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Protein

CUB and sushi domain-containing protein 2

Gene

CSMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CUB and sushi domain-containing protein 2
Alternative name(s):
CUB and sushi multiple domains protein 2
Gene namesi
Name:CSMD2
Synonyms:KIAA1884
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19290. CSMD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 34083408ExtracellularSequence analysisAdd
BLAST
Transmembranei3409 – 342921HelicalSequence analysisAdd
BLAST
Topological domaini3430 – 348758CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134884681.

Polymorphism and mutation databases

BioMutaiCSMD2.
DMDMi116241318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34873487CUB and sushi domain-containing protein 2PRO_0000079405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi26 ↔ 52By similarity
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence analysis
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi139 ↔ 179By similarity
Disulfide bondi165 ↔ 196By similarity
Disulfide bondi202 ↔ 228By similarity
Disulfide bondi343 ↔ 383By similarity
Disulfide bondi369 ↔ 400By similarity
Disulfide bondi405 ↔ 431By similarity
Disulfide bondi521 ↔ 561By similarity
Disulfide bondi547 ↔ 574By similarity
Disulfide bondi578 ↔ 604By similarity
Glycosylationi581 – 5811N-linked (GlcNAc...)Sequence analysis
Glycosylationi680 – 6801N-linked (GlcNAc...)Sequence analysis
Disulfide bondi691 ↔ 732By similarity
Disulfide bondi717 ↔ 748By similarity
Disulfide bondi752 ↔ 778By similarity
Disulfide bondi867 ↔ 907By similarity
Disulfide bondi893 ↔ 920By similarity
Disulfide bondi924 ↔ 950By similarity
Glycosylationi949 – 9491N-linked (GlcNAc...)Sequence analysis
Glycosylationi983 – 9831N-linked (GlcNAc...)Sequence analysis
Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence analysis
Glycosylationi1028 – 10281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1039 ↔ 1079By similarity
Disulfide bondi1065 ↔ 1094By similarity
Disulfide bondi1098 ↔ 1124By similarity
Glycosylationi1158 – 11581N-linked (GlcNAc...)Sequence analysis
Glycosylationi1178 – 11781N-linked (GlcNAc...)Sequence analysis
Glycosylationi1194 – 11941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1211 ↔ 1252By similarity
Disulfide bondi1238 ↔ 1267By similarity
Disulfide bondi1271 ↔ 1298By similarity
Disulfide bondi1385 ↔ 1425By similarity
Glycosylationi1393 – 13931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1411 ↔ 1441By similarity
Disulfide bondi1445 ↔ 1471By similarity
Disulfide bondi1558 ↔ 1598By similarity
Glycosylationi1566 – 15661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1584 ↔ 1615By similarity
Disulfide bondi1619 ↔ 1645By similarity
Glycosylationi1638 – 16381N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1735 ↔ 1775By similarity
Disulfide bondi1761 ↔ 1792By similarity
Glycosylationi1786 – 17861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1796 ↔ 1822By similarity
Glycosylationi1799 – 17991N-linked (GlcNAc...)Sequence analysis
Glycosylationi1876 – 18761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1909 ↔ 1949By similarity
Disulfide bondi1935 ↔ 1964By similarity
Disulfide bondi1968 ↔ 1994By similarity
Glycosylationi2012 – 20121N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2123 ↔ 2163By similarity
Disulfide bondi2149 ↔ 2178By similarity
Disulfide bondi2182 ↔ 2208By similarity
Glycosylationi2185 – 21851N-linked (GlcNAc...)Sequence analysis
Glycosylationi2190 – 21901N-linked (GlcNAc...)Sequence analysis
Glycosylationi2223 – 22231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2294 ↔ 2336By similarity
Disulfide bondi2322 ↔ 2351By similarity
Disulfide bondi2355 ↔ 2383By similarity
Glycosylationi2394 – 23941N-linked (GlcNAc...)Sequence analysis
Glycosylationi2430 – 24301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2468 ↔ 2509By similarity
Disulfide bondi2495 ↔ 2526By similarity
Disulfide bondi2531 ↔ 2573By similarity
Disulfide bondi2557 ↔ 2588By similarity
Disulfide bondi2593 ↔ 2638By similarity
Disulfide bondi2624 ↔ 2653By similarity
Disulfide bondi2658 ↔ 2698By similarity
Disulfide bondi2684 ↔ 2711By similarity
Disulfide bondi2716 ↔ 2756By similarity
Glycosylationi2731 – 27311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2742 ↔ 2769By similarity
Disulfide bondi2774 ↔ 2814By similarity
Disulfide bondi2800 ↔ 2827By similarity
Glycosylationi2809 – 28091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2835 ↔ 2875By similarity
Disulfide bondi2861 ↔ 2888By similarity
Glycosylationi2878 – 28781N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2893 ↔ 2934By similarity
Disulfide bondi2920 ↔ 2947By similarity
Glycosylationi2937 – 29371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2952 ↔ 2994By similarity
Glycosylationi2971 – 29711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi2978 ↔ 3007By similarity
Glycosylationi3001 – 30011N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3012 ↔ 3052By similarity
Disulfide bondi3038 ↔ 3065By similarity
Glycosylationi3055 – 30551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3070 ↔ 3110By similarity
Disulfide bondi3096 ↔ 3123By similarity
Disulfide bondi3131 ↔ 3172By similarity
Glycosylationi3143 – 31431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3158 ↔ 3185By similarity
Glycosylationi3175 – 31751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3190 ↔ 3232By similarity
Disulfide bondi3217 ↔ 3245By similarity
Glycosylationi3307 – 33071N-linked (GlcNAc...)Sequence analysis
Glycosylationi3407 – 34071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z408.
PRIDEiQ7Z408.

