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Protein

Zinc finger FYVE domain-containing protein 16

Gene

ZFYVE16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri747 – 805FYVE-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

  • 1-phosphatidylinositol binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • BMP signaling pathway Source: Reactome
  • endosomal transport Source: UniProtKB
  • protein targeting to lysosome Source: UniProtKB
  • regulation of endocytosis Source: UniProtKB
  • signal transduction Source: UniProtKB
  • vesicle organization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-201451. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger FYVE domain-containing protein 16
Alternative name(s):
Endofin
Endosome-associated FYVE domain protein
Gene namesi
Name:ZFYVE16
Synonyms:KIAA0305
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:20756. ZFYVE16.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication

  • Note: Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi753C → S: Abolishes localization to endosomes and association with PI3P. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000039319.
PharmGKBiPA134873366.

Polymorphism and mutation databases

BioMutaiZFYVE16.
DMDMi296453075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000987161 – 1539Zinc finger FYVE domain-containing protein 16Add BLAST1539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1
Modified residuei446PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei896PhosphoserineBy similarity1
Modified residuei939PhosphoserineCombined sources1
Modified residuei946PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z3T8.
MaxQBiQ7Z3T8.
PaxDbiQ7Z3T8.
PeptideAtlasiQ7Z3T8.
PRIDEiQ7Z3T8.

PTM databases

iPTMnetiQ7Z3T8.
PhosphoSitePlusiQ7Z3T8.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000039319.
CleanExiHS_ZFYVE16.
ExpressionAtlasiQ7Z3T8. baseline and differential.
GenevisibleiQ7Z3T8. HS.

Organism-specific databases

HPAiHPA035935.
HPA035936.

Interactioni

Subunit structurei

Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TOM1O607845EBI-298055,EBI-74634

Protein-protein interaction databases

BioGridi115111. 8 interactors.
IntActiQ7Z3T8. 7 interactors.
MINTiMINT-1196290.
STRINGi9606.ENSP00000337159.

Structurei

Secondary structure

11539
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni737 – 739Combined sources3
Helixi747 – 749Combined sources3
Turni754 – 756Combined sources3
Beta strandi762 – 764Combined sources3
Turni770 – 772Combined sources3
Helixi778 – 780Combined sources3
Beta strandi783 – 786Combined sources4
Turni788 – 790Combined sources3
Beta strandi791 – 796Combined sources6
Helixi798 – 807Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T7LX-ray1.09A733-820[»]
ProteinModelPortaliQ7Z3T8.
SMRiQ7Z3T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.1 Publication

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri747 – 805FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1841. Eukaryota.
ENOG410XSEQ. LUCA.
GeneTreeiENSGT00840000129741.
HOVERGENiHBG098617.
InParanoidiQ7Z3T8.
KOiK04679.
OMAiFEQNPDE.
OrthoDBiEOG091G0VJ6.
PhylomeDBiQ7Z3T8.
TreeFamiTF324904.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022557. DUF3480.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR017165. Znf_FYVE_endofin.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF43. PTHR22835:SF43. 4 hits.
PfamiPF11979. DUF3480. 1 hit.
PF01363. FYVE. 1 hit.
[Graphical view]
PIRSFiPIRSF037289. SARA/endofin. 1 hit.
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3T8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSYFKAAVS DLDKLLDDFE QNPDEQDYLQ DVQNAYDSNH CSVSSELASS
60 70 80 90 100
QRTSLLPKDQ ECVNSCASSE TSYGTNESSL NEKTLKGLTS IQNEKNVTGL
110 120 130 140 150
DLLSSVDGGT SDEIQPLYMG RCSKPICDLI SDMGNLVHAT NSEEDIKKLL
160 170 180 190 200
PDDFKSNADS LIGLDLSSVS DTPCVSSTDH DSDTVREQQN DISSELQNRE
210 220 230 240 250
IGGIKELGIK VDTTLSDSYN YSGTENLKDK KIFNQLESIV DFNMSSALTR
260 270 280 290 300
QSSKMFHAKD KLQHKSQPCG LLKDVGLVKE EVDVAVITAA ECLKEEGKTS
310 320 330 340 350
ALTCSLPKNE DLCLNDSNSR DENFKLPDFS FQEDKTVIKQ SAQEDSKSLD
360 370 380 390 400
LKDNDVIQDS SSALHVSSKD VPSSLSCLPA SGSMCGSLIE SKARGDFLPQ
410 420 430 440 450
HEHKDNIQDA VTIHEEIQNS VVLGGEPFKE NDLLKQEKCK SILLQSLIEG
460 470 480 490 500
MEDRKIDPDQ TVIRAESLDG GDTSSTVVES QEGLSGTHVP ESSDCCEGFI
510 520 530 540 550
NTFSSNDMDG QDLDYFNIDE GAKSGPLISD AELDAFLTEQ YLQTTNIKSF
560 570 580 590 600
EENVNDSKSQ MNQIDMKGLD DGNINNIYFN AEAGAIGESH GINIICEIVD
610 620 630 640 650
KQNTIENGLS LGEKSTIPVQ QGLPTSKSEI TNQLSVSDIN SQSVGGARPK
660 670 680 690 700
QLFSLPSRTR SSKDLNKPDV PDTIESEPST ADTVVPITCA IDSTADPQVS
710 720 730 740 750
FNSNYIDIES NSEGGSSFVT ANEDSVPENT CKEGLVLGQK QPTWVPDSEA
760 770 780 790 800
PNCMNCQVKF TFTKRRHHCR ACGKVFCGVC CNRKCKLQYL EKEARVCVVC
810 820 830 840 850
YETISKAQAF ERMMSPTGSN LKSNHSDECT TVQPPQENQT SSIPSPATLP
860 870 880 890 900
VSALKQPGVE GLCSKEQKRV WFADGILPNG EVADTTKLSS GSKRCSEDFS
910 920 930 940 950
PLSPDVPMTV NTVDHSHSTT VEKPNNETGD ITRNEIIQSP ISQVPSVEKL
960 970 980 990 1000
SMNTGNEGLP TSGSFTLDDD VFAETEEPSS PTGVLVNSNL PIASISDYRL
1010 1020 1030 1040 1050
LCDINKYVCN KISLLPNDED SLPPLLVASG EKGSVPVVEE HPSHEQIILL
1060 1070 1080 1090 1100
LEGESFHPVT FVLNANLLVN VKFIFYSSDK YWYFSTNGLH GLGQAEIIIL
1110 1120 1130 1140 1150
LLCLPNEDTI PKDIFRLFIT IYKDALKGKY IENLDNITFT ESFLSSKDHG
1160 1170 1180 1190 1200
GFLFITPTFQ KLDDLSLPSN PFLCGILIQK LEIPWAKVFP MRLMLRLGAE
1210 1220 1230 1240 1250
YKAYPAPLTS IRGRKPLFGE IGHTIMNLLV DLRNYQYTLH NIDQLLIHME
1260 1270 1280 1290 1300
MGKSCIKIPR KKYSDVMKVL NSSNEHVISI GASFSTEADS HLVCIQNDGI
1310 1320 1330 1340 1350
YETQANSATG HPRKVTGASF VVFNGALKTS SGFLAKSSIV EDGLMVQITP
1360 1370 1380 1390 1400
ETMNGLRLAL REQKDFKITC GKVDAVDLRE YVDICWVDAE EKGNKGVISS
1410 1420 1430 1440 1450
VDGISLQGFP SEKIKLEADF ETDEKIVKCT EVFYFLKDQD LSILSTSYQF
1460 1470 1480 1490 1500
AKEIAMACSA ALCPHLKTLK SNGMNKIGLR VSIDTDMVEF QAGSEGQLLP
1510 1520 1530
QHYLNDLDSA LIPVIHGGTS NSSLPLEIEL VFFIIEHLF
Length:1,539
Mass (Da):168,903
Last modified:May 18, 2010 - v3
Checksum:iD9C2F8DDE12D69E2
GO
Isoform 2 (identifier: Q7Z3T8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     807-809: AQA → GEC
     810-1539: Missing.

Note: No experimental confirmation available.
Show »
Length:809
Mass (Da):88,377
Checksum:iCD3523B4CB36000A
GO

Sequence cautioni

The sequence BAA20764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82E → K in AAH30808 (PubMed:15489334).Curated1
Sequence conflicti151P → L in CAI45932 (PubMed:17974005).Curated1
Sequence conflicti385C → S in CAD97666 (PubMed:17974005).Curated1
Sequence conflicti487T → A in CAD89968 (PubMed:17974005).Curated1
Sequence conflicti616T → I in CAD89968 (PubMed:17974005).Curated1
Sequence conflicti934N → D in CAD89968 (PubMed:17974005).Curated1
Sequence conflicti1217L → F in CAI45932 (PubMed:17974005).Curated1
Sequence conflicti1308A → T in CAD97666 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05749235A → E.Corresponds to variant rs6893297dbSNPEnsembl.1
Natural variantiVAR_019489192I → T.4 PublicationsCorresponds to variant rs2544600dbSNPEnsembl.1
Natural variantiVAR_069368380A → V.1 PublicationCorresponds to variant rs752702732dbSNPEnsembl.1
Natural variantiVAR_019490598I → T.4 PublicationsCorresponds to variant rs259028dbSNPEnsembl.1
Natural variantiVAR_0194911055S → G.3 PublicationsCorresponds to variant rs249038dbSNPEnsembl.1
Natural variantiVAR_0574931519T → N.Corresponds to variant rs16877836dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011019807 – 809AQA → GEC in isoform 2. 1 Publication3
Alternative sequenceiVSP_011020810 – 1539Missing in isoform 2. 1 PublicationAdd BLAST730

