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Protein

CUB and sushi domain-containing protein 3

Gene

CSMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CUB and sushi domain-containing protein 3
Alternative name(s):
CUB and sushi multiple domains protein 3
Gene namesi
Name:CSMD3
Synonyms:KIAA1894
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:19291. CSMD3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42CytoplasmicSequence analysisAdd BLAST42
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 3630ExtracellularSequence analysisAdd BLAST3567
Transmembranei3631 – 3651HelicalSequence analysisAdd BLAST21
Topological domaini3652 – 3707CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114788.
OpenTargetsiENSG00000164796.
PharmGKBiPA134926063.

Polymorphism and mutation databases

BioMutaiCSMD3.
DMDMi257051058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000210271 – 3707CUB and sushi domain-containing protein 3Add BLAST3707

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 91By similarity
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi178 ↔ 218By similarity
Disulfide bondi204 ↔ 235By similarity
Disulfide bondi241 ↔ 267By similarity
Glycosylationi361N-linked (GlcNAc...)Sequence analysis1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi486 ↔ 526By similarity
Disulfide bondi512 ↔ 543By similarity
Disulfide bondi548 ↔ 574By similarity
Disulfide bondi664 ↔ 704By similarity
Disulfide bondi690 ↔ 717By similarity
Disulfide bondi721 ↔ 747By similarity
Glycosylationi724N-linked (GlcNAc...)Sequence analysis1
Glycosylationi823N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi834 ↔ 875By similarity
Disulfide bondi860 ↔ 891By similarity
Disulfide bondi895 ↔ 921By similarity
Glycosylationi966N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1010 ↔ 1050By similarity
Disulfide bondi1036 ↔ 1063By similarity
Disulfide bondi1067 ↔ 1093By similarity
Glycosylationi1092N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1171N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1182 ↔ 1222By similarity
Disulfide bondi1208 ↔ 1237By similarity
Disulfide bondi1241 ↔ 1267By similarity
Glycosylationi1280N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1354 ↔ 1395By similarity
Disulfide bondi1381 ↔ 1410By similarity
Disulfide bondi1414 ↔ 1441By similarity
Disulfide bondi1528 ↔ 1568By similarity
Glycosylationi1536N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1554 ↔ 1584By similarity
Disulfide bondi1588 ↔ 1614By similarity
Glycosylationi1591N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1701 ↔ 1741By similarity
Glycosylationi1709N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1727 ↔ 1758By similarity
Disulfide bondi1762 ↔ 1788By similarity
Glycosylationi1781N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1878 ↔ 1918By similarity
Disulfide bondi1904 ↔ 1935By similarity
Glycosylationi1929N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1939 ↔ 1965By similarity
Glycosylationi2019N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2052 ↔ 2092By similarity
Disulfide bondi2078 ↔ 2107By similarity
Disulfide bondi2111 ↔ 2137By similarity
Glycosylationi2155N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2224 ↔ 2264By similarity
Disulfide bondi2250 ↔ 2279By similarity
Disulfide bondi2283 ↔ 2309By similarity
Glycosylationi2286N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2291N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2324N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2395 ↔ 2437By similarity
Disulfide bondi2423 ↔ 2452By similarity
Disulfide bondi2456 ↔ 2484By similarity
Glycosylationi2495N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2537N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2569 ↔ 2610By similarity
Disulfide bondi2596 ↔ 2627By similarity
Disulfide bondi2632 ↔ 2674By similarity
Disulfide bondi2658 ↔ 2689By similarity
Disulfide bondi2694 ↔ 2739By similarity
Glycosylationi2711N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2725 ↔ 2754By similarity
Glycosylationi2742N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2759 ↔ 2799By similarity
Disulfide bondi2785 ↔ 2812By similarity
Disulfide bondi2817 ↔ 2857By similarity
Disulfide bondi2843 ↔ 2870By similarity
Glycosylationi2862N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2875 ↔ 2915By similarity
Disulfide bondi2901 ↔ 2928By similarity
Glycosylationi2932N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2933 ↔ 2977By similarity
Glycosylationi2952N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi2963 ↔ 2990By similarity
Disulfide bondi2995 ↔ 3035By similarity
Disulfide bondi3021 ↔ 3048By similarity
Disulfide bondi3056 ↔ 3096By similarity
Disulfide bondi3082 ↔ 3109By similarity
Glycosylationi3099N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3114 ↔ 3155By similarity
Disulfide bondi3141 ↔ 3168By similarity
Glycosylationi3158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3167N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3173 ↔ 3215By similarity
Glycosylationi3194N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3199 ↔ 3228By similarity
Glycosylationi3208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3218N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3233 ↔ 3273By similarity
Disulfide bondi3259 ↔ 3286By similarity
Glycosylationi3276N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3291 ↔ 3331By similarity
Disulfide bondi3317 ↔ 3344By similarity
Disulfide bondi3352 ↔ 3393By similarity
Glycosylationi3364N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3379 ↔ 3406By similarity
Disulfide bondi3411 ↔ 3453By similarity
Disulfide bondi3438 ↔ 3466By similarity
Glycosylationi3522N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3529N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3612N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3618N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3627N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7Z407.
PaxDbiQ7Z407.
PeptideAtlasiQ7Z407.
PRIDEiQ7Z407.

PTM databases

iPTMnetiQ7Z407.
PhosphoSitePlusiQ7Z407.

Expressioni

Tissue specificityi

Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, thalamus, spinal cord, hippocampus and fetal brain. Also expressed in testis.2 Publications

Gene expression databases

BgeeiENSG00000164796.
CleanExiHS_CSMD3.
ExpressionAtlasiQ7Z407. baseline and differential.
GenevisibleiQ7Z407. HS.

Organism-specific databases

HPAiHPA029007.

Interactioni

Protein-protein interaction databases

BioGridi125350. 1 interactor.
STRINGi9606.ENSP00000297405.

Structurei

3D structure databases

ProteinModelPortaliQ7Z407.
SMRiQ7Z407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 173CUB 1PROSITE-ProRule annotationAdd BLAST109
Domaini176 – 237Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini241 – 345CUB 2PROSITE-ProRule annotationAdd BLAST105
Domaini484 – 545Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini548 – 659CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini662 – 719Sushi 3PROSITE-ProRule annotationAdd BLAST58
Domaini721 – 829CUB 4PROSITE-ProRule annotationAdd BLAST109
Domaini832 – 893Sushi 4PROSITE-ProRule annotationAdd BLAST62
Domaini895 – 1003CUB 5PROSITE-ProRule annotationAdd BLAST109
Domaini1008 – 1065Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini1067 – 1177CUB 6PROSITE-ProRule annotationAdd BLAST111
Domaini1180 – 1239Sushi 6PROSITE-ProRule annotationAdd BLAST60
Domaini1241 – 1349CUB 7PROSITE-ProRule annotationAdd BLAST109
Domaini1352 – 1412Sushi 7PROSITE-ProRule annotationAdd BLAST61
Domaini1414 – 1523CUB 8PROSITE-ProRule annotationAdd BLAST110
Domaini1526 – 1586Sushi 8PROSITE-ProRule annotationAdd BLAST61
Domaini1588 – 1696CUB 9PROSITE-ProRule annotationAdd BLAST109
Domaini1699 – 1760Sushi 9PROSITE-ProRule annotationAdd BLAST62
Domaini1762 – 1870CUB 10PROSITE-ProRule annotationAdd BLAST109
Domaini1876 – 1937Sushi 10PROSITE-ProRule annotationAdd BLAST62
Domaini1939 – 2047CUB 11PROSITE-ProRule annotationAdd BLAST109
Domaini2050 – 2109Sushi 11PROSITE-ProRule annotationAdd BLAST60
Domaini2111 – 2219CUB 12PROSITE-ProRule annotationAdd BLAST109
Domaini2222 – 2281Sushi 12PROSITE-ProRule annotationAdd BLAST60
Domaini2283 – 2394CUB 13PROSITE-ProRule annotationAdd BLAST112
Domaini2393 – 2454Sushi 13PROSITE-ProRule annotationAdd BLAST62
Domaini2456 – 2567CUB 14PROSITE-ProRule annotationAdd BLAST112
Domaini2567 – 2629Sushi 14PROSITE-ProRule annotationAdd BLAST63
Domaini2630 – 2691Sushi 15PROSITE-ProRule annotationAdd BLAST62
Domaini2692 – 2756Sushi 16PROSITE-ProRule annotationAdd BLAST65
Domaini2757 – 2814Sushi 17PROSITE-ProRule annotationAdd BLAST58
Domaini2815 – 2872Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2873 – 2930Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2931 – 2992Sushi 20PROSITE-ProRule annotationAdd BLAST62
Domaini2993 – 3050Sushi 21PROSITE-ProRule annotationAdd BLAST58
Domaini3054 – 3111Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini3112 – 3170Sushi 23PROSITE-ProRule annotationAdd BLAST59
Domaini3171 – 3230Sushi 24PROSITE-ProRule annotationAdd BLAST60
Domaini3231 – 3288Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini3289 – 3346Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3350 – 3408Sushi 27PROSITE-ProRule annotationAdd BLAST59
Domaini3409 – 3468Sushi 28PROSITE-ProRule annotationAdd BLAST60

Sequence similaritiesi

Belongs to the CSMD family.Curated
Contains 14 CUB domains.PROSITE-ProRule annotation
Contains 28 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000112015.
HOVERGENiHBG051134.
InParanoidiQ7Z407.
KOiK17495.
OMAiILRFECQ.
OrthoDBiEOG091G00EH.
PhylomeDBiQ7Z407.
TreeFamiTF316872.

Family and domain databases

CDDicd00033. CCP. 28 hits.
cd00041. CUB. 14 hits.
Gene3Di2.60.120.290. 14 hits.
InterProiIPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00431. CUB. 14 hits.
PF00084. Sushi. 28 hits.
[Graphical view]
SMARTiSM00032. CCP. 28 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 14 hits.
SSF57535. SSF57535. 28 hits.
PROSITEiPS01180. CUB. 14 hits.
PS50923. SUSHI. 28 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z407-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGIRKGESR AKESKPWEPG KRRCAKCGRL DFILMKKMGI KSGFTFWNLV
60 70 80 90 100
FLLTVSCVKG FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER
110 120 130 140 150
NRIQIVFQSF ALEEEYDYLS LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV
160 170 180 190 200
FSLRLTSDFA VSAHGFKVYY EELQSSSCGN PGVPPKGVLY GTRFDVGDKI
210 220 230 240 250
RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA CGGTMRGSSG
260 270 280 290 300
IISSPSFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
310 320 330 340 350
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQGSSTLTH
360 370 380 390 400
TTSTGELEEH NRTTTGAIAV ASTPADVTVS SVTAVTIHRL SEEQRVQVTS
410 420 430 440 450
LRNSGLDPNT SKDGLSPHPA DTQSTRRRPR HAEQIERTKE LAVVTHRVKK
460 470 480 490 500
AIDFKSRGFK LFPGKDNSNK FSILNEGGIK TASNLCPDPG EPENGKRIGS
510 520 530 540 550
DFSLGSTVQF SCDEDYVLQG AKSITCQRIA EVFAAWSDHR PVCKVKTCGS
560 570 580 590 600
NLQGPSGTFT SPNFPFQYDS NAQCVWVITA VNTNKVIQIN FEEFDLEIGY
610 620 630 640 650
DTLTIGDGGE VGDPRTVLQV LTGSFVPDLI VSMSSQMWLH LQTDESVGSV
660 670 680 690 700
GFKVNYKEIE KESCGDPGTP LYGIREGDGF SNRDVLRFEC QFGFELIGEK
710 720 730 740 750
SIVCQENNQW SANIPICIFP CLSNFTAPMG TVLSPDYPEG YGNNLNCIWT
760 770 780 790 800
IISDPGSRIH LSFNDFDLES QFDFLAVKDG DSPESPILGT FTGAEVPSHL
810 820 830 840 850
TSNSHILRLE FQADHSMSGR GFNITYNTFG HNECPDPGIP INARRFGDNF
860 870 880 890 900
QLGSSISVIC EEGFIKTQGT ETITCILMDG KVMWSGLIPK CGAPCGGHFS
910 920 930 940 950
APSGVILSPG WPGYYKDSLN CEWVIEAEPG HSIKITFERF QTELNYDVLE
960 970 980 990 1000
VHDGPNLLSP LLGSYNGTQV PQFLFSSSNF IYLLFTTDNS RSNNGFKIHY
1010 1020 1030 1040 1050
ESVTVNTYSC LDPGIPVHGR RYGHDFSIGS TVSFSCDSGY RLSHEEPLLC
1060 1070 1080 1090 1100
EKNHWWSHPL PTCDALCGGD VRGPSGTILS PGYPEFYPNS LNCTWTVDVT
1110 1120 1130 1140 1150
HGKGVQFNFH TFHLEDHHDY LLITENGSFT QPLARLTGSD LPPTINAGLY
1160 1170 1180 1190 1200
GNFRAQLRFI SDFSISYEGF NITFSEYNLE PCEDPGIPQY GSRIGFNFGI
1210 1220 1230 1240 1250
GDTLTFSCSS GYRLEGTSEI ICLGGGRRVW SAPLPRCVAE CGASATNNEG
1260 1270 1280 1290 1300
ILLSPNYPLN YENNHECIYS IQVQAGKGIN ISARTFHLAQ GDVLKIYDGK
1310 1320 1330 1340 1350
DKTTHLLGAF TGASMRGLTL SSTSNQLWLE FNSDTEGTDE GFQLVYTSFE
1360 1370 1380 1390 1400
LSHCEDPGIP QFGYKISDQG HFAGSTIIYG CNPGYTLHGS SLLKCMTGER
1410 1420 1430 1440 1450
RAWDYPLPSC IAECGGRFKG ESSGRILSPG YPFPYDNNLR CMWMIEVDPG
1460 1470 1480 1490 1500
NIVSLQFLAF DTEASHDILR VWDGPPENDM LLKEISGSLI PEGIHSTLNI
1510 1520 1530 1540 1550
VTIQFDTDFY ISKSGFAIQF SSSVATACRD PGVPMNGTRN GDGREPGDTV
1560 1570 1580 1590 1600
VFQCDPGYEL QGEERITCIQ VENRYFWQPS PPVCIAPCGG NLTGSSGFIL
1610 1620 1630 1640 1650
SPNFPHPYPH SRDCDWTITV NADYVISLAF ISFSIEPNYD FLYIYDGPDS
1660 1670 1680 1690 1700
NSPLIGSFQD SKLPERIESS SNTMHLAFRS DGSVSYTGFH LEYKAKLRES
1710 1720 1730 1740 1750
CFDPGNIMNG TRLGMDYKLG STVTYYCDAG YVLQGYSTLT CIMGDDGRPG
1760 1770 1780 1790 1800
WNRALPSCHA PCGSRSTGSE GTVLSPNYPK NYSVGHNCVY SIAVPKEFVV
1810 1820 1830 1840 1850
FGQFVFFQTS LHDVVEVYDG PTQQSSLLSS LSGSHSGESL PLSSGNQITI
1860 1870 1880 1890 1900
RFTSVGPITA KGFHFVYQAV PRTSSTQCSS VPEPRFGRRI GNEFAVGSSV
1910 1920 1930 1940 1950
LFDCNPGYIL HGSIAIRCET VPNSLAQWND SLPTCIVPCG GILTKRKGTI
1960 1970 1980 1990 2000
LSPGYPEPYD NNLNCVWKIT VPEGAGIQVQ VVSFATEHNW DSLDFYDGGD
2010 2020 2030 2040 2050
NNAPRLGSYS GTTIPHLLNS TSNNLYLNFQ SDISVSAAGF HLEYTAIGLD
2060 2070 2080 2090 2100
SCPEPQTPSS GIKIGDRYMV GDVVSFQCDQ GYSLQGHSHI TCMPGPVRRW
2110 2120 2130 2140 2150
NYPIPICLAQ CGGAMSDFSG VILSPGFPGN YPSSLDCTWT INLPIGFGVH
2160 2170 2180 2190 2200
LQFVNFSTET IHDYLEVRSG SSETSTVIGR LSGPQIPSSL FSTTHETSLY
2210 2220 2230 2240 2250
FHSDYSQNKQ GFHIVYQAYQ LQSCPDPRPF RNGFVIGNDF TVGQTISFEC
2260 2270 2280 2290 2300
FPGYTLIGNS ALTCLHGVSR NWNHPLPRCE ALCGGNITAM NGTIYSPGYP
2310 2320 2330 2340 2350
