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Protein

Transmembrane channel-like protein 7

Gene

TMC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable ion channel.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane channel-like protein 7
Gene namesi
Name:TMC7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:23000. TMC7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 168ExtracellularSequence analysisAdd BLAST168
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 219CytoplasmicSequence analysisAdd BLAST30
Transmembranei220 – 240HelicalSequence analysisAdd BLAST21
Topological domaini241 – 263ExtracellularSequence analysisAdd BLAST23
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 362CytoplasmicSequence analysisAdd BLAST78
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 404ExtracellularSequence analysisAdd BLAST21
Transmembranei405 – 425HelicalSequence analysisAdd BLAST21
Topological domaini426 – 494CytoplasmicSequence analysisAdd BLAST69
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 555ExtracellularSequence analysisAdd BLAST40
Transmembranei556 – 576HelicalSequence analysisAdd BLAST21
Topological domaini577 – 601CytoplasmicSequence analysisAdd BLAST25
Transmembranei602 – 622HelicalSequence analysisAdd BLAST21
Topological domaini623 – 665ExtracellularSequence analysisAdd BLAST43
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Topological domaini687 – 723CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170537.
PharmGKBiPA134988099.

Polymorphism and mutation databases

BioMutaiTMC7.
DMDMi74713450.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871651 – 723Transmembrane channel-like protein 7Add BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Modified residuei89PhosphoserineCombined sources1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi638N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z402.
MaxQBiQ7Z402.
PaxDbiQ7Z402.
PeptideAtlasiQ7Z402.
PRIDEiQ7Z402.

PTM databases

iPTMnetiQ7Z402.
PhosphoSitePlusiQ7Z402.

Expressioni

Gene expression databases

BgeeiENSG00000170537.
CleanExiHS_TMC7.
ExpressionAtlasiQ7Z402. baseline and differential.
GenevisibleiQ7Z402. HS.

Organism-specific databases

HPAiHPA029465.

Interactioni

Protein-protein interaction databases

BioGridi122988. 4 interactors.
STRINGi9606.ENSP00000304710.

Structurei

3D structure databases

ProteinModelPortaliQ7Z402.
SMRiQ7Z402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIGT. Eukaryota.
ENOG410Y7QP. LUCA.
GeneTreeiENSGT00760000119171.
HOVERGENiHBG101778.
InParanoidiQ7Z402.
PhylomeDBiQ7Z402.
TreeFamiTF313462.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z402-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSESSGSALQ PGRPSRQPAV HPENLSLDSS CFSSPPVNFL QELPSYRSIA
60 70 80 90 100
RRRTTVHSRD KQSGTLLKPT DSYSSQLEDR IAENLSSHSL RNYALNISEK
110 120 130 140 150
RRLRDIQETQ MKYLSEWDQW KRYSSKSWKR FLEKAREMTT HLELWREDIR
160 170 180 190 200
SIEGKFGTGI QSYFSFLRFL VLLNLVIFLI IFMLVLLPVL LTKYKITNSS
210 220 230 240 250
FVLIPFKDMD KQCTVYPVSS SGLIYFYSYI IDLLSGTGFL EETSLFYGHY
260 270 280 290 300
TIDGVKFQNF TYDLPLAYLL STIASLALSL LWIVKRSVEG FKINLIRSEE
310 320 330 340 350
HFQSYCNKIF AGWDFCITNR SMADLKHSSL RYELRADLEE ERMRQKIAER
360 370 380 390 400
TSEETIRIYS LRLFLNCIVL AVLGACFYAI YVATVFSQEH MKKEIDKMVF
410 420 430 440 450
GENLFILYLP SIVITLANFI TPMIFAKIIR YEDYSPGFEI RLTILRCVFM
460 470 480 490 500
RLATICVLVF TLGSKITSCD DDTCDLCGYN QKLYPCWETQ VGQEMYKLMI
510 520 530 540 550
FDFIIILAVT LFVDFPRKLL VTYCSSCKLI QCWGQQEFAI PDNVLGIVYG
560 570 580 590 600
QTICWIGAFF SPLLPAIATL KFIIIFYVKE WSLLYTCRPS PRPFRASNSN
610 620 630 640 650
FFFLLVLLIG LCLAIIPLTI SISRIPSSKA CGPFTNFNTT WEVIPKTVST
660 670 680 690 700
FPSSLQSFIH GVTSEAFAVP FFMIICLIMF YFIALAGAHK RVVIQLREQL
710 720
SLESRDKCYL IQKLTEAQRD MRN
Length:723
Mass (Da):83,502
Last modified:October 1, 2003 - v1
Checksum:i1390BF6E450EDE60
GO
Isoform 2 (identifier: Q7Z402-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Note: No experimental confirmation available.
Show »
Length:613
Mass (Da):71,121
Checksum:i9B52BE005338B9B5
GO