PTM databases

PhosphoSiteiQ7Z408.

Expressioni

Tissue specificityi

Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain. Overexpressed in some head and neck cancer cell lines.2 Publications

Gene expression databases

BgeeiQ7Z408.
ExpressionAtlasiQ7Z408. baseline and differential.
GenevisibleiQ7Z408. HS.

Organism-specific databases

HPAiHPA008622.

Interactioni

Protein-protein interaction databases

BioGridi125346. 1 interaction.
IntActiQ7Z408. 7 interactions.
MINTiMINT-7240859.
STRINGi9606.ENSP00000241312.

Structurei

3D structure databases

ProteinModelPortaliQ7Z408.
SMRiQ7Z408. Positions 25-313, 343-3274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 134109CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 19862Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini202 – 306105CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini341 – 40262Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini405 – 516112CUB 3PROSITE-ProRule annotationAdd
BLAST
Domaini519 – 57658Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini578 – 686109CUB 4PROSITE-ProRule annotationAdd
BLAST
Domaini689 – 75062Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini752 – 860109CUB 5PROSITE-ProRule annotationAdd
BLAST
Domaini865 – 92258Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini924 – 1034111CUB 6PROSITE-ProRule annotationAdd
BLAST
Domaini1037 – 109660Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini1098 – 1206109CUB 7PROSITE-ProRule annotationAdd
BLAST
Domaini1209 – 126961Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini1271 – 1380110CUB 8PROSITE-ProRule annotationAdd
BLAST
Domaini1383 – 144361Sushi 8PROSITE-ProRule annotationAdd
BLAST
Domaini1445 – 1553109CUB 9PROSITE-ProRule annotationAdd
BLAST
Domaini1556 – 161762Sushi 9PROSITE-ProRule annotationAdd
BLAST
Domaini1619 – 1727109CUB 10PROSITE-ProRule annotationAdd
BLAST
Domaini1733 – 179462Sushi 10PROSITE-ProRule annotationAdd
BLAST
Domaini1796 – 1904109CUB 11PROSITE-ProRule annotationAdd
BLAST
Domaini1907 – 196660Sushi 11PROSITE-ProRule annotationAdd
BLAST
Domaini1968 – 2076109CUB 12PROSITE-ProRule annotationAdd
BLAST
Domaini2121 – 218060Sushi 12PROSITE-ProRule annotationAdd
BLAST
Domaini2182 – 2293112CUB 13PROSITE-ProRule annotationAdd
BLAST
Domaini2292 – 235362Sushi 13PROSITE-ProRule annotationAdd
BLAST
Domaini2355 – 2466112CUB 14PROSITE-ProRule annotationAdd
BLAST
Domaini2466 – 252863Sushi 14PROSITE-ProRule annotationAdd
BLAST
Domaini2529 – 259062Sushi 15PROSITE-ProRule annotationAdd
BLAST
Domaini2591 – 265565Sushi 16PROSITE-ProRule annotationAdd
BLAST
Domaini2656 – 271358Sushi 17PROSITE-ProRule annotationAdd
BLAST
Domaini2714 – 277158Sushi 18PROSITE-ProRule annotationAdd
BLAST
Domaini2772 – 282958Sushi 19PROSITE-ProRule annotationAdd
BLAST
Domaini2833 – 289058Sushi 20PROSITE-ProRule annotationAdd
BLAST
Domaini2891 – 294959Sushi 21PROSITE-ProRule annotationAdd
BLAST
Domaini2950 – 300960Sushi 22PROSITE-ProRule annotationAdd
BLAST
Domaini3010 – 306758Sushi 23PROSITE-ProRule annotationAdd
BLAST
Domaini3068 – 312558Sushi 24PROSITE-ProRule annotationAdd
BLAST
Domaini3129 – 318759Sushi 25PROSITE-ProRule annotationAdd
BLAST
Domaini3188 – 324760Sushi 26PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CSMD family.Curated
Contains 14 CUB domains.PROSITE-ProRule annotation
Contains 26 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000112015.
HOVERGENiHBG051134.
InParanoidiQ7Z408.
KOiK17495.
OMAiAQVRFIS.
OrthoDBiEOG7FNC6J.
PhylomeDBiQ7Z408.
TreeFamiTF316872.

