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Q7Z412

- PEX26_HUMAN

UniProt

Q7Z412 - PEX26_HUMAN

Protein

Peroxisome assembly protein 26

Gene

PEX26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.2 Publications

    GO - Molecular functioni

    1. ATPase binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. protein complex binding Source: UniProtKB
    4. protein C-terminus binding Source: UniProtKB

    GO - Biological processi

    1. protein import into peroxisome matrix Source: UniProtKB
    2. protein import into peroxisome membrane Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Protein family/group databases

    TCDBi3.A.20.1.1. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome assembly protein 26
    Alternative name(s):
    Peroxin-26
    Gene namesi
    Name:PEX26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:22965. PEX26.

    Subcellular locationi

    Peroxisome membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: InterPro
    2. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    Pathology & Biotechi

    Involvement in diseasei

    Peroxisome biogenesis disorder complementation group 8 (PBD-CG8) [MIM:614872]: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Peroxisome biogenesis disorder 7A (PBD7A) [MIM:614872]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti89 – 891G → R in PBD7A. 1 Publication
    VAR_018648
    Peroxisome biogenesis disorder 7B (PBD7B) [MIM:614873]: A peroxisome biogenesis disorder that includes neonatal adrenoleukodystrophy (NALD) and infantile Refsum disease (IRD), two milder manifestations of the Zellweger disease spectrum. The clinical course of patients with the NALD and IRD presentation is variable and may include developmental delay, hypotonia, liver dysfunction, sensorineural hearing loss, retinal dystrophy and vision impairment. Children with the NALD presentation may reach their teens, while patients with the IRD presentation may reach adulthood. The clinical conditions are often slowly progressive in particular with respect to loss of hearing and vision. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451L → P in PBD7B; infantile Refsum disease. 1 Publication
    VAR_018647
    Natural varianti98 – 981R → W in PBD7B; neonatal adrenoleukodystrophy; affects the interaction with PEX6. 2 Publications
    VAR_018649

    Keywords - Diseasei

    Disease mutation, Peroxisome biogenesis disorder, Zellweger syndrome

    Organism-specific databases

    MIMi614872. phenotype.
    614873. phenotype.
    Orphaneti772. Infantile Refsum disease.
    44. Neonatal adrenoleukodystrophy.
    912. Zellweger syndrome.
    PharmGKBiPA134983458.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Peroxisome assembly protein 26PRO_0000058340Add
    BLAST

    Proteomic databases

    MaxQBiQ7Z412.
    PaxDbiQ7Z412.
    PRIDEiQ7Z412.

    PTM databases

    PhosphoSiteiQ7Z412.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in kidney, liver, brain and skeletal muscles. Expressed at intermediate level in pancreas, placenta and heart. Weakly expressed in lung.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z412.
    BgeeiQ7Z412.
    CleanExiHS_PEX26.
    GenevestigatoriQ7Z412.

    Interactioni

    Subunit structurei

    Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PEX19P408556EBI-752057,EBI-594747
    SUFUQ9UMX12EBI-752057,EBI-740595

    Protein-protein interaction databases

    BioGridi120802. 6 interactions.
    IntActiQ7Z412. 6 interactions.
    MINTiMINT-7995635.
    STRINGi9606.ENSP00000331106.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z412.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 246246CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 30538Peroxisomal matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei247 – 26721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-26 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44501.
    HOVERGENiHBG053574.
    KOiK13340.
    OMAiLLYSKVG.
    OrthoDBiEOG712TWV.
    PhylomeDBiQ7Z412.
    TreeFamiTF332318.

