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Protein

Keratin, type I cytoskeletal 28

Gene

KRT28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).HMP:

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).IKR:

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 28
Alternative name(s):
Cytokeratin-28
Short name:
CK-28
Keratin-25D
Short name:
K25D
Keratin-28
Short name:
K28
Type I inner root sheath-specific keratin-K25irs4
Gene namesi
Name:KRT28TAS:
Synonyms:KRT25DTAS:
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173908.8.
HGNCiHGNC:30842. KRT28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173908.
PharmGKBiPA134871316.

Polymorphism and mutation databases

BioMutaiKRT28.
DMDMi294862446.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127051 – 464Keratin, type I cytoskeletal 28Add BLAST464

Proteomic databases

PaxDbiQ7Z3Y7.
PeptideAtlasiQ7Z3Y7.
PRIDEiQ7Z3Y7.

PTM databases

iPTMnetiQ7Z3Y7.
PhosphoSitePlusiQ7Z3Y7.
SwissPalmiQ7Z3Y7.

Expressioni

Tissue specificityi

Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000173908.
CleanExiHS_KRT28.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.IKR:

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127825. 1 interactor.
IntActiQ7Z3Y7. 16 interactors.
STRINGi9606.ENSP00000305263.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Y7.
SMRiQ7Z3Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 401IF rodIEP:Add BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 85HeadIEP:Add BLAST85
Regioni86 – 121Coil 1AIEP:Add BLAST36
Regioni122 – 143Linker 1IEP:Add BLAST22
Regioni144 – 235Coil 1BIEP:Add BLAST92
Regioni236 – 258Linker 12IEP:Add BLAST23
Regioni259 – 397Coil 2IEP:Add BLAST139
Regioni398 – 464TailIEP:Add BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 84Gly-richIEP:Add BLAST68

Sequence similaritiesi

Belongs to the intermediate filament family.IEP:

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00900000140820.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ7Z3Y7.
KOiK07604.
OMAiELQFESL.
OrthoDBiEOG091G087I.
PhylomeDBiQ7Z3Y7.
TreeFamiTF332742.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR002957. Keratin_I.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
PRINTSiPR01248. TYPE1KERATIN.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.
PROSITEiView protein in PROSITE
PS51842. IF_ROD_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7Z3Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQFSNGSR HVCLRSGAGS VRPLNGGAGF AGSSACGGSV AGSEFSCALG
60 70 80 90 100
GGLGSVPGGS HAGGALGNAA CIGFAGSEGG LLSGNEKVTM QNLNDRLASY
110 120 130 140 150
LDNVRALEEA NAELERKIKG WYEKYGPGSC RGLDHDYSRY HLTIEDLKNK
160 170 180 190 200
IISSTTTNAN VILQIDNARL AADDFRLKYE NELTLHQNVE ADINGLRRVL
210 220 230 240 250
DELTLCRTDQ ELQYESLSEE MTYLKKNHEE EMKALQCAAG GNVNVEMNAA
260 270 280 290 300
PGVDLAVLLN NMRAEYEALA EQNRKDAEAW FNEKSASLQQ QISHDSGAAT
310 320 330 340 350
FARSQLTEMR RTLQTLEIQL QSLMATKHSL ECSLTETESN YCTQLAQIQA
360 370 380 390 400
QIGALEEQLH QVRTETEGQK LEYEHLLDVK VHLEKEIETY CRLIDGDGNS
410 420 430 440 450
CSKSKGFGSG SPGNSSKDLS KTTLVKTVVE ELDQRGKVLS SRIHSIEEKT
460
SKMTNGKTEQ RVPF
Length:464
Mass (Da):50,567
Last modified:April 20, 2010 - v2
Checksum:i34BA7243B68EF42C
GO

Sequence cautioni

The sequence BAC85240 differs from that shown. Reason: Erroneous initiation.IKR:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05600952G → D. Corresponds to variant dbSNP:rs7209228Ensembl.1
Natural variantiVAR_06023662A → V1 PublicationCorresponds to variant dbSNP:rs4624233Ensembl.1
Natural variantiVAR_056010286A → T. Corresponds to variant dbSNP:rs17558995Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564207 mRNA. Translation: CAD91907.1.
AK129827 mRNA. Translation: BAC85240.1. Different initiation.
AC090283 Genomic DNA. No translation available.
CCDSiCCDS11376.1.
RefSeqiNP_853513.2. NM_181535.3.
UniGeneiHs.59736.

Genome annotation databases

EnsembliENST00000306658; ENSP00000305263; ENSG00000173908.
GeneIDi162605.
KEGGihsa:162605.
UCSCiuc002hvh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK1C28_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Y7
Secondary accession number(s): Q6ZP84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 20, 2010
Last modified: October 25, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families