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Protein
Submitted name:

Putative uncharacterized protein DKFZp686C2469

Gene

DKFZp686C2469

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  1. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein DKFZp686C2469Imported
Gene namesi
Name:DKFZp686C2469Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ7Z3U6.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3U6.
SMRiQ7Z3U6. Positions 682-769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains N-terminal Ras-GEF domain.SAAS annotation
Contains Ras-GEF domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG005864.

Family and domain databases

Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 1 hit.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKPVGEPT QEVSKFKLST KVESTGHWLV EDHVRIWEVL KTEESSIQDW
60 70 80 90 100
GEEVEEGAVY HVTLKRVQIQ QAANKGARWL GVEGDQLPPG HAVSQYETCK
110 120 130 140 150
IRTIKAGTLE KLVENLLTAF GDNDFTYISI FLSTYRGFAS TKEVLELLLD
160 170 180 190 200
RYGNLTSPNC EEDGSQSSSE SKMVIRNAIA SILRAWLDQC AEDFREPPHF
210 220 230 240 250
PCLQKLLDYL TRMMPGSDPE RRAQNLLEQF QKQEVETDNG LPNTISFSLE
260 270 280 290 300
EEEELEGGES AEFTCFSEDL VAEQLTYMDA QLFKKVVPHH CLGCIWSRRD
310 320 330 340 350
KKENKHLAPT IRATISQFNT LTKCVVSTIL GGKELKTQQR AKIIEKWINI
360 370 380 390 400
AHECRLLKNF SSLRAIVSAL QSNSIYRLKK TWAAVPRDRM LMFEELSDIF
410 420 430 440 450
SDHNNHLTSR ELLMKEGTSK FANLDSSVKE NQKRTQRRLQ LQKDMGVMQG
460 470 480 490 500
TVPYLGTFLT DLTMLDTALQ DYIEGGLVNF EKRRREFEVI AQIKLLQSAC
510 520 530 540 550
NSYCMTPDQK FIQWFQRQQL LTEEESYALS CEIEAAADAS TTSPKPRKSM
560 570 580 590 600
VKRLSLLFLG SDMITSPTPT KEQPKSTASG SSGESMDSVS VSSCESNHSE
610 620 630 640 650
AEEGSITPMD TPDEPQKKLS ESSSSCSSIH SMDTNSSGMS SLINPLSSPP
660 670 680 690 700
SCNNNPKIHK RSVSVTSITS TVLPPVYNQQ NEDTCIIRIS VEDNNGNMYK
710 720 730 740 750
SIMLTSQDKT PAVIQRAMLK HNLDSDPAEE YELVQVISED KELVIPDSAN
760 770 780 790 800
VFYAMNSQVN FDFILRKKNS MEEQVKLRSR TSLTLPRTAK RGCWSNRHSK

ITL
Length:803
Mass (Da):90,646
Last modified:October 1, 2003 - v1
Checksum:iE411018F59BAED85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537416 mRNA. Translation: CAD97658.1.
UniGeneiHs.497148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537416 mRNA. Translation: CAD97658.1.
UniGeneiHs.497148.

3D structure databases

ProteinModelPortaliQ7Z3U6.
SMRiQ7Z3U6. Positions 682-769.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7Z3U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005864.

Family and domain databases

Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. Ras-assoc.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 1 hit.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Ansorge W., Krieger S., Regiert T., Rittmueller C., Schwager B., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Human endometrium carcinoma cell lineImported.

Entry informationi

Entry nameiQ7Z3U6_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3U6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: April 29, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.