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Protein

Keratin, type I cytoskeletal 25

Gene

KRT25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).By similarity

GO - Molecular functioni

GO - Biological processi

  • aging Source: UniProtKB
  • hair cycle Source: UniProtKB
  • hair follicle morphogenesis Source: Ensembl
  • intermediate filament organization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 25
Alternative name(s):
Cytokeratin-25
Short name:
CK-25
Keratin-25
Short name:
K25
Keratin-25A
Short name:
K25A
Type I inner root sheath-specific keratin-K25irs1
Gene namesi
Name:KRT25Imported
Synonyms:KRT25AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30839. KRT25.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977088.

Polymorphism and mutation databases

BioMutaiKRT25.
DMDMi74723316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Keratin, type I cytoskeletal 25PRO_0000312691Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei442 – 4421PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z3Z0.
MaxQBiQ7Z3Z0.
PaxDbiQ7Z3Z0.
PRIDEiQ7Z3Z0.

PTM databases

iPTMnetiQ7Z3Z0.
PhosphoSiteiQ7Z3Z0.

Expressioni

Tissue specificityi

Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications

Gene expression databases

BgeeiQ7Z3Z0.
CleanExiHS_KRT25.
GenevisibleiQ7Z3Z0. HS.

Organism-specific databases

HPAiHPA053977.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).By similarityCurated

Protein-protein interaction databases

STRINGi9606.ENSP00000310573.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Z0.
SMRiQ7Z3Z0. Positions 139-229, 247-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7878HeadSequence analysisAdd
BLAST
Regioni79 – 390312RodSequence analysisAdd
BLAST
Regioni79 – 11436Coil 1ASequence analysisAdd
BLAST
Regioni115 – 13622Linker 1Sequence analysisAdd
BLAST
Regioni137 – 22892Coil 1BSequence analysisAdd
BLAST
Regioni229 – 25123Linker 12Sequence analysisAdd
BLAST
Regioni252 – 390139Coil 2Sequence analysisAdd
BLAST
Regioni391 – 45060TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 7753Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Z0.
KOiK07604.
OMAiEGACKSG.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ7Z3Z0.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRLSSASR RSCPRPTTGS LRLYGGGTSF GTGNSCGISG IGSGFSSAFG
60 70 80 90 100
GSSSGGNTGG GNPCAGFTVN ERGLLSGNEK VTMQNLNDRL ASYLDSVHAL
110 120 130 140 150
EEANADLEQK IKGWYEKFGP GSCRGLDHDY SRYFPIIDDL KNQIIASTTS
160 170 180 190 200
NANAVLQIDN ARLTADDFRL KYENELALHQ SVEADVNGLR RVLDEITLCR
210 220 230 240 250
TDLEIQYETL SEEMTYLKKN HKEEMQVLQC AAGGNVNVEM NAAPGVDLTV
260 270 280 290 300
LLNNMRAEYE ALAEQNRRDA EAWFNEKSAS LQQQISEDVG ATTSARNELT
310 320 330 340 350
EMKRTLQTLE IELQSLLATK HSLECSLTET ESNYCAQLAQ IQAQIGALEE
360 370 380 390 400
QLHQVRTETE GQKLEYEQLL DIKLHLEKEI ETYCLLIGGD DGACKSGGYK
410 420 430 440 450
SKDYGSGNVG SQVKDPAKAI VVKKVLEEVD QRSKILTTRL HSLEEKSQSN
Length:450
Mass (Da):49,318
Last modified:October 1, 2003 - v1
Checksum:i12AB5BF74BA426FF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541S → L.
Corresponds to variant rs12951399 [ dbSNP | Ensembl ].
VAR_049786

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564204 mRNA. Translation: CAD91904.1.
CH471152 Genomic DNA. Translation: EAW60676.1.
CCDSiCCDS11373.1.
RefSeqiNP_853512.1. NM_181534.3.
UniGeneiHs.55412.

Genome annotation databases

EnsembliENST00000312150; ENSP00000310573; ENSG00000204897.
GeneIDi147183.
KEGGihsa:147183.
UCSCiuc002hve.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564204 mRNA. Translation: CAD91904.1.
CH471152 Genomic DNA. Translation: EAW60676.1.
CCDSiCCDS11373.1.
RefSeqiNP_853512.1. NM_181534.3.
UniGeneiHs.55412.

3D structure databases

ProteinModelPortaliQ7Z3Z0.
SMRiQ7Z3Z0. Positions 139-229, 247-389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310573.

PTM databases

iPTMnetiQ7Z3Z0.
PhosphoSiteiQ7Z3Z0.

Polymorphism and mutation databases

BioMutaiKRT25.
DMDMi74723316.

Proteomic databases

EPDiQ7Z3Z0.
MaxQBiQ7Z3Z0.
PaxDbiQ7Z3Z0.
PRIDEiQ7Z3Z0.

Protocols and materials databases

DNASUi147183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312150; ENSP00000310573; ENSG00000204897.
GeneIDi147183.
KEGGihsa:147183.
UCSCiuc002hve.3. human.

Organism-specific databases

CTDi147183.
GeneCardsiKRT25.
H-InvDBHIX0027280.
HGNCiHGNC:30839. KRT25.
HPAiHPA053977.
MIMi616646. gene.
neXtProtiNX_Q7Z3Z0.
PharmGKBiPA134977088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Z0.
KOiK07604.
OMAiEGACKSG.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ7Z3Z0.
TreeFamiTF332742.

Miscellaneous databases

GenomeRNAii147183.
NextBioi85566.
PROiQ7Z3Z0.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z3Z0.
CleanExiHS_KRT25.
GenevisibleiQ7Z3Z0. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: ScalpImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle."
    Langbein L., Rogers M.A., Praetzel-Wunder S., Helmke B., Schirmacher P., Schweizer J.
    J. Invest. Dermatol. 126:2377-2386(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiK1C25_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.