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Q7Z3T1 (OR2W3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2W3
Alternative name(s):
Olfactory receptor 2W8
Olfactory receptor OR1-49
Gene names
Name:OR2W3
Synonyms:OR2W3P, OR2W8P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 2W3
PRO_0000150512

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential

Natural variations

Natural variant1691C → S.
Corresponds to variant rs12083024 [ dbSNP | Ensembl ].
VAR_034180
Natural variant1791R → C.
Corresponds to variant rs10888267 [ dbSNP | Ensembl ].
VAR_034181
Natural variant1901V → I.
Corresponds to variant rs12135078 [ dbSNP | Ensembl ].
VAR_034182
Natural variant1961E → D. Ref.2
Corresponds to variant rs12139390 [ dbSNP | Ensembl ].
VAR_034183
Natural variant2721M → K. Ref.2
Corresponds to variant rs11204545 [ dbSNP | Ensembl ].
VAR_034184
Natural variant2751M → T. Ref.2
Corresponds to variant rs11204546 [ dbSNP | Ensembl ].
VAR_034185

Sequences

Sequence LengthMass (Da)Tools
Q7Z3T1 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 3F53BC5912B7D6BC

FASTA31434,789
        10         20         30         40         50         60 
MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR LDPHLHTPMY 

        70         80         90        100        110        120 
FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ LFLFLGLGGV ECLLLAVMAY 

       130        140        150        160        170        180 
DRCVAICKPL HYMVIMNPRL CRGLVSVTWG CGVANSLAMS PVTLRLPRCG HHEVDHFLRE 

       190        200        210        220        230        240 
MPALIRMACV STVAIEGTVF VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT 

       250        260        270        280        290        300 
CGSHLTVVSL FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA 

       310 
LGRLLLGKRE LGKE 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-196; LYS-272 AND THR-275.
Tissue: Fetal brain.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065949 Genomic DNA. Translation: BAC06162.1.
BX537432 mRNA. Translation: CAD97674.1.
BK004456 Genomic DNA. Translation: DAA04854.1. Sequence problems.
CCDSCCDS31099.1.
RefSeqNP_001001957.2. NM_001001957.2.
UniGeneHs.269151.

3D structure databases

ProteinModelPortalQ7Z3T1.
SMRQ7Z3T1. Positions 26-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000353516.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM83305196.

Proteomic databases

PaxDbQ7Z3T1.
PRIDEQ7Z3T1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360358; ENSP00000353516; ENSG00000238243.
ENST00000537741; ENSP00000445853; ENSG00000238243.
GeneID343171.
KEGGhsa:343171.
UCSCuc001idp.1. human.

Organism-specific databases

CTD343171.
GeneCardsGC01P248031.
HGNCHGNC:15021. OR2W3.
HPAHPA045594.
neXtProtNX_Q7Z3T1.
PharmGKBPA32216.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG67819.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ7Z3T1.
KOK04257.
OMANPRLCRG.
OrthoDBEOG78SQJ9.
PhylomeDBQ7Z3T1.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ7Z3T1.
CleanExHS_OR2W3.
GenevestigatorQ7Z3T1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2W3.
GenomeRNAi343171.
NextBio98483.
PROQ7Z3T1.

Entry information

Entry nameOR2W3_HUMAN
AccessionPrimary (citable) accession number: Q7Z3T1
Secondary accession number(s): Q6IF06, Q8NG86
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries