Reviewed, UniProtKB/Swiss-Prot Q7Z408 (CSMD2_HUMAN)

Names and origin

Protein names

Recommended name:
    CUB and sushi domain-containing protein 2
Alternative name(s):
    CUB and sushi multiple domains protein 2

Gene names

Name:	CSMD2
Synonyms:	KIAA1884

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3487 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Tissue specificity	Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain. Overexpressed in some head and neck cancer cell lines. Ref.1 Ref.5
Sequence similarities	Belongs to the CSMD family. Contains 14 CUB domains. Contains 26 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Sushi Transmembrane
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ABL1	P00519	1	EBI-1957312,EBI-375543
CRK	P46108	1	EBI-1957312,EBI-886
FYN	P06241	1	EBI-1957312,EBI-515315
NCK1	P16333	1	EBI-1957312,EBI-389883
PLCG1	P19174	1	EBI-1957312,EBI-79387

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z408-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z408-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1087: Missing.
     1088-1095: SSPLPRCV → MVIVILFP
     2075-2116: Missing.
     2288-2296: AYPLTKCPP → GHLAAVCTL
     2297-3487: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q7Z408-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-403: Missing.
     443-443: V → VGGDPGNIQCNKEGLSVETQSLRLRNRSCLLGNSKDNGCCVPNPVHGTGLQV
     576-577: FS → CK
     578-3487: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3487	3487	CUB and sushi domain-containing protein 2		PRO_0000079405
Regions
	Topological domain	1 – 3408	3408	Extracellular Potential
	Transmembrane	3409 – 3429	21	Potential
	Topological domain	3430 – 3487	58	Cytoplasmic Potential
	Domain	26 – 134	109	CUB 1
	Domain	137 – 198	62	Sushi 1
	Domain	202 – 306	105	CUB 2
	Domain	341 – 402	62	Sushi 2
	Domain	405 – 516	112	CUB 3
	Domain	519 – 576	58	Sushi 3
	Domain	578 – 686	109	CUB 4
	Domain	689 – 750	62	Sushi 4
	Domain	752 – 860	109	CUB 5
	Domain	865 – 922	58	Sushi 5
	Domain	924 – 1034	111	CUB 6
	Domain	1037 – 1096	60	Sushi 6
	Domain	1098 – 1206	109	CUB 7
	Domain	1209 – 1269	61	Sushi 7
	Domain	1271 – 1380	110	CUB 8
	Domain	1383 – 1443	61	Sushi 8
	Domain	1445 – 1553	109	CUB 9
	Domain	1556 – 1617	62	Sushi 9
	Domain	1619 – 1727	109	CUB 10
	Domain	1733 – 1794	62	Sushi 10
	Domain	1796 – 1904	109	CUB 11
	Domain	1907 – 1966	60	Sushi 11
	Domain	1968 – 2076	109	CUB 12
	Domain	2121 – 2180	60	Sushi 12
	Domain	2182 – 2293	112	CUB 13
	Domain	2292 – 2353	62	Sushi 13
	Domain	2355 – 2466	112	CUB 14
	Domain	2466 – 2528	63	Sushi 14
	Domain	2529 – 2590	62	Sushi 15
	Domain	2591 – 2655	65	Sushi 16
	Domain	2656 – 2713	58	Sushi 17
	Domain	2714 – 2771	58	Sushi 18
	Domain	2772 – 2829	58	Sushi 19
	Domain	2833 – 2890	58	Sushi 20
	Domain	2891 – 2949	59	Sushi 21
	Domain	2950 – 3009	60	Sushi 22
	Domain	3010 – 3067	58	Sushi 23
	Domain	3068 – 3125	58	Sushi 24
	Domain	3129 – 3187	59	Sushi 25
	Domain	3188 – 3247	60	Sushi 26
Amino acid modifications
	Glycosylation	25	1	N-linked (GlcNAc...) Potential
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Glycosylation	581	1	N-linked (GlcNAc...) Potential
	Glycosylation	680	1	N-linked (GlcNAc...) Potential
	Glycosylation	949	1	N-linked (GlcNAc...) Potential
	Glycosylation	983	1	N-linked (GlcNAc...) Potential
	Glycosylation	1009	1	N-linked (GlcNAc...) Potential
