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Q7Z429

- LFG1_HUMAN

UniProt

Q7Z429 - LFG1_HUMAN

Protein

Protein lifeguard 1

Gene

GRINA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Potential apoptotic regulator.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 1
    Alternative name(s):
    Glutamate [NMDA] receptor-associated protein 1
    NMDA receptor glutamate-binding subunit
    Putative MAPK-activating protein PM02
    Transmembrane BAX inhibitor motif-containing protein 3
    Gene namesi
    Name:GRINA
    Synonyms:LFG1, NMDARA1, TMBIM3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:4589. GRINA.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28985.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Protein lifeguard 1PRO_0000314439Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z429.
    PRIDEiQ7Z429.

    PTM databases

    PhosphoSiteiQ7Z429.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z429.
    BgeeiQ7Z429.
    CleanExiHS_GRINA.
    GenevestigatoriQ7Z429.

    Organism-specific databases

    HPAiHPA036980.
    HPA036981.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-47262N.
    IntActiQ7Z429. 3 interactions.
    MINTiMINT-6630936.
    STRINGi9606.ENSP00000314380.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z429.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei283 – 30321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 139125Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    InParanoidiQ7Z429.
    KOiK06890.
    OMAiFQPSPYG.
    PhylomeDBiQ7Z429.
    TreeFamiTF319996.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z429-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS    50
    PYGQPGYPHG PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP 100
    QGPYPQSPFP PNPYGQPQVF PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT 150
    NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV SVFTFVAEVK GFVRENVWTY 200
    YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY MVGMIASFYN 250
    TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC 300
    IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN 350
    LYTDIINIFL YILTIIGRAK E 371
    Length:371
    Mass (Da):41,203
    Last modified:October 1, 2003 - v1
    Checksum:i62E012DFB0E7DEEB
    GO

    Sequence cautioni

    The sequence AAB94292.1 differs from that shown. Reason: Frameshift at positions 224 and 371.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241H → R in AAB94292. 1 PublicationCurated
    Sequence conflicti317 – 3171A → P in AAB94292. 1 PublicationCurated
    Sequence conflicti332 – 3365LGNKQ → REQA in AAB94292. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 1071S → N.1 Publication
    Corresponds to variant rs17854152 [ dbSNP | Ensembl ].
    VAR_037875

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097026 mRNA. Translation: BAC77379.1.
    AK127640 mRNA. Translation: BAG54539.1.
    CH471416 Genomic DNA. Translation: EAW52305.1.
    BC041788 mRNA. Translation: AAH41788.2.
    BC084553 mRNA. Translation: AAH84553.1.
    U44954 mRNA. Translation: AAB94292.1. Frameshift.
    CCDSiCCDS34961.1.
    RefSeqiNP_000828.1. NM_000837.1.
    NP_001009184.1. NM_001009184.1.
    XP_005250956.1. XM_005250899.1.
    UniGeneiHs.594634.

    Genome annotation databases

    EnsembliENST00000313269; ENSP00000314380; ENSG00000178719.
    ENST00000395068; ENSP00000378507; ENSG00000178719.
    GeneIDi2907.
    KEGGihsa:2907.
    UCSCiuc003zan.1. human.

    Polymorphism databases

    DMDMi74738689.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB097026 mRNA. Translation: BAC77379.1 .
    AK127640 mRNA. Translation: BAG54539.1 .
    CH471416 Genomic DNA. Translation: EAW52305.1 .
    BC041788 mRNA. Translation: AAH41788.2 .
    BC084553 mRNA. Translation: AAH84553.1 .
    U44954 mRNA. Translation: AAB94292.1 . Frameshift.
    CCDSi CCDS34961.1.
    RefSeqi NP_000828.1. NM_000837.1.
    NP_001009184.1. NM_001009184.1.
    XP_005250956.1. XM_005250899.1.
    UniGenei Hs.594634.

    3D structure databases

    ProteinModelPortali Q7Z429.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-47262N.
    IntActi Q7Z429. 3 interactions.
    MINTi MINT-6630936.
    STRINGi 9606.ENSP00000314380.

    Chemistry

    BindingDBi Q7Z429.

    PTM databases

    PhosphoSitei Q7Z429.

    Polymorphism databases

    DMDMi 74738689.

    Proteomic databases

    PaxDbi Q7Z429.
    PRIDEi Q7Z429.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313269 ; ENSP00000314380 ; ENSG00000178719 .
    ENST00000395068 ; ENSP00000378507 ; ENSG00000178719 .
    GeneIDi 2907.
    KEGGi hsa:2907.
    UCSCi uc003zan.1. human.

    Organism-specific databases

    CTDi 2907.
    GeneCardsi GC08P145064.
    HGNCi HGNC:4589. GRINA.
    HPAi HPA036980.
    HPA036981.
    MIMi 138251. gene.
    neXtProti NX_Q7Z429.
    PharmGKBi PA28985.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0670.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    InParanoidi Q7Z429.
    KOi K06890.
    OMAi FQPSPYG.
    PhylomeDBi Q7Z429.
    TreeFami TF319996.

    Miscellaneous databases

    ChiTaRSi GRINA. human.
    GenomeRNAii 2907.
    NextBioi 11511.
    PROi Q7Z429.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z429.
    Bgeei Q7Z429.
    CleanExi HS_GRINA.
    Genevestigatori Q7Z429.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-107.
      Tissue: Pancreas and Prostate.
    5. Won M., Moon K.-M., Lee C.-E., Yoo H.S.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 218-371.
      Tissue: Liver.
    6. "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively."
      Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W., Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R.
      Genomics 17:237-239(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "LFG: a candidate apoptosis regulatory gene family."
      Hu L., Smith T.F., Goldberger G.
      Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiLFG1_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z429
    Secondary accession number(s): B3KXM7, O43836, Q8IVW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3