DEYPNFQDCF WLVRVPPGNG IYINFTVLQT EPIYDFITVW DGPDQNSPQI
2360 2370 2380 2390 2400
GQFSGNTALE SVYSTSNQIL IKFHSDFTTS GFFVLSYHAY QLRVCQPPPP
2410 2420 2430 2440 2450
VPNAEILTED DEFEIGDIIR YQCLPGFTLV GNAILTCRLG ERLQMDGAPP
2460 2470 2480 2490 2500
VCQVLCPANE LRLDSTGVIL SPGYPDSYPN LQMCAWSISV EKGYNITMFV
2510 2520 2530 2540 2550
EFFQTEKEFD VLQVYDGPNI QSPVLISLSG DYSSAFNITS NGHEVFLQWS
2560 2570 2580 2590 2600
ADHGNNKKGF RIRYIAFYCS TPESPPHGYI ISQTGGQLNS VVRWACDRGF
2610 2620 2630 2640 2650
RLVGKSSAVC RKSSYGYHAW DAPVPACQAI SCGIPKAPTN GGILTTDYLV
2660 2670 2680 2690 2700
GTRVTYFCND GYRLSSKELT TAVCQSDGTW SNHNKTPRCV VVTCPSINSF
2710 2720 2730 2740 2750
ILEHGRWRIV NGSHYEYKTK VVFSCDPGYH GLGPASIECL PNGTWSWRNE
2760 2770 2780 2790 2800
RPYCQIISCG ELPTPPNGNK IGTQTSYGST AIFTCDLGFM LVGSAVRECL
2810 2820 2830 2840 2850
SSGLWSESET RCLAGHCGIP ELIVNGQVIG ENYGYRDTVV YQCNPGFRLI
2860 2870 2880 2890 2900
GSSVRICQQD HNWSGQLPSC VPVSCGHPGS PIYGRTSGNG FNFNDVVTFS
2910 2920 2930 2940 2950
CNIGYLMQGP TKAQCQANRQ WSHPPPMCKV VNCSDPGIPA NSKRESKIEH
2960 2970 2980 2990 3000
GNFTYGTVVF YDCNPGYFLF GSSVLICQPN GQWDKPLPEC IMIDCGHPGV
3010 3020 3030 3040 3050
PPNAVLSGEK YTFGSTVHYS CTGKRSLLGQ SSRTCQLNGH WSGSQPHCSG
3060 3070 3080 3090 3100
DATGTCGDPG TPGHGSRQES NFRTKSTVRY ACDTGYILHG SEERTCLANG
3110 3120 3130 3140 3150
SWTGRQPECK AVQCGNPGTT ANGKVFRIDG TTFSSSVIYS CMEGYILSGP
3160 3170 3180 3190 3200
SVRQCTANGT WSGTLPNCTI ISCGDPGIPA NGLRYGDDYV VGQNVSYMCQ
3210 3220 3230 3240 3250
PGYTMELNGS RIRTCTINGT WSGVMPTCRA VTCPTPPQIS NGRLEGTNFD
3260 3270 3280 3290 3300
WGFSISYICS PGYELSFPAV LTCVGNGTWS GEVPQCLPKF CGDPGIPAQG
3310 3320 3330 3340 3350
KREGKSFIYQ SEVSFSCNFP FILVGSSTRI CQADGTWSGS SPHCIEPTQT
3360 3370 3380 3390 3400
SCENPGVPRH GSQNNTFGFQ VGSVVQFHCK KGHLLQGSTT RTCLPDLTWS
3410 3420 3430 3440 3450
GIQPECIPHS CKQPETPAHA NVVGMDLPSH GYTLIYTCQP GFFLAGGTEH
3460 3470 3480 3490 3500
RVCRSDNTWT GKVPICEAGS KILVKDPRPA LGTPSPKLSV PDDVFAQNYI
3510 3520 3530 3540 3550
WKGSYNFKGR KQPMTLTVTS FNASTGRVNA TLSNSNMELL LSGVYKSQEA
3560 3570 3580 3590 3600
RLMLRIYLIK VPAHASVKKM KEENWAMDGF VSAEPDGATY VFQGFIQGKD
3610 3620 3630 3640 3650
YGQFGLQRLG LNMSEGSNSS NQPHGTNSSS VAIAILVPFF ALIFAGFGFY
3660 3670 3680 3690 3700
LYKQRTAPKT QYTGCSVHEN NNGQAAFENP MYDTNAKSVE GKAVRFDPNL

