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Protein

Keratin, type I cytoskeletal 26

Gene

KRT26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 26
Alternative name(s):
Cytokeratin-26
Short name:
CK-26
Keratin-25B
Short name:
K25B
Keratin-26
Short name:
K26
Type I inner root sheath-specific keratin-K25irs2
Gene namesi
Name:KRT26Imported
Synonyms:KRT25BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30840. KRT26.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863261.

Polymorphism and mutation databases

BioMutaiKRT26.
DMDMi162416254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Keratin, type I cytoskeletal 26PRO_0000312697Add
BLAST

Proteomic databases

EPDiQ7Z3Y9.
MaxQBiQ7Z3Y9.
PaxDbiQ7Z3Y9.
PRIDEiQ7Z3Y9.

PTM databases

iPTMnetiQ7Z3Y9.
PhosphoSiteiQ7Z3Y9.

Expressioni

Tissue specificityi

Strongly expressed in skin and scalp, and weak expression observed in thymus and tongue. In the hair follicle, expression is restricted to the mid- to upper inner root sheath cuticle, being present slightly above the apex of the dermal papilla (at protein level).2 Publications

Gene expression databases

BgeeiQ7Z3Y9.
CleanExiHS_KRT26.

Organism-specific databases

HPAiHPA055193.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

BioGridi131677. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Y9.
SMRiQ7Z3Y9. Positions 304-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8282HeadSequence analysisAdd
BLAST
Regioni83 – 394312RodSequence analysisAdd
BLAST
Regioni83 – 11836Coil 1ASequence analysisAdd
BLAST
Regioni119 – 14022Linker 1Sequence analysisAdd
BLAST
Regioni141 – 23292Coil 1BSequence analysisAdd
BLAST
Regioni233 – 25523Linker 12Sequence analysisAdd
BLAST
Regioni256 – 394139Coil 2Sequence analysisAdd
BLAST
Regioni395 – 46571TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 7367Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JA2D. Eukaryota.
ENOG4111D4X. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Y9.
KOiK07604.
OMAiRYFSVIE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ7Z3Y9.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRLSGGSR RICSRTGSGR LSGGGTGFVA GNVCVGSGAR SSFSCTLEGI
60 70 80 90 100
SSGGSFCNSG GGLGSGACAG FLGNEHSLLS GNEKVTMQNL NDRLASYLDH
110 120 130 140 150
VHALEEANAD LEQKIKGWYE KCEPGSSREH DHDYSRYFSV IEDLKRQIIS
160 170 180 190 200
ATICNASIVL QNDNARLTAD DFRLKYENEL ALHHSVEADT SGLRRVLDEL
210 220 230 240 250
TLCTTDLEIQ CETLSEELTY LKKSHEEEME VLQYTAGGNV NVEMNATPGV
260 270 280 290 300
DLTVLLNNMR AEYEDLAEQN RKDAEAWFNE RSATLQQQIS DHEGAATAAR
310 320 330 340 350
NELTELKRNL QTLEIELQSL MAVKHSYECS LAETEGNYCN QLQQIQDQIG
360 370 380 390 400
VMEEQLQQIR TETEGQKLEY EQLLDVKIFL EKEIDIYCNL LDGEERKSKS
410 420 430 440 450
TCYKSKGYRP VNSGNQAKDS TEETIVKTVV EELDQIGNLL SLRVHSVEEK
460
SSKISNITVE QRVPSKAP
Length:468
Mass (Da):51,911
Last modified:December 4, 2007 - v2
Checksum:iE21E4E13443C5209
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491I → T in CAD91905 (PubMed:15617563).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181W → R.1 Publication
Corresponds to variant rs9898164 [ dbSNP | Ensembl ].
VAR_056006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564205 mRNA. Translation: CAD91905.1.
CH471152 Genomic DNA. Translation: EAW60677.1.
BC132951 mRNA. Translation: AAI32952.1.
BC136896 mRNA. Translation: AAI36897.1.
CCDSiCCDS11374.1.
RefSeqiNP_853517.2. NM_181539.4.
UniGeneiHs.592133.

Genome annotation databases

EnsembliENST00000335552; ENSP00000334798; ENSG00000186393.
GeneIDi353288.
KEGGihsa:353288.
UCSCiuc002hvf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564205 mRNA. Translation: CAD91905.1.
CH471152 Genomic DNA. Translation: EAW60677.1.
BC132951 mRNA. Translation: AAI32952.1.
BC136896 mRNA. Translation: AAI36897.1.
CCDSiCCDS11374.1.
RefSeqiNP_853517.2. NM_181539.4.
UniGeneiHs.592133.

3D structure databases

ProteinModelPortaliQ7Z3Y9.
SMRiQ7Z3Y9. Positions 304-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131677. 1 interaction.

PTM databases

iPTMnetiQ7Z3Y9.
PhosphoSiteiQ7Z3Y9.

Polymorphism and mutation databases

BioMutaiKRT26.
DMDMi162416254.

Proteomic databases

EPDiQ7Z3Y9.
MaxQBiQ7Z3Y9.
PaxDbiQ7Z3Y9.
PRIDEiQ7Z3Y9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335552; ENSP00000334798; ENSG00000186393.
GeneIDi353288.
KEGGihsa:353288.
UCSCiuc002hvf.4. human.

Organism-specific databases

CTDi353288.
GeneCardsiKRT26.
HGNCiHGNC:30840. KRT26.
HPAiHPA055193.
MIMi616675. gene.
neXtProtiNX_Q7Z3Y9.
PharmGKBiPA134863261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JA2D. Eukaryota.
ENOG4111D4X. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Y9.
KOiK07604.
OMAiRYFSVIE.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ7Z3Y9.
TreeFamiTF332742.

Miscellaneous databases

GenomeRNAii353288.
NextBioi99760.
PROiQ7Z3Y9.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z3Y9.
CleanExiHS_KRT26.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ARG-118.
    Tissue: ScalpImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle."
    Langbein L., Rogers M.A., Praetzel-Wunder S., Helmke B., Schirmacher P., Schweizer J.
    J. Invest. Dermatol. 126:2377-2386(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiK1C26_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Y9
Secondary accession number(s): A2RUL2, B2RNH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: May 11, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.