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Protein

Nuclear fragile X mental retardation-interacting protein 2

Gene

NUFIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds RNA.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: HGNC
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear fragile X mental retardation-interacting protein 2
Alternative name(s):
82 kDa FMRP-interacting protein
Short name:
82-FIP
Cell proliferation-inducing gene 1 protein
FMRP-interacting protein 2
Gene namesi
Name:NUFIP2
Synonyms:KIAA1321
ORF Names:PIG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17634. NUFIP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic stress granule Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • polysomal ribosome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57532.
OpenTargetsiENSG00000108256.
PharmGKBiPA143485564.

Polymorphism and mutation databases

BioMutaiNUFIP2.
DMDMi74713454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455211 – 695Nuclear fragile X mental retardation-interacting protein 2Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphothreonineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei212PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei218PhosphotyrosineCombined sources1
Modified residuei219PhosphothreonineCombined sources1
Modified residuei220PhosphothreonineCombined sources1
Modified residuei291Omega-N-methylarginineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Cross-linki307Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei376PhosphoserineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1 Publication1
Modified residuei633PhosphothreonineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei652PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei692PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7Z417.
MaxQBiQ7Z417.
PaxDbiQ7Z417.
PeptideAtlasiQ7Z417.
PRIDEiQ7Z417.

PTM databases

iPTMnetiQ7Z417.
PhosphoSitePlusiQ7Z417.
SwissPalmiQ7Z417.

Expressioni

Gene expression databases

BgeeiENSG00000108256.
CleanExiHS_NUFIP2.
ExpressionAtlasiQ7Z417. baseline and differential.
GenevisibleiQ7Z417. HS.

Organism-specific databases

HPAiHPA017344.
HPA067443.

Interactioni

Subunit structurei

Interacts with FMR1 (via N-terminus). Interacts with DDX6 (PubMed:26184334).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603704EBI-1210753,EBI-10172150
KRTAP10-8P604104EBI-1210753,EBI-10171774
KRTAP2-3P0C7H84EBI-1210753,EBI-10196781
KRTAP4-12Q9BQ664EBI-1210753,EBI-739863
KRTAP5-2Q701N44EBI-1210753,EBI-11958178
KRTAP9-2Q9BYQ44EBI-1210753,EBI-1044640
KRTAP9-3Q9BYQ34EBI-1210753,EBI-1043191
KRTAP9-8Q9BYQ04EBI-1210753,EBI-11958364

Protein-protein interaction databases

BioGridi121591. 49 interactors.
DIPiDIP-29023N.
IntActiQ7Z417. 53 interactors.
MINTiMINT-4657915.
STRINGi9606.ENSP00000225388.

Structurei

3D structure databases

ProteinModelPortaliQ7Z417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 60His-richAdd BLAST49
Compositional biasi373 – 415Ser-richAdd BLAST43

Phylogenomic databases

eggNOGiENOG410IGEW. Eukaryota.
ENOG41102P5. LUCA.
GeneTreeiENSGT00440000038328.
HOGENOMiHOG000220869.
HOVERGENiHBG065794.
InParanoidiQ7Z417.
OMAiEMESVWN.
OrthoDBiEOG091G040J.
PhylomeDBiQ7Z417.
TreeFamiTF332832.

Family and domain databases

InterProiIPR032747. NUFIP2.
[Graphical view]
PANTHERiPTHR28333. PTHR28333. 1 hit.
PfamiPF15293. NUFIP2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKPGQPQP QHHHSHHHPH HHPQQQQQQP HHHHHYYFYN HSHNHHHHHH
60 70 80 90 100
HQQPHQYLQH GAEGSPKAQP KPLKHEQKHT LQQHQETPKK KTGYGELNGN
110 120 130 140 150
AGEREISLKN LSSDEATNPI SRVLNGNQQV VDTSLKQTVK ANTFGKAGIK
160 170 180 190 200
TKNFIQKNSM DKKNGKSYEN KSGENQSVDK SDTIPIPNGV VTNNSGYITN
210 220 230 240 250
GYMGKGADND GSGSESGYTT PKKRKARRNS AKGCENLNIV QDKIMQQETS
260 270 280 290 300
VPTLKQGLET FKPDYSEQKG NRVDGSKPIW KYETGPGGTS RGKPAVGDML
310 320 330 340 350
RKSSDSKPGV SSKKFDDRPK GKHASAVASK EDSWTLFKPP PVFPVDNSSA
360 370 380 390 400
KIVPKISYAS KVKENLNKTI QNSSVSPTSS SSSSSSTGET QTQSSSRLSQ
410 420 430 440 450
VPMSALKSVT SANFSNGPVL AGTDGNVYPP GGQPLLTTAA NTLTPISSGT
460 470 480 490 500
DSVLQDMSLT SAAVEQIKTS LFIYPSNMQT MLLSTAQVDL PSQTDQQNLG
510 520 530 540 550
DIFQNQWGLS FINEPSAGPE TVTGKSSEHK VMEVTFQGEY PATLVSQGAE
560 570 580 590 600
IIPSGTEHPV FPKAYELEKR TSPQVLGSIL KSGTTSESGA LSLEPSHIGD
610 620 630 640 650
LQKADTSSQG ALVFLSKDYE IESQNPLASP TNTLLGSAKE QRYQRGLERN
660 670 680 690
DSWGSFDLRA AIVYHTKEME SIWNLQKQDP KRIITYNEAM DSPDQ
Length:695
Mass (Da):76,121
Last modified:October 1, 2003 - v1
Checksum:iBB5C94131F5B5426
GO
Isoform 2 (identifier: Q7Z417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-667: Missing.

Show »
Length:120
Mass (Da):14,643
Checksum:i3C9F1A1AAACA7535
GO

Sequence cautioni

The sequence BAA92559 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05617793 – 667Missing in isoform 2. 2 PublicationsAdd BLAST575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ493465 mRNA. Translation: CAD38278.1.
AY232289 mRNA. Translation: AAP69984.1.
AB037742 mRNA. Translation: BAA92559.1. Different initiation.
AK297732 mRNA. Translation: BAG60082.1.
AC005412 Genomic DNA. No translation available.
BC129989 mRNA. Translation: AAI29990.1.
BC108307 mRNA. Translation: AAI08308.1.
CCDSiCCDS32600.1. [Q7Z417-1]
RefSeqiNP_065823.1. NM_020772.2. [Q7Z417-1]
UniGeneiHs.462598.

Genome annotation databases

EnsembliENST00000225388; ENSP00000225388; ENSG00000108256. [Q7Z417-1]
ENST00000579665; ENSP00000463450; ENSG00000108256. [Q7Z417-2]
GeneIDi57532.
KEGGihsa:57532.
UCSCiuc002hdx.5. human. [Q7Z417-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ493465 mRNA. Translation: CAD38278.1.
AY232289 mRNA. Translation: AAP69984.1.
AB037742 mRNA. Translation: BAA92559.1. Different initiation.
AK297732 mRNA. Translation: BAG60082.1.
AC005412 Genomic DNA. No translation available.
BC129989 mRNA. Translation: AAI29990.1.
BC108307 mRNA. Translation: AAI08308.1.
CCDSiCCDS32600.1. [Q7Z417-1]
RefSeqiNP_065823.1. NM_020772.2. [Q7Z417-1]
UniGeneiHs.462598.

3D structure databases

ProteinModelPortaliQ7Z417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121591. 49 interactors.
DIPiDIP-29023N.
IntActiQ7Z417. 53 interactors.
MINTiMINT-4657915.
STRINGi9606.ENSP00000225388.

PTM databases

iPTMnetiQ7Z417.
PhosphoSitePlusiQ7Z417.
SwissPalmiQ7Z417.

Polymorphism and mutation databases

BioMutaiNUFIP2.
DMDMi74713454.

Proteomic databases

EPDiQ7Z417.
MaxQBiQ7Z417.
PaxDbiQ7Z417.
PeptideAtlasiQ7Z417.
PRIDEiQ7Z417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225388; ENSP00000225388; ENSG00000108256. [Q7Z417-1]
ENST00000579665; ENSP00000463450; ENSG00000108256. [Q7Z417-2]
GeneIDi57532.
KEGGihsa:57532.
UCSCiuc002hdx.5. human. [Q7Z417-1]

Organism-specific databases

CTDi57532.
DisGeNETi57532.
GeneCardsiNUFIP2.
HGNCiHGNC:17634. NUFIP2.
HPAiHPA017344.
HPA067443.
MIMi609356. gene.
neXtProtiNX_Q7Z417.
OpenTargetsiENSG00000108256.
PharmGKBiPA143485564.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGEW. Eukaryota.
ENOG41102P5. LUCA.
GeneTreeiENSGT00440000038328.
HOGENOMiHOG000220869.
HOVERGENiHBG065794.
InParanoidiQ7Z417.
OMAiEMESVWN.
OrthoDBiEOG091G040J.
PhylomeDBiQ7Z417.
TreeFamiTF332832.

Miscellaneous databases

ChiTaRSiNUFIP2. human.
GeneWikiiNUFIP2.
GenomeRNAii57532.
PROiQ7Z417.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108256.
CleanExiHS_NUFIP2.
ExpressionAtlasiQ7Z417. baseline and differential.
GenevisibleiQ7Z417. HS.

Family and domain databases

InterProiIPR032747. NUFIP2.
[Graphical view]
PANTHERiPTHR28333. PTHR28333. 1 hit.
PfamiPF15293. NUFIP2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUFP2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z417
Secondary accession number(s): A1L3A6, Q9P2M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.