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Protein

Protein lifeguard 1

Gene

GRINA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Putative MAPK-activating protein PM02
Transmembrane BAX inhibitor motif-containing protein 3
Gene namesi
Name:GRINA
Synonyms:LFG1, NMDARA1, TMBIM3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000178719.16
HGNCiHGNC:4589 GRINA
MIMi138251 gene
neXtProtiNX_Q7Z429

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei253 – 273HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Transmembranei307 – 327HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2907
OpenTargetsiENSG00000178719
PharmGKBiPA28985

Polymorphism and mutation databases

BioMutaiGRINA
DMDMi74738689

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144391 – 371Protein lifeguard 1Add BLAST371

Proteomic databases

EPDiQ7Z429
PaxDbiQ7Z429
PeptideAtlasiQ7Z429
PRIDEiQ7Z429
TopDownProteomicsiQ7Z429

PTM databases

iPTMnetiQ7Z429
PhosphoSitePlusiQ7Z429

Expressioni

Gene expression databases

BgeeiENSG00000178719
CleanExiHS_GRINA
ExpressionAtlasiQ7Z429 baseline and differential
GenevisibleiQ7Z429 HS

Organism-specific databases

HPAiHPA036980
HPA036981

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-47262N
IntActiQ7Z429, 8 interactors
MINTiQ7Z429
STRINGi9606.ENSP00000314380

Structurei

3D structure databases

ProteinModelPortaliQ7Z429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 139Pro-richAdd BLAST125

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2322 Eukaryota
COG0670 LUCA
GeneTreeiENSGT00500000044791
HOGENOMiHOG000060393
HOVERGENiHBG012084
InParanoidiQ7Z429
KOiK06890
OMAiDNYPPPN
OrthoDBiEOG091G0JRK
PhylomeDBiQ7Z429
TreeFamiTF319996

Family and domain databases

InterProiView protein in InterPro
IPR006214 Bax_inhibitor_1-related
PANTHERiPTHR23291 PTHR23291, 1 hit
PfamiView protein in Pfam
PF01027 Bax1-I, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS
60 70 80 90 100
PYGQPGYPHG PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP
110 120 130 140 150
QGPYPQSPFP PNPYGQPQVF PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT
160 170 180 190 200
NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV SVFTFVAEVK GFVRENVWTY
210 220 230 240 250
YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY MVGMIASFYN
260 270 280 290 300
TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
310 320 330 340 350
IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN
360 370
LYTDIINIFL YILTIIGRAK E
Length:371
Mass (Da):41,203
Last modified:October 1, 2003 - v1
Checksum:i62E012DFB0E7DEEB
GO

Sequence cautioni

The sequence AAB94292 differs from that shown. Reason: Frameshift at positions 224 and 371.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224H → R in AAB94292 (Ref. 5) Curated1
Sequence conflicti317A → P in AAB94292 (Ref. 5) Curated1
Sequence conflicti332 – 336LGNKQ → REQA in AAB94292 (Ref. 5) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037875107S → N1 PublicationCorresponds to variant dbSNP:rs17854152Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097026 mRNA Translation: BAC77379.1
AK127640 mRNA Translation: BAG54539.1
CH471416 Genomic DNA Translation: EAW52305.1
BC041788 mRNA Translation: AAH41788.2
BC084553 mRNA Translation: AAH84553.1
U44954 mRNA Translation: AAB94292.1 Frameshift.
CCDSiCCDS34961.1
RefSeqiNP_000828.1, NM_000837.1
NP_001009184.1, NM_001009184.1
UniGeneiHs.594634

Genome annotation databases

EnsembliENST00000313269; ENSP00000314380; ENSG00000178719
ENST00000395068; ENSP00000378507; ENSG00000178719
GeneIDi2907
KEGGihsa:2907
UCSCiuc003zan.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLFG1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z429
Secondary accession number(s): B3KXM7, O43836, Q8IVW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2003
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health