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Q7Z408 (CSMD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CUB and sushi domain-containing protein 2
Alternative name(s):
CUB and sushi multiple domains protein 2
Gene names
Name:CSMD2
Synonyms:KIAA1884
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length3487 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass membrane protein Potential.

Tissue specificity

Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain. Overexpressed in some head and neck cancer cell lines. Ref.1 Ref.5

Sequence similarities

Belongs to the CSMD family.

Contains 14 CUB domains.

Contains 26 Sushi (CCP/SCR) domains.

Sequence caution

The sequence BAC04593.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z408-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z408-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1087: Missing.
     1088-1095: SSPLPRCV → MVIVILFP
     2075-2116: Missing.
     2288-2296: AYPLTKCPP → GHLAAVCTL
     2297-3487: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q7Z408-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-403: Missing.
     443-443: V → VGGDPGNIQCNKEGLSVETQSLRLRNRSCLLGNSKDNGCCVPNPVHGTGLQV
     576-577: FS → CK
     578-3487: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 34873487CUB and sushi domain-containing protein 2
PRO_0000079405

Regions

Topological domain1 – 34083408Extracellular Potential
Transmembrane3409 – 342921Helical; Potential
Topological domain3430 – 348758Cytoplasmic Potential
Domain26 – 134109CUB 1
Domain137 – 19862Sushi 1
Domain202 – 306105CUB 2
Domain341 – 40262Sushi 2
Domain405 – 516112CUB 3
Domain519 – 57658Sushi 3
Domain578 – 686109CUB 4
Domain689 – 75062Sushi 4
Domain752 – 860109CUB 5
Domain865 – 92258Sushi 5
Domain924 – 1034111CUB 6
Domain1037 – 109660Sushi 6
Domain1098 – 1206109CUB 7
Domain1209 – 126961Sushi 7
Domain1271 – 1380110CUB 8
Domain1383 – 144361Sushi 8
Domain1445 – 1553109CUB 9
Domain1556 – 161762Sushi 9
Domain1619 – 1727109CUB 10
Domain1733 – 179462Sushi 10
Domain1796 – 1904109CUB 11
Domain1907 – 196660Sushi 11
Domain1968 – 2076109CUB 12
Domain2121 – 218060Sushi 12
Domain2182 – 2293112CUB 13
Domain2292 – 235362Sushi 13
Domain2355 – 2466112CUB 14
Domain2466 – 252863Sushi 14
Domain2529 – 259062Sushi 15
Domain2591 – 265565Sushi 16
Domain2656 – 271358Sushi 17
Domain2714 – 277158Sushi 18
Domain2772 – 282958Sushi 19
Domain2833 – 289058Sushi 20
Domain2891 – 294959Sushi 21
Domain2950 – 300960Sushi 22
Domain3010 – 306758Sushi 23
Domain3068 – 312558Sushi 24
Domain3129 – 318759Sushi 25
Domain3188 – 324760Sushi 26

