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Protein

Myosin-14

Gene

MYH14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2058ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • actin filament-based movement Source: Ensembl
  • actomyosin structure organization Source: UniProtKB
  • mitochondrion morphogenesis Source: UniProtKB
  • neuronal action potential Source: UniProtKB
  • regulation of cell shape Source: UniProtKB-KW
  • sensory perception of sound Source: UniProtKB
  • skeletal muscle contraction Source: UniProtKB
  • skeletal muscle tissue development Source: UniProtKB
  • vocalization behavior Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Cell shape

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-14
Alternative name(s):
Myosin heavy chain 14
Myosin heavy chain, non-muscle IIc
Non-muscle myosin heavy chain IIc
Short name:
NMHC II-C
Gene namesi
Name:MYH14
Synonyms:KIAA2034
ORF Names:FP17425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23212. MYH14.

Subcellular locationi

GO - Cellular componenti

  • actomyosin Source: UniProtKB
  • axon Source: Ensembl
  • brush border Source: Ensembl
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • growth cone Source: Ensembl
  • membrane Source: UniProtKB
  • myelin sheath Source: Ensembl
  • myosin II complex Source: UniProtKB
  • myosin II filament Source: UniProtKB
  • stress fiber Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal dominant, 4A (DFNA4A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
See also OMIM:600652
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201S → L in DFNA4A. 1 Publication
Corresponds to variant rs119103281 [ dbSNP | Ensembl ].
VAR_037302
Natural varianti376 – 3761G → C in DFNA4A. 1 Publication
Corresponds to variant rs119103280 [ dbSNP | Ensembl ].
VAR_022867
Natural varianti726 – 7261R → S in DFNA4A. 1 Publication
Corresponds to variant rs28940307 [ dbSNP | Ensembl ].
VAR_022868
Natural varianti976 – 9761L → F in DFNA4A. 1 Publication
Corresponds to variant rs28940306 [ dbSNP | Ensembl ].
VAR_022869
Peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
See also OMIM:614369
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti933 – 9331R → L in PNMHH. 1 Publication
Corresponds to variant rs113993956 [ dbSNP | Ensembl ].
VAR_066338

Keywords - Diseasei

Deafness, Disease mutation, Neuropathy, Non-syndromic deafness

Organism-specific databases

MalaCardsiMYH14.
MIMi600652. phenotype.
614369. phenotype.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
397744. Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome.
PharmGKBiPA134935217.

Polymorphism and mutation databases

BioMutaiMYH14.
DMDMi327478526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 19951994Myosin-14PRO_0000123431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei1194 – 11941PhosphothreonineCombined sources
Modified residuei1969 – 19691PhosphoserineCombined sources
Modified residuei1980 – 19801PhosphoserineCombined sources
Modified residuei1983 – 19831PhosphoserineCombined sources
Modified residuei1989 – 19891PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z406.
MaxQBiQ7Z406.
PaxDbiQ7Z406.
PeptideAtlasiQ7Z406.
PRIDEiQ7Z406.

PTM databases

iPTMnetiQ7Z406.
PhosphoSiteiQ7Z406.
SwissPalmiQ7Z406.

Expressioni

Tissue specificityi

High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes.3 Publications

Gene expression databases

BgeeiQ7Z406.
ExpressionAtlasiQ7Z406. baseline and differential.
GenevisibleiQ7Z406. HS.

Interactioni

Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

Protein-protein interaction databases

BioGridi122884. 43 interactions.
DIPiDIP-33170N.
IntActiQ7Z406. 23 interactions.
MINTiMINT-1146777.
STRINGi9606.ENSP00000262269.

