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Protein

SUZ domain-containing protein 1

Gene

SZRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SUZ domain-containing protein 1
Alternative name(s):
Putative MAPK-activating protein PM18/PM20/PM22
Gene namesi
Name:SZRD1
Synonyms:C1orf144
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30232. SZRD1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000055070.
PharmGKBiPA142672461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030681 – 152SUZ domain-containing protein 1Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei107PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z422.
MaxQBiQ7Z422.
PaxDbiQ7Z422.
PeptideAtlasiQ7Z422.
PRIDEiQ7Z422.
TopDownProteomicsiQ7Z422-1. [Q7Z422-1]
Q7Z422-2. [Q7Z422-2]
Q7Z422-3. [Q7Z422-3]
Q7Z422-4. [Q7Z422-4]

PTM databases

iPTMnetiQ7Z422.
PhosphoSitePlusiQ7Z422.

Expressioni

Gene expression databases

BgeeiENSG00000055070.
CleanExiHS_C1orf144.
ExpressionAtlasiQ7Z422. baseline and differential.
GenevisibleiQ7Z422. HS.

Organism-specific databases

HPAiHPA024221.

Interactioni

Protein-protein interaction databases

BioGridi117549. 13 interactors.
IntActiQ7Z422. 3 interactors.
STRINGi9606.ENSP00000383866.

Structurei

3D structure databases

ProteinModelPortaliQ7Z422.
SMRiQ7Z422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107SUZPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the SZRD1 family.Curated
Contains 1 SUZ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IG3N. Eukaryota.
ENOG4111N0B. LUCA.
GeneTreeiENSGT00390000005532.
HOGENOMiHOG000231189.
HOVERGENiHBG057301.
InParanoidiQ7Z422.
OMAiTSGFRLC.
OrthoDBiEOG091G18Z5.
PhylomeDBiQ7Z422.
TreeFamiTF324643.

Family and domain databases

InterProiIPR024771. SUZ.
IPR024642. SUZ-C.
[Graphical view]
PfamiPF12752. SUZ. 1 hit.
PF12901. SUZ-C. 1 hit.
[Graphical view]
PROSITEiPS51673. SUZ. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z422-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD
60 70 80 90 100
SLPAGPPPQI RILKRPTSNG VVSSPNSTSR PTLPVKSLAQ REAEYAEARK
110 120 130 140 150
RILGSASPEE EQEKPILDRP TRISQPEDSR QPNNVIRQPL GPDGSQGFKQ

RR
Length:152
Mass (Da):16,997
Last modified:October 1, 2003 - v1
Checksum:i07F735690D669778
GO
Isoform 2 (identifier: Q7Z422-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: MEDEEVAESWEEAADSGEIDRRLEKKLKITQKESR → MRRSLRAGKRRQTAG

Show »
Length:132
Mass (Da):14,605
Checksum:i09739EF3FA39D8CD
GO
Isoform 3 (identifier: Q7Z422-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-35: Missing.

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):14,744
Checksum:iCAC73453FE73D851
GO
Isoform 4 (identifier: Q7Z422-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MEDEEVAESWEEAADSGEIDRRLEKKLKITQKES → MRRSLRAGKRRQTAG

Show »
Length:133
Mass (Da):14,761
Checksum:i5DE84B0CC8611759
GO
Isoform 5 (identifier: Q7Z422-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-34: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:151
Mass (Da):16,910
Checksum:iE60DFB37FDB93EB0
GO

Sequence cautioni

The sequence CAB43245 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC82500 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0279951 – 35MEDEE…QKESR → MRRSLRAGKRRQTAG in isoform 2. 2 PublicationsAdd BLAST35
Alternative sequenceiVSP_0279961 – 34MEDEE…TQKES → MRRSLRAGKRRQTAG in isoform 4. 2 PublicationsAdd BLAST34
Alternative sequenceiVSP_02799718 – 35Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_05569034Missing in isoform 5. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097042 mRNA. Translation: BAC77395.1.
AB097044 mRNA. Translation: BAC77397.1.
AB097046 mRNA. Translation: BAC77399.1.
AJ295987 mRNA. Translation: CAC82500.1. Different initiation.
AL050028 mRNA. Translation: CAB43245.1. Different initiation.
AL358794 Genomic DNA. Translation: CAH73775.1.
BC023988 mRNA. Translation: AAH23988.1.
BC065538 mRNA. Translation: AAH65538.1.
CCDSiCCDS44065.1. [Q7Z422-1]
CCDS60000.1. [Q7Z422-5]
PIRiT08712.
RefSeqiNP_001108072.1. NM_001114600.2. [Q7Z422-1]
NP_001258798.1. NM_001271869.1. [Q7Z422-5]
UniGeneiHs.252967.