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation5811N-linked (GlcNAc...) Potential
Glycosylation6801N-linked (GlcNAc...) Potential
Glycosylation9491N-linked (GlcNAc...) Potential
Glycosylation9831N-linked (GlcNAc...) Potential
Glycosylation10091N-linked (GlcNAc...) Potential
Glycosylation10281N-linked (GlcNAc...) Potential
Glycosylation11581N-linked (GlcNAc...) Potential
Glycosylation11781N-linked (GlcNAc...) Potential
Glycosylation11941N-linked (GlcNAc...) Potential
Glycosylation13931N-linked (GlcNAc...) Potential
Glycosylation15661N-linked (GlcNAc...) Potential
Glycosylation16381N-linked (GlcNAc...) Potential
Glycosylation17861N-linked (GlcNAc...) Potential
Glycosylation17991N-linked (GlcNAc...) Potential
Glycosylation18761N-linked (GlcNAc...) Potential
Glycosylation20121N-linked (GlcNAc...) Potential
Glycosylation21851N-linked (GlcNAc...) Potential
Glycosylation21901N-linked (GlcNAc...) Potential
Glycosylation22231N-linked (GlcNAc...) Potential
Glycosylation23941N-linked (GlcNAc...) Potential
Glycosylation24301N-linked (GlcNAc...) Potential
Glycosylation27311N-linked (GlcNAc...) Potential
Glycosylation28091N-linked (GlcNAc...) Potential
Glycosylation28781N-linked (GlcNAc...) Potential
Glycosylation29371N-linked (GlcNAc...) Potential
Glycosylation29711N-linked (GlcNAc...) Potential
Glycosylation30011N-linked (GlcNAc...) Potential
Glycosylation30551N-linked (GlcNAc...) Potential
Glycosylation31431N-linked (GlcNAc...) Potential
Glycosylation31751N-linked (GlcNAc...) Potential
Glycosylation33071N-linked (GlcNAc...) Potential
Glycosylation34071N-linked (GlcNAc...) Potential
Disulfide bond26 ↔ 52 By similarity
Disulfide bond139 ↔ 179 By similarity
Disulfide bond165 ↔ 196 By similarity
Disulfide bond202 ↔ 228 By similarity
Disulfide bond343 ↔ 383 By similarity
Disulfide bond369 ↔ 400 By similarity
Disulfide bond405 ↔ 431 By similarity
Disulfide bond521 ↔ 561 By similarity
Disulfide bond547 ↔ 574 By similarity
Disulfide bond578 ↔ 604 By similarity
Disulfide bond691 ↔ 732 By similarity
Disulfide bond717 ↔ 748 By similarity
Disulfide bond752 ↔ 778 By similarity
Disulfide bond867 ↔ 907 By similarity
Disulfide bond893 ↔ 920 By similarity
Disulfide bond924 ↔ 950 By similarity
Disulfide bond1039 ↔ 1079 By similarity
Disulfide bond1065 ↔ 1094 By similarity
Disulfide bond1098 ↔ 1124 By similarity
Disulfide bond1211 ↔ 1252 By similarity
Disulfide bond1238 ↔ 1267 By similarity
Disulfide bond1271 ↔ 1298 By similarity
Disulfide bond1385 ↔ 1425 By similarity
Disulfide bond1411 ↔ 1441 By similarity
Disulfide bond1445 ↔ 1471 By similarity
Disulfide bond1558 ↔ 1598 By similarity
Disulfide bond1584 ↔ 1615 By similarity
Disulfide bond1619 ↔ 1645 By similarity
Disulfide bond1735 ↔ 1775 By similarity
Disulfide bond1761 ↔ 1792 By similarity
Disulfide bond1796 ↔ 1822 By similarity
Disulfide bond1909 ↔ 1949 By similarity
Disulfide bond1935 ↔ 1964 By similarity
Disulfide bond1968 ↔ 1994 By similarity
Disulfide bond2123 ↔ 2163 By similarity
Disulfide bond2149 ↔ 2178 By similarity
Disulfide bond2182 ↔ 2208 By similarity
Disulfide bond2294 ↔ 2336 By similarity
Disulfide bond2322 ↔ 2351 By similarity
Disulfide bond2355 ↔ 2383 By similarity
Disulfide bond2468 ↔ 2509 By similarity
Disulfide bond2495 ↔ 2526 By similarity
Disulfide bond2531 ↔ 2573 By similarity
Disulfide bond2557 ↔ 2588 By similarity
Disulfide bond2593 ↔ 2638 By similarity
Disulfide bond2624 ↔ 2653 By similarity
Disulfide bond2658 ↔ 2698 By similarity
Disulfide bond2684 ↔ 2711 By similarity
Disulfide bond2716 ↔ 2756 By similarity
Disulfide bond2742 ↔ 2769 By similarity
Disulfide bond2774 ↔ 2814 By similarity
Disulfide bond2800 ↔ 2827 By similarity
Disulfide bond2835 ↔ 2875 By similarity
Disulfide bond2861 ↔ 2888 By similarity
Disulfide bond2893 ↔ 2934 By similarity
Disulfide bond2920 ↔ 2947 By similarity
Disulfide bond2952 ↔ 2994 By similarity
Disulfide bond2978 ↔ 3007 By similarity
Disulfide bond3012 ↔ 3052 By similarity
Disulfide bond3038 ↔ 3065 By similarity
Disulfide bond3070 ↔ 3110 By similarity
Disulfide bond3096 ↔ 3123 By similarity
Disulfide bond3131 ↔ 3172 By similarity
Disulfide bond3158 ↔ 3185 By similarity
Disulfide bond3190 ↔ 3232 By similarity
Disulfide bond3217 ↔ 3245 By similarity

