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Protein

Olfactory receptor 2W3

Gene

OR2W3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2W3
Alternative name(s):
Olfactory receptor 2W8
Olfactory receptor OR1-49
Gene namesi
Name:OR2W3
Synonyms:OR2W3P, OR2W8P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15021. OR2W3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 2W3PRO_0000150512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z3T1.
PRIDEiQ7Z3T1.

Expressioni

Gene expression databases

BgeeiQ7Z3T1.
CleanExiHS_OR2W3.
GenevestigatoriQ7Z3T1.

Organism-specific databases

HPAiHPA045594.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353516.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3T1.
SMRiQ7Z3T1. Positions 26-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG67819.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ7Z3T1.
KOiK04257.
OMAiQTHFILL.
OrthoDBiEOG78SQJ9.
PhylomeDBiQ7Z3T1.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR
60 70 80 90 100
LDPHLHTPMY FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ
110 120 130 140 150
LFLFLGLGGV ECLLLAVMAY DRCVAICKPL HYMVIMNPRL CRGLVSVTWG
160 170 180 190 200
CGVANSLAMS PVTLRLPRCG HHEVDHFLRE MPALIRMACV STVAIEGTVF
210 220 230 240 250
VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT CGSHLTVVSL
260 270 280 290 300
FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA
310
LGRLLLGKRE LGKE
Length:314
Mass (Da):34,789
Last modified:December 5, 2005 - v2
Checksum:i3F53BC5912B7D6BC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691C → S.
Corresponds to variant rs12083024 [ dbSNP | Ensembl ].
VAR_034180
Natural varianti179 – 1791R → C.
Corresponds to variant rs10888267 [ dbSNP | Ensembl ].
VAR_034181
Natural varianti190 – 1901V → I.
Corresponds to variant rs12135078 [ dbSNP | Ensembl ].
VAR_034182
Natural varianti196 – 1961E → D.1 Publication
Corresponds to variant rs12139390 [ dbSNP | Ensembl ].
VAR_034183
Natural varianti272 – 2721M → K.1 Publication
Corresponds to variant rs11204545 [ dbSNP | Ensembl ].
VAR_034184
Natural varianti275 – 2751M → T.1 Publication
Corresponds to variant rs11204546 [ dbSNP | Ensembl ].
VAR_034185

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065949 Genomic DNA. Translation: BAC06162.1.
BX537432 mRNA. Translation: CAD97674.1.
BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
CCDSiCCDS31099.1.
RefSeqiNP_001001957.2. NM_001001957.2.
UniGeneiHs.269151.

Genome annotation databases

EnsembliENST00000360358; ENSP00000353516; ENSG00000238243.
GeneIDi343171.
KEGGihsa:343171.
UCSCiuc001idp.1. human.

Polymorphism databases

DMDMi83305196.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065949 Genomic DNA. Translation: BAC06162.1.
BX537432 mRNA. Translation: CAD97674.1.
BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
CCDSiCCDS31099.1.
RefSeqiNP_001001957.2. NM_001001957.2.
UniGeneiHs.269151.

3D structure databases

ProteinModelPortaliQ7Z3T1.
SMRiQ7Z3T1. Positions 26-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353516.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi83305196.

Proteomic databases

PaxDbiQ7Z3T1.
PRIDEiQ7Z3T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360358; ENSP00000353516; ENSG00000238243.
GeneIDi343171.
KEGGihsa:343171.
UCSCiuc001idp.1. human.

Organism-specific databases

CTDi343171.
GeneCardsiGC01P248031.
HGNCiHGNC:15021. OR2W3.
HPAiHPA045594.
neXtProtiNX_Q7Z3T1.
PharmGKBiPA32216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG67819.
GeneTreeiENSGT00760000118914.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ7Z3T1.
KOiK04257.
OMAiQTHFILL.
OrthoDBiEOG78SQJ9.
PhylomeDBiQ7Z3T1.
TreeFamiTF336512.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2W3.
GenomeRNAii343171.
NextBioi98483.
PROiQ7Z3T1.

Gene expression databases

BgeeiQ7Z3T1.
CleanExiHS_OR2W3.
GenevestigatoriQ7Z3T1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-196; LYS-272 AND THR-275.
    Tissue: Fetal brain.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR2W3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3T1
Secondary accession number(s): Q6IF06, Q8NG86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 18, 2005
Last sequence update: December 5, 2005
Last modified: January 6, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.