Genome annotation databases

EnsembliENST00000401088; ENSP00000383866; ENSG00000055070. [Q7Z422-1]
ENST00000401089; ENSP00000383867; ENSG00000055070. [Q7Z422-4]
ENST00000471507; ENSP00000419589; ENSG00000055070. [Q7Z422-5]
ENST00000492354; ENSP00000418012; ENSG00000055070. [Q7Z422-2]
GeneIDi26099.
KEGGihsa:26099.
UCSCiuc001ayi.6. human. [Q7Z422-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097042 mRNA. Translation: BAC77395.1.
AB097044 mRNA. Translation: BAC77397.1.
AB097046 mRNA. Translation: BAC77399.1.
AJ295987 mRNA. Translation: CAC82500.1. Different initiation.
AL050028 mRNA. Translation: CAB43245.1. Different initiation.
AL358794 Genomic DNA. Translation: CAH73775.1.
BC023988 mRNA. Translation: AAH23988.1.
BC065538 mRNA. Translation: AAH65538.1.
CCDSiCCDS44065.1. [Q7Z422-1]
CCDS60000.1. [Q7Z422-5]
PIRiT08712.
RefSeqiNP_001108072.1. NM_001114600.2. [Q7Z422-1]
NP_001258798.1. NM_001271869.1. [Q7Z422-5]
UniGeneiHs.252967.

3D structure databases

ProteinModelPortaliQ7Z422.
SMRiQ7Z422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117549. 13 interactors.
IntActiQ7Z422. 3 interactors.
STRINGi9606.ENSP00000383866.

PTM databases

iPTMnetiQ7Z422.
PhosphoSitePlusiQ7Z422.

Proteomic databases

EPDiQ7Z422.
MaxQBiQ7Z422.
PaxDbiQ7Z422.
PeptideAtlasiQ7Z422.
PRIDEiQ7Z422.
TopDownProteomicsiQ7Z422-1. [Q7Z422-1]
Q7Z422-2. [Q7Z422-2]
Q7Z422-3. [Q7Z422-3]
Q7Z422-4. [Q7Z422-4]

Protocols and materials databases

DNASUi26099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401088; ENSP00000383866; ENSG00000055070. [Q7Z422-1]
ENST00000401089; ENSP00000383867; ENSG00000055070. [Q7Z422-4]
ENST00000471507; ENSP00000419589; ENSG00000055070. [Q7Z422-5]
ENST00000492354; ENSP00000418012; ENSG00000055070. [Q7Z422-2]
GeneIDi26099.
KEGGihsa:26099.
UCSCiuc001ayi.6. human. [Q7Z422-1]

Organism-specific databases

CTDi26099.
GeneCardsiSZRD1.
HGNCiHGNC:30232. SZRD1.
HPAiHPA024221.
neXtProtiNX_Q7Z422.
OpenTargetsiENSG00000055070.
PharmGKBiPA142672461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG3N. Eukaryota.
ENOG4111N0B. LUCA.
GeneTreeiENSGT00390000005532.
HOGENOMiHOG000231189.
HOVERGENiHBG057301.
InParanoidiQ7Z422.
OMAiTSGFRLC.
OrthoDBiEOG091G18Z5.
PhylomeDBiQ7Z422.
TreeFamiTF324643.

Miscellaneous databases

GenomeRNAii26099.
PROiQ7Z422.

Gene expression databases

BgeeiENSG00000055070.
CleanExiHS_C1orf144.
ExpressionAtlasiQ7Z422. baseline and differential.
GenevisibleiQ7Z422. HS.

Family and domain databases

InterProiIPR024771. SUZ.
IPR024642. SUZ-C.
[Graphical view]
PfamiPF12752. SUZ. 1 hit.
PF12901. SUZ-C. 1 hit.
[Graphical view]
PROSITEiPS51673. SUZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSZRD1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z422
Secondary accession number(s): A8MXJ2
, C9K0U0, Q7Z424, Q8IVM2, Q8TBV3, Q9Y403
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.