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Q7Z403

- TMC6_HUMAN

UniProt

Q7Z403 - TMC6_HUMAN

Protein

Transmembrane channel-like protein 6

Gene

TMC6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Probable ion channel.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProt

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi1.A.17.4.10. the calcium-dependent chloride channel (ca-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane channel-like protein 6
    Alternative name(s):
    Epidermodysplasia verruciformis protein 1
    Protein LAK-4
    Gene namesi
    Name:TMC6
    Synonyms:EVER1, EVIN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18021. TMC6.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProt
    2. endoplasmic reticulum Source: UniProt
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. Golgi apparatus Source: UniProt
    6. integral component of membrane Source: UniProtKB-KW
    7. nuclear membrane Source: UniProt

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Epidermodysplasia verruciformis (EV) [MIM:226400]: Rare autosomal recessive genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses. Infection leads to persistent wart-like or macular lesions.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi226400. phenotype.
    Orphaneti302. Epidermodysplasia verruciformis.
    PharmGKBiPA134949466.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Transmembrane channel-like protein 6PRO_0000185384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ7Z403.
    PaxDbiQ7Z403.
    PRIDEiQ7Z403.

    PTM databases

    PhosphoSiteiQ7Z403.

    Expressioni

    Tissue specificityi

    Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ7Z403.
    BgeeiQ7Z403.
    CleanExiHS_TMC6.
    GenevestigatoriQ7Z403.

    Organism-specific databases

    HPAiHPA051430.

    Interactioni

    Protein-protein interaction databases

    BioGridi116453. 1 interaction.
    IntActiQ7Z403. 1 interaction.
    STRINGi9606.ENSP00000313408.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z403.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 209209LumenalSequence AnalysisAdd
    BLAST
    Topological domaini231 – 24919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini271 – 33868LumenalSequence AnalysisAdd
    BLAST
    Topological domaini360 – 43172CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini453 – 46917LumenalSequence AnalysisAdd
    BLAST
    Topological domaini491 – 50515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini527 – 55327LumenalSequence AnalysisAdd
    BLAST
    Topological domaini575 – 60430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini626 – 65025LumenalSequence AnalysisAdd
    BLAST
    Topological domaini672 – 72251CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini744 – 80562LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei210 – 23021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei470 – 49021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei554 – 57421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei605 – 62521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei651 – 67121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei723 – 74321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMC family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG78295.
    HOVERGENiHBG061579.
    InParanoidiQ7Z403.
    OMAiVYVAICR.
    OrthoDBiEOG7D85XD.
    PhylomeDBiQ7Z403.

    Family and domain databases

    InterProiIPR012496. TMC.
    [Graphical view]
    PfamiPF07810. TMC. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z403-1) [UniParc]FASTAAdd to Basket

    Also known as: Large EVER1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQPLAFILD VPETPGDQGQ GPSPYDESEV HDSFQQLIQE QSQCTAQEGL    50
    ELQQREREVT GSSQQTLWRP EGTQSTATLR ILASMPSRTI GRSRGAIISQ 100
    YYNRTVQLRC RSSRPLLGNF VRSAWPSLRL YDLELDPTAL EEEEKQSLLV 150
    KELQSLAVAQ RDHMLRGMPL SLAEKRSLRE KSRTPRGKWR GQPGSGGVCS 200
    CCGRLRYACV LALHSLGLAL LSALQALMPW RYALKRIGGQ FGSSVLSYFL 250
    FLKTLLAFNA LLLLLLVAFI MGPQVAFPPA LPGPAPVCTG LELLTGAGCF 300
    THTVMYYGHY SNATLNQPCG SPLDGSQCTP RVGGLPYNMP LAYLSTVGVS 350
    FFITCITLVY SMAHSFGESY RVGSTSGIHA ITVFCSWDYK VTQKRASRLQ 400
    QDNIRTRLKE LLAEWQLRHS PRSVCGRLRQ AAVLGLVWLL CLGTALGCAV 450
    AVHVFSEFMI QSPEAAGQEA VLLVLPLVVG LLNLGAPYLC RVLAALEPHD 500
    SPVLEVYVAI CRNLILKLAI LGTLCYHWLG RRVGVLQGQC WEDFVGQELY 550
    RFLVMDFVLM LLDTLFGELV WRIISEKKLK RRRKPEFDIA RNVLELIYGQ 600
    TLTWLGVLFS PLLPAVQIIK LLLVFYVKKT SLLANCQAPR RPWLASHMST 650
    VFLTLLCFPA FLGAAVFLCY AVWQVKPSST CGPFRTLDTM YEAGRVWVRH 700
    LEAAGPRVSW LPWVHRYLME NTFFVFLVSA LLLAVIYLNI QVVRGQRKVI 750
    CLLKEQISNE GEDKIFLINK LHSIYERKER EERSRVGTTE EAAAPPALLT 800
    DEQDA 805
    Length:805
    Mass (Da):90,045
    Last modified:December 6, 2005 - v2
    Checksum:i9A9A5C43FBA86AD4
    GO
    Isoform 2 (identifier: Q7Z403-2) [UniParc]FASTAAdd to Basket

    Also known as: Small EVER1

    The sequence of this isoform differs from the canonical sequence as follows:
         410-760: Missing.

    Show »
    Length:454
    Mass (Da):50,259
    Checksum:i0195CCD92CB21D94
    GO
    Isoform 3 (identifier: Q7Z403-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-361: Missing.
         512-571: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:384
    Mass (Da):43,343
    Checksum:i845D2E11F8FCDCE2
    GO
    Isoform 4 (identifier: Q7Z403-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-227: Missing.
         513-525: NLILKLAILGTLC → CVAAHENIIWCWS
         526-805: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:298
    Mass (Da):32,485
    Checksum:i249E60460853BA27
    GO

    Sequence cautioni

    The sequence AAH35648.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA24179.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB84891.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti266 – 2661L → P in AAP69874. (PubMed:12906855)Curated
    Sequence conflicti274 – 2774QVAF → PRVR in AAH35648. (PubMed:15489334)Curated
    Sequence conflicti556 – 5561D → G in AAP69874. (PubMed:12906855)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251W → R.1 Publication
    Corresponds to variant rs2748427 [ dbSNP | Ensembl ].
    VAR_023963
    Natural varianti153 – 1531L → F.1 Publication
    Corresponds to variant rs12449858 [ dbSNP | Ensembl ].
    VAR_052336
    Natural varianti191 – 1911G → D.
    Corresponds to variant rs34712518 [ dbSNP | Ensembl ].
    VAR_061851

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 361361Missing in isoform 3. 1 PublicationVSP_016437Add
    BLAST
    Alternative sequencei1 – 227227Missing in isoform 4. 1 PublicationVSP_016438Add
    BLAST
    Alternative sequencei410 – 760351Missing in isoform 2. 1 PublicationVSP_016439Add
    BLAST
    Alternative sequencei512 – 57160Missing in isoform 3. 1 PublicationVSP_016440Add
    BLAST
    Alternative sequencei513 – 52513NLILK…LGTLC → CVAAHENIIWCWS in isoform 4. 1 PublicationVSP_016441Add
    BLAST
    Alternative sequencei526 – 805280Missing in isoform 4. 1 PublicationVSP_016442Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY057379 mRNA. Translation: AAL25836.1.
    AY099356 mRNA. Translation: AAM44452.1.
    AY099357 mRNA. Translation: AAM44453.1.
    AY236496 mRNA. Translation: AAP69874.1.
    DQ104440 mRNA. Translation: AAZ20186.1.
    AK021738 mRNA. Translation: BAB13884.1.
    AK074065 mRNA. Translation: BAB84891.1. Different initiation.
    BC023597 mRNA. Translation: AAH23597.1.
    BC035648 mRNA. Translation: AAH35648.1. Different initiation.
    AB002405 mRNA. Translation: BAA24179.2. Different initiation.
    CCDSiCCDS32748.1. [Q7Z403-1]
    RefSeqiNP_001120670.1. NM_001127198.1. [Q7Z403-1]
    NP_009198.4. NM_007267.6. [Q7Z403-1]
    XP_005257052.1. XM_005256995.1. [Q7Z403-1]
    XP_005257053.1. XM_005256996.1. [Q7Z403-1]
    UniGeneiHs.632227.

    Genome annotation databases

    EnsembliENST00000306591; ENSP00000306405; ENSG00000141524. [Q7Z403-2]
    ENST00000322914; ENSP00000313408; ENSG00000141524. [Q7Z403-1]
    ENST00000392467; ENSP00000376260; ENSG00000141524. [Q7Z403-1]
    ENST00000589553; ENSP00000465359; ENSG00000141524. [Q7Z403-4]
    ENST00000590602; ENSP00000465261; ENSG00000141524. [Q7Z403-1]
    ENST00000591436; ENSP00000464853; ENSG00000141524. [Q7Z403-3]
    GeneIDi11322.
    KEGGihsa:11322.
    UCSCiuc002jui.1. human. [Q7Z403-3]
    uc002juj.1. human. [Q7Z403-1]
    uc002juo.2. human. [Q7Z403-4]
    uc010dhg.1. human. [Q7Z403-2]