Structurei

Secondary structure

1
1995
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi51 – 533Combined sources
Beta strandi55 – 606Combined sources
Turni61 – 633Combined sources
Beta strandi64 – 7310Combined sources
Beta strandi75 – 828Combined sources
Turni83 – 853Combined sources
Beta strandi88 – 925Combined sources
Helixi93 – 953Combined sources
Helixi102 – 1043Combined sources
Helixi110 – 1123Combined sources
Helixi118 – 13013Combined sources
Beta strandi135 – 1384Combined sources
Beta strandi141 – 1455Combined sources
Helixi156 – 1627Combined sources
Helixi167 – 1693Combined sources
Helixi174 – 18815Combined sources
Beta strandi192 – 1976Combined sources
Helixi204 – 21815Combined sources
Beta strandi222 – 2243Combined sources
Beta strandi226 – 2283Combined sources
Turni237 – 2393Combined sources
Helixi241 – 2499Combined sources
Beta strandi259 – 27012Combined sources
Beta strandi276 – 2849Combined sources
Helixi288 – 2914Combined sources
Helixi302 – 3109Combined sources
Helixi313 – 3186Combined sources
Helixi324 – 3263Combined sources
Turni338 – 3403Combined sources
Helixi341 – 35414Combined sources
Helixi359 – 37416Combined sources
Helixi375 – 3773Combined sources
Beta strandi384 – 3863Combined sources
Helixi395 – 4039Combined sources
Helixi408 – 4169Combined sources
Beta strandi419 – 42810Combined sources
Helixi433 – 46331Combined sources
Beta strandi471 – 4788Combined sources
Beta strandi486 – 4883Combined sources
Helixi490 – 51021Combined sources
Helixi512 – 5209Combined sources
Helixi535 – 5428Combined sources
Beta strandi545 – 5473Combined sources
Helixi550 – 5567Combined sources
Beta strandi557 – 5604Combined sources
Helixi565 – 57612Combined sources
Turni587 – 5893Combined sources
Beta strandi592 – 5987Combined sources
Beta strandi601 – 6055Combined sources
Helixi610 – 6156Combined sources
Helixi620 – 6278Combined sources
Helixi632 – 6376Combined sources
Helixi670 – 68617Combined sources
Beta strandi688 – 6969Combined sources
Turni709 – 7113Combined sources
Helixi712 – 7198Combined sources
Helixi721 – 73010Combined sources
Beta strandi734 – 7374Combined sources
Helixi738 – 7458Combined sources
Helixi746 – 7483Combined sources
Turni750 – 7523Combined sources
Beta strandi771 – 78313Combined sources
Helixi787 – 79913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YCUX-ray2.25A47-799[»]
ProteinModelPortaliQ7Z406.
SMRiQ7Z406. Positions 47-921.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini105 – 800696Myosin motorAdd
BLAST
Domaini803 – 83230IQPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili862 – 19471086Sequence analysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.By similarity