    Family and domain databases

    InterProiIPR010797. Pex26.
    [Graphical view]
    PfamiPF07163. Pex26. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z412-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSDSSTSAA PLRGLGGPLR SSEPVRAVPA RAPAVDLLEE AADLLVVHLD    50
    FRAALETCER AWQSLANHAV AEEPAGTSLE VKCSLCVVGI QALAEMDRWQ 100
    EVLSWVLQYY QVPEKLPPKV LELCILLYSK MQEPGAVLDV VGAWLQDPAN 150
    QNLPEYGALA EFHVQRVLLP LGCLSEAEEL VVGSAAFGEE RRLDVLQAIH 200
    TARQQQKQEH SGSEEAQKPN LEGSVSHKFL SLPMLVRQLW DSAVSHFFSL 250
    PFKKSLLAAL ILCLLVVRFD PASPSSLHFL YKLAQLFRWI RKAAFSRLYQ 300
    LRIRD 305
    Length:305
    Mass (Da):33,898
    Last modified:May 24, 2004 - v2
    Checksum:i0B9FCF8E2B3178E1
    GO
    Isoform 2 (identifier: Q7Z412-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         223-271: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:256
    Mass (Da):28,388
    Checksum:iD53D85F08A6DA5BB
    GO

    Sequence cautioni

    The sequence BAA90920.1 differs from that shown. Reason: Erroneous termination at position 253. Translated as Lys.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti304 – 3041R → H in AAH16280. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451L → P in PBD7B; infantile Refsum disease. 1 Publication
    VAR_018647
    Natural varianti89 – 891G → R in PBD7A. 1 Publication
    VAR_018648
    Natural varianti98 – 981R → W in PBD7B; neonatal adrenoleukodystrophy; affects the interaction with PEX6. 2 Publications
    VAR_018649
    Natural varianti153 – 1531L → V.1 Publication
    Corresponds to variant rs12484657 [ dbSNP | Ensembl ].
    VAR_034146

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei223 – 27149Missing in isoform 2. 1 PublicationVSP_053499Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089678 mRNA. Translation: BAC66616.1.
    AB103106 mRNA. Translation: BAC78804.1.
    AB103107 mRNA. Translation: BAC78805.1.
    AB103108 mRNA. Translation: BAC78806.1.
    AB103109 mRNA. Translation: BAC78807.1.
    AB103110 mRNA. Translation: BAC78808.1.
    AK000065 mRNA. Translation: BAA90920.1. Sequence problems.
    AK000702 mRNA. Translation: BAA91329.1.
    CR456362 mRNA. Translation: CAG30248.1.
    AC008079 Genomic DNA. No translation available.
    AC016027 Genomic DNA. No translation available.
    BC016280 mRNA. Translation: AAH16280.1.
    BC047320 mRNA. Translation: AAH47320.1.
    BF930319 mRNA. No translation available.
    CCDSiCCDS13750.1. [Q7Z412-1]
    CCDS56221.1. [Q7Z412-2]
    RefSeqiNP_001121121.1. NM_001127649.2. [Q7Z412-1]
    NP_001186248.1. NM_001199319.1. [Q7Z412-2]
    NP_060399.1. NM_017929.5. [Q7Z412-1]
    UniGeneiHs.517400.

    Genome annotation databases

    EnsembliENST00000329627; ENSP00000331106; ENSG00000215193. [Q7Z412-1]
    ENST00000399744; ENSP00000382648; ENSG00000215193. [Q7Z412-1]
    ENST00000428061; ENSP00000412441; ENSG00000215193. [Q7Z412-2]
    GeneIDi55670.
    KEGGihsa:55670.
    UCSCiuc002znp.4. human. [Q7Z412-1]

    Polymorphism databases

    DMDMi47606028.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    dbPEX, PEX Gene Database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB089678 mRNA. Translation: BAC66616.1 .
    AB103106 mRNA. Translation: BAC78804.1 .
    AB103107 mRNA. Translation: BAC78805.1 .
    AB103108 mRNA. Translation: BAC78806.1 .
    AB103109 mRNA. Translation: BAC78807.1 .
    AB103110 mRNA. Translation: BAC78808.1 .
    AK000065 mRNA. Translation: BAA90920.1 . Sequence problems.
    AK000702 mRNA. Translation: BAA91329.1 .
    CR456362 mRNA. Translation: CAG30248.1 .
    AC008079 Genomic DNA. No translation available.
    AC016027 Genomic DNA. No translation available.
    BC016280 mRNA. Translation: AAH16280.1 .
    BC047320 mRNA. Translation: AAH47320.1 .
    BF930319 mRNA. No translation available.
    CCDSi CCDS13750.1. [Q7Z412-1 ]
    CCDS56221.1. [Q7Z412-2 ]
    RefSeqi NP_001121121.1. NM_001127649.2. [Q7Z412-1 ]
    NP_001186248.1. NM_001199319.1. [Q7Z412-2 ]
    NP_060399.1. NM_017929.5. [Q7Z412-1 ]
    UniGenei Hs.517400.