Sequence cautioni

The sequence BAB15032 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18P → Q in AAP78780 (PubMed:12812529).Curated1
Sequence conflicti18P → Q in AAH36205 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03227859R → W.1 PublicationCorresponds to variant rs17854512dbSNPEnsembl.1
Natural variantiVAR_032279254G → E.4 PublicationsCorresponds to variant rs28583298dbSNPEnsembl.1
Natural variantiVAR_061852355T → S.Corresponds to variant rs55796412dbSNPEnsembl.1
Natural variantiVAR_032280635T → I.Corresponds to variant rs11864159dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0542261 – 110Missing in isoform 2. 2 PublicationsAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263165 mRNA. Translation: AAP78780.1.
AY236498 mRNA. Translation: AAP69876.1.
AC099518 Genomic DNA. No translation available.
BC036205 mRNA. Translation: AAH36205.1.
BC047719 mRNA. Translation: AAH47719.1.
CR933669 mRNA. Translation: CAI45966.1.
AK024893 mRNA. Translation: BAB15032.1. Different initiation.
CCDSiCCDS10573.1. [Q7Z402-1]
CCDS53992.1. [Q7Z402-2]
RefSeqiNP_001153836.1. NM_001160364.2. [Q7Z402-2]
NP_079123.3. NM_024847.4. [Q7Z402-1]
UniGeneiHs.187377.
Hs.531661.

Genome annotation databases

EnsembliENST00000304381; ENSP00000304710; ENSG00000170537. [Q7Z402-1]
ENST00000421369; ENSP00000397081; ENSG00000170537. [Q7Z402-2]
GeneIDi79905.
KEGGihsa:79905.
UCSCiuc002dfq.4. human. [Q7Z402-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY263165 mRNA. Translation: AAP78780.1.
AY236498 mRNA. Translation: AAP69876.1.
AC099518 Genomic DNA. No translation available.
BC036205 mRNA. Translation: AAH36205.1.
BC047719 mRNA. Translation: AAH47719.1.
CR933669 mRNA. Translation: CAI45966.1.
AK024893 mRNA. Translation: BAB15032.1. Different initiation.
CCDSiCCDS10573.1. [Q7Z402-1]
CCDS53992.1. [Q7Z402-2]
RefSeqiNP_001153836.1. NM_001160364.2. [Q7Z402-2]
NP_079123.3. NM_024847.4. [Q7Z402-1]
UniGeneiHs.187377.
Hs.531661.

3D structure databases

ProteinModelPortaliQ7Z402.
SMRiQ7Z402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122988. 4 interactors.
STRINGi9606.ENSP00000304710.

PTM databases

iPTMnetiQ7Z402.
PhosphoSitePlusiQ7Z402.

Polymorphism and mutation databases

BioMutaiTMC7.
DMDMi74713450.

Proteomic databases

EPDiQ7Z402.
MaxQBiQ7Z402.
PaxDbiQ7Z402.
PeptideAtlasiQ7Z402.
PRIDEiQ7Z402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304381; ENSP00000304710; ENSG00000170537. [Q7Z402-1]
ENST00000421369; ENSP00000397081; ENSG00000170537. [Q7Z402-2]
GeneIDi79905.
KEGGihsa:79905.
UCSCiuc002dfq.4. human. [Q7Z402-1]

Organism-specific databases

CTDi79905.
GeneCardsiTMC7.
HGNCiHGNC:23000. TMC7.
HPAiHPA029465.
neXtProtiNX_Q7Z402.
OpenTargetsiENSG00000170537.
PharmGKBiPA134988099.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIGT. Eukaryota.
ENOG410Y7QP. LUCA.
GeneTreeiENSGT00760000119171.
HOVERGENiHBG101778.
InParanoidiQ7Z402.
PhylomeDBiQ7Z402.
TreeFamiTF313462.

Miscellaneous databases

ChiTaRSiTMC7. human.
GenomeRNAii79905.
PROiQ7Z402.

Gene expression databases

BgeeiENSG00000170537.
CleanExiHS_TMC7.
ExpressionAtlasiQ7Z402. baseline and differential.
GenevisibleiQ7Z402. HS.

Family and domain databases

InterProiIPR012496. TMC.
[Graphical view]
PfamiPF07810. TMC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMC7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z402
Secondary accession number(s): E7ERB6
, Q5H9Q8, Q7Z5M4, Q86WX0, Q9H766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.