Natural variations

Alternative sequence1 – 10871087Missing in isoform 2.
VSP_009038
Alternative sequence1 – 403403Missing in isoform 3.
VSP_009043
Alternative sequence4431V → VGGDPGNIQCNKEGLSVETQ SLRLRNRSCLLGNSKDNGCC VPNPVHGTGLQV in isoform 3.
VSP_009044
Alternative sequence576 – 5772FS → CK in isoform 3.
VSP_009045
Alternative sequence578 – 34872910Missing in isoform 3.
VSP_009046
Alternative sequence1088 – 10958SSPLPRCV → MVIVILFP in isoform 2.
VSP_009039
Alternative sequence2075 – 211642Missing in isoform 2.
VSP_009040
Alternative sequence2288 – 22969AYPLTKCPP → GHLAAVCTL in isoform 2.
VSP_009041
Alternative sequence2297 – 34871191Missing in isoform 2.
VSP_009042
Natural variant1671L → P.
Corresponds to variant rs16836099 [ dbSNP | Ensembl ].
VAR_028081
Natural variant5381H → R.
Corresponds to variant rs474474 [ dbSNP | Ensembl ].
VAR_024330
Natural variant20961R → K.
Corresponds to variant rs1874045 [ dbSNP | Ensembl ].
VAR_028082
Natural variant21171A → V.
Corresponds to variant rs11588581 [ dbSNP | Ensembl ].
VAR_028083
Natural variant25541M → V.
Corresponds to variant rs2641962 [ dbSNP | Ensembl ].
VAR_028084
Natural variant26611L → R.
Corresponds to variant rs3820206 [ dbSNP | Ensembl ].
VAR_028085
Natural variant26611L → V.
Corresponds to variant rs34850622 [ dbSNP | Ensembl ].
VAR_050917
Natural variant34061S → F.
Corresponds to variant rs1617468 [ dbSNP | Ensembl ].
VAR_028086

Experimental info

Sequence conflict1331V → A in AAO34701. Ref.1
Sequence conflict11041G → A in BAC87101. Ref.2
Sequence conflict11751V → E in BAC87101. Ref.2
Sequence conflict16951E → G in BAC87101. Ref.2
Sequence conflict32511S → N in AAO34701. Ref.1
Sequence conflict32511S → N in BAB67777. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 3A2A1A2911EFC1F4

FASTA3,487380,039
        10         20         30         40         50         60 
MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE 

        70         80         90        100        110        120 
QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT TLSLRLISDY 

       130        140        150        160        170        180 
AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH 

       190        200        210        220        230        240 
AGSENSATWD FPLPSCRADD ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI 

       250        260        270        280        290        300 
ALVFIDFQLE DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS 

       310        320        330        340        350        360 
AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR 

       370        380        390        400        410        420 
LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC RARMCDAHLR GPSGIITSPN 

       430        440        450        460        470        480 
FPIQYDNNAH CVWIITALNP SKVIKLAFEE FDLERGYDTL TVGDGGQDGD QKTVLYILTG 

       490        500        510        520        530        540 
TSVPDLIVST NHQMWLLFQT DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG 

       550        560        570        580        590        600 
DTLKFECQPA FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN 

       610        620        630        640        650        660 
HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG NQLPSSITSS 

       670        680        690        700        710        720 
GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG KRFGDSLQLG SSISFLCDEG 

       730        740        750        760        770        780 
FLGTQGSETI TCVLKEGSVV WNSAVLRCEA PCGGHLTSPS GTILSPGWPG FYKDALSCAW 

