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Q7Z3U6

- Q7Z3U6_HUMAN

UniProt

Q7Z3U6 - Q7Z3U6_HUMAN

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Protein
Submitted name:

Putative uncharacterized protein DKFZp686C2469

Gene
DKFZp686C2469
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein DKFZp686C2469Imported
Gene namesi
Name:DKFZp686C2469Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ7Z3U6.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3U6.
SMRiQ7Z3U6. Positions 682-769.

Family & Domainsi

Sequence similaritiesi

Contains N-terminal Ras-GEF domain.SAAS annotations
Contains Ras-GEF domain.SAAS annotations

Phylogenomic databases

HOVERGENiHBG005864.

Family and domain databases

Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3U6-1 [UniParc]FASTAAdd to Basket

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MEVKPVGEPT QEVSKFKLST KVESTGHWLV EDHVRIWEVL KTEESSIQDW    50
GEEVEEGAVY HVTLKRVQIQ QAANKGARWL GVEGDQLPPG HAVSQYETCK 100
IRTIKAGTLE KLVENLLTAF GDNDFTYISI FLSTYRGFAS TKEVLELLLD 150
RYGNLTSPNC EEDGSQSSSE SKMVIRNAIA SILRAWLDQC AEDFREPPHF 200
PCLQKLLDYL TRMMPGSDPE RRAQNLLEQF QKQEVETDNG LPNTISFSLE 250
EEEELEGGES AEFTCFSEDL VAEQLTYMDA QLFKKVVPHH CLGCIWSRRD 300
KKENKHLAPT IRATISQFNT LTKCVVSTIL GGKELKTQQR AKIIEKWINI 350
AHECRLLKNF SSLRAIVSAL QSNSIYRLKK TWAAVPRDRM LMFEELSDIF 400
SDHNNHLTSR ELLMKEGTSK FANLDSSVKE NQKRTQRRLQ LQKDMGVMQG 450
TVPYLGTFLT DLTMLDTALQ DYIEGGLVNF EKRRREFEVI AQIKLLQSAC 500
NSYCMTPDQK FIQWFQRQQL LTEEESYALS CEIEAAADAS TTSPKPRKSM 550
VKRLSLLFLG SDMITSPTPT KEQPKSTASG SSGESMDSVS VSSCESNHSE 600
AEEGSITPMD TPDEPQKKLS ESSSSCSSIH SMDTNSSGMS SLINPLSSPP 650
SCNNNPKIHK RSVSVTSITS TVLPPVYNQQ NEDTCIIRIS VEDNNGNMYK 700
SIMLTSQDKT PAVIQRAMLK HNLDSDPAEE YELVQVISED KELVIPDSAN 750
VFYAMNSQVN FDFILRKKNS MEEQVKLRSR TSLTLPRTAK RGCWSNRHSK 800
ITL 803
Length:803
Mass (Da):90,646
Last modified:October 1, 2003 - v1
Checksum:iE411018F59BAED85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX537416 mRNA. Translation: CAD97658.1.
UniGeneiHs.497148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX537416 mRNA. Translation: CAD97658.1 .
UniGenei Hs.497148.

3D structure databases

ProteinModelPortali Q7Z3U6.
SMRi Q7Z3U6. Positions 682-769.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q7Z3U6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005864.

Family and domain databases

Gene3Di 1.10.840.10. 2 hits.
InterProi IPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Ansorge W., Krieger S., Regiert T., Rittmueller C., Schwager B., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Human endometrium carcinoma cell lineImported.

Entry informationi

Entry nameiQ7Z3U6_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3U6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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