	Glycosylation	1028	1	N-linked (GlcNAc...) Potential
	Glycosylation	1158	1	N-linked (GlcNAc...) Potential
	Glycosylation	1178	1	N-linked (GlcNAc...) Potential
	Glycosylation	1194	1	N-linked (GlcNAc...) Potential
	Glycosylation	1393	1	N-linked (GlcNAc...) Potential
	Glycosylation	1566	1	N-linked (GlcNAc...) Potential
	Glycosylation	1638	1	N-linked (GlcNAc...) Potential
	Glycosylation	1786	1	N-linked (GlcNAc...) Potential
	Glycosylation	1799	1	N-linked (GlcNAc...) Potential
	Glycosylation	1876	1	N-linked (GlcNAc...) Potential
	Glycosylation	2012	1	N-linked (GlcNAc...) Potential
	Glycosylation	2185	1	N-linked (GlcNAc...) Potential
	Glycosylation	2190	1	N-linked (GlcNAc...) Potential
	Glycosylation	2223	1	N-linked (GlcNAc...) Potential
	Glycosylation	2394	1	N-linked (GlcNAc...) Potential
	Glycosylation	2430	1	N-linked (GlcNAc...) Potential
	Glycosylation	2731	1	N-linked (GlcNAc...) Potential
	Glycosylation	2809	1	N-linked (GlcNAc...) Potential
	Glycosylation	2878	1	N-linked (GlcNAc...) Potential
	Glycosylation	2937	1	N-linked (GlcNAc...) Potential
	Glycosylation	2971	1	N-linked (GlcNAc...) Potential
	Glycosylation	3001	1	N-linked (GlcNAc...) Potential
	Glycosylation	3055	1	N-linked (GlcNAc...) Potential
	Glycosylation	3143	1	N-linked (GlcNAc...) Potential
	Glycosylation	3175	1	N-linked (GlcNAc...) Potential
	Glycosylation	3307	1	N-linked (GlcNAc...) Potential
	Glycosylation	3407	1	N-linked (GlcNAc...) Potential
	Disulfide bond	26 ↔ 52		By similarity
	Disulfide bond	139 ↔ 179		By similarity
	Disulfide bond	165 ↔ 196		By similarity
	Disulfide bond	202 ↔ 228		By similarity
	Disulfide bond	343 ↔ 383		By similarity
	Disulfide bond	369 ↔ 400		By similarity
	Disulfide bond	405 ↔ 431		By similarity
	Disulfide bond	521 ↔ 561		By similarity
	Disulfide bond	547 ↔ 574		By similarity
	Disulfide bond	578 ↔ 604		By similarity
	Disulfide bond	691 ↔ 732		By similarity
	Disulfide bond	717 ↔ 748		By similarity
	Disulfide bond	752 ↔ 778		By similarity
	Disulfide bond	867 ↔ 907		By similarity
	Disulfide bond	893 ↔ 920		By similarity
	Disulfide bond	924 ↔ 950		By similarity
	Disulfide bond	1039 ↔ 1079		By similarity
	Disulfide bond	1065 ↔ 1094		By similarity
	Disulfide bond	1098 ↔ 1124		By similarity
	Disulfide bond	1211 ↔ 1252		By similarity
	Disulfide bond	1238 ↔ 1267		By similarity
	Disulfide bond	1271 ↔ 1298		By similarity
	Disulfide bond	1385 ↔ 1425		By similarity
	Disulfide bond	1411 ↔ 1441		By similarity
	Disulfide bond	1445 ↔ 1471		By similarity
	Disulfide bond	1558 ↔ 1598		By similarity
	Disulfide bond	1584 ↔ 1615		By similarity
	Disulfide bond	1619 ↔ 1645		By similarity
	Disulfide bond	1735 ↔ 1775		By similarity
	Disulfide bond	1761 ↔ 1792		By similarity
	Disulfide bond	1796 ↔ 1822		By similarity
	Disulfide bond	1909 ↔ 1949		By similarity
	Disulfide bond	1935 ↔ 1964		By similarity
	Disulfide bond	1968 ↔ 1994		By similarity
	Disulfide bond	2123 ↔ 2163		By similarity
	Disulfide bond	2149 ↔ 2178		By similarity
	Disulfide bond	2182 ↔ 2208		By similarity
	Disulfide bond	2294 ↔ 2336		By similarity
	Disulfide bond	2322 ↔ 2351		By similarity
	Disulfide bond	2355 ↔ 2383		By similarity
	Disulfide bond	2468 ↔ 2509		By similarity
	Disulfide bond	2495 ↔ 2526		By similarity
	Disulfide bond	2531 ↔ 2573		By similarity
	Disulfide bond	2557 ↔ 2588		By similarity