    Polymorphism databases

    DMDMi83305925.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    TMC6base

    TMC6 mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY057379 mRNA. Translation: AAL25836.1 .
    AY099356 mRNA. Translation: AAM44452.1 .
    AY099357 mRNA. Translation: AAM44453.1 .
    AY236496 mRNA. Translation: AAP69874.1 .
    DQ104440 mRNA. Translation: AAZ20186.1 .
    AK021738 mRNA. Translation: BAB13884.1 .
    AK074065 mRNA. Translation: BAB84891.1 . Different initiation.
    BC023597 mRNA. Translation: AAH23597.1 .
    BC035648 mRNA. Translation: AAH35648.1 . Different initiation.
    AB002405 mRNA. Translation: BAA24179.2 . Different initiation.
    CCDSi CCDS32748.1. [Q7Z403-1 ]
    RefSeqi NP_001120670.1. NM_001127198.1. [Q7Z403-1 ]
    NP_009198.4. NM_007267.6. [Q7Z403-1 ]
    XP_005257052.1. XM_005256995.1. [Q7Z403-1 ]
    XP_005257053.1. XM_005256996.1. [Q7Z403-1 ]
    UniGenei Hs.632227.

    3D structure databases

    ProteinModelPortali Q7Z403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116453. 1 interaction.
    IntActi Q7Z403. 1 interaction.
    STRINGi 9606.ENSP00000313408.

    Protein family/group databases

    TCDBi 1.A.17.4.10. the calcium-dependent chloride channel (ca-clc) family.

    PTM databases

    PhosphoSitei Q7Z403.

    Polymorphism databases

    DMDMi 83305925.

    Proteomic databases

    MaxQBi Q7Z403.
    PaxDbi Q7Z403.
    PRIDEi Q7Z403.

    Protocols and materials databases

    DNASUi 11322.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306591 ; ENSP00000306405 ; ENSG00000141524 . [Q7Z403-2 ]
    ENST00000322914 ; ENSP00000313408 ; ENSG00000141524 . [Q7Z403-1 ]
    ENST00000392467 ; ENSP00000376260 ; ENSG00000141524 . [Q7Z403-1 ]
    ENST00000589553 ; ENSP00000465359 ; ENSG00000141524 . [Q7Z403-4 ]
    ENST00000590602 ; ENSP00000465261 ; ENSG00000141524 . [Q7Z403-1 ]
    ENST00000591436 ; ENSP00000464853 ; ENSG00000141524 . [Q7Z403-3 ]
    GeneIDi 11322.
    KEGGi hsa:11322.
    UCSCi uc002jui.1. human. [Q7Z403-3 ]
    uc002juj.1. human. [Q7Z403-1 ]
    uc002juo.2. human. [Q7Z403-4 ]
    uc010dhg.1. human. [Q7Z403-2 ]

    Organism-specific databases

    CTDi 11322.
    GeneCardsi GC17M076108.
    H-InvDB HIX0200093.
    HGNCi HGNC:18021. TMC6.
    HPAi HPA051430.
    MIMi 226400. phenotype.
    605828. gene.
    neXtProti NX_Q7Z403.
    Orphaneti 302. Epidermodysplasia verruciformis.
    PharmGKBi PA134949466.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78295.
    HOVERGENi HBG061579.
    InParanoidi Q7Z403.
    OMAi VYVAICR.
    OrthoDBi EOG7D85XD.
    PhylomeDBi Q7Z403.

    Miscellaneous databases

    GeneWikii TMC6.
    GenomeRNAii 11322.
    NextBioi 43015.
    PROi Q7Z403.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z403.
    Bgeei Q7Z403.
    CleanExi HS_TMC6.
    Genevestigatori Q7Z403.

    Family and domain databases

    InterProi IPR012496. TMC.
    [Graphical view ]
    Pfami PF07810. TMC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis."
      Ramoz N., Rueda L.-A., Bouadjar B., Montoya L.-S., Orth G., Favre M.
      Nat. Genet. 32:579-581(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, INVOLVEMENT IN EPIDERMODYSPLASIA VERRUCIFORMIS, VARIANT ARG-125.
    2. "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis."
      Kurima K., Yang Y., Sorber K., Griffith A.J.
      Genomics 82:300-308(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. Lin L., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Li H., Yang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    5. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PHE-153.
      Tissue: B-cell and Brain.
    7. "LAK-4 clone from the membrane lymphotoxin expressing subtraction library."
      Abe Y., Takaoka Y.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 345-805.
      Tissue: Lymphoid tissue.
    8. "Novel mutations of EVER1/TMC6 gene in a Japanese patient with epidermodysplasia verruciformis."
      Tate G., Suzuki T., Kishimoto K., Mitsuya T.
      J. Hum. Genet. 49:223-225(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN EPIDERMODYSPLASIA VERRUCIFORMIS.

    Entry informationi

    Entry nameiTMC6_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z403
    Secondary accession number(s): O43284
    , Q45VJ2, Q8IU98, Q8IUI7, Q8IWU8, Q8TEQ7, Q9HAG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3