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Protein

Keratin, type I cytoskeletal 26

Gene

KRT26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 26
Alternative name(s):
Cytokeratin-26
Short name:
CK-26
Keratin-25B
Short name:
K25B
Keratin-26
Short name:
K26
Type I inner root sheath-specific keratin-K25irs2
Gene namesi
Name:KRT26Imported
Synonyms:KRT25BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000186393.5
HGNCiHGNC:30840 KRT26
MIMi616675 gene
neXtProtiNX_Q7Z3Y9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186393
PharmGKBiPA134863261

Polymorphism and mutation databases

BioMutaiKRT26
DMDMi162416254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126971 – 468Keratin, type I cytoskeletal 26Add BLAST468

Proteomic databases

PaxDbiQ7Z3Y9
PeptideAtlasiQ7Z3Y9
PRIDEiQ7Z3Y9

PTM databases

iPTMnetiQ7Z3Y9
PhosphoSitePlusiQ7Z3Y9
SwissPalmiQ7Z3Y9

Expressioni

Tissue specificityi

Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present slightly above the apex of the dermal papilla (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000186393
CleanExiHS_KRT26

Organism-specific databases

HPAiHPA026890

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131677, 1 interactor
IntActiQ7Z3Y9, 17 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Y9
SMRiQ7Z3Y9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 398IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadSequence analysisAdd BLAST82
Regioni83 – 118Coil 1ASequence analysisAdd BLAST36
Regioni119 – 140Linker 1Sequence analysisAdd BLAST22
Regioni141 – 232Coil 1BSequence analysisAdd BLAST92
Regioni233 – 255Linker 12Sequence analysisAdd BLAST23
Regioni256 – 394Coil 2Sequence analysisAdd BLAST139
Regioni395 – 465TailSequence analysisAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 73Gly-richSequence analysisAdd BLAST67

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA2D Eukaryota
ENOG4111D4X LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ7Z3Y9
KOiK07604
OMAiRYFSVIE
OrthoDBiEOG091G087I
PhylomeDBiQ7Z3Y9
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z3Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRLSGGSR RICSRTGSGR LSGGGTGFVA GNVCVGSGAR SSFSCTLEGI
60 70 80 90 100
SSGGSFCNSG GGLGSGACAG FLGNEHSLLS GNEKVTMQNL NDRLASYLDH
110 120 130 140 150
VHALEEANAD LEQKIKGWYE KCEPGSSREH DHDYSRYFSV IEDLKRQIIS
160 170 180 190 200
ATICNASIVL QNDNARLTAD DFRLKYENEL ALHHSVEADT SGLRRVLDEL
210 220 230 240 250
TLCTTDLEIQ CETLSEELTY LKKSHEEEME VLQYTAGGNV NVEMNATPGV
260 270 280 290 300
DLTVLLNNMR AEYEDLAEQN RKDAEAWFNE RSATLQQQIS DHEGAATAAR
310 320 330 340 350
NELTELKRNL QTLEIELQSL MAVKHSYECS LAETEGNYCN QLQQIQDQIG
360 370 380 390 400
VMEEQLQQIR TETEGQKLEY EQLLDVKIFL EKEIDIYCNL LDGEERKSKS
410 420 430 440 450
TCYKSKGYRP VNSGNQAKDS TEETIVKTVV EELDQIGNLL SLRVHSVEEK
460
SSKISNITVE QRVPSKAP
Length:468
Mass (Da):51,911
Last modified:December 4, 2007 - v2
Checksum:iE21E4E13443C5209
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149I → T in CAD91905 (PubMed:15617563).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056006118W → R1 PublicationCorresponds to variant dbSNP:rs9898164Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564205 mRNA Translation: CAD91905.1
CH471152 Genomic DNA Translation: EAW60677.1
BC132951 mRNA Translation: AAI32952.1
BC136896 mRNA Translation: AAI36897.1
CCDSiCCDS11374.1
RefSeqiNP_853517.2, NM_181539.4
UniGeneiHs.592133

Genome annotation databases

EnsembliENST00000335552; ENSP00000334798; ENSG00000186393
GeneIDi353288
KEGGihsa:353288
UCSCiuc002hvf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK1C26_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Y9
Secondary accession number(s): A2RUL2, B2RNH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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