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434817 mRNA. Translation: AAL30772.1.
AB002303 mRNA. Translation: BAA20764.2. Different initiation.
AL833087 mRNA. Translation: CAD89968.1.
BX537424 mRNA. Translation: CAD97666.1.
CR933621 mRNA. Translation: CAI45932.1.
AC008771 Genomic DNA. No translation available.
BC030808 mRNA. Translation: AAH30808.1.
CCDSiCCDS4050.1. [Q7Z3T8-1]
RefSeqiNP_001098721.1. NM_001105251.2.
NP_001271165.1. NM_001284236.1.
NP_001271166.1. NM_001284237.1.
NP_055548.3. NM_014733.4.
XP_005248689.1. XM_005248632.4. [Q7Z3T8-1]
XP_011542055.1. XM_011543753.2. [Q7Z3T8-1]
XP_016865580.1. XM_017010091.1. [Q7Z3T8-1]
XP_016865581.1. XM_017010092.1. [Q7Z3T8-1]
UniGeneiHs.482660.
Hs.660410.

Genome annotation databases

EnsembliENST00000338008; ENSP00000337159; ENSG00000039319. [Q7Z3T8-1]
ENST00000505560; ENSP00000426848; ENSG00000039319. [Q7Z3T8-1]
ENST00000510158; ENSP00000423663; ENSG00000039319. [Q7Z3T8-1]
GeneIDi9765.
KEGGihsa:9765.
UCSCiuc003kgq.6. human. [Q7Z3T8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434817 mRNA. Translation: AAL30772.1.
AB002303 mRNA. Translation: BAA20764.2. Different initiation.
AL833087 mRNA. Translation: CAD89968.1.
BX537424 mRNA. Translation: CAD97666.1.
CR933621 mRNA. Translation: CAI45932.1.
AC008771 Genomic DNA. No translation available.
BC030808 mRNA. Translation: AAH30808.1.
CCDSiCCDS4050.1. [Q7Z3T8-1]
RefSeqiNP_001098721.1. NM_001105251.2.
NP_001271165.1. NM_001284236.1.
NP_001271166.1. NM_001284237.1.
NP_055548.3. NM_014733.4.
XP_005248689.1. XM_005248632.4. [Q7Z3T8-1]
XP_011542055.1. XM_011543753.2. [Q7Z3T8-1]
XP_016865580.1. XM_017010091.1. [Q7Z3T8-1]
XP_016865581.1. XM_017010092.1. [Q7Z3T8-1]
UniGeneiHs.482660.
Hs.660410.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T7LX-ray1.09A733-820[»]
ProteinModelPortaliQ7Z3T8.
SMRiQ7Z3T8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115111. 8 interactors.
IntActiQ7Z3T8. 7 interactors.
MINTiMINT-1196290.
STRINGi9606.ENSP00000337159.

PTM databases

iPTMnetiQ7Z3T8.
PhosphoSitePlusiQ7Z3T8.

Polymorphism and mutation databases

BioMutaiZFYVE16.
DMDMi296453075.

Proteomic databases

EPDiQ7Z3T8.
MaxQBiQ7Z3T8.
PaxDbiQ7Z3T8.
PeptideAtlasiQ7Z3T8.
PRIDEiQ7Z3T8.

Protocols and materials databases

DNASUi9765.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338008; ENSP00000337159; ENSG00000039319. [Q7Z3T8-1]
ENST00000505560; ENSP00000426848; ENSG00000039319. [Q7Z3T8-1]
ENST00000510158; ENSP00000423663; ENSG00000039319. [Q7Z3T8-1]
GeneIDi9765.
KEGGihsa:9765.
UCSCiuc003kgq.6. human. [Q7Z3T8-1]

Organism-specific databases

CTDi9765.
GeneCardsiZFYVE16.
HGNCiHGNC:20756. ZFYVE16.
HPAiHPA035935.
HPA035936.
MIMi608880. gene.
neXtProtiNX_Q7Z3T8.
OpenTargetsiENSG00000039319.
PharmGKBiPA134873366.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1841. Eukaryota.
ENOG410XSEQ. LUCA.
GeneTreeiENSGT00840000129741.
HOVERGENiHBG098617.
InParanoidiQ7Z3T8.
KOiK04679.
OMAiFEQNPDE.
OrthoDBiEOG091G0VJ6.
PhylomeDBiQ7Z3T8.
TreeFamiTF324904.

Enzyme and pathway databases

ReactomeiR-HSA-201451. Signaling by BMP.

Miscellaneous databases

ChiTaRSiZFYVE16. human.
GeneWikiiZFYVE16.
GenomeRNAii9765.
PROiQ7Z3T8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000039319.
CleanExiHS_ZFYVE16.
ExpressionAtlasiQ7Z3T8. baseline and differential.
GenevisibleiQ7Z3T8. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022557. DUF3480.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR017165. Znf_FYVE_endofin.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR22835:SF43. PTHR22835:SF43. 4 hits.
PfamiPF11979. DUF3480. 1 hit.
PF01363. FYVE. 1 hit.
[Graphical view]
PIRSFiPIRSF037289. SARA/endofin. 1 hit.
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFY16_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3T8
Secondary accession number(s): O15023
, Q5H9U2, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.