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Protein

Keratin, type I cytoskeletal 27

Gene

KRT27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 27
Alternative name(s):
Cytokeratin-27
Short name:
CK-27
Keratin-25C
Short name:
K25C
Keratin-27
Short name:
K27
Type I inner root sheath-specific keratin-K25irs3
Gene namesi
Name:KRT27Imported
Synonyms:KRT25CImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30841. KRT27.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134990976.

Polymorphism and mutation databases

BioMutaiKRT27.
DMDMi296434549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Keratin, type I cytoskeletal 27PRO_0000312701Add
BLAST

Proteomic databases

EPDiQ7Z3Y8.
PaxDbiQ7Z3Y8.
PRIDEiQ7Z3Y8.
TopDownProteomicsiQ7Z3Y8.

PTM databases

iPTMnetiQ7Z3Y8.
PhosphoSiteiQ7Z3Y8.

Expressioni

Tissue specificityi

Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications

Gene expression databases

BgeeiQ7Z3Y8.
CleanExiHS_KRT27.
GenevisibleiQ7Z3Y8. HS.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).By similarityCurated

Protein-protein interaction databases

IntActiQ7Z3Y8. 2 interactions.
STRINGi9606.ENSP00000301656.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Y8.
SMRiQ7Z3Y8. Positions 144-234, 306-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8383HeadSequence analysisAdd
BLAST
Regioni84 – 395312RodSequence analysisAdd
BLAST
Regioni84 – 11936Coil 1ASequence analysisAdd
BLAST
Regioni120 – 14122Linker 1Sequence analysisAdd
BLAST
Regioni142 – 23392Coil 1BSequence analysisAdd
BLAST
Regioni234 – 25623Linker 12Sequence analysisAdd
BLAST
Regioni257 – 395139Coil 2Sequence analysisAdd
BLAST
Regioni396 – 45964TailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 8270Gly-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Y8.
KOiK07604.
OMAiSRVHTME.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ7Z3Y8.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCGVPG IGSGFSCAFG
60 70 80 90 100
GSSSAGGYGG GLGGGSASCA AFTGNEHGLL SGNEKVTMQN LNDRLASYLE
110 120 130 140 150
NVRALEEANA DLEQKIKGWY EKFGPGSCRG LDHDYSRYFP IIDELKNQII
160 170 180 190 200
SATTSNAHVV LQNDNARLTA DDFRLKFENE LALHQSVEAD INGLRRVLDE
210 220 230 240 250
LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN VNVEMNAAPG
260 270 280 290 300
VDLTVLLNNM RAEYEALAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA
310 320 330 340 350
RNELIEMKRT LQTLEIELQS LLATKHSLEC SLTETESNYC AQLAQIQAQI
360 370 380 390 400
GALEEQLHQV RTETEGQKLE YEQLLDIKVH LEKEIETYCL LIDGEDGSCS
410 420 430 440 450
KSKGYGGPGN QTKDSSKTTI VKTVVEEIDP RGKVLSSRVH TVEEKSTKVN

NKNEQRVSS
Length:459
Mass (Da):49,822
Last modified:May 18, 2010 - v2
Checksum:iF5DD71FE7FEFFF62
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521S → T.1 Publication
Corresponds to variant rs2469826 [ dbSNP | Ensembl ].
VAR_063138
Natural varianti144 – 1441E → K.1 Publication
Corresponds to variant rs12453124 [ dbSNP | Ensembl ].
VAR_063139
Natural varianti193 – 1931G → S.
Corresponds to variant rs17558560 [ dbSNP | Ensembl ].
VAR_056007
Natural varianti284 – 2841A → T.
Corresponds to variant rs17558532 [ dbSNP | Ensembl ].
VAR_056008
Natural varianti305 – 3051I → T.1 Publication
Corresponds to variant rs981684 [ dbSNP | Ensembl ].
VAR_063140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564206 mRNA. Translation: CAD91906.1.
AC090283 Genomic DNA. No translation available.
CCDSiCCDS11375.1.
RefSeqiNP_853515.2. NM_181537.3.
UniGeneiHs.59363.

Genome annotation databases

EnsembliENST00000301656; ENSP00000301656; ENSG00000171446.
GeneIDi342574.
KEGGihsa:342574.
UCSCiuc002hvg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564206 mRNA. Translation: CAD91906.1.
AC090283 Genomic DNA. No translation available.
CCDSiCCDS11375.1.
RefSeqiNP_853515.2. NM_181537.3.
UniGeneiHs.59363.

3D structure databases

ProteinModelPortaliQ7Z3Y8.
SMRiQ7Z3Y8. Positions 144-234, 306-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z3Y8. 2 interactions.
STRINGi9606.ENSP00000301656.

PTM databases

iPTMnetiQ7Z3Y8.
PhosphoSiteiQ7Z3Y8.

Polymorphism and mutation databases

BioMutaiKRT27.
DMDMi296434549.

Proteomic databases

EPDiQ7Z3Y8.
PaxDbiQ7Z3Y8.
PRIDEiQ7Z3Y8.
TopDownProteomicsiQ7Z3Y8.

Protocols and materials databases

DNASUi342574.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301656; ENSP00000301656; ENSG00000171446.
GeneIDi342574.
KEGGihsa:342574.
UCSCiuc002hvg.3. human.

Organism-specific databases

CTDi342574.
GeneCardsiKRT27.
H-InvDBHIX0039055.
HGNCiHGNC:30841. KRT27.
MIMi616676. gene.
neXtProtiNX_Q7Z3Y8.
PharmGKBiPA134990976.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Y8.
KOiK07604.
OMAiSRVHTME.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ7Z3Y8.
TreeFamiTF332742.

Miscellaneous databases

GenomeRNAii342574.
NextBioi98318.
PROiQ7Z3Y8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z3Y8.
CleanExiHS_KRT27.
GenevisibleiQ7Z3Y8. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
    Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.
    Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS THR-52; LYS-144 AND THR-305.
    Tissue: ScalpImported.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle."
    Langbein L., Rogers M.A., Praetzel-Wunder S., Helmke B., Schirmacher P., Schweizer J.
    J. Invest. Dermatol. 126:2377-2386(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiK1C27_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.