Family and domain databases

Gene3Di2.60.120.290. 14 hits.
InterProiIPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00431. CUB. 14 hits.
PF00084. Sushi. 26 hits.
[Graphical view]
SMARTiSM00032. CCP. 26 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 14 hits.
SSF57535. SSF57535. 26 hits.
PROSITEiPS01180. CUB. 14 hits.
PS50923. SUSHI. 26 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA
60 70 80 90 100
NCTWTITAEE QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ
110 120 130 140 150
LPATIVSAAT TLSLRLISDY AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ
160 170 180 190 200
QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH AGSENSATWD FPLPSCRADD
210 220 230 240 250
ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI ALVFIDFQLE
260 270 280 290 300
DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS
310 320 330 340 350
AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE
360 370 380 390 400
RGKRLGSDFR LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC
410 420 430 440 450
RARMCDAHLR GPSGIITSPN FPIQYDNNAH CVWIITALNP SKVIKLAFEE
460 470 480 490 500
FDLERGYDTL TVGDGGQDGD QKTVLYILTG TSVPDLIVST NHQMWLLFQT
510 520 530 540 550
DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG DTLKFECQPA
560 570 580 590 600
FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN
610 620 630 640 650
HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG
660 670 680 690 700
NQLPSSITSS GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG
710 720 730 740 750
KRFGDSLQLG SSISFLCDEG FLGTQGSETI TCVLKEGSVV WNSAVLRCEA
760 770 780 790 800
PCGGHLTSPS GTILSPGWPG FYKDALSCAW VIEAQPGYPI KITFDRFKTE
810 820 830 840 850
VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL LFSTDKSHSD
860 870 880 890 900
IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS
910 920 930 940 950
DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC
960 970 980 990 1000
TWIIETSHGK GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA
1010 1020 1030 1040 1050
PISAGLYGNF TAQVRFISDF SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR
1060 1070 1080 1090 1100
KGLQFGVGDT LTFSCFPGYR LEGTARITCL GGRRRLWSSP LPRCVAECGN
1110 1120 1130 1140 1150
SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA RAFELSEGDV
1160 1170 1180 1190 1200
LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE
1210 1220 1230 1240 1250
LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL
1260 1270 1280 1290 1300
LCLSGERRTW DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW
1310 1320 1330 1340 1350
TIEAEAGCTI GLHFLVFDTE EVHDVLRIWD GPVESGVLLK ELSGPALPKD
1360 1370 1380 1390 1400
LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS TATSCNDPGI PQNGSRSGDS
1410 1420 1430 1440 1450
WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT CIAPCGGDLT
1460 1470 1480 1490 1500
GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH
1510 1520 1530 1540 1550
IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY
1560 1570 1580 1590 1600
TENPRESCFD PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL
1610 1620 1630 1640 1650
GPDGKPVWNN PRPVCTAPCG GQYVGSDGVV LSPNYPQNYT SGQICLYFVT
1660 1670 1680 1690 1700
VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ HSRLLSSLSG SHTGESLPLA
1710 1720 1730 1740 1750
TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE PRYGKRLGSD
1760 1770 1780 1790 1800
FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL
1810 1820 1830 1840 1850
TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL
1860 1870 1880 1890 1900
EVFDGADNTV TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE
1910 1920 1930 1940 1950
YKTVGLSSCP EPAVPSNGVK TGERYLVNDV VSFQCEPGYA LQGHAHISCM
1960 1970 1980 1990 2000
PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL SPGFPGNYPS NMDCSWKIAL
2010 2020 2030 2040 2050
PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG SELPSSLLST
2060 2070 2080 2090 2100
SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST
2110 2120 2130 2140 2150
PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL
2160 2170 2180 2190 2200
PGYQLTGHPV LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS
2210 2220 2230 2240 2250
PYSSSQDCVW LITVPIGHGV RLNLSLLQTE PSGDFITIWD GPQQTAPRLG
2260 2270 2280 2290 2300
VFTRSMAKKT VQSSSNQVLL KFHRDAATGG IFAIAFSAYP LTKCPPPTIL
2310 2320 2330 2340 2350
PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT YLQFEGPPPI
2360 2370 2380 2390 2400
CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE
2410 2420 2430 2440 2450
YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS
2460 2470 2480 2490 2500
DHAYNRKGFK IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR
2510 2520 2530 2540 2550
LVGHSMAICT RHPQGYHLWS EAIPLCQALS CGLPEAPKNG MVFGKEYTVG
2560 2570 2580 2590 2600
TKAMYSCSEG YHLQAGAEAT AECLDTGLWS NRNVPPQCVP VTCPDVSSIS
2610 2620 2630 2640 2650
VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA NGKWSLGDST
2660 2670 2680 2690 2700
PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA
2710 2720 2730 2740 2750
NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG
2760 2770 2780 2790 2800
MSVRICQQDH HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC
2810 2820 2830 2840 2850
IGKRTLVGNS TRMCGLDGHW TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS
2860 2870 2880 2890 2900
FDPGTVMRFS CEAGHVLRGS SERTCQANGS WSGSQPECGV ISCGNPGTPS
2910 2920 2930 2940 2950
NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW TGSDPECLVI
2960 2970 2980 2990 3000
NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW
3010 3020 3030 3040 3050
NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF
3060 3070 3080 3090 3100
TCEGNGSWTG ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL
3110 3120 3130 3140 3150
VLVGSPRRFC QSDGTWSGTQ PSCIDPTLTT CADPGVPQFG IQNNSQGYQV
3160 3170 3180 3190 3200
GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG TPPDCVPHHC RQPETPTHAN
3210 3220 3230 3240 3250
VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG KPPICLEVRP
3260 3270 3280 3290 3300
SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ
3310 3320 3330 3340 3350
VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK
3360 3370 3380 3390 3400
DDHWALDGHV SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI
3410 3420 3430 3440 3450
GRHFASNSSS VAAAILVPFI ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN
3460 3470 3480
TNVRATFENP MYDRNIQPTD IMASEAEFTV STVCTAV
Length:3,487
Mass (Da):380,039
Last modified:October 17, 2006 - v2
Checksum:i3A2A1A2911EFC1F4
GO
Isoform 2 (identifier: Q7Z408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1087: Missing.
     1088-1095: SSPLPRCV → MVIVILFP
     2075-2116: Missing.
     2288-2296: AYPLTKCPP → GHLAAVCTL
     2297-3487: Missing.

