Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7Z3T1

- OR2W3_HUMAN

UniProt

Q7Z3T1 - OR2W3_HUMAN

Protein

Olfactory receptor 2W3

Gene

OR2W3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2W3
    Alternative name(s):
    Olfactory receptor 2W8
    Olfactory receptor OR1-49
    Gene namesi
    Name:OR2W3
    Synonyms:OR2W3P, OR2W8P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15021. OR2W3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32216.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 2W3PRO_0000150512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7Z3T1.
    PRIDEiQ7Z3T1.

    Expressioni

    Gene expression databases

    BgeeiQ7Z3T1.
    CleanExiHS_OR2W3.
    GenevestigatoriQ7Z3T1.

    Organism-specific databases

    HPAiHPA045594.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353516.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z3T1.
    SMRiQ7Z3T1. Positions 26-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG67819.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ7Z3T1.
    KOiK04257.
    OMAiNPRLCRG.
    OrthoDBiEOG78SQJ9.
    PhylomeDBiQ7Z3T1.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z3T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR    50
    LDPHLHTPMY FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ 100
    LFLFLGLGGV ECLLLAVMAY DRCVAICKPL HYMVIMNPRL CRGLVSVTWG 150
    CGVANSLAMS PVTLRLPRCG HHEVDHFLRE MPALIRMACV STVAIEGTVF 200
    VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT CGSHLTVVSL 250
    FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA 300
    LGRLLLGKRE LGKE 314
    Length:314
    Mass (Da):34,789
    Last modified:December 6, 2005 - v2
    Checksum:i3F53BC5912B7D6BC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti169 – 1691C → S.
    Corresponds to variant rs12083024 [ dbSNP | Ensembl ].
    VAR_034180
    Natural varianti179 – 1791R → C.
    Corresponds to variant rs10888267 [ dbSNP | Ensembl ].
    VAR_034181
    Natural varianti190 – 1901V → I.
    Corresponds to variant rs12135078 [ dbSNP | Ensembl ].
    VAR_034182
    Natural varianti196 – 1961E → D.1 Publication
    Corresponds to variant rs12139390 [ dbSNP | Ensembl ].
    VAR_034183
    Natural varianti272 – 2721M → K.1 Publication
    Corresponds to variant rs11204545 [ dbSNP | Ensembl ].
    VAR_034184
    Natural varianti275 – 2751M → T.1 Publication
    Corresponds to variant rs11204546 [ dbSNP | Ensembl ].
    VAR_034185

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065949 Genomic DNA. Translation: BAC06162.1.
    BX537432 mRNA. Translation: CAD97674.1.
    BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
    CCDSiCCDS31099.1.
    RefSeqiNP_001001957.2. NM_001001957.2.
    UniGeneiHs.269151.

    Genome annotation databases

    EnsembliENST00000360358; ENSP00000353516; ENSG00000238243.
    GeneIDi343171.
    KEGGihsa:343171.
    UCSCiuc001idp.1. human.

    Polymorphism databases

    DMDMi83305196.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065949 Genomic DNA. Translation: BAC06162.1 .
    BX537432 mRNA. Translation: CAD97674.1 .
    BK004456 Genomic DNA. Translation: DAA04854.1 . Sequence problems.
    CCDSi CCDS31099.1.
    RefSeqi NP_001001957.2. NM_001001957.2.
    UniGenei Hs.269151.

    3D structure databases

    ProteinModelPortali Q7Z3T1.
    SMRi Q7Z3T1. Positions 26-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353516.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 83305196.

    Proteomic databases

    PaxDbi Q7Z3T1.
    PRIDEi Q7Z3T1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360358 ; ENSP00000353516 ; ENSG00000238243 .
    GeneIDi 343171.
    KEGGi hsa:343171.
    UCSCi uc001idp.1. human.

    Organism-specific databases

    CTDi 343171.
    GeneCardsi GC01P248031.
    HGNCi HGNC:15021. OR2W3.
    HPAi HPA045594.
    neXtProti NX_Q7Z3T1.
    PharmGKBi PA32216.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG67819.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q7Z3T1.
    KOi K04257.
    OMAi NPRLCRG.
    OrthoDBi EOG78SQJ9.
    PhylomeDBi Q7Z3T1.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2W3.
    GenomeRNAii 343171.
    NextBioi 98483.
    PROi Q7Z3T1.

    Gene expression databases

    Bgeei Q7Z3T1.
    CleanExi HS_OR2W3.
    Genevestigatori Q7Z3T1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-196; LYS-272 AND THR-275.
      Tissue: Fetal brain.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR2W3_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3T1
    Secondary accession number(s): Q6IF06, Q8NG86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3