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Q7Z429 (LFG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Putative MAPK-activating protein PM02
Transmembrane BAX inhibitor motif-containing protein 3
Gene names
Name:GRINA
Synonyms:LFG1, NMDARA1, TMBIM3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential apoptotic regulator.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Sequence caution

The sequence AAB94292.1 differs from that shown. Reason: Frameshift at positions 224 and 371.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Protein lifeguard 1
PRO_0000314439

Regions

Transmembrane165 – 18521Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane228 – 24821Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane283 – 30321Helical; Potential
Transmembrane307 – 32721Helical; Potential
Transmembrane346 – 36621Helical; Potential
Compositional bias15 – 139125Pro-rich

Natural variations

Natural variant1071S → N. Ref.4
Corresponds to variant rs17854152 [ dbSNP | Ensembl ].
VAR_037875

Experimental info

Sequence conflict2241H → R in AAB94292. Ref.5
Sequence conflict3171A → P in AAB94292. Ref.5
Sequence conflict332 – 3365LGNKQ → REQA in AAB94292. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q7Z429 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 62E012DFB0E7DEEB

FASTA37141,203
        10         20         30         40         50         60 
MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG 

        70         80         90        100        110        120 
PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF 

       130        140        150        160        170        180 
PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV 

       190        200        210        220        230        240 
SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY 

       250        260        270        280        290        300 
MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC 

       310        320        330        340        350        360 
IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL 

       370 
YILTIIGRAK E 

« Hide

References

« Hide 'large scale' references
[1]"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-107.
Tissue: Pancreas and Prostate.
[5]Won M., Moon K.-M., Lee C.-E., Yoo H.S.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-371.
Tissue: Liver.
[6]"Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively."
Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W., Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R.
Genomics 17:237-239(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"LFG: a candidate apoptosis regulatory gene family."
Hu L., Smith T.F., Goldberger G.
Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB097026 mRNA. Translation: BAC77379.1.
AK127640 mRNA. Translation: BAG54539.1.
CH471416 Genomic DNA. Translation: EAW52305.1.
BC041788 mRNA. Translation: AAH41788.2.
BC084553 mRNA. Translation: AAH84553.1.
U44954 mRNA. Translation: AAB94292.1. Frameshift.
CCDSCCDS34961.1.
RefSeqNP_000828.1. NM_000837.1.
NP_001009184.1. NM_001009184.1.
XP_005250956.1. XM_005250899.1.
UniGeneHs.594634.

3D structure databases

ProteinModelPortalQ7Z429.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-47262N.
IntActQ7Z429. 2 interactions.
MINTMINT-6630936.
STRING9606.ENSP00000314380.

Chemistry

BindingDBQ7Z429.

PTM databases

PhosphoSiteQ7Z429.

Polymorphism databases

DMDM74738689.

Proteomic databases

PaxDbQ7Z429.
PRIDEQ7Z429.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313269; ENSP00000314380; ENSG00000178719.
ENST00000395068; ENSP00000378507; ENSG00000178719.
ENST00000569564; ENSP00000456043; ENSG00000261721.
GeneID2907.
KEGGhsa:2907.
UCSCuc003zan.1. human.

Organism-specific databases

CTD2907.
GeneCardsGC08P145064.
HGNCHGNC:4589. GRINA.
HPAHPA036980.
HPA036981.
MIM138251. gene.
neXtProtNX_Q7Z429.
PharmGKBPA28985.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0670.
HOGENOMHOG000060393.
HOVERGENHBG012084.
InParanoidQ7Z429.
KOK06890.
OMAFQPSPYG.
PhylomeDBQ7Z429.
TreeFamTF319996.

Gene expression databases

ArrayExpressQ7Z429.
BgeeQ7Z429.
CleanExHS_GRINA.
GenevestigatorQ7Z429.

Family and domain databases

InterProIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERPTHR23291. PTHR23291. 1 hit.
PfamPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGRINA. human.
GenomeRNAi2907.
NextBio11511.
PROQ7Z429.
SOURCESearch...

Entry information

Entry nameLFG1_HUMAN
AccessionPrimary (citable) accession number: Q7Z429
Secondary accession number(s): B3KXM7, O43836, Q8IVW7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM