Q7Z3U6 (Q7Z3U6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein DKFZp686C2469 EMBL CAD97658.1

Gene names

Name:

DKFZp686C2469 EMBL CAD97658.1

Organism

Homo sapiens (Human) EMBL CAD97658.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	803 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 N-terminal Ras-GEF domain. SAAS SAAS000651 Contains 1 Ras-GEF domain. SAAS SAAS000651

Ontologies

Keywords
Molecular function	Guanine-nucleotide releasing factor SAAS SAAS000651
Gene Ontology (GO)
Biological_process	regulation of small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7Z3U6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: E411018F59BAED85	FASTA	803	90,646
	10 20 30 40 50 60 MEVKPVGEPT QEVSKFKLST KVESTGHWLV EDHVRIWEVL KTEESSIQDW GEEVEEGAVY 70 80 90 100 110 120 HVTLKRVQIQ QAANKGARWL GVEGDQLPPG HAVSQYETCK IRTIKAGTLE KLVENLLTAF 130 140 150 160 170 180 GDNDFTYISI FLSTYRGFAS TKEVLELLLD RYGNLTSPNC EEDGSQSSSE SKMVIRNAIA 190 200 210 220 230 240 SILRAWLDQC AEDFREPPHF PCLQKLLDYL TRMMPGSDPE RRAQNLLEQF QKQEVETDNG 250 260 270 280 290 300 LPNTISFSLE EEEELEGGES AEFTCFSEDL VAEQLTYMDA QLFKKVVPHH CLGCIWSRRD 310 320 330 340 350 360 KKENKHLAPT IRATISQFNT LTKCVVSTIL GGKELKTQQR AKIIEKWINI AHECRLLKNF 370 380 390 400 410 420 SSLRAIVSAL QSNSIYRLKK TWAAVPRDRM LMFEELSDIF SDHNNHLTSR ELLMKEGTSK 430 440 450 460 470 480 FANLDSSVKE NQKRTQRRLQ LQKDMGVMQG TVPYLGTFLT DLTMLDTALQ DYIEGGLVNF 490 500 510 520 530 540 EKRRREFEVI AQIKLLQSAC NSYCMTPDQK FIQWFQRQQL LTEEESYALS CEIEAAADAS 550 560 570 580 590 600 TTSPKPRKSM VKRLSLLFLG SDMITSPTPT KEQPKSTASG SSGESMDSVS VSSCESNHSE 610 620 630 640 650 660 AEEGSITPMD TPDEPQKKLS ESSSSCSSIH SMDTNSSGMS SLINPLSSPP SCNNNPKIHK 670 680 690 700 710 720 RSVSVTSITS TVLPPVYNQQ NEDTCIIRIS VEDNNGNMYK SIMLTSQDKT PAVIQRAMLK 730 740 750 760 770 780 HNLDSDPAEE YELVQVISED KELVIPDSAN VFYAMNSQVN FDFILRKKNS MEEQVKLRSR 790 800 TSLTLPRTAK RGCWSNRHSK ITL

References

[1]	Ansorge W., Krieger S., Regiert T., Rittmueller C., Schwager B., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Human endometrium carcinoma cell line EMBL CAD97658.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX537416 mRNA. Translation: CAD97658.1.
IPI	IPI00299679.
UniGene	Hs.497148.
3D structure databases
HSSP	HSSP built from PDB template 1EF5 based on UniProtKB Q60695.
ProteinModelPortal	Q7Z3U6.
SMR	Q7Z3U6. Positions 682-769.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7Z3U6.
Proteomic databases
PRIDE	Q7Z3U6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005864.
Gene expression databases
ArrayExpress	Q7Z3U6.
Family and domain databases
Gene3D	1.10.840.10. 2 hits.
InterPro	IPR000159. Ras-assoc. IPR000651. Ras-like_Gua-exchang_fac_N. IPR019804. Ras_G-nucl-exch_fac_CS. IPR008937. Ras_GEF. IPR023578. Ras_GEF_dom. IPR001895. RasGRF_CDC25. [Graphical view]
PANTHER	PTHR23113. PTHR23113. 1 hit.
Pfam	PF00788. RA. 1 hit. PF00617. RasGEF. 1 hit. PF00618. RasGEF_N. 1 hit. [Graphical view]
SMART	SM00314. RA. 1 hit. SM00147. RasGEF. 1 hit. SM00229. RasGEFN. 1 hit. [Graphical view]
SUPFAM	SSF48366. Ras_GEF. 1 hit.
PROSITE	PS50200. RA. 1 hit. PS00720. RASGEF. 1 hit. PS50009. RASGEF_CAT. 1 hit. PS50212. RASGEF_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7Z3U6_HUMAN

Accession

Primary (citable) accession number: Q7Z3U6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	March 6, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.