Q7Z3T1 (OR2W3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2W3

Alternative name(s):
Olfactory receptor 2W8
Olfactory receptor OR1-49

Gene names

Name:	OR2W3
Synonyms:	OR2W3P, OR2W8P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 2W3		PRO_0000150512
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 219	24	Helical; Name=5; Potential
	Topological domain	220 – 236	17	Cytoplasmic Potential
	Transmembrane	237 – 259	23	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 292	20	Helical; Name=7; Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	169	1	C → S. Corresponds to variant rs12083024 [ dbSNP | Ensembl ].		VAR_034180
	Natural variant	179	1	R → C. Corresponds to variant rs10888267 [ dbSNP | Ensembl ].		VAR_034181
	Natural variant	190	1	V → I. Corresponds to variant rs12135078 [ dbSNP | Ensembl ].		VAR_034182
	Natural variant	196	1	E → D. Ref.2 Corresponds to variant rs12139390 [ dbSNP | Ensembl ].		VAR_034183
	Natural variant	272	1	M → K. Ref.2 Corresponds to variant rs11204545 [ dbSNP | Ensembl ].		VAR_034184
	Natural variant	275	1	M → T. Ref.2 Corresponds to variant rs11204546 [ dbSNP | Ensembl ].		VAR_034185

Sequences

	Sequence		Length	Mass (Da)
	Q7Z3T1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 3F53BC5912B7D6BC	FASTA	314	34,789
	10 20 30 40 50 60 MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR LDPHLHTPMY 70 80 90 100 110 120 FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ LFLFLGLGGV ECLLLAVMAY 130 140 150 160 170 180 DRCVAICKPL HYMVIMNPRL CRGLVSVTWG CGVANSLAMS PVTLRLPRCG HHEVDHFLRE 190 200 210 220 230 240 MPALIRMACV STVAIEGTVF VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT 250 260 270 280 290 300 CGSHLTVVSL FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA 310 LGRLLLGKRE LGKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-196; LYS-272 AND THR-275. Tissue: Fetal brain.
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065949 Genomic DNA. Translation: BAC06162.1. BX537432 mRNA. Translation: CAD97674.1. BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
IPI	IPI00607597.
RefSeq	NP_001001957.2. NM_001001957.2.
UniGene	Hs.269151.
3D structure databases
ProteinModelPortal	Q7Z3T1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353516.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	83305196.
Proteomic databases
PaxDb	Q7Z3T1.
PRIDE	Q7Z3T1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360358; ENSP00000353516; ENSG00000238243. ENST00000537741; ENSP00000445853; ENSG00000238243.
GeneID	343171.
KEGG	hsa:343171.
UCSC	uc001idp.1. human.
Organism-specific databases
CTD	343171.
GeneCards	GC01P248031.
HGNC	HGNC:15021. OR2W3.
HPA	HPA045594.
neXtProt	NX_Q7Z3T1.
PharmGKB	PA32216.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG67819.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q7Z3T1.
KO	K04257.
OMA	CVNTAAI.
OrthoDB	EOG4S7JQH.
PhylomeDB	Q7Z3T1.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q7Z3T1.
CleanEx	HS_OR2W3.
Genevestigator	Q7Z3T1.
GermOnline	ENSG00000198281. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	343171.
NextBio	98483.

Entry information

Entry name

OR2W3_HUMAN

Accession

Primary (citable) accession number: Q7Z3T1
Secondary accession number(s): Q6IF06, Q8NG86

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.