NTVCTMV
Length:3,707
Mass (Da):406,000
Last modified:September 1, 2009 - v3
Checksum:i3194CBF8FE56ED76
GO
Isoform 2 (identifier: Q7Z407-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: MKGIRKGESR...VFLLTVSCVK → MWSWFLCWKPVQLDRQTAS

Show »
Length:3,667
Mass (Da):401,589
Checksum:iD19690D7B345E3E5
GO
Isoform 3 (identifier: Q7Z407-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     344-447: Missing.
     2692-2756: Missing.

Show »
Length:3,538
Mass (Da):387,329
Checksum:i80C4FC2F5C6A7CA3
GO
Isoform 4 (identifier: Q7Z407-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1799-1868: Missing.

Note: No experimental confirmation available.
Show »
Length:3,637
Mass (Da):398,452
Checksum:i9247DF4CE5A4FB19
GO
Isoform 5 (identifier: Q7Z407-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2629-2675: AISCGIPKAP...SKELTTAVCQ → GEVYYAKMNK...IVNSFHKNKA
     2676-3707: Missing.

Note: No experimental confirmation available.
Show »
Length:2,675
Mass (Da):294,834
Checksum:i44F9DC603F514419
GO

Sequence cautioni

The sequence AAO34702 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti510F → L in AAO34702 (PubMed:12906867).Curated1
Sequence conflicti726T → A in AAO34702 (PubMed:12906867).Curated1
Sequence conflicti977S → I in BAB67787 (PubMed:11572484).Curated1
Sequence conflicti2104I → T in AAO34702 (PubMed:12906867).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017404219I → M.1 PublicationCorresponds to variant rs2219898dbSNPEnsembl.1
Natural variantiVAR_035688322W → G in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0647032020S → C Found in a renal cell carcinoma case; somatic mutation. 1 Publication1
Natural variantiVAR_0174053000V → L.Corresponds to variant rs2193430dbSNPEnsembl.1
Natural variantiVAR_0356893079R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs780986269dbSNPEnsembl.1
Natural variantiVAR_0356903359R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs139968762dbSNPEnsembl.1
Natural variantiVAR_0174063621N → H.1 PublicationCorresponds to variant rs1592624dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0090471 – 59MKGIR…VSCVK → MWSWFLCWKPVQLDRQTAS in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_009048344 – 447Missing in isoform 3. 1 PublicationAdd BLAST104
Alternative sequenceiVSP_0090501799 – 1868Missing in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0090512629 – 2675AISCG…TAVCQ → GEVYYAKMNKNMNVRLAPFN VFIWITHFSENGNIRKHIVN SFHKNKA in isoform 5. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_0090522676 – 3707Missing in isoform 5. 1 PublicationAdd BLAST1032
Alternative sequenceiVSP_0090492692 – 2756Missing in isoform 3. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY210419 mRNA. Translation: AAO34702.1. Different initiation.
AB114604 mRNA. Translation: BAC82443.1.
AB114605 mRNA. Translation: BAC82444.1.
AB067481 mRNA. Translation: BAB67787.2.
AK126252 mRNA. No translation available.
CCDSiCCDS6315.1. [Q7Z407-1]
CCDS6316.2. [Q7Z407-3]
CCDS6317.1. [Q7Z407-2]
RefSeqiNP_443132.3. NM_052900.2. [Q7Z407-3]
NP_937756.1. NM_198123.1. [Q7Z407-1]
NP_937757.1. NM_198124.1. [Q7Z407-2]
XP_016868498.1. XM_017013009.1. [Q7Z407-4]
UniGeneiHs.91381.

