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Q7Z429

- LFG1_HUMAN

UniProt

Q7Z429 - LFG1_HUMAN

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Protein

Protein lifeguard 1

Gene

GRINA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Putative MAPK-activating protein PM02
Transmembrane BAX inhibitor motif-containing protein 3
Gene namesi
Name:GRINA
Synonyms:LFG1, NMDARA1, TMBIM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:4589. GRINA.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Protein lifeguard 1PRO_0000314439Add
BLAST

Proteomic databases

PaxDbiQ7Z429.
PRIDEiQ7Z429.

PTM databases

PhosphoSiteiQ7Z429.

Expressioni

Gene expression databases

BgeeiQ7Z429.
CleanExiHS_GRINA.
ExpressionAtlasiQ7Z429. baseline and differential.
GenevestigatoriQ7Z429.

Organism-specific databases

HPAiHPA036980.
HPA036981.

Interactioni

Protein-protein interaction databases

DIPiDIP-47262N.
IntActiQ7Z429. 3 interactions.
MINTiMINT-6630936.
STRINGi9606.ENSP00000314380.

Structurei

3D structure databases

ProteinModelPortaliQ7Z429.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence AnalysisAdd
BLAST
Transmembranei307 – 32721HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 139125Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ7Z429.
KOiK06890.
OMAiFQPSPYG.
PhylomeDBiQ7Z429.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z429-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS
60 70 80 90 100
PYGQPGYPHG PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP
110 120 130 140 150
QGPYPQSPFP PNPYGQPQVF PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT
160 170 180 190 200
NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV SVFTFVAEVK GFVRENVWTY
210 220 230 240 250
YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY MVGMIASFYN
260 270 280 290 300
TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
310 320 330 340 350
IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN
360 370
LYTDIINIFL YILTIIGRAK E
Length:371
Mass (Da):41,203
Last modified:October 1, 2003 - v1
Checksum:i62E012DFB0E7DEEB
GO

Sequence cautioni

The sequence AAB94292.1 differs from that shown. Reason: Frameshift at positions 224 and 371.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241H → R in AAB94292. 1 PublicationCurated
Sequence conflicti317 – 3171A → P in AAB94292. 1 PublicationCurated
Sequence conflicti332 – 3365LGNKQ → REQA in AAB94292. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071S → N.1 Publication
Corresponds to variant rs17854152 [ dbSNP | Ensembl ].
VAR_037875

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097026 mRNA. Translation: BAC77379.1.
AK127640 mRNA. Translation: BAG54539.1.
CH471416 Genomic DNA. Translation: EAW52305.1.
BC041788 mRNA. Translation: AAH41788.2.
BC084553 mRNA. Translation: AAH84553.1.
U44954 mRNA. Translation: AAB94292.1. Frameshift.
CCDSiCCDS34961.1.
RefSeqiNP_000828.1. NM_000837.1.
NP_001009184.1. NM_001009184.1.
XP_005250956.1. XM_005250899.1.
UniGeneiHs.594634.

Genome annotation databases

EnsembliENST00000313269; ENSP00000314380; ENSG00000178719.
ENST00000395068; ENSP00000378507; ENSG00000178719.
GeneIDi2907.
KEGGihsa:2907.
UCSCiuc003zan.1. human.

Polymorphism databases

DMDMi74738689.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB097026 mRNA. Translation: BAC77379.1 .
AK127640 mRNA. Translation: BAG54539.1 .
CH471416 Genomic DNA. Translation: EAW52305.1 .
BC041788 mRNA. Translation: AAH41788.2 .
BC084553 mRNA. Translation: AAH84553.1 .
U44954 mRNA. Translation: AAB94292.1 . Frameshift.
CCDSi CCDS34961.1.
RefSeqi NP_000828.1. NM_000837.1.
NP_001009184.1. NM_001009184.1.
XP_005250956.1. XM_005250899.1.
UniGenei Hs.594634.

3D structure databases

ProteinModelPortali Q7Z429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-47262N.
IntActi Q7Z429. 3 interactions.
MINTi MINT-6630936.
STRINGi 9606.ENSP00000314380.

Chemistry

BindingDBi Q7Z429.

PTM databases

PhosphoSitei Q7Z429.

Polymorphism databases

DMDMi 74738689.

Proteomic databases

PaxDbi Q7Z429.
PRIDEi Q7Z429.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313269 ; ENSP00000314380 ; ENSG00000178719 .
ENST00000395068 ; ENSP00000378507 ; ENSG00000178719 .
GeneIDi 2907.
KEGGi hsa:2907.
UCSCi uc003zan.1. human.

Organism-specific databases

CTDi 2907.
GeneCardsi GC08P145064.
HGNCi HGNC:4589. GRINA.
HPAi HPA036980.
HPA036981.
MIMi 138251. gene.
neXtProti NX_Q7Z429.
PharmGKBi PA28985.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0670.
GeneTreei ENSGT00500000044791.
HOGENOMi HOG000060393.
HOVERGENi HBG012084.
InParanoidi Q7Z429.
KOi K06890.
OMAi FQPSPYG.
PhylomeDBi Q7Z429.
TreeFami TF319996.

Miscellaneous databases

ChiTaRSi GRINA. human.
GenomeRNAii 2907.
NextBioi 11511.
PROi Q7Z429.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z429.
CleanExi HS_GRINA.
ExpressionAtlasi Q7Z429. baseline and differential.
Genevestigatori Q7Z429.

Family and domain databases

InterProi IPR006214. Bax_inhibitor_1-related.
[Graphical view ]
PANTHERi PTHR23291. PTHR23291. 1 hit.
Pfami PF01027. Bax1-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-107.
    Tissue: Pancreas and Prostate.
  5. Won M., Moon K.-M., Lee C.-E., Yoo H.S.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-371.
    Tissue: Liver.
  6. "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively."
    Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W., Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R.
    Genomics 17:237-239(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLFG1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z429
Secondary accession number(s): B3KXM7, O43836, Q8IVW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3