       790        800        810        820        830        840 
VIEAQPGYPI KITFDRFKTE VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL 

       850        860        870        880        890        900 
LFSTDKSHSD IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS 

       910        920        930        940        950        960 
DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC TWIIETSHGK 

       970        980        990       1000       1010       1020 
GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA PISAGLYGNF TAQVRFISDF 

      1030       1040       1050       1060       1070       1080 
SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR KGLQFGVGDT LTFSCFPGYR LEGTARITCL 

      1090       1100       1110       1120       1130       1140 
GGRRRLWSSP LPRCVAECGN SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA 

      1150       1160       1170       1180       1190       1200 
RAFELSEGDV LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE 

      1210       1220       1230       1240       1250       1260 
LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL LCLSGERRTW 

      1270       1280       1290       1300       1310       1320 
DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE 

      1330       1340       1350       1360       1370       1380 
EVHDVLRIWD GPVESGVLLK ELSGPALPKD LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS 

      1390       1400       1410       1420       1430       1440 
TATSCNDPGI PQNGSRSGDS WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT 

      1450       1460       1470       1480       1490       1500 
CIAPCGGDLT GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH 

      1510       1520       1530       1540       1550       1560 
IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY TENPRESCFD 

      1570       1580       1590       1600       1610       1620 
PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG 

      1630       1640       1650       1660       1670       1680 
GQYVGSDGVV LSPNYPQNYT SGQICLYFVT VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ 

      1690       1700       1710       1720       1730       1740 
HSRLLSSLSG SHTGESLPLA TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE 

      1750       1760       1770       1780       1790       1800 
PRYGKRLGSD FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL 

      1810       1820       1830       1840       1850       1860 
TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL EVFDGADNTV 

      1870       1880       1890       1900       1910       1920 
TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK 

      1930       1940       1950       1960       1970       1980 
TGERYLVNDV VSFQCEPGYA LQGHAHISCM PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL 

      1990       2000       2010       2020       2030       2040 
SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG 

      2050       2060       2070       2080       2090       2100 
SELPSSLLST SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST 

      2110       2120       2130       2140       2150       2160 
PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL PGYQLTGHPV 

      2170       2180       2190       2200       2210       2220 
LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS PYSSSQDCVW LITVPIGHGV 

      2230       2240       2250       2260       2270       2280 
RLNLSLLQTE PSGDFITIWD GPQQTAPRLG VFTRSMAKKT VQSSSNQVLL KFHRDAATGG 

      2290       2300       2310       2320       2330       2340 
IFAIAFSAYP LTKCPPPTIL PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT 

      2350       2360       2370       2380       2390       2400 
YLQFEGPPPI CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE 

      2410       2420       2430       2440       2450       2460 
YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS DHAYNRKGFK 

      2470       2480       2490       2500       2510       2520 
IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR LVGHSMAICT RHPQGYHLWS 

      2530       2540       2550       2560       2570       2580 
EAIPLCQALS CGLPEAPKNG MVFGKEYTVG TKAMYSCSEG YHLQAGAEAT AECLDTGLWS 

      2590       2600       2610       2620       2630       2640 
NRNVPPQCVP VTCPDVSSIS VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA 

      2650       2660       2670       2680       2690       2700 
NGKWSLGDST PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA 

      2710       2720       2730       2740       2750       2760 
NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG MSVRICQQDH 

      2770       2780       2790       2800       2810       2820 
HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC IGKRTLVGNS TRMCGLDGHW 

      2830       2840       2850       2860       2870       2880 
TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS FDPGTVMRFS CEAGHVLRGS SERTCQANGS 

      2890       2900       2910       2920       2930       2940 
WSGSQPECGV ISCGNPGTPS NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW 

      2950       2960       2970       2980       2990       3000 
TGSDPECLVI NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW 

      3010       3020       3030       3040       3050       3060 
NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF TCEGNGSWTG 

      3070       3080       3090       3100       3110       3120 
ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL VLVGSPRRFC QSDGTWSGTQ 

      3130       3140       3150       3160       3170       3180 
PSCIDPTLTT CADPGVPQFG IQNNSQGYQV GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG 

