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Protein

Olfactory receptor 2W3

Gene

OR2W3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2W3
Alternative name(s):
Olfactory receptor 2W8
Olfactory receptor OR1-49
Gene namesi
Name:OR2W3
Synonyms:OR2W3P, OR2W8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15021. OR2W3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi343171.
OpenTargetsiENSG00000238243.
PharmGKBiPA32216.

Polymorphism and mutation databases

BioMutaiOR2W3.
DMDMi83305196.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505121 – 314Olfactory receptor 2W3Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z3T1.
PRIDEiQ7Z3T1.

Expressioni

Gene expression databases

BgeeiENSG00000238243.
CleanExiHS_OR2W3.
GenevisibleiQ7Z3T1. HS.

Organism-specific databases

HPAiHPA045594.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353516.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVPF. Eukaryota.
ENOG411156X. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ7Z3T1.
KOiK04257.
OMAiQTHFILL.
OrthoDBiEOG091G0CI3.
PhylomeDBiQ7Z3T1.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR
60 70 80 90 100
LDPHLHTPMY FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ
110 120 130 140 150
LFLFLGLGGV ECLLLAVMAY DRCVAICKPL HYMVIMNPRL CRGLVSVTWG
160 170 180 190 200
CGVANSLAMS PVTLRLPRCG HHEVDHFLRE MPALIRMACV STVAIEGTVF
210 220 230 240 250
VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT CGSHLTVVSL
260 270 280 290 300
FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA
310
LGRLLLGKRE LGKE
Length:314
Mass (Da):34,789
Last modified:December 6, 2005 - v2
Checksum:i3F53BC5912B7D6BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074043142R → W Found in a family with retinitis pigmentosa. 1 PublicationCorresponds to variant rs189993261dbSNPEnsembl.1
Natural variantiVAR_034180169C → S.Corresponds to variant rs12083024dbSNPEnsembl.1
Natural variantiVAR_034181179R → C.Corresponds to variant rs10888267dbSNPEnsembl.1
Natural variantiVAR_034182190V → I.Corresponds to variant rs12135078dbSNPEnsembl.1
Natural variantiVAR_034183196E → D.1 PublicationCorresponds to variant rs12139390dbSNPEnsembl.1
Natural variantiVAR_034184272M → K.1 PublicationCorresponds to variant rs11204545dbSNPEnsembl.1
Natural variantiVAR_034185275M → T.1 PublicationCorresponds to variant rs11204546dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065949 Genomic DNA. Translation: BAC06162.1.
BX537432 mRNA. Translation: CAD97674.1.
BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
CCDSiCCDS31099.1.
RefSeqiNP_001001957.2. NM_001001957.2.
UniGeneiHs.269151.

Genome annotation databases

EnsembliENST00000360358; ENSP00000353516; ENSG00000238243.
GeneIDi343171.
KEGGihsa:343171.
UCSCiuc010pzb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065949 Genomic DNA. Translation: BAC06162.1.
BX537432 mRNA. Translation: CAD97674.1.
BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
CCDSiCCDS31099.1.
RefSeqiNP_001001957.2. NM_001001957.2.
UniGeneiHs.269151.

3D structure databases

ProteinModelPortaliQ7Z3T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353516.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2W3.
DMDMi83305196.

Proteomic databases

PaxDbiQ7Z3T1.
PRIDEiQ7Z3T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360358; ENSP00000353516; ENSG00000238243.
GeneIDi343171.
KEGGihsa:343171.
UCSCiuc010pzb.2. human.

Organism-specific databases

CTDi343171.
DisGeNETi343171.
GeneCardsiOR2W3.
HGNCiHGNC:15021. OR2W3.
HPAiHPA045594.
neXtProtiNX_Q7Z3T1.
OpenTargetsiENSG00000238243.
PharmGKBiPA32216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVPF. Eukaryota.
ENOG411156X. LUCA.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ7Z3T1.
KOiK04257.
OMAiQTHFILL.
OrthoDBiEOG091G0CI3.
PhylomeDBiQ7Z3T1.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2W3.
GenomeRNAii343171.
PROiQ7Z3T1.

Gene expression databases

BgeeiENSG00000238243.
CleanExiHS_OR2W3.
GenevisibleiQ7Z3T1. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2W3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3T1
Secondary accession number(s): Q6IF06, Q8NG86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.