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOVERGENiHBG004704.
InParanoidiQ7Z406.
KOiK10352.
OMAiTARRMVW.
OrthoDBiEOG71CFK3.
PhylomeDBiQ7Z406.
TreeFamiTF333601.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z406-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVTMSVPG RKAPPRPGPV PEAAQPFLFT PRGPSAGGGP GSGTSPQVEW
60 70 80 90 100
TARRLVWVPS ELHGFEAAAL RDEGEEEAEV ELAESGRRLR LPRDQIQRMN
110 120 130 140 150
PPKFSKAEDM AELTCLNEAS VLHNLRERYY SGLIYTYSGL FCVVINPYKQ
160 170 180 190 200
LPIYTEAIVE MYRGKKRHEV PPHVYAVTEG AYRSMLQDRE DQSILCTGES
210 220 230 240 250
GAGKTENTKK VIQYLAHVAS SPKGRKEPGV PGELERQLLQ ANPILEAFGN
260 270 280 290 300
AKTVKNDNSS RFGKFIRINF DVAGYIVGAN IETYLLEKSR AIRQAKDECS
310 320 330 340 350
FHIFYQLLGG AGEQLKADLL LEPCSHYRFL TNGPSSSPGQ ERELFQETLE
360 370 380 390 400
SLRVLGFSHE EIISMLRMVS AVLQFGNIAL KRERNTDQAT MPDNTAAQKL
410 420 430 440 450
CRLLGLGVTD FSRALLTPRI KVGRDYVQKA QTKEQADFAL EALAKATYER
460 470 480 490 500
LFRWLVLRLN RALDRSPRQG ASFLGILDIA GFEIFQLNSF EQLCINYTNE
510 520 530 540 550
KLQQLFNHTM FVLEQEEYQR EGIPWTFLDF GLDLQPCIDL IERPANPPGL
560 570 580 590 600
LALLDEECWF PKATDKSFVE KVAQEQGGHP KFQRPRHLRD QADFSVLHYA
610 620 630 640 650
GKVDYKANEW LMKNMDPLND NVAALLHQST DRLTAEIWKD VEGIVGLEQV
660 670 680 690 700
SSLGDGPPGG RPRRGMFRTV GQLYKESLSR LMATLSNTNP SFVRCIVPNH
710 720 730 740 750
EKRAGKLEPR LVLDQLRCNG VLEGIRICRQ GFPNRILFQE FRQRYEILTP
760 770 780 790 800
NAIPKGFMDG KQACEKMIQA LELDPNLYRV GQSKIFFRAG VLAQLEEERD
810 820 830 840 850
LKVTDIIVSF QAAARGYLAR RAFQKRQQQQ SALRVMQRNC AAYLKLRHWQ
860 870 880 890 900
WWRLFTKVKP LLQVTRQDEV LQARAQELQK VQELQQQSAR EVGELQGRVA
910 920 930 940 950
QLEEERARLA EQLRAEAELC AEAEETRGRL AARKQELELV VSELEARVGE
960 970 980 990 1000
EEECSRQMQT EKKRLQQHIQ ELEAHLEAEE GARQKLQLEK VTTEAKMKKF
1010 1020 1030 1040 1050
EEDLLLLEDQ NSKLSKERKL LEDRLAEFSS QAAEEEEKVK SLNKLRLKYE
1060 1070 1080 1090 1100
ATIADMEDRL RKEEKGRQEL EKLKRRLDGE SSELQEQMVE QQQRAEELRA
1110 1120 1130 1140 1150
QLGRKEEELQ AALARAEDEG GARAQLLKSL REAQAALAEA QEDLESERVA
1160 1170 1180 1190 1200
RTKAEKQRRD LGEELEALRG ELEDTLDSTN AQQELRSKRE QEVTELKKTL
1210 1220 1230 1240 1250
EEETRIHEAA VQELRQRHGQ ALGELAEQLE QARRGKGAWE KTRLALEAEV
1260 1270 1280 1290 1300
SELRAELSSL QTARQEGEQR RRRLELQLQE VQGRAGDGER ARAEAAEKLQ
1310 1320 1330 1340 1350
RAQAELENVS GALNEAESKT IRLSKELSST EAQLHDAQEL LQEETRAKLA
1360 1370 1380 1390 1400
LGSRVRAMEA EAAGLREQLE EEAAARERAG RELQTAQAQL SEWRRRQEEE
1410 1420 1430 1440 1450
AGALEAGEEA RRRAAREAEA LTQRLAEKTE TVDRLERGRR RLQQELDDAT
1460 1470 1480 1490 1500
MDLEQQRQLV STLEKKQRKF DQLLAEEKAA VLRAVEERER AEAEGREREA
1510 1520 1530 1540 1550
RALSLTRALE EEQEAREELE RQNRALRAEL EALLSSKDDV GKSVHELERA
1560 1570 1580 1590 1600
CRVAEQAAND LRAQVTELED ELTAAEDAKL RLEVTVQALK TQHERDLQGR
1610 1620 1630 1640 1650
DEAGEERRRQ LAKQLRDAEV ERDEERKQRT LAVAARKKLE GELEELKAQM
1660 1670 1680 1690 1700
ASAGQGKEEA VKQLRKMQAQ MKELWREVEE TRTSREEIFS QNRESEKRLK
1710 1720 1730 1740 1750
GLEAEVLRLQ EELAASDRAR RQAQQDRDEM ADEVANGNLS KAAILEEKRQ
1760 1770 1780 1790 1800
LEGRLGQLEE ELEEEQSNSE LLNDRYRKLL LQVESLTTEL SAERSFSAKA
1810 1820 1830 1840 1850
ESGRQQLERQ IQELRGRLGE EDAGARARHK MTIAALESKL AQAEEQLEQE
1860 1870 1880 1890 1900
TRERILSGKL VRRAEKRLKE VVLQVEEERR VADQLRDQLE KGNLRVKQLK
1910 1920 1930 1940 1950
RQLEEAEEEA SRAQAGRRRL QRELEDVTES AESMNREVTT LRNRLRRGPL
1960 1970 1980 1990
TFTTRTVRQV FRLEEGVASD EEAEEAQPGS GPSPEPEGSP PAHPQ
Length:1,995
Mass (Da):227,871
Last modified:April 5, 2011 - v2
Checksum:iC77AAB26817B773B
GO
Isoform 2 (identifier: Q7Z406-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-231: P → PASVSTVSY
     640-640: D → DEHGGFQQFSFLGSFPPSPPGSAERCSSAISPPG

Show »
Length:2,036
Mass (Da):232,011
Checksum:i44C56941E575A56D
GO
Isoform 4 (identifier: Q7Z406-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1532: Missing.

Show »
Length:1,779
Mass (Da):202,995
Checksum:iCB3D84684472B2A1
GO
Isoform 5 (identifier: Q7Z406-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1451-1478: MDLEQQRQLVSTLEKKQRKFDQLLAEEK → LSPDALTDGAQPPSSLDPTGPCPRNPAL
     1479-1995: Missing.

Show »
Length:1,478
Mass (Da):167,896
Checksum:i24968D882FF859BD
GO
Isoform 6 (identifier: Q7Z406-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-231: P → PASVSTVSY

Show »
Length:2,003
Mass (Da):228,665
Checksum:iA8B40CFA23A27902
GO

Sequence cautioni

The sequence AAO39147.1 differs from that shown. Reason: Frameshift at positions 1017 and 1057. Curated
The sequence AAP34449.1 differs from that shown. Reason: Frameshift at positions 1016, 1057, 1490 and 1755. Curated
The sequence AAP34449.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14735.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BG468611 differs from that shown. Reason: Erroneous termination at position 403. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti411 – 4111F → S in BG468611 (PubMed:15489334).Curated
Sequence conflicti444 – 4441A → G in BG468611 (PubMed:15489334).Curated
Sequence conflicti446 – 4461A → D in BG468611 (PubMed:15489334).Curated
Sequence conflicti458 – 4581R → S in BG468611 (PubMed:15489334).Curated
Sequence conflicti466 – 4661S → D in BG468611 (PubMed:15489334).Curated
Sequence conflicti473 – 4731F → L in BG468611 (PubMed:15489334).Curated
Sequence conflicti997 – 9971M → I in AAH18933 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201S → L in DFNA4A. 1 Publication
Corresponds to variant rs119103281 [ dbSNP | Ensembl ].
VAR_037302
Natural varianti266 – 2661I → V.1 Publication
Corresponds to variant rs200424400 [ dbSNP | Ensembl ].
VAR_022866
Natural varianti334 – 3341P → A.
Corresponds to variant rs34498817 [ dbSNP | Ensembl ].
VAR_056176
Natural varianti376 – 3761G → C in DFNA4A. 1 Publication
Corresponds to variant rs119103280 [ dbSNP | Ensembl ].
VAR_022867
Natural varianti726 – 7261R → S in DFNA4A. 1 Publication
Corresponds to variant rs28940307 [ dbSNP | Ensembl ].
VAR_022868
Natural varianti933 – 9331R → L in PNMHH. 1 Publication
Corresponds to variant rs113993956 [ dbSNP | Ensembl ].
VAR_066338
Natural varianti976 – 9761L → F in DFNA4A. 1 Publication
Corresponds to variant rs28940306 [ dbSNP | Ensembl ].
VAR_022869
Natural varianti1154 – 11541A → V.1 Publication
VAR_066339
Natural varianti1209 – 12091A → E.
Corresponds to variant rs11669191 [ dbSNP | Ensembl ].
VAR_056177
Natural varianti1540 – 15401V → I.
Corresponds to variant rs680446 [ dbSNP | Ensembl ].
VAR_056178
Natural varianti1559 – 15591N → S.1 Publication
Corresponds to variant rs769482601 [ dbSNP | Ensembl ].
VAR_022870

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei231 – 2311P → PASVSTVSY in isoform 2 and isoform 6. 3 PublicationsVSP_040881
Alternative sequencei640 – 6401D → DEHGGFQQFSFLGSFPPSPP GSAERCSSAISPPG in isoform 2. 2 PublicationsVSP_040882
Alternative sequencei1317 – 1532216Missing in isoform 4. 1 PublicationVSP_014628Add
BLAST
Alternative sequencei1451 – 147828MDLEQ…LAEEK → LSPDALTDGAQPPSSLDPTG PCPRNPAL in isoform 5. 1 PublicationVSP_014629Add
BLAST
Alternative sequencei1479 – 1995517Missing in isoform 5. 1 PublicationVSP_014630Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165122 mRNA. Translation: AAO39147.1. Frameshift.
AB111886 mRNA. Translation: BAC98374.1.
AB290169 mRNA. Translation: BAG06723.1.
AC008655 Genomic DNA. No translation available.
AC010515 Genomic DNA. No translation available.
AC020906 Genomic DNA. No translation available.
BC000676 mRNA. Translation: AAH00676.2.
BC004396 mRNA. Translation: AAH04396.1.
BC007877 mRNA. Translation: AAH07877.2.
BC018933 mRNA. Translation: AAH18933.2.
FJ041910 mRNA. Translation: ACM78630.1.
BG468611 mRNA. No translation available.
AY203926 mRNA. Translation: AAP34449.1. Sequence problems.
CR936653 mRNA. Translation: CAI56791.1.
AK023943 mRNA. Translation: BAB14735.1. Different initiation.
CCDSiCCDS46151.1. [Q7Z406-6]
CCDS54295.1. [Q7Z406-2]
CCDS59411.1. [Q7Z406-1]
RefSeqiNP_001070654.1. NM_001077186.1. [Q7Z406-6]
NP_001139281.1. NM_001145809.1. [Q7Z406-2]
NP_079005.3. NM_024729.3. [Q7Z406-1]
XP_006723449.1. XM_006723386.2. [Q7Z406-6]
XP_011525625.1. XM_011527323.1. [Q7Z406-6]
UniGeneiHs.467142.

Genome annotation databases

EnsembliENST00000376970; ENSP00000366169; ENSG00000105357. [Q7Z406-1]
ENST00000425460; ENSP00000407879; ENSG00000105357. [Q7Z406-6]
ENST00000596571; ENSP00000472819; ENSG00000105357. [Q7Z406-1]
ENST00000598205; ENSP00000472543; ENSG00000105357. [Q7Z406-6]
ENST00000601313; ENSP00000470298; ENSG00000105357. [Q7Z406-2]
GeneIDi79784.
KEGGihsa:79784.
UCSCiuc002prq.2. human. [Q7Z406-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY165122 mRNA. Translation: AAO39147.1. Frameshift.
AB111886 mRNA. Translation: BAC98374.1.
AB290169 mRNA. Translation: BAG06723.1.
AC008655 Genomic DNA. No translation available.
AC010515 Genomic DNA. No translation available.
AC020906 Genomic DNA. No translation available.
BC000676 mRNA. Translation: AAH00676.2.
BC004396 mRNA. Translation: AAH04396.1.
BC007877 mRNA. Translation: AAH07877.2.
BC018933 mRNA. Translation: AAH18933.2.
FJ041910 mRNA. Translation: ACM78630.1.
BG468611 mRNA. No translation available.
AY203926 mRNA. Translation: AAP34449.1. Sequence problems.
CR936653 mRNA. Translation: CAI56791.1.
AK023943 mRNA. Translation: BAB14735.1. Different initiation.
CCDSiCCDS46151.1. [Q7Z406-6]
CCDS54295.1. [Q7Z406-2]
CCDS59411.1. [Q7Z406-1]
RefSeqiNP_001070654.1. NM_001077186.1. [Q7Z406-6]
NP_001139281.1. NM_001145809.1. [Q7Z406-2]
NP_079005.3. NM_024729.3. [Q7Z406-1]
XP_006723449.1. XM_006723386.2. [Q7Z406-6]
XP_011525625.1. XM_011527323.1. [Q7Z406-6]
UniGeneiHs.467142.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YCUX-ray2.25A47-799[»]
ProteinModelPortaliQ7Z406.
SMRiQ7Z406. Positions 47-921.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122884. 43 interactions.
DIPiDIP-33170N.
IntActiQ7Z406. 23 interactions.
MINTiMINT-1146777.
STRINGi9606.ENSP00000262269.

PTM databases

iPTMnetiQ7Z406.
PhosphoSiteiQ7Z406.
SwissPalmiQ7Z406.

Polymorphism and mutation databases

BioMutaiMYH14.
DMDMi327478526.

Proteomic databases

EPDiQ7Z406.
MaxQBiQ7Z406.
PaxDbiQ7Z406.
PeptideAtlasiQ7Z406.
PRIDEiQ7Z406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376970; ENSP00000366169; ENSG00000105357. [Q7Z406-1]
ENST00000425460; ENSP00000407879; ENSG00000105357. [Q7Z406-6]
ENST00000596571; ENSP00000472819; ENSG00000105357. [Q7Z406-1]
ENST00000598205; ENSP00000472543; ENSG00000105357. [Q7Z406-6]
ENST00000601313; ENSP00000470298; ENSG00000105357. [Q7Z406-2]
GeneIDi79784.
KEGGihsa:79784.
UCSCiuc002prq.2. human. [Q7Z406-1]

Organism-specific databases

CTDi79784.
GeneCardsiMYH14.
GeneReviewsiMYH14.
H-InvDBHIX0015356.
HGNCiHGNC:23212. MYH14.
MalaCardsiMYH14.
MIMi600652. phenotype.
608568. gene.
614369. phenotype.
neXtProtiNX_Q7Z406.
Orphaneti90635. Autosomal dominant non-syndromic sensorineural deafness type DFNA.
397744. Peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome.
PharmGKBiPA134935217.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOVERGENiHBG004704.
InParanoidiQ7Z406.
KOiK10352.
OMAiTARRMVW.
OrthoDBiEOG71CFK3.
PhylomeDBiQ7Z406.
TreeFamiTF333601.

Enzyme and pathway databases

ReactomeiR-HSA-3928663. EPHA-mediated growth cone collapse.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-5625740. RHO GTPases activate PKNs.
R-HSA-5625900. RHO GTPases activate CIT.
R-HSA-5627117. RHO GTPases Activate ROCKs.
R-HSA-5627123. RHO GTPases activate PAKs.

Miscellaneous databases

ChiTaRSiMYH14. human.
GeneWikiiMYH14.
GenomeRNAii79784.
PROiQ7Z406.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z406.
ExpressionAtlasiQ7Z406. baseline and differential.
GenevisibleiQ7Z406. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Sciatic nerve.
  2. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Yamakawa H., Ohara O.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Bienvenut W.V., Heiserich L., Boulahbel H., Gottlieb E.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 190-204; 343-353; 403-413; 434-445; 607-613; 669-675; 718-726; 839-845; 899-906; 957-963; 984-990; 1105-1115; 1244-1264; 1469-1478; 1553-1562 AND 1686-1693, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-998 AND 1740-1995 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1297-1995 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1297-1995 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 209-477 (ISOFORM 6).
    Tissue: Colon, Lung, Muscle and Placenta.
  6. "An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation."
    Jana S.S., Kim K.Y., Mao J., Kawamoto S., Sellers J.R., Adelstein R.S.
    J. Biol. Chem. 284:11563-11571(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 590-773 (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Brain.
  7. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 964-1995 (ISOFORM 1).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1335-1995 (ISOFORM 1).
    Tissue: Lymph node.
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1431-1995 (ISOFORM 1).
    Tissue: Thyroid.
  10. "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family."
    Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H.
    Mol. Biol. Evol. 19:375-393(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  11. "Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family."
    Golomb E., Ma X., Jana S.S., Preston Y.A., Kawamoto S., Shoham N.G., Goldin E., Conti M.A., Sellers J.R., Adelstein R.S.
    J. Biol. Chem. 279:2800-2808(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1969 AND SER-1989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-1969; SER-1980; SER-1983 AND SER-1989, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  17. "Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)."
    Donaudy F., Snoeckx R., Pfister M., Zenner H.-P., Blin N., Di Stazio M., Ferrara A., Lanzara C., Ficarella R., Declau F., Pusch C.M., Nuernberg P., Melchionda S., Zelante L., Ballana E., Estivill X., Van Camp G., Gasparini P., Savoia A.
    Am. J. Hum. Genet. 74:770-776(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS DFNA4A CYS-376; SER-726 AND PHE-976, VARIANTS VAL-266 AND SER-1559.
  18. "Genetic heterogeneity of deafness phenotypes linked to DFNA4."
    Yang T., Pfister M., Blin N., Zenner H.P., Pusch C.M., Smith R.J.H.
    Am. J. Med. Genet. A 139:9-12(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT DFNA4A LEU-120.
  19. "A complex phenotype of peripheral neuropathy, myopathy, hoarseness, and hearing loss is linked to an autosomal dominant mutation in MYH14."
    Choi B.O., Kang S.H., Hyun Y.S., Kanwal S., Park S.W., Koo H., Kim S.B., Choi Y.C., Yoo J.H., Kim J.W., Park K.D., Choi K.G., Kim S.J., Zuchner S., Chung K.W.
    Hum. Mutat. 32:669-677(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PNMHH LEU-933, VARIANT VAL-1154.

Entry informationi

Entry nameiMYH14_HUMAN
AccessioniPrimary (citable) accession number: Q7Z406
Secondary accession number(s): B0I1S2
, C3TTN4, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.