKD1L3.

Interactioni

Subunit structurei

Calcium channels are probably composed of 3 subunit of PKD2L1 and 1 subunit of PKD1L3.

Protein-protein interaction databases

BioGridi131173. 1 interactor.
IntActiQ7Z443. 1 interactor.
MINTiMINT-6743423.

Structurei

3D structure databases

ProteinModelPortaliQ7Z443.
SMRiQ7Z443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 138C-type lectinAdd BLAST109
Domaini632 – 681GPSPROSITE-ProRule annotationAdd BLAST50
Domaini743 – 860PLATPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1613 – 1651Channel pore-regionAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1274 – 1277Poly-Lys4

Sequence similaritiesi

Belongs to the polycystin family.Curated
Contains 1 C-type lectin domain.Curated
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230856.
HOVERGENiHBG066396.
InParanoidiQ7Z443.
KOiK04989.
OMAiAKCSSSV.
OrthoDBiEOG091G004D.
PhylomeDBiQ7Z443.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000203. GPS.
IPR000434. PC1.
IPR013122. PKD1_2_channel.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PfamiPF01825. GPS. 1 hit.
PF00059. Lectin_C. 1 hit.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00500. POLYCYSTIN1.
SMARTiSM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50221. GPS. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFKGGSWLW LYIRTSIILG SELNSPAPHG QNNCYQLNRF QCSFEEAQHY
60 70 80 90 100
CHVQRGFLAH IWNKEVQDLI RDYLEEGKKW WIGQNVMPLK KHQDNKYPAD
110 120 130 140 150
VAANGPPKPL SCTYLSRNFI RISSKGDKCL LKYYFICQTG DFLDGDAHYE
160 170 180 190 200
RNGNNSHLYQ RHKKTKRGVA IARDKMPPGP GHLPTTCHYP LPAHLSKTLC
210 220 230 240 250
HPISQFPSVL SSITSQVTSA ASEPSSQPLP VITQLTMPVS VTHAGQSLAE
260 270 280 290 300
TTSSPKEEGH PNTFTSYLQV SLQKASGQVI DEIAGNFSRA VHGLQALNKL
310 320 330 340 350
QEACEFLQKL TALTPRFSKP AQVNLINSLI YLSEELLRIP FQNNNSLGFK
360 370 380 390 400
VPPTVCPFHS LNNVTKAGEG SWLESKRHTE PVEDILEMSL VEFGNIGEAF
410 420 430 440 450
LEQNQSPESS VTLTSANATL LLSRQNISTL PLSSYTLGHP APVRLGFPSA
460 470 480 490 500
LALKELLNKH PGVNVQITGL AFNPFKDLDN RNIVGSIGSV LLSANRKLLQ
510 520 530 540 550
VHDLMEDIEI MLWRNVSLET HPTSLNMSTH QLTITVNVTS LEKSLIVSID
560 570 580 590 600
PDSPLLMTLY LGFQYQPNCT HFHLNITLPK DKVWQKDEEY TWVLNPEHLQ
610 620 630 640 650
HGIGTYYITA VLSERQEGAQ QTPSLVSVIT AVTQCYYWEI HNQTWSSAGC
660 670 680 690 700
QVGPQSTILR TQCLCNHLTF FASDFFVVPR TVNVEDTIKL FLRVTNNPVG
710 720 730 740 750
VSLLASLLGF YVITVVWARK KDQADMQKVK VTVLADNDPS AQFHYLIQVY
760 770 780 790 800
TGYRRSAATT AKVVITLYGS EGRSEPHHLC DPQKTVFERG GLDVFLLTTW
810 820 830 840 850
TSLGNLHSLR LWHDNSGVSP SWYVSQVIVC DMAVKRKWHF LCNCWLAVDL
860 870 880 890 900
GDCELDRVFI PVSKRELFSF RHLFSSMIVE KFTQDYLWLS IATRHPWNQF
910 920 930 940 950
TRVQRLSCCM TLLLCNMVIN VMFWKINSTT AKRDEQMRPF AVAWSELLVS
960 970 980 990 1000
IHTAVILFPI NLVIGRLFPL IEPQETLPLF PPIQASCLSD ASVEPLSATM
1010 1020 1030 1040 1050
VVEELKETVR FLLRRNTYLL SKCEQPPWSS WDITKLVKLL SSLVSSHLEG
1060 1070 1080 1090 1100
QGCHQQGERH WARVVPENHH HFCCYLHRVL QRLKSHLGTL GLTQGHQSCD
1110 1120 1130 1140 1150
FLDAASQLQK LQELLETHIL PTEQEPSREV TSFAILSSEE GKKPISNGLS
1160 1170 1180 1190 1200
KWLTSVCWLL LGFTSLASAF FTALYSLELS KDQATSWMIS IILSVLQNIF
1210 1220 1230 1240 1250
ISQPVKVVFF TFLYSLMMSR MPRLNKENEQ QTKRILALLA KCSSSVPGSR
1260 1270 1280 1290 1300
DKNNPVYVAP AINSPTKHPE RTLKKKKLFK LTGDILVQIL FLTLLMTAIY
1310 1320 1330 1340 1350
SAKNSNRFYL HQAIWKTFSH QFSEIKLLQD FYPWANHILL PSLYGDYRGK
1360 1370 1380 1390 1400
NAVLEPSHCK CGVQLIFQIP RTKTYEKVDE GQLAFCDNGH TCGRPKSLFP
1410 1420 1430 1440 1450
GLHLRRFSYI CSPRPMVLIP TDELHERLTS KNENGFSYIM RGAFFTSLRL
1460 1470 1480 1490 1500
ESFTSLQMSK KGCVWSIISQ VIYYLLVCYY AFIQGCQLKQ QKWRFFTGKR
1510 1520 1530 1540 1550
NILDTSIILI SFILLGLDMK SISLHKKNMA RYRDDQDRFI SFYEAVKVNS
1560 1570 1580 1590 1600
AATHLVGFPV LLATVQLWNL LRHSPRLRVI SRTLSRAWDE VVGFLLIILI
1610 1620 1630 1640 1650
LLTGYAIAFN LLFGCSISDY RTFFSSAVTV VGLLMGISHQ EEVFALDPVL
1660 1670 1680 1690 1700
GTFLILTSVI LMVLVVINLF VSAILMAFGK ERKSLKKEAA LIDTLLQKLS
1710 1720 1730
NLLGISWPQK TSSEQAATTA VGSDTEVLDE LP
Length:1,732
Mass (Da):195,894
Last modified:October 1, 2003 - v1
Checksum:i64847A1C8BE5A6A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039453120I → F.Corresponds to variant rs16973585dbSNPEnsembl.1
Natural variantiVAR_039454211S → P.Corresponds to variant rs4788591dbSNPEnsembl.1
Natural variantiVAR_039455274K → E.Corresponds to variant rs12708923dbSNPEnsembl.1
Natural variantiVAR_039456429T → S.Corresponds to variant rs7185272dbSNPEnsembl.1
Natural variantiVAR_039457471A → D.Corresponds to variant rs16973537dbSNPEnsembl.1
Natural variantiVAR_039458571H → Q.Corresponds to variant rs1559401dbSNPEnsembl.1
Natural variantiVAR_039459593V → M.Corresponds to variant rs9925415dbSNPEnsembl.1
Natural variantiVAR_039460903V → I.Corresponds to variant rs9921412dbSNPEnsembl.1
Natural variantiVAR_0394611176S → R.Corresponds to variant rs1035543dbSNPEnsembl.1
Natural variantiVAR_0394621474Y → C.Corresponds to variant rs13335617dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164485 mRNA. Translation: AAO32798.1.
CCDSiCCDS73912.1.
RefSeqiNP_853514.1. NM_181536.1.
UniGeneiHs.675286.

