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Protein

Piwi-like protein 3

Gene

PIWIL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Meiosis, RNA-mediated gene silencing, Spermatogenesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Piwi-like protein 3
Gene namesi
Name:PIWIL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:18443. PIWIL3.

Subcellular locationi

  • Cytoplasm

  • Note: Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38332.

Polymorphism and mutation databases

BioMutaiPIWIL3.
DMDMi229485673.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Piwi-like protein 3PRO_0000234571Add
BLAST

Proteomic databases

PaxDbiQ7Z3Z3.
PeptideAtlasiQ7Z3Z3.
PRIDEiQ7Z3Z3.

PTM databases

iPTMnetiQ7Z3Z3.
PhosphoSiteiQ7Z3Z3.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000184571.
CleanExiHS_PIWIL3.
ExpressionAtlasiQ7Z3Z3. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi136921. 1 interaction.
STRINGi9606.ENSP00000330031.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Z3.
SMRiQ7Z3Z3. Positions 119-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini289 – 406118PAZPROSITE-ProRule annotationAdd
BLAST
Domaini578 – 868291PiwiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the argonaute family. Piwi subfamily.Curated
Contains 1 PAZ domain.PROSITE-ProRule annotation
Contains 1 Piwi domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1042. Eukaryota.
ENOG410XNRH. LUCA.
GeneTreeiENSGT00760000119148.
HOGENOMiHOG000254789.
HOVERGENiHBG049411.
InParanoidiQ7Z3Z3.
KOiK02156.
OMAiQKSIAGF.
OrthoDBiEOG091G020J.
PhylomeDBiQ7Z3Z3.
TreeFamiTF354206.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGRARTRAR GRARRRESYQ QEAPGGPRAP GSATTQEPPQ LQSTPRPLQE
60 70 80 90 100
EVPVVRPLQP RAARGGAGGG AQSQGVKEPG PEAGLHTAPL QERRIGGVFQ
110 120 130 140 150
DLVVNTRQDM KHVKDSKTGS EGTVVQLLAN HFRVISRPQW VAYKYNVDYK
160 170 180 190 200
PDIEDGNLRT ILLDQHRRKF GERHIFDGNS LLLSRPLKER RVEWLSTTKD
210 220 230 240 250
KNIVKITVEF SKELTPTSPD CLRYYNILFR RTFKLLDFEQ VGRNYYTKKK
260 270 280 290 300
AIQLYRHGTS LEIWLGYVTS VLQYENSITL CADVSHKLLR IETAYDFIKR
310 320 330 340 350
TSAQAQTGNI REEVTNKLIG SIVLTKYNNK TYRVDDIDWK QNPEDTFNKS
360 370 380 390 400
DGSKITYIDY YRQQHKEIVT VKKQPLLVSQ GRWKKGLTGT QREPILLIPQ
410 420 430 440 450
LCHMTGLTDE ICKDYSIVKE LAKHTRLSPR RRHHTLKEFI NTLQDNKKVR
460 470 480 490 500
ELLQLWDLKF DTNFLSVPGR VLKNANIVQG RRMVKANSQG DWSREIRELP
510 520 530 540 550
LLNAMPLHSW LILYSRSSHR EAMSLKGHLQ SVTAPMGITM KPAEMIEVDG
560 570 580 590 600
DANSYIDTLR KYTRPTLQMG MSCLLVFKVI CILPNDDKRR YDSIKRYLCT
610 620 630 640 650
KCPIPSQCVV KKTLEKVQAR TIVTKIAQQM NCKMGGALWK VETDVQRTMF
660 670 680 690 700
VGIDCFHDIV NRQKSIAGFV ASTNAELTKW YSQCVIQKTG EELVKELEIC
710 720 730 740 750
LKAALDVWCK NESSMPHSVI VYRDGVGDGQ LQALLDHEAK KMSTYLKTIS
760 770 780 790 800
PNNFTLAFIV VKKRINTRFF LKHGSNFQNP PPGTVIDVEL TRNEWYDFFI
810 820 830 840 850
VSQSVQDGTV TPTHYNVIYD TIGLSPDTVQ RLTYCLCHMY YNLPGIIRVP
860 870 880
APCHYAHKLA YLVGQSIHQE PNRSLSTRLF YL
Length:882
Mass (Da):101,089
Last modified:March 24, 2009 - v2
Checksum:i5646695FE070469B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861P → L.
Corresponds to variant rs61083377 [ dbSNP | Ensembl ].
VAR_061024
Natural varianti375 – 3751P → S.
Corresponds to variant rs1475853 [ dbSNP | Ensembl ].
VAR_034383
Natural varianti412 – 4121C → R.
Corresponds to variant rs1892722 [ dbSNP | Ensembl ].
VAR_034384
Natural varianti418 – 4181V → M.1 Publication
Corresponds to variant rs1892723 [ dbSNP | Ensembl ].
VAR_034385
Natural varianti471 – 4711V → I.
Corresponds to variant rs11703684 [ dbSNP | Ensembl ].
VAR_054774
Natural varianti589 – 5891R → C.
Corresponds to variant rs738826 [ dbSNP | Ensembl ].
VAR_059130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079368 mRNA. Translation: BAC81343.1.
AP000358 Genomic DNA. No translation available.
AP000359 Genomic DNA. No translation available.
CCDSiCCDS33623.1.
RefSeqiNP_001008496.2. NM_001008496.3.
UniGeneiHs.448343.

Genome annotation databases

EnsembliENST00000332271; ENSP00000330031; ENSG00000184571.
ENST00000616349; ENSP00000479524; ENSG00000184571.
GeneIDi440822.
KEGGihsa:440822.
UCSCiuc003abd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079368 mRNA. Translation: BAC81343.1.
AP000358 Genomic DNA. No translation available.
AP000359 Genomic DNA. No translation available.
CCDSiCCDS33623.1.
RefSeqiNP_001008496.2. NM_001008496.3.
UniGeneiHs.448343.

3D structure databases

ProteinModelPortaliQ7Z3Z3.
SMRiQ7Z3Z3. Positions 119-861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136921. 1 interaction.
STRINGi9606.ENSP00000330031.

PTM databases

iPTMnetiQ7Z3Z3.
PhosphoSiteiQ7Z3Z3.

Polymorphism and mutation databases

BioMutaiPIWIL3.
DMDMi229485673.

Proteomic databases

PaxDbiQ7Z3Z3.
PeptideAtlasiQ7Z3Z3.
PRIDEiQ7Z3Z3.

Protocols and materials databases

DNASUi440822.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332271; ENSP00000330031; ENSG00000184571.
ENST00000616349; ENSP00000479524; ENSG00000184571.
GeneIDi440822.
KEGGihsa:440822.
UCSCiuc003abd.3. human.

Organism-specific databases

CTDi440822.
GeneCardsiPIWIL3.
H-InvDBHIX0041116.
HGNCiHGNC:18443. PIWIL3.
MIMi610314. gene.
neXtProtiNX_Q7Z3Z3.
PharmGKBiPA38332.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1042. Eukaryota.
ENOG410XNRH. LUCA.
GeneTreeiENSGT00760000119148.
HOGENOMiHOG000254789.
HOVERGENiHBG049411.
InParanoidiQ7Z3Z3.
KOiK02156.
OMAiQKSIAGF.
OrthoDBiEOG091G020J.
PhylomeDBiQ7Z3Z3.
TreeFamiTF354206.

Miscellaneous databases

GenomeRNAii440822.
PROiQ7Z3Z3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184571.
CleanExiHS_PIWIL3.
ExpressionAtlasiQ7Z3Z3. baseline and differential.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR003100. PAZ_dom.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]
SMARTiSM00949. PAZ. 1 hit.
SM00950. Piwi. 1 hit.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiPS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIWL3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 24, 2009
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.