Genome annotation databases

EnsembliENST00000297405; ENSP00000297405; ENSG00000164796. [Q7Z407-1]
ENST00000343508; ENSP00000345799; ENSG00000164796. [Q7Z407-2]
ENST00000455883; ENSP00000412263; ENSG00000164796. [Q7Z407-3]
GeneIDi114788.
KEGGihsa:114788.
UCSCiuc003ynt.4. human. [Q7Z407-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY210419 mRNA. Translation: AAO34702.1. Different initiation.
AB114604 mRNA. Translation: BAC82443.1.
AB114605 mRNA. Translation: BAC82444.1.
AB067481 mRNA. Translation: BAB67787.2.
AK126252 mRNA. No translation available.
CCDSiCCDS6315.1. [Q7Z407-1]
CCDS6316.2. [Q7Z407-3]
CCDS6317.1. [Q7Z407-2]
RefSeqiNP_443132.3. NM_052900.2. [Q7Z407-3]
NP_937756.1. NM_198123.1. [Q7Z407-1]
NP_937757.1. NM_198124.1. [Q7Z407-2]
XP_016868498.1. XM_017013009.1. [Q7Z407-4]
UniGeneiHs.91381.

3D structure databases

ProteinModelPortaliQ7Z407.
SMRiQ7Z407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125350. 1 interactor.
STRINGi9606.ENSP00000297405.

PTM databases

iPTMnetiQ7Z407.
PhosphoSitePlusiQ7Z407.

Polymorphism and mutation databases

BioMutaiCSMD3.
DMDMi257051058.

Proteomic databases

MaxQBiQ7Z407.
PaxDbiQ7Z407.
PeptideAtlasiQ7Z407.
PRIDEiQ7Z407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297405; ENSP00000297405; ENSG00000164796. [Q7Z407-1]
ENST00000343508; ENSP00000345799; ENSG00000164796. [Q7Z407-2]
ENST00000455883; ENSP00000412263; ENSG00000164796. [Q7Z407-3]
GeneIDi114788.
KEGGihsa:114788.
UCSCiuc003ynt.4. human. [Q7Z407-1]

Organism-specific databases

CTDi114788.
DisGeNETi114788.
GeneCardsiCSMD3.
HGNCiHGNC:19291. CSMD3.
HPAiHPA029007.
MIMi608399. gene.
neXtProtiNX_Q7Z407.
OpenTargetsiENSG00000164796.
PharmGKBiPA134926063.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000112015.
HOVERGENiHBG051134.
InParanoidiQ7Z407.
KOiK17495.
OMAiILRFECQ.
OrthoDBiEOG091G00EH.
PhylomeDBiQ7Z407.
TreeFamiTF316872.

Miscellaneous databases

GenomeRNAii114788.
PROiQ7Z407.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164796.
CleanExiHS_CSMD3.
ExpressionAtlasiQ7Z407. baseline and differential.
GenevisibleiQ7Z407. HS.

Family and domain databases

CDDicd00033. CCP. 28 hits.
cd00041. CUB. 14 hits.
Gene3Di2.60.120.290. 14 hits.
InterProiIPR000859. CUB_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00431. CUB. 14 hits.
PF00084. Sushi. 28 hits.
[Graphical view]
SMARTiSM00032. CCP. 28 hits.
SM00042. CUB. 14 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 14 hits.
SSF57535. SSF57535. 28 hits.
PROSITEiPS01180. CUB. 14 hits.
PS50923. SUSHI. 28 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSMD3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z407
Secondary accession number(s): Q96PZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: September 1, 2009
Last modified: November 30, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.