Genome annotation databases

EnsembliENST00000620267; ENSP00000480090; ENSG00000277481.
GeneIDi342372.
KEGGihsa:342372.
UCSCiuc059wxm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164485 mRNA. Translation: AAO32798.1.
CCDSiCCDS73912.1.
RefSeqiNP_853514.1. NM_181536.1.
UniGeneiHs.675286.

3D structure databases

ProteinModelPortaliQ7Z443.
SMRiQ7Z443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131173. 1 interactor.
IntActiQ7Z443. 1 interactor.
MINTiMINT-6743423.

Protein family/group databases

TCDBi1.A.5.1.2. the polycystin cation channel (pcc) family.

PTM databases

iPTMnetiQ7Z443.
PhosphoSitePlusiQ7Z443.

Polymorphism and mutation databases

BioMutaiPKD1L3.
DMDMi74713456.

Proteomic databases

EPDiQ7Z443.
MaxQBiQ7Z443.
PeptideAtlasiQ7Z443.
PRIDEiQ7Z443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000620267; ENSP00000480090; ENSG00000277481.
GeneIDi342372.
KEGGihsa:342372.
UCSCiuc059wxm.1. human.

Organism-specific databases

CTDi342372.
DisGeNETi342372.
GeneCardsiPKD1L3.
H-InvDBHIX0038832.
HGNCiHGNC:21716. PKD1L3.
MIMi607895. gene.
neXtProtiNX_Q7Z443.
OpenTargetsiENSG00000277481.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00700000104221.
HOGENOMiHOG000230856.
HOVERGENiHBG066396.
InParanoidiQ7Z443.
KOiK04989.
OMAiAKCSSSV.
OrthoDBiEOG091G004D.
PhylomeDBiQ7Z443.

Enzyme and pathway databases

BioCyciZFISH:G66-32457-MONOMER.

Miscellaneous databases

GenomeRNAii342372.
PROiQ7Z443.
SOURCEiSearch...

Gene expression databases

CleanExiHS_PKD1L3.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000203. GPS.
IPR000434. PC1.
IPR013122. PKD1_2_channel.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PfamiPF01825. GPS. 1 hit.
PF00059. Lectin_C. 1 hit.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00500. POLYCYSTIN1.
SMARTiSM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50221. GPS. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPK1L3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PKD1L3 and PKD2L1 have been defined as sour taste receptor in gustatory cells based on a number of indirect evidences in mouse. Some data confirm this hypothesis in human: in 2 patients with sour ageusia that are unresponsive to sour stimuli, but show normal responses to bitter, sweet, and salty stimuli, expression of PKD1L3 and PKD2L1 is absent in the anterior part of the tongue (PubMed:19812697). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.