Q7Z429 (LFG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein lifeguard 1

Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Putative MAPK-activating protein PM02
Transmembrane BAX inhibitor motif-containing protein 3

Gene names

Name:	GRINA
Synonyms:	LFG1, NMDARA1, TMBIM3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential apoptotic regulator.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the BI1 family. LFG subfamily.
Sequence caution	The sequence AAB94292.1 differs from that shown. Reason: Frameshift at positions 224 and 371.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Protein lifeguard 1		PRO_0000314439
Regions
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential
	Transmembrane	283 – 303	21	Helical; Potential
	Transmembrane	307 – 327	21	Helical; Potential
	Transmembrane	346 – 366	21	Helical; Potential
	Compositional bias	15 – 139	125	Pro-rich
Natural variations
	Natural variant	107	1	S → N. Ref.4 Corresponds to variant rs17854152 [ dbSNP | Ensembl ].		VAR_037875
Experimental info
	Sequence conflict	224	1	H → R in AAB94292. Ref.5
	Sequence conflict	317	1	A → P in AAB94292. Ref.5
	Sequence conflict	332 – 336	5	LGNKQ → REQA in AAB94292. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q7Z429 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 62E012DFB0E7DEEB	FASTA	371	41,203
	10 20 30 40 50 60 MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG 70 80 90 100 110 120 PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF 130 140 150 160 170 180 PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV 190 200 210 220 230 240 SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY 250 260 270 280 290 300 MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC 310 320 330 340 350 360 IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL 370 YILTIIGRAK E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S. Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-107. Tissue: Pancreas and Prostate.
[5]	Won M., Moon K.-M., Lee C.-E., Yoo H.S. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-371. Tissue: Liver.
[6]	"Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively." Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W., Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R. Genomics 17:237-239(1993) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"LFG: a candidate apoptosis regulatory gene family." Hu L., Smith T.F., Goldberger G. Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB097026 mRNA. Translation: BAC77379.1. AK127640 mRNA. Translation: BAG54539.1. CH471416 Genomic DNA. Translation: EAW52305.1. BC041788 mRNA. Translation: AAH41788.2. BC084553 mRNA. Translation: AAH84553.1. U44954 mRNA. Translation: AAB94292.1. Frameshift.
IPI	IPI00292999.
RefSeq	NP_000828.1. NM_000837.1. NP_001009184.1. NM_001009184.1.
UniGene	Hs.594634.
3D structure databases
ProteinModelPortal	Q7Z429.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47262N.
IntAct	Q7Z429. 2 interactions.
MINT	MINT-6630936.
STRING	9606.ENSP00000314380.
PTM databases
PhosphoSite	Q7Z429.
Polymorphism databases
DMDM	74738689.
Proteomic databases
PaxDb	Q7Z429.
PRIDE	Q7Z429.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313269; ENSP00000314380; ENSG00000178719. ENST00000395068; ENSP00000378507; ENSG00000178719. ENST00000569564; ENSP00000456043; ENSG00000261721.
GeneID	2907.
KEGG	hsa:2907.
UCSC	uc003zan.1. human.
Organism-specific databases
CTD	2907.
GeneCards	GC08P145064.
HGNC	HGNC:4589. GRINA.
HPA	HPA036980. HPA036981.
MIM	138251. gene.
neXtProt	NX_Q7Z429.
PharmGKB	PA28985.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0670.
HOGENOM	HOG000060393.
HOVERGEN	HBG012084.
InParanoid	Q7Z429.
KO	K06890.
OMA	FQPSPYG.
OrthoDB	EOG41G358.
PhylomeDB	Q7Z429.
Gene expression databases
ArrayExpress	Q7Z429.
Bgee	Q7Z429.
CleanEx	HS_GRINA.
Genevestigator	Q7Z429.
Family and domain databases
InterPro	IPR006214. Bax_inhibitor_1-related. [Graphical view]
PANTHER	PTHR23291. PTHR23291. 1 hit.
Pfam	PF01027. Bax1-I. 1 hit. [Graphical view]
PROSITE	PS01243. BI1. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q7Z429.
ChEMBL	CHEMBL4704.
ChiTaRS	GRINA. human.
GenomeRNAi	2907.
NextBio	11511.
SOURCE	Search...

Entry information

Entry name

LFG1_HUMAN

Accession

Primary (citable) accession number: Q7Z429
Secondary accession number(s): B3KXM7, O43836, Q8IVW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 1, 2003
Last modified:	May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.