	Disulfide bond	2593 ↔ 2638		By similarity
	Disulfide bond	2624 ↔ 2653		By similarity
	Disulfide bond	2658 ↔ 2698		By similarity
	Disulfide bond	2684 ↔ 2711		By similarity
	Disulfide bond	2716 ↔ 2756		By similarity
	Disulfide bond	2742 ↔ 2769		By similarity
	Disulfide bond	2774 ↔ 2814		By similarity
	Disulfide bond	2800 ↔ 2827		By similarity
	Disulfide bond	2835 ↔ 2875		By similarity
	Disulfide bond	2861 ↔ 2888		By similarity
	Disulfide bond	2893 ↔ 2934		By similarity
	Disulfide bond	2920 ↔ 2947		By similarity
	Disulfide bond	2952 ↔ 2994		By similarity
	Disulfide bond	2978 ↔ 3007		By similarity
	Disulfide bond	3012 ↔ 3052		By similarity
	Disulfide bond	3038 ↔ 3065		By similarity
	Disulfide bond	3070 ↔ 3110		By similarity
	Disulfide bond	3096 ↔ 3123		By similarity
	Disulfide bond	3131 ↔ 3172		By similarity
	Disulfide bond	3158 ↔ 3185		By similarity
	Disulfide bond	3190 ↔ 3232		By similarity
	Disulfide bond	3217 ↔ 3245		By similarity
Natural variations
	Alternative sequence	1 – 1087	1087	Missing in isoform 2.		VSP_009038
	Alternative sequence	1 – 403	403	Missing in isoform 3.		VSP_009043
	Alternative sequence	443	1	V → VGGDPGNIQCNKEGLSVETQ SLRLRNRSCLLGNSKDNGCC VPNPVHGTGLQV in isoform 3.		VSP_009044
	Alternative sequence	576 – 577	2	FS → CK in isoform 3.		VSP_009045
	Alternative sequence	578 – 3487	2910	Missing in isoform 3.		VSP_009046
	Alternative sequence	1088 – 1095	8	SSPLPRCV → MVIVILFP in isoform 2.		VSP_009039
	Alternative sequence	2075 – 2116	42	Missing in isoform 2.		VSP_009040
	Alternative sequence	2288 – 2296	9	AYPLTKCPP → GHLAAVCTL in isoform 2.		VSP_009041
	Alternative sequence	2297 – 3487	1191	Missing in isoform 2.		VSP_009042
	Natural variant	167	1	L → P: dbSNP rs16836099.		VAR_028081
	Natural variant	538	1	H → R: dbSNP rs474474.		VAR_024330
	Natural variant	2096	1	R → K: dbSNP rs1874045.		VAR_028082
	Natural variant	2117	1	A → V: dbSNP rs11588581.		VAR_028083
	Natural variant	2554	1	M → V: dbSNP rs2641962.		VAR_028084
	Natural variant	2661	1	L → R: dbSNP rs3820206.		VAR_028085
	Natural variant	2661	1	L → V: dbSNP rs34850622.		VAR_050917
	Natural variant	3406	1	S → F: dbSNP rs1617468.		VAR_028086
Experimental info
	Sequence conflict	133	1	V → A in AAO34701. Ref.1
	Sequence conflict	1104	1	G → A in BAC87101. Ref.2
	Sequence conflict	1175	1	V → E in BAC87101. Ref.2
	Sequence conflict	1695	1	E → G in BAC87101. Ref.2
	Sequence conflict	3251	1	S → N in AAO34701. Ref.1
	Sequence conflict	3251	1	S → N in BAB67777. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 3A2A1A2911EFC1F4	FASTA	3,487	380,039
	10 20 30 40 50 60 MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE 70 80 90 100 110 120 QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT TLSLRLISDY 130 140 150 160 170 180 AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH 190 200 210 220 230 240 AGSENSATWD FPLPSCRADD ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI 250 260 270 280 290 300 ALVFIDFQLE DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS 310 320 330 340 350 360 AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR 370 380 390 400 410 420 LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC RARMCDAHLR GPSGIITSPN 430 440 450 460 470 480 FPIQYDNNAH CVWIITALNP SKVIKLAFEE FDLERGYDTL TVGDGGQDGD QKTVLYILTG 490 500 510 520 530 540 TSVPDLIVST NHQMWLLFQT DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG 550 560 570 580 590 600 DTLKFECQPA FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN 610 620 630 640 650 660 HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG NQLPSSITSS 670 680 690 700 710 720 GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG KRFGDSLQLG SSISFLCDEG 730 740 750 760 770 780 FLGTQGSETI TCVLKEGSVV WNSAVLRCEA PCGGHLTSPS GTILSPGWPG FYKDALSCAW 790 800 810 820 830 840 VIEAQPGYPI KITFDRFKTE VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL 850 860 870 880 890 900 LFSTDKSHSD IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS 910 920 930 940 950 960 DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC TWIIETSHGK 970 980 990 1000 1010 1020 GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA PISAGLYGNF TAQVRFISDF 1030 1040 1050 1060 1070 1080 SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR KGLQFGVGDT LTFSCFPGYR LEGTARITCL 1090 1100 1110 1120 1130 1140 GGRRRLWSSP LPRCVAECGN SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA 1150 1160 1170 1180 1190 1200 RAFELSEGDV LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE 1210 1220 1230 1240 1250 1260 LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL LCLSGERRTW 1270 1280 1290 1300 1310 1320 DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE 1330 1340 1350 1360 1370 1380 EVHDVLRIWD GPVESGVLLK ELSGPALPKD LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS 1390 1400 1410 1420 1430 1440 TATSCNDPGI PQNGSRSGDS WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT 1450 1460 1470 1480 1490 1500 CIAPCGGDLT GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH 1510 1520 1530 1540 1550 1560 IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY TENPRESCFD 1570 1580 1590 1600 1610 1620 PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG 1630 1640 1650 1660 1670 1680 GQYVGSDGVV LSPNYPQNYT SGQICLYFVT VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ 1690 1700 1710 1720 1730 1740 HSRLLSSLSG SHTGESLPLA TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE 1750 1760 1770 1780 1790 1800 PRYGKRLGSD FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL 1810 1820 1830 1840 1850 1860 TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL EVFDGADNTV 1870 1880 1890 1900 1910 1920 TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK 1930 1940 1950 1960 1970 1980 TGERYLVNDV VSFQCEPGYA LQGHAHISCM PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL 1990 2000 2010 2020 2030 2040 SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG 2050 2060 2070 2080 2090 2100 SELPSSLLST SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST 2110 2120 2130 2140 2150 2160 PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL PGYQLTGHPV 2170 2180 2190 2200 2210 2220 LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS PYSSSQDCVW LITVPIGHGV 2230 2240 2250 2260 2270 2280 RLNLSLLQTE PSGDFITIWD GPQQTAPRLG VFTRSMAKKT VQSSSNQVLL KFHRDAATGG 2290 2300 2310 2320 2330 2340 IFAIAFSAYP LTKCPPPTIL PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT 2350 2360 2370 2380 2390 2400 YLQFEGPPPI CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE 2410 2420 2430 2440 2450 2460 YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS DHAYNRKGFK 2470 2480 2490 2500 2510 2520 IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR LVGHSMAICT RHPQGYHLWS 2530 2540 2550 2560 2570 2580 EAIPLCQALS CGLPEAPKNG MVFGKEYTVG TKAMYSCSEG YHLQAGAEAT AECLDTGLWS 2590 2600 2610 2620 2630 2640 NRNVPPQCVP VTCPDVSSIS VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA 2650 2660 2670 2680 2690 2700 NGKWSLGDST PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA 2710 2720 2730 2740 2750 2760 NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG MSVRICQQDH 2770 2780 2790 2800 2810 2820 HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC IGKRTLVGNS TRMCGLDGHW 2830 2840 2850 2860 2870 2880 TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS FDPGTVMRFS CEAGHVLRGS SERTCQANGS 2890 2900 2910 2920 2930 2940 WSGSQPECGV ISCGNPGTPS NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW 2950 2960 2970 2980 2990 3000 TGSDPECLVI NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW 3010 3020 3030 3040 3050 3060 NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF TCEGNGSWTG 3070 3080 3090 3100 3110 3120 ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL VLVGSPRRFC QSDGTWSGTQ 3130 3140 3150 3160 3170 3180 PSCIDPTLTT CADPGVPQFG IQNNSQGYQV GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG 3190 3200 3210 3220 3230 3240 TPPDCVPHHC RQPETPTHAN VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG 3250 3260 3270 3280 3290 3300 KPPICLEVRP SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ 3310 3320 3330 3340 3350 3360 VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK DDHWALDGHV 3370 3380 3390 3400 3410 3420 SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI GRHFASNSSS VAAAILVPFI 3430 3440 3450 3460 3470 3480 ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN TNVRATFENP MYDRNIQPTD IMASEAEFTV STVCTAV
	Isoform 2. Checksum: A01099D90B049710	FASTA	1,167	126,167
	10 20 30 40 50 60 MVIVILFPAE CGNSVTGTQG TLLSPNFPVN YNNNHECIYS IQTQPGKGIQ LKARAFELSE 70 80 90 100 110 120 GDVLKVYDGN NNSARLLGVF SHSEMMGVTL NSTSSSLWLD FITDAENTSK GFELHFSSFE 130 140 150 160 170 180 LIKCEDPGTP KFGYKVHDEG HFAGSSVSFS CDPGYSLRGS EELLCLSGER RTWDRPLPTC 190 200 210 220 230 240 VAECGGTVRG EVSGQVLSPG YPAPYEHNLN CIWTIEAEAG CTIGLHFLVF DTEEVHDVLR 250 260 270 280 290 300 IWDGPVESGV LLKELSGPAL PKDLHSTFNS VVLQFSTDFF TSKQGFAIQF SVSTATSCND 310 320 330 340 350 360 PGIPQNGSRS GDSWEAGDST VFQCDPGYAL QGSAEISCVK IENRFFWQPS PPTCIAPCGG 370 380 390 400 410 420 DLTGPSGVIL SPNYPEPYPP GKECDWKVTV SPDYVIALVF NIFNLEPGYD FLHIYDGRDS 430 440 450 460 470 480 LSPLIGSFYG SQLPGRIESS SNSLFLAFRS DASVSNAGFV IDYTENPRES CFDPGSIKNG 490 500 510 520 530 540 TRVGSDLKLG SSVTYYCHGG YEVEGTSTLS CILGPDGKPV WNNPRPVCTA PCGGQYVGSD 550 560 570 580 590 600 GVVLSPNYPQ NYTSGQICLY FVTVPKDYVV FGQFAFFHTA LNDVVEVHDG HSQHSRLLSS 610 620 630 640 650 660 LSGSHTGESL PLATSNQVLI KFSAKGLAPA RGFHFVYQAV PRTSATQCSS VPEPRYGKRL 670 680 690 700 710 720 GSDFSVGAIV RFECNSGYAL QGSPEIECLP VPGALAQWNV SAPTCVVPCG GNLTERRGTI 730 740 750 760 770 780 LSPGFPEPYL NSLNCVWKIV VPEGAGIQIQ VVSFVTEQNW DSLEVFDGAD NTVTMLGSFS 790 800 810 820 830 840 GTTVPALLNS TSNQLYLHFY SDISVSAAGF HLEYKTVGLS SCPEPAVPSN GVKTGERYLV 850 860 870 880 890 900 NDVVSFQCEP GYALQGHAHI SCMPGTVRRW NYPPPLCIAQ CGGTVEEMEG VILSPGFPGN 910 920 930 940 950 960 YPSNMDCSWK IALPVGFGAH IQFLNFSTEP NHDYIEIRNG PYETSRMMGR FSGSELPSSL 970 980 990 1000 1010 1020 LSTSHETTVY FHSDHSQNRP GFKLEYQAYE LQECPDPEPF ANGIVRGAGY NVGQSVTFEC 1030 1040 1050 1060 1070 1080 LPGYQLTGHP VLTCQHGTNR NWDHPLPKCE VPCGGNITSS NGTVYSPGFP SPYSSSQDCV 1090 1100 1110 1120 1130 1140 WLITVPIGHG VRLNLSLLQT EPSGDFITIW DGPQQTAPRL GVFTRSMAKK TVQSSSNQVL 1150 1160 LKFHRDAATG GIFAIAFSGH LAAVCTL
