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Protein

Protein lifeguard 1

Gene

GRINA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.

GO - Biological processi

  1. endoplasmic reticulum calcium ion homeostasis Source: Ensembl
  2. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Putative MAPK-activating protein PM02
Transmembrane BAX inhibitor motif-containing protein 3
Gene namesi
Name:GRINA
Synonyms:LFG1, NMDARA1, TMBIM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:4589. GRINA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28985.

Polymorphism and mutation databases

BioMutaiGRINA.
DMDMi74738689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Protein lifeguard 1PRO_0000314439Add
BLAST

Proteomic databases

PaxDbiQ7Z429.
PRIDEiQ7Z429.

PTM databases

PhosphoSiteiQ7Z429.

Expressioni

Gene expression databases

BgeeiQ7Z429.
CleanExiHS_GRINA.
ExpressionAtlasiQ7Z429. baseline and differential.
GenevestigatoriQ7Z429.

Organism-specific databases

HPAiHPA036980.
HPA036981.

Interactioni

Protein-protein interaction databases

DIPiDIP-47262N.
IntActiQ7Z429. 3 interactions.
MINTiMINT-6630936.
STRINGi9606.ENSP00000314380.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 139125Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ7Z429.
KOiK06890.
OMAiFQPSPYG.
PhylomeDBiQ7Z429.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS
60 70 80 90 100
PYGQPGYPHG PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP
110 120 130 140 150
QGPYPQSPFP PNPYGQPQVF PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT
160 170 180 190 200
NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV SVFTFVAEVK GFVRENVWTY
210 220 230 240 250
YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY MVGMIASFYN
260 270 280 290 300
TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
310 320 330 340 350
IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN
360 370
LYTDIINIFL YILTIIGRAK E
Length:371
Mass (Da):41,203
Last modified:October 1, 2003 - v1
Checksum:i62E012DFB0E7DEEB
GO

Sequence cautioni

The sequence AAB94292.1 differs from that shown. Reason: Frameshift at positions 224 and 371. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241H → R in AAB94292 (Ref. 5) Curated
Sequence conflicti317 – 3171A → P in AAB94292 (Ref. 5) Curated
Sequence conflicti332 – 3365LGNKQ → REQA in AAB94292 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071S → N.1 Publication
Corresponds to variant rs17854152 [ dbSNP | Ensembl ].
VAR_037875

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097026 mRNA. Translation: BAC77379.1.
AK127640 mRNA. Translation: BAG54539.1.
CH471416 Genomic DNA. Translation: EAW52305.1.
BC041788 mRNA. Translation: AAH41788.2.
BC084553 mRNA. Translation: AAH84553.1.
U44954 mRNA. Translation: AAB94292.1. Frameshift.
CCDSiCCDS34961.1.
RefSeqiNP_000828.1. NM_000837.1.
NP_001009184.1. NM_001009184.1.
XP_005250956.1. XM_005250899.2.
UniGeneiHs.594634.

Genome annotation databases

EnsembliENST00000313269; ENSP00000314380; ENSG00000178719.
ENST00000395068; ENSP00000378507; ENSG00000178719.
GeneIDi2907.
KEGGihsa:2907.
UCSCiuc003zan.1. human.

Polymorphism and mutation databases

BioMutaiGRINA.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097026 mRNA. Translation: BAC77379.1.
AK127640 mRNA. Translation: BAG54539.1.
CH471416 Genomic DNA. Translation: EAW52305.1.
BC041788 mRNA. Translation: AAH41788.2.
BC084553 mRNA. Translation: AAH84553.1.
U44954 mRNA. Translation: AAB94292.1. Frameshift.
CCDSiCCDS34961.1.
RefSeqiNP_000828.1. NM_000837.1.
NP_001009184.1. NM_001009184.1.
XP_005250956.1. XM_005250899.2.
UniGeneiHs.594634.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-47262N.
IntActiQ7Z429. 3 interactions.
MINTiMINT-6630936.
STRINGi9606.ENSP00000314380.

PTM databases

PhosphoSiteiQ7Z429.

Polymorphism and mutation databases

BioMutaiGRINA.
DMDMi74738689.

Proteomic databases

PaxDbiQ7Z429.
PRIDEiQ7Z429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313269; ENSP00000314380; ENSG00000178719.
ENST00000395068; ENSP00000378507; ENSG00000178719.
GeneIDi2907.
KEGGihsa:2907.
UCSCiuc003zan.1. human.

Organism-specific databases

CTDi2907.
GeneCardsiGC08P145064.
HGNCiHGNC:4589. GRINA.
HPAiHPA036980.
HPA036981.
MIMi138251. gene.
neXtProtiNX_Q7Z429.
PharmGKBiPA28985.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ7Z429.
KOiK06890.
OMAiFQPSPYG.
PhylomeDBiQ7Z429.
TreeFamiTF319996.

Miscellaneous databases

ChiTaRSiGRINA. human.
GenomeRNAii2907.
NextBioi11511.
PROiQ7Z429.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z429.
CleanExiHS_GRINA.
ExpressionAtlasiQ7Z429. baseline and differential.
GenevestigatoriQ7Z429.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-107.
    Tissue: Pancreas and Prostate.
  5. Won M., Moon K.-M., Lee C.-E., Yoo H.S.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-371.
    Tissue: Liver.
  6. "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively."
    Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W., Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R.
    Genomics 17:237-239(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLFG1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z429
Secondary accession number(s): B3KXM7, O43836, Q8IVW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.