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Protein

Piwi-like protein 3

Gene

PIWIL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Piwi-like protein 3
Gene namesi
Name:PIWIL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000184571.13
HGNCiHGNC:18443 PIWIL3
MIMi610314 gene
neXtProtiNX_Q7Z3Z3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi440822
OpenTargetsiENSG00000184571
PharmGKBiPA38332

Polymorphism and mutation databases

BioMutaiPIWIL3
DMDMi229485673

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345711 – 882Piwi-like protein 3Add BLAST882

Proteomic databases

PaxDbiQ7Z3Z3
PeptideAtlasiQ7Z3Z3
PRIDEiQ7Z3Z3

PTM databases

iPTMnetiQ7Z3Z3
PhosphoSitePlusiQ7Z3Z3

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000184571
CleanExiHS_PIWIL3
ExpressionAtlasiQ7Z3Z3 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi136921, 2 interactors
STRINGi9606.ENSP00000330031

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Z3
SMRiQ7Z3Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini289 – 406PAZPROSITE-ProRule annotationAdd BLAST118
Domaini578 – 868PiwiPROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Belongs to the argonaute family. Piwi subfamily.Curated

Phylogenomic databases

eggNOGiKOG1042 Eukaryota
ENOG410XNRH LUCA
GeneTreeiENSGT00760000119148
HOGENOMiHOG000254789
HOVERGENiHBG049411
InParanoidiQ7Z3Z3
KOiK02156
OMAiDCLRYYN
OrthoDBiEOG091G020J
PhylomeDBiQ7Z3Z3
TreeFamiTF354206

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR003165 Piwi
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF02170 PAZ, 1 hit
PF02171 Piwi, 1 hit
SMARTiView protein in SMART
SM00949 PAZ, 1 hit
SM00950 Piwi, 1 hit
SUPFAMiSSF101690 SSF101690, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821 PAZ, 1 hit
PS50822 PIWI, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z3Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGRARTRAR GRARRRESYQ QEAPGGPRAP GSATTQEPPQ LQSTPRPLQE
60 70 80 90 100
EVPVVRPLQP RAARGGAGGG AQSQGVKEPG PEAGLHTAPL QERRIGGVFQ
110 120 130 140 150
DLVVNTRQDM KHVKDSKTGS EGTVVQLLAN HFRVISRPQW VAYKYNVDYK
160 170 180 190 200
PDIEDGNLRT ILLDQHRRKF GERHIFDGNS LLLSRPLKER RVEWLSTTKD
210 220 230 240 250
KNIVKITVEF SKELTPTSPD CLRYYNILFR RTFKLLDFEQ VGRNYYTKKK
260 270 280 290 300
AIQLYRHGTS LEIWLGYVTS VLQYENSITL CADVSHKLLR IETAYDFIKR
310 320 330 340 350
TSAQAQTGNI REEVTNKLIG SIVLTKYNNK TYRVDDIDWK QNPEDTFNKS
360 370 380 390 400
DGSKITYIDY YRQQHKEIVT VKKQPLLVSQ GRWKKGLTGT QREPILLIPQ
410 420 430 440 450
LCHMTGLTDE ICKDYSIVKE LAKHTRLSPR RRHHTLKEFI NTLQDNKKVR
460 470 480 490 500
ELLQLWDLKF DTNFLSVPGR VLKNANIVQG RRMVKANSQG DWSREIRELP
510 520 530 540 550
LLNAMPLHSW LILYSRSSHR EAMSLKGHLQ SVTAPMGITM KPAEMIEVDG
560 570 580 590 600
DANSYIDTLR KYTRPTLQMG MSCLLVFKVI CILPNDDKRR YDSIKRYLCT
610 620 630 640 650
KCPIPSQCVV KKTLEKVQAR TIVTKIAQQM NCKMGGALWK VETDVQRTMF
660 670 680 690 700
VGIDCFHDIV NRQKSIAGFV ASTNAELTKW YSQCVIQKTG EELVKELEIC
710 720 730 740 750
LKAALDVWCK NESSMPHSVI VYRDGVGDGQ LQALLDHEAK KMSTYLKTIS
760 770 780 790 800
PNNFTLAFIV VKKRINTRFF LKHGSNFQNP PPGTVIDVEL TRNEWYDFFI
810 820 830 840 850
VSQSVQDGTV TPTHYNVIYD TIGLSPDTVQ RLTYCLCHMY YNLPGIIRVP
860 870 880
APCHYAHKLA YLVGQSIHQE PNRSLSTRLF YL
Length:882
Mass (Da):101,089
Last modified:March 24, 2009 - v2
Checksum:i5646695FE070469B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061024186P → L. Corresponds to variant dbSNP:rs61083377Ensembl.1
Natural variantiVAR_034383375P → S. Corresponds to variant dbSNP:rs1475853Ensembl.1
Natural variantiVAR_034384412C → R. Corresponds to variant dbSNP:rs1892722Ensembl.1
Natural variantiVAR_034385418V → M1 PublicationCorresponds to variant dbSNP:rs1892723Ensembl.1
Natural variantiVAR_054774471V → I. Corresponds to variant dbSNP:rs11703684Ensembl.1
Natural variantiVAR_059130589R → C. Corresponds to variant dbSNP:rs738826Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079368 mRNA Translation: BAC81343.1
AP000358 Genomic DNA No translation available.
AP000359 Genomic DNA No translation available.
CCDSiCCDS33623.1
RefSeqiNP_001008496.2, NM_001008496.3
UniGeneiHs.448343

Genome annotation databases

EnsembliENST00000332271; ENSP00000330031; ENSG00000184571
ENST00000616349; ENSP00000479524; ENSG00000184571
GeneIDi440822
KEGGihsa:440822
UCSCiuc003abd.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPIWL3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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