Note: No experimental confirmation available.
Show »
Length:1,167
Mass (Da):126,167
Checksum:iA01099D90B049710
GO
Isoform 3 (identifier: Q7Z408-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-403: Missing.
     443-443: V → VGGDPGNIQCNKEGLSVETQSLRLRNRSCLLGNSKDNGCCVPNPVHGTGLQV
     576-577: FS → CK
     578-3487: Missing.

Note: No experimental confirmation available.
Show »
Length:225
Mass (Da):24,393
Checksum:iF807E3CE7EC32C31
GO
Isoform 4 (identifier: Q7Z408-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MRLISIAPGPRWQVQSHHPRS → MPRSRGRELG...GCGLLSVSAA
     2075-2116: Missing.
     2712-2712: L → LATQTKLHSIFYKLLFDVLSSPSLTK
     2770-2770: V → VPITCGHPGN...TWDRPRPQCL

Show »
Length:3,631
Mass (Da):394,998
Checksum:i812D81D0F716FE2A
GO

Sequence cautioni

The sequence BAC04593.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331V → A in AAO34701 (PubMed:12906867).Curated
Sequence conflicti1104 – 11041G → A in BAC87101 (PubMed:14702039).Curated
Sequence conflicti1175 – 11751V → E in BAC87101 (PubMed:14702039).Curated
Sequence conflicti1695 – 16951E → G in BAC87101 (PubMed:14702039).Curated
Sequence conflicti3251 – 32511S → N in AAO34701 (PubMed:12906867).Curated
Sequence conflicti3251 – 32511S → N in BAB67777 (PubMed:11572484).Curated
Sequence conflicti3251 – 32511S → N in BAD97692 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671L → P.
Corresponds to variant rs16836099 [ dbSNP | Ensembl ].
VAR_028081
Natural varianti538 – 5381H → R.
Corresponds to variant rs474474 [ dbSNP | Ensembl ].
VAR_024330
Natural varianti2096 – 20961R → K.
Corresponds to variant rs1874045 [ dbSNP | Ensembl ].
VAR_028082
Natural varianti2117 – 21171A → V.
Corresponds to variant rs11588581 [ dbSNP | Ensembl ].
VAR_028083
Natural varianti2554 – 25541M → V.1 Publication
Corresponds to variant rs2641962 [ dbSNP | Ensembl ].
VAR_028084
Natural varianti2661 – 26611L → R.
Corresponds to variant rs3820206 [ dbSNP | Ensembl ].
VAR_028085
Natural varianti2661 – 26611L → V.
Corresponds to variant rs34850622 [ dbSNP | Ensembl ].
VAR_050917
Natural varianti3406 – 34061S → F.
Corresponds to variant rs1617468 [ dbSNP | Ensembl ].
VAR_028086

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10871087Missing in isoform 2. 1 PublicationVSP_009038Add
BLAST
Alternative sequencei1 – 403403Missing in isoform 3. 1 PublicationVSP_009043Add
BLAST
Alternative sequencei1 – 2121MRLIS…HHPRS → MPRSRGRELGRCGCPAGRAR GETGISALVPGAGSRWGRPP PPTPPPLLLLLGCGLLSVSA A in isoform 4. CuratedVSP_055687Add
BLAST
Alternative sequencei443 – 4431V → VGGDPGNIQCNKEGLSVETQ SLRLRNRSCLLGNSKDNGCC VPNPVHGTGLQV in isoform 3. 1 PublicationVSP_009044
Alternative sequencei576 – 5772FS → CK in isoform 3. 1 PublicationVSP_009045
Alternative sequencei578 – 34872910Missing in isoform 3. 1 PublicationVSP_009046Add
BLAST
Alternative sequencei1088 – 10958SSPLPRCV → MVIVILFP in isoform 2. 1 PublicationVSP_009039
Alternative sequencei2075 – 211642Missing in isoform 2 and isoform 4. 1 PublicationVSP_009040Add
BLAST
Alternative sequencei2288 – 22969AYPLTKCPP → GHLAAVCTL in isoform 2. 1 PublicationVSP_009041
Alternative sequencei2297 – 34871191Missing in isoform 2. 1 PublicationVSP_009042Add
BLAST
Alternative sequencei2712 – 27121L → LATQTKLHSIFYKLLFDVLS SPSLTK in isoform 4. CuratedVSP_055688
Alternative sequencei2770 – 27701V → VPITCGHPGNPVNGLTQGNQ FNLNDVVKFVCNPGYMAEGA ARSQCLASGQWSDMLPTCRI INCTDPGHQENSVRQVHASG PHRFSFGTTVSYRCNHGFYL LGTPVLSCQGDGTWDRPRPQ CL in isoform 4. CuratedVSP_055689

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY210418 mRNA. Translation: AAO34701.1.
AB212622 mRNA. Translation: BAD97692.1.
AK095627 mRNA. Translation: BAC04593.1. Different initiation.
AK127722 mRNA. Translation: BAC87101.1.
AC115285 Genomic DNA. No translation available.
AC115286 Genomic DNA. No translation available.
AC116993 Genomic DNA. No translation available.
AL121980 Genomic DNA. No translation available.
AL139140 Genomic DNA. No translation available.
AL355178, AL161643 Genomic DNA. Translation: CAI23434.1.
AL161643, AL355178 Genomic DNA. Translation: CAI23498.1.
AL596224 Genomic DNA. No translation available.
AL607106 Genomic DNA. No translation available.
BC031871 mRNA. Translation: AAH31871.1.
AB067471 mRNA. Translation: BAB67777.1.
CCDSiCCDS380.1. [Q7Z408-1]
CCDS60082.1. [Q7Z408-4]
RefSeqiNP_001268885.1. NM_001281956.1. [Q7Z408-4]
NP_443128.2. NM_052896.4. [Q7Z408-1]
UniGeneiHs.656915.

