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Protein

Zinc finger protein 571

Gene

ZNF571

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18926C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 571
Gene namesi
Name:ZNF571
ORF Names:HSPC059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25000. ZNF571.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134892585.

Polymorphism and mutation databases

BioMutaiZNF571.
DMDMi134047978.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Zinc finger protein 571PRO_0000047662Add
BLAST

Proteomic databases

EPDiQ7Z3V5.
PaxDbiQ7Z3V5.
PRIDEiQ7Z3V5.

PTM databases

PhosphoSiteiQ7Z3V5.

Expressioni

Gene expression databases

BgeeiQ7Z3V5.
CleanExiHS_ZNF571.
ExpressionAtlasiQ7Z3V5. baseline and differential.
GenevisibleiQ7Z3V5. HS.

Organism-specific databases

HPAiHPA054762.
HPA059966.

Interactioni

Protein-protein interaction databases

BioGridi119428. 2 interactions.
MINTiMINT-2808017.
STRINGi9606.ENSP00000333660.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3V5.
SMRiQ7Z3V5. Positions 6-45, 148-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 8479KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 16123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 18926C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri195 – 21723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri223 – 24523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri251 – 27323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 30123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri307 – 32923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri335 – 35723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri363 – 38523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri391 – 41323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri474 – 49623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri502 – 52423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri558 – 58023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri586 – 60823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z3V5.
KOiK09228.
OMAiKAFICGK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ7Z3V5.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3V5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHLLVTFRD VAIDFSQEEW ECLDPAQRDL YRDVMLENYS NLISLDLESS
60 70 80 90 100
CVTKKLSPEK EIYEMESLQW ENMGKRINHH LQYNGLGDNM ECKGNLEGQE
110 120 130 140 150
ASQEGLYMCV KITCEEKATE SHSTSSTFHR IIPTKEKLYK CKECRQGFSY
160 170 180 190 200
LSCLIQHEEN HNIEKCSEVK KHRNTFSKKP SYIQHQRIQT GEKPYECMEC
210 220 230 240 250
GKAFGRTSDL IQHQKIHTNE KPYQCNACGK AFIRGSQLTE HQRVHTGEKP
260 270 280 290 300
YECKKCGKAF SYCSQYTLHQ RIHSGEKPYE CKDCGKAFIL GSQLTYHQRI
310 320 330 340 350
HSGEKPYECK ECGKAFILGS HLTYHQRVHT GEKPYICKEC GKAFLCASQL
360 370 380 390 400
NEHQRIHTGE KPYECKECGK TFFRGSQLTY HLRVHSGERP YKCKECGKAF
410 420 430 440 450
ISNSNLIQHQ RIHTGEKPYK CKECGKAFIC GKQLSEHQRI HTGEKPFECK
460 470 480 490 500
ECGKAFIRVA YLTQHEKIHG EKHYECKECG KTFVRATQLT YHQRIHTGEK
510 520 530 540 550
PYKCKECDKA FIYGSQLSEH QRIHRGEKPY ECKQCGKAFI RGSHLTEHLR
560 570 580 590 600
THTGEKPYEC KECGRAFSRG SELTLHQRIH TGEKPYTCVQ CGKDFRCPSQ

LTQHTRLHN
Length:609
Mass (Da):70,792
Last modified:March 20, 2007 - v3
Checksum:i7DAA91B38A806EF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621I → V in CAD97643 (PubMed:17974005).Curated
Sequence conflicti102 – 1021S → N in AAH40591 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701K → M.
Corresponds to variant rs16973893 [ dbSNP | Ensembl ].
VAR_052869
Natural varianti189 – 1891Q → H.2 Publications
Corresponds to variant rs8111790 [ dbSNP | Ensembl ].
VAR_023953
Natural varianti252 – 2521E → D.1 Publication
Corresponds to variant rs28512414 [ dbSNP | Ensembl ].
VAR_023954
Natural varianti573 – 5731L → H.1 Publication
Corresponds to variant rs4802029 [ dbSNP | Ensembl ].
VAR_023955
Natural varianti593 – 5931K → E.
Corresponds to variant rs16973890 [ dbSNP | Ensembl ].
VAR_031093

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161544 mRNA. Translation: AAF29031.2.
BX537401 mRNA. Translation: CAD97643.1.
BC040591 mRNA. Translation: AAH40591.1.
BC113870 mRNA. Translation: AAI13871.1.
CCDSiCCDS12505.1.
RefSeqiNP_001277243.1. NM_001290314.1.
NP_057620.3. NM_016536.4.
XP_005259034.1. XM_005258977.2.
UniGeneiHs.590944.

Genome annotation databases

EnsembliENST00000328550; ENSP00000333660; ENSG00000180479.
ENST00000358744; ENSP00000351594; ENSG00000180479.
ENST00000451802; ENSP00000392638; ENSG00000180479.
ENST00000593133; ENSP00000467572; ENSG00000180479.
GeneIDi51276.
KEGGihsa:51276.
UCSCiuc002ogt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161544 mRNA. Translation: AAF29031.2.
BX537401 mRNA. Translation: CAD97643.1.
BC040591 mRNA. Translation: AAH40591.1.
BC113870 mRNA. Translation: AAI13871.1.
CCDSiCCDS12505.1.
RefSeqiNP_001277243.1. NM_001290314.1.
NP_057620.3. NM_016536.4.
XP_005259034.1. XM_005258977.2.
UniGeneiHs.590944.

3D structure databases

ProteinModelPortaliQ7Z3V5.
SMRiQ7Z3V5. Positions 6-45, 148-608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119428. 2 interactions.
MINTiMINT-2808017.
STRINGi9606.ENSP00000333660.

PTM databases

PhosphoSiteiQ7Z3V5.

Polymorphism and mutation databases

BioMutaiZNF571.
DMDMi134047978.

Proteomic databases

EPDiQ7Z3V5.
PaxDbiQ7Z3V5.
PRIDEiQ7Z3V5.

Protocols and materials databases

DNASUi51276.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328550; ENSP00000333660; ENSG00000180479.
ENST00000358744; ENSP00000351594; ENSG00000180479.
ENST00000451802; ENSP00000392638; ENSG00000180479.
ENST00000593133; ENSP00000467572; ENSG00000180479.
GeneIDi51276.
KEGGihsa:51276.
UCSCiuc002ogt.4. human.

Organism-specific databases

CTDi51276.
GeneCardsiZNF571.
HGNCiHGNC:25000. ZNF571.
HPAiHPA054762.
HPA059966.
neXtProtiNX_Q7Z3V5.
PharmGKBiPA134892585.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z3V5.
KOiK09228.
OMAiKAFICGK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ7Z3V5.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GeneWikiiZNF571.
GenomeRNAii51276.
NextBioi54489.
PROiQ7Z3V5.

Gene expression databases

BgeeiQ7Z3V5.
CleanExiHS_ZNF571.
ExpressionAtlasiQ7Z3V5. baseline and differential.
GenevisibleiQ7Z3V5. HS.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 16 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-252 AND HIS-573.
    Tissue: Umbilical cord blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-189.
    Tissue: Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-189.
    Tissue: Testis.

Entry informationi

Entry nameiZN571_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3V5
Secondary accession number(s): Q2HIY0, Q3ZCU3, Q9NZX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 20, 2007
Last modified: May 11, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.