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Protein

Keratin, type I cytoskeletal 25

Gene

KRT25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (PubMed:26902920).By similarity1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • structural molecule activity Source: InterPro

GO - Biological processi

  • aging Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • hair cycle Source: UniProtKB
  • hair follicle morphogenesis Source: Ensembl
  • intermediate filament organization Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32798-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 25
Alternative name(s):
Cytokeratin-25
Short name:
CK-25
Keratin-25
Short name:
K25
Keratin-25A
Short name:
K25A
Type I inner root sheath-specific keratin-K25irs1
Gene namesi
Name:KRT25Imported
Synonyms:KRT25AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30839. KRT25.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Involvement in diseasei

Woolly hair autosomal recessive 3 (ARWH3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis.
See also OMIM:616760
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076303238V → L in ARWH3; reduces keratin intermediate filamen formation; impairs cytoskeleton assembly. 1 Publication1
Natural variantiVAR_076304317L → P in ARWH3. 1 PublicationCorresponds to variant rs766783183dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi147183.
MIMi616760. phenotype.
OpenTargetsiENSG00000204897.
PharmGKBiPA134977088.

Polymorphism and mutation databases

BioMutaiKRT25.
DMDMi74723316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126911 – 450Keratin, type I cytoskeletal 25Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei442PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7Z3Z0.
PeptideAtlasiQ7Z3Z0.
PRIDEiQ7Z3Z0.

PTM databases

iPTMnetiQ7Z3Z0.
PhosphoSitePlusiQ7Z3Z0.
SwissPalmiQ7Z3Z0.

Expressioni

Tissue specificityi

Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000204897.
CleanExiHS_KRT25.
GenevisibleiQ7Z3Z0. HS.

Organism-specific databases

HPAiHPA053977.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins (PubMed:26902920). Interacts with KRT6A to form filaments (By similarity).By similarityCurated1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

IntActiQ7Z3Z0. 21 interactors.
STRINGi9606.ENSP00000310573.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Z0.
SMRiQ7Z3Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 78HeadSequence analysisAdd BLAST78
Regioni79 – 390RodSequence analysisAdd BLAST312
Regioni79 – 114Coil 1ASequence analysisAdd BLAST36
Regioni115 – 136Linker 1Sequence analysisAdd BLAST22
Regioni137 – 228Coil 1BSequence analysisAdd BLAST92
Regioni229 – 251Linker 12Sequence analysisAdd BLAST23
Regioni252 – 390Coil 2Sequence analysisAdd BLAST139
Regioni391 – 450TailSequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 77Gly-richSequence analysisAdd BLAST53

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Z0.
KOiK07604.
OMAiEGACKSG.
OrthoDBiEOG091G087I.
PhylomeDBiQ7Z3Z0.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRLSSASR RSCPRPTTGS LRLYGGGTSF GTGNSCGISG IGSGFSSAFG
60 70 80 90 100
GSSSGGNTGG GNPCAGFTVN ERGLLSGNEK VTMQNLNDRL ASYLDSVHAL
110 120 130 140 150
EEANADLEQK IKGWYEKFGP GSCRGLDHDY SRYFPIIDDL KNQIIASTTS
160 170 180 190 200
NANAVLQIDN ARLTADDFRL KYENELALHQ SVEADVNGLR RVLDEITLCR
210 220 230 240 250
TDLEIQYETL SEEMTYLKKN HKEEMQVLQC AAGGNVNVEM NAAPGVDLTV
260 270 280 290 300
LLNNMRAEYE ALAEQNRRDA EAWFNEKSAS LQQQISEDVG ATTSARNELT
310 320 330 340 350
EMKRTLQTLE IELQSLLATK HSLECSLTET ESNYCAQLAQ IQAQIGALEE
360 370 380 390 400
QLHQVRTETE GQKLEYEQLL DIKLHLEKEI ETYCLLIGGD DGACKSGGYK
410 420 430 440 450
SKDYGSGNVG SQVKDPAKAI VVKKVLEEVD QRSKILTTRL HSLEEKSQSN
Length:450
Mass (Da):49,318
Last modified:October 1, 2003 - v1
Checksum:i12AB5BF74BA426FF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04978654S → L.Corresponds to variant rs12951399dbSNPEnsembl.1
Natural variantiVAR_076303238V → L in ARWH3; reduces keratin intermediate filamen formation; impairs cytoskeleton assembly. 1 Publication1
Natural variantiVAR_076304317L → P in ARWH3. 1 PublicationCorresponds to variant rs766783183dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564204 mRNA. Translation: CAD91904.1.
CH471152 Genomic DNA. Translation: EAW60676.1.
CCDSiCCDS11373.1.
RefSeqiNP_853512.1. NM_181534.3.
UniGeneiHs.55412.

Genome annotation databases

EnsembliENST00000312150; ENSP00000310573; ENSG00000204897.
GeneIDi147183.
KEGGihsa:147183.
UCSCiuc002hve.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564204 mRNA. Translation: CAD91904.1.
CH471152 Genomic DNA. Translation: EAW60676.1.
CCDSiCCDS11373.1.
RefSeqiNP_853512.1. NM_181534.3.
UniGeneiHs.55412.

3D structure databases

ProteinModelPortaliQ7Z3Z0.
SMRiQ7Z3Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z3Z0. 21 interactors.
STRINGi9606.ENSP00000310573.

PTM databases

iPTMnetiQ7Z3Z0.
PhosphoSitePlusiQ7Z3Z0.
SwissPalmiQ7Z3Z0.

Polymorphism and mutation databases

BioMutaiKRT25.
DMDMi74723316.

Proteomic databases

PaxDbiQ7Z3Z0.
PeptideAtlasiQ7Z3Z0.
PRIDEiQ7Z3Z0.

Protocols and materials databases

DNASUi147183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312150; ENSP00000310573; ENSG00000204897.
GeneIDi147183.
KEGGihsa:147183.
UCSCiuc002hve.3. human.

Organism-specific databases

CTDi147183.
DisGeNETi147183.
GeneCardsiKRT25.
H-InvDBHIX0027280.
HGNCiHGNC:30839. KRT25.
HPAiHPA053977.
MIMi616646. gene.
616760. phenotype.
neXtProtiNX_Q7Z3Z0.
OpenTargetsiENSG00000204897.
PharmGKBiPA134977088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Z0.
KOiK07604.
OMAiEGACKSG.
OrthoDBiEOG091G087I.
PhylomeDBiQ7Z3Z0.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:G66-32798-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii147183.
PROiQ7Z3Z0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204897.
CleanExiHS_KRT25.
GenevisibleiQ7Z3Z0. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C25_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.