Genome annotation databases

EnsembliENST00000241312; ENSP00000241312; ENSG00000121904. [Q7Z408-1]
ENST00000373380; ENSP00000362478; ENSG00000121904. [Q7Z408-2]
ENST00000373381; ENSP00000362479; ENSG00000121904. [Q7Z408-4]
ENST00000373388; ENSP00000362486; ENSG00000121904. [Q7Z408-1]
GeneIDi114784.
KEGGihsa:114784.
UCSCiuc001bxm.2. human. [Q7Z408-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY210418 mRNA. Translation: AAO34701.1.
AB212622 mRNA. Translation: BAD97692.1.
AK095627 mRNA. Translation: BAC04593.1. Different initiation.
AK127722 mRNA. Translation: BAC87101.1.
AC115285 Genomic DNA. No translation available.
AC115286 Genomic DNA. No translation available.
AC116993 Genomic DNA. No translation available.
AL121980 Genomic DNA. No translation available.
AL139140 Genomic DNA. No translation available.
AL355178, AL161643 Genomic DNA. Translation: CAI23434.1.
AL161643, AL355178 Genomic DNA. Translation: CAI23498.1.
AL596224 Genomic DNA. No translation available.
AL607106 Genomic DNA. No translation available.
BC031871 mRNA. Translation: AAH31871.1.
AB067471 mRNA. Translation: BAB67777.1.
CCDSiCCDS380.1. [Q7Z408-1]
CCDS60082.1. [Q7Z408-4]
RefSeqiNP_001268885.1. NM_001281956.1. [Q7Z408-4]
NP_443128.2. NM_052896.4. [Q7Z408-1]
UniGeneiHs.656915.

3D structure databases

ProteinModelPortaliQ7Z408.
SMRiQ7Z408. Positions 25-313, 343-3274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125346. 1 interaction.
IntActiQ7Z408. 7 interactions.
MINTiMINT-7240859.
STRINGi9606.ENSP00000241312.

PTM databases

PhosphoSiteiQ7Z408.

Polymorphism and mutation databases

BioMutaiCSMD2.
DMDMi116241318.

Proteomic databases

PaxDbiQ7Z408.
PRIDEiQ7Z408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000241312; ENSP00000241312; ENSG00000121904. [Q7Z408-1]
ENST00000373380; ENSP00000362478; ENSG00000121904. [Q7Z408-2]
ENST00000373381; ENSP00000362479; ENSG00000121904. [Q7Z408-4]
ENST00000373388; ENSP00000362486; ENSG00000121904. [Q7Z408-1]
GeneIDi114784.
KEGGihsa:114784.
UCSCiuc001bxm.2. human. [Q7Z408-1]

Organism-specific databases

CTDi114784.
GeneCardsiCSMD2.
H-InvDBHIX0000395.
HGNCiHGNC:19290. CSMD2.
HPAiHPA008622.
MIMi608398. gene.
neXtProtiNX_Q7Z408.
PharmGKBiPA134884681.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000112015.
HOVERGENiHBG051134.
InParanoidiQ7Z408.
KOiK17495.
OMAiAQVRFIS.
OrthoDBiEOG7FNC6J.
PhylomeDBiQ7Z408.
TreeFamiTF316872.

Miscellaneous databases

ChiTaRSiCSMD2. human.
GeneWikiiCSMD2.
GenomeRNAii114784.
NextBioi35500462.
PROiQ7Z408.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z408.
ExpressionAtlasiQ7Z408. baseline and differential.
GenevisibleiQ7Z408. HS.

Family and domain databases

Gene3Di2.60.120.290. 14 hits.
InterProiIPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00431. CUB. 14 hits.
PF00084. Sushi. 26 hits.
[Graphical view]
SMARTiSM00032. CCP. 26 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 14 hits.
SSF57535. SSF57535. 26 hits.
PROSITEiPS01180. CUB. 14 hits.
PS50923. SUSHI. 26 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two new members of the CSMD gene family."
    Lau W.L., Scholnick S.B.
    Genomics 82:412-415(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Comparative analysis of CSMD families."
    Shimizu A., Sasaki T., Asakawa S., Shimizu N.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 4), VARIANT VAL-2554.
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 2969-3487 (ISOFORM 1).
    Tissue: Brain and Teratocarcinoma.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  6. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2542-3487 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.

Entry informationi

Entry nameiCSMD2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z408
Secondary accession number(s): B1AM50
, E7EUA6, Q53TY4, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 17, 2006
Last modified: March 16, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.