	Isoform 3. Checksum: F807E3CE7EC32C31	FASTA	225	24,393
	10 20 30 40 50 60 MCDAHLRGPS GIITSPNFPI QYDNNAHCVW IITALNPSKV GGDPGNIQCN KEGLSVETQS 70 80 90 100 110 120 LRLRNRSCLL GNSKDNGCCV PNPVHGTGLQ VIKLAFEEFD LERGYDTLTV GDGGQDGDQK 130 140 150 160 170 180 TVLYILTGTS VPDLIVSTNH QMWLLFQTDG SGSSLGFKAS YEEIEQGSCG DPGIPAYGRR 190 200 210 220 EGSRFHHGDT LKFECQPAFE LVGQKAITCQ KNNQWSAKKP GCVCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two new members of the CSMD gene family." Lau W.L., Scholnick S.B. Genomics 82:412-415(2003) [PubMed: 12906867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 2969-3487 (ISOFORM 1). Tissue: Brain and Teratocarcinoma.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[5]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed: 11572484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2542-3487 (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY210418 mRNA. Translation: AAO34701.1. AK095627 mRNA. Translation: BAC04593.1. Different initiation. AK127722 mRNA. Translation: BAC87101.1. AC115285 Genomic DNA. No translation available. AC115286 Genomic DNA. No translation available. AC116993 Genomic DNA. No translation available. AL121980 Genomic DNA. No translation available. AL139140 Genomic DNA. No translation available. AL355178, AL161643 Genomic DNA. Translation: CAI23434.1. AL161643, AL355178 Genomic DNA. Translation: CAI23498.1. AL596224 Genomic DNA. No translation available. AL607106 Genomic DNA. No translation available. BC031871 mRNA. Translation: AAH31871.1. AB067471 mRNA. Translation: BAB67777.1.
IPI	IPI00289802. IPI00394771. IPI00746532.
RefSeq	NP_443128.2.
UniGene	Hs.656915
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z408. 5 interactions.
Proteomic databases
PRIDE	Q7Z408.
Genome annotation databases
Ensembl	ENST00000241312; ENSP00000241312; ENSG00000121904; Homo sapiens. [Genome view]
GeneID	114784.
KEGG	hsa:114784.
UCSC	uc001bxn.1. human. uc001bxo.1. human.
Organism-specific databases
CTD	114784.
GeneCards	GC01M033752.
H-InvDB	HIX0000395.
HGNC	HGNC:19290. CSMD2.
HPA	HPA008622.
MIM	608398. gene.
PharmGKB	PA134884681.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7Z408.
PhylomeDB	Q7Z408.
Gene expression databases
ArrayExpress	Q7Z408.
Bgee	Q7Z408.
Genevestigator	Q7Z408.
GermOnline	ENSG00000121904. Homo sapiens.
Family and domain databases
InterPro	IPR016060. Complement_control_module. IPR000859. CUB. IPR000436. Sushi_SCR_CCP. [Graphical view]
Gene3D	G3DSA:2.10.70.10. Complement_control_module. 19 hits. G3DSA:2.60.120.290. CUB. 14 hits.
Pfam	PF00431. CUB. 14 hits. PF00084. Sushi. 26 hits. [Graphical view]
SMART	SM00032. CCP. 26 hits. SM00042. CUB. 14 hits. [Graphical view]
PROSITE	PS01180. CUB. 14 hits. PS50923. SUSHI. 26 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	79171.
SOURCE	Search...

Entry information

Entry name

CSMD2_HUMAN

Accession

Primary (citable) accession number: Q7Z408
Secondary accession number(s): B1AM50 , Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	October 17, 2006
Last modified:	January 19, 2010
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.