    3D structure databases

    ProteinModelPortali Q7Z412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120802. 6 interactions.
    IntActi Q7Z412. 6 interactions.
    MINTi MINT-7995635.
    STRINGi 9606.ENSP00000331106.

    Protein family/group databases

    TCDBi 3.A.20.1.1. the peroxisomal protein importer (ppi) family.

    PTM databases

    PhosphoSitei Q7Z412.

    Polymorphism databases

    DMDMi 47606028.

    Proteomic databases

    MaxQBi Q7Z412.
    PaxDbi Q7Z412.
    PRIDEi Q7Z412.

    Protocols and materials databases

    DNASUi 55670.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329627 ; ENSP00000331106 ; ENSG00000215193 . [Q7Z412-1 ]
    ENST00000399744 ; ENSP00000382648 ; ENSG00000215193 . [Q7Z412-1 ]
    ENST00000428061 ; ENSP00000412441 ; ENSG00000215193 . [Q7Z412-2 ]
    GeneIDi 55670.
    KEGGi hsa:55670.
    UCSCi uc002znp.4. human. [Q7Z412-1 ]

    Organism-specific databases

    CTDi 55670.
    GeneCardsi GC22P018560.
    GeneReviewsi PEX26.
    H-InvDB HIX0016222.
    HGNCi HGNC:22965. PEX26.
    MIMi 608666. gene.
    614872. phenotype.
    614873. phenotype.
    neXtProti NX_Q7Z412.
    Orphaneti 772. Infantile Refsum disease.
    44. Neonatal adrenoleukodystrophy.
    912. Zellweger syndrome.
    PharmGKBi PA134983458.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44501.
    HOVERGENi HBG053574.
    KOi K13340.
    OMAi LLYSKVG.
    OrthoDBi EOG712TWV.
    PhylomeDBi Q7Z412.
    TreeFami TF332318.

    Miscellaneous databases

    GeneWikii PEX26.
    GenomeRNAii 55670.
    NextBioi 60440.
    PROi Q7Z412.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z412.
    Bgeei Q7Z412.
    CleanExi HS_PEX26.
    Genevestigatori Q7Z412.

    Family and domain databases

    InterProi IPR010797. Pex26.
    [Graphical view ]
    Pfami PF07163. Pex26. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes."
      Matsumoto N., Tamura S., Fujiki Y.
      Nat. Cell Biol. 5:454-460(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, DISEASE, INTERACTION WITH PEX1 AND PEX6, VARIANT PBD7B TRP-98.
      Tissue: Fibroblast.
    2. "Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation."
      Matsumoto N., Tamura S., Furuki S., Miyata N., Moser A., Shimozawa N., Moser H.W., Suzuki Y., Kondo N., Fujiki Y.
      Am. J. Hum. Genet. 73:233-246(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT PBD7A ARG-89, VARIANTS PBD7B PRO-45 AND TRP-98.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon and Ileal mucosa.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Uterus.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-305 (ISOFORM 2).
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders."
      Yik W.Y., Steinberg S.J., Moser A.B., Moser H.W., Hacia J.G.
      Hum. Mutat. 30:E467-E480(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-153.

    Entry informationi

    Entry nameiPEX26_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z412
    Secondary accession number(s): F6UBB5
    , Q7Z413, Q7Z414, Q7Z415, Q7Z416, Q96B12, Q9NWQ0, Q9NXU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3