      3190       3200       3210       3220       3230       3240 
TPPDCVPHHC RQPETPTHAN VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG 

      3250       3260       3270       3280       3290       3300 
KPPICLEVRP SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ 

      3310       3320       3330       3340       3350       3360 
VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK DDHWALDGHV 

      3370       3380       3390       3400       3410       3420 
SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI GRHFASNSSS VAAAILVPFI 

      3430       3440       3450       3460       3470       3480 
ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN TNVRATFENP MYDRNIQPTD IMASEAEFTV 


STVCTAV

« Hide

Isoform 2 [UniParc].

Checksum: A01099D90B049710
Show »

FASTA1,167126,167
Isoform 3 [UniParc].

Checksum: F807E3CE7EC32C31
Show »

FASTA22524,393

References

« Hide 'large scale' references
[1]"Identification of two new members of the CSMD gene family."
Lau W.L., Scholnick S.B.
Genomics 82:412-415(2003) [PubMed: 12906867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 2969-3487 (ISOFORM 1).
Tissue: Brain and Teratocarcinoma.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[5]"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:179-187(2001) [PubMed: 11572484] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2542-3487 (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY210418 mRNA. Translation: AAO34701.1.
AK095627 mRNA. Translation: BAC04593.1. Different initiation.
AK127722 mRNA. Translation: BAC87101.1.
AC115285 Genomic DNA. No translation available.
AC115286 Genomic DNA. No translation available.
AC116993 Genomic DNA. No translation available.
AL121980 Genomic DNA. No translation available.
AL139140 Genomic DNA. No translation available.
AL355178, AL161643 Genomic DNA. Translation: CAI23434.1.
AL161643, AL355178 Genomic DNA. Translation: CAI23498.1.
AL596224 Genomic DNA. No translation available.
AL607106 Genomic DNA. No translation available.
BC031871 mRNA. Translation: AAH31871.1.
AB067471 mRNA. Translation: BAB67777.1.
IPIIPI00289802.
IPI00394771.
IPI00746532.
RefSeqNP_443128.2. NM_052896.3.
UniGeneHs.656915.

3D structure databases

ProteinModelPortalQ7Z408.
SMRQ7Z408. Positions 23-3274.
ModBaseSearch...

Protein-protein interaction databases

IntActQ7Z408. 5 interactions.
MINTMINT-7240859.
STRINGQ7Z408.

PTM databases

PhosphoSiteQ7Z408.

Polymorphism databases

DMDM116241318.

Proteomic databases

PRIDEQ7Z408.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000241312; ENSP00000241312; ENSG00000121904.
GeneID114784.
KEGGhsa:114784.
UCSCuc001bxn.1. human.
uc001bxo.1. human.

Organism-specific databases

CTD114784.
GeneCardsGC01M033979.
H-InvDBHIX0000395.
HGNCHGNC:19290. CSMD2.
HPAHPA008622.
MIM608398. gene.
neXtProtNX_Q7Z408.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00600000084158.
HOVERGENHBG051134.
PhylomeDBQ7Z408.

Gene expression databases

ArrayExpressQ7Z408.
BgeeQ7Z408.
GenevestigatorQ7Z408.
GermOnlineENSG00000121904. Homo sapiens.

Family and domain databases

InterProIPR016060. Complement_control_module.
IPR000859. CUB.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
Gene3DG3DSA:2.10.70.10. Complement_control_module. 26 hits.
G3DSA:2.60.120.290. CUB. 14 hits.
PfamPF00431. CUB. 14 hits.
PF00084. Sushi. 26 hits.
[Graphical view]
SMARTSM00032. CCP. 26 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMSSF57535. Complement_control_module. 26 hits.
SSF49854. CUB. 14 hits.
PROSITEPS01180. CUB. 14 hits.
PS50923. SUSHI. 26 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio79171.
SOURCESearch...

Entry information

Entry nameCSMD2_HUMAN
AccessionPrimary (citable) accession number: Q7Z408
Secondary accession number(s): B1AM50 expand/collapse secondary AC list , Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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