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Protein

Notch homolog 2 N-terminal-like protein

Gene

NOTCH2NL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in the Notch signaling pathway and regulate neutrophil differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Notch signaling pathway

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-31048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Notch homolog 2 N-terminal-like protein
Gene namesi
Name:NOTCH2NL
Synonyms:N2N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31862. NOTCH2NL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000264343.
ENSG00000271383.
PharmGKBiPA134983899.

Polymorphism and mutation databases

DMDMi74750065.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371031 – 236Notch homolog 2 N-terminal-like proteinAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi14 ↔ 23PROSITE-ProRule annotation
Disulfide bondi29 ↔ 40PROSITE-ProRule annotation
Disulfide bondi34 ↔ 51PROSITE-ProRule annotation
Disulfide bondi53 ↔ 62PROSITE-ProRule annotation
Disulfide bondi70 ↔ 82PROSITE-ProRule annotation
Disulfide bondi76 ↔ 92PROSITE-ProRule annotation
Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Disulfide bondi114 ↔ 129PROSITE-ProRule annotation
Disulfide bondi131 ↔ 140PROSITE-ProRule annotation
Disulfide bondi147 ↔ 159PROSITE-ProRule annotation
Disulfide bondi153 ↔ 168PROSITE-ProRule annotation
Disulfide bondi170 ↔ 179PROSITE-ProRule annotation
Disulfide bondi186 ↔ 197PROSITE-ProRule annotation
Disulfide bondi191 ↔ 207PROSITE-ProRule annotation

Post-translational modificationi

Cleaved by ELANE.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7Z3S9.
PaxDbiQ7Z3S9.
PeptideAtlasiQ7Z3S9.
PRIDEiQ7Z3S9.
TopDownProteomicsiQ7Z3S9-3. [Q7Z3S9-3]

Miscellaneous databases

PMAP-CutDBQ7Z3S9.

Expressioni

Tissue specificityi

Widely expressed with higher levels in leukocytes and lymph nodes.1 Publication

Gene expression databases

BgeeiENSG00000213240.
CleanExiHS_NOTCH2NL.
GenevisibleiQ7Z3S9. HS.

Organism-specific databases

HPAiCAB004669.
HPA046392.

Interactioni

Subunit structurei

Interacts with ELANE.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q5BKY63EBI-945833,EBI-10243533
Q9NWL93EBI-945833,EBI-10315054
ACY3Q96HD93EBI-945833,EBI-3916242
ADAMTSL3P829873EBI-945833,EBI-10221726
ADAMTSL5Q6ZMM2-23EBI-945833,EBI-10254938
ADCK5Q3MIX33EBI-945833,EBI-3923548
AESQ081173EBI-945833,EBI-717810
ALDH3B1P433533EBI-945833,EBI-2558314
ALPIP099233EBI-945833,EBI-1052631
AQP1P299725EBI-945833,EBI-745213
AQP5P550643EBI-945833,EBI-746103
ARID3AQ998563EBI-945833,EBI-5458244
ASPSCR1Q9BZE93EBI-945833,EBI-1993677
ATG9AQ7Z3C63EBI-945833,EBI-727146
BCL6BA8KA133EBI-945833,EBI-10174813
BLCAPP629523EBI-945833,EBI-3895726
BMP7A8K5713EBI-945833,EBI-10174327
C11orf87Q6NUJ23EBI-945833,EBI-6660291
C16orf59Q7L2K03EBI-945833,EBI-8465456
C5orf60A6NFR6-43EBI-945833,EBI-10173955
CA6Q8N4G43EBI-945833,EBI-10265475
CARHSP1Q9Y2V23EBI-945833,EBI-718719
CATSPER1Q8NEC55EBI-945833,EBI-744545
CCDC26Q8TAB73EBI-945833,EBI-10271580
CCER1Q8TC903EBI-945833,EBI-746041
CD164Q049003EBI-945833,EBI-2115896
CDK5R1Q8N6193EBI-945833,EBI-10266998
CDK5R1Q8TAM43EBI-945833,EBI-10271838
CERKQ8TCT03EBI-945833,EBI-10274247
CHCHD3Q9NX633EBI-945833,EBI-743375
CHDHQ8NE623EBI-945833,EBI-7127986
CHIC2Q9UKJ53EBI-945833,EBI-741528
CHRDQ9H2X05EBI-945833,EBI-947551
CHRNGP075103EBI-945833,EBI-9008836
CLDN2P577393EBI-945833,EBI-751440
CLEC18AA5D8T83EBI-945833,EBI-10173491
COL8A1P276585EBI-945833,EBI-747133
CRACR2AQ9BSW25EBI-945833,EBI-739773
CRCT1Q9UGL93EBI-945833,EBI-713677
CREB5Q02930-35EBI-945833,EBI-10192698
CSF1P096033EBI-945833,EBI-2872294
CST2P092285EBI-945833,EBI-8832659
CST9LQ9H4G13EBI-945833,EBI-3923092
CTSGP083113EBI-945833,EBI-5462635
CTSZQ9UBR25EBI-945833,EBI-8636823
CXCL5Q6I9S73EBI-945833,EBI-10249885
DHRS1Q96LJ75EBI-945833,EBI-746300
DMRT3Q9NQL95EBI-945833,EBI-9679045
DNAL4O960153EBI-945833,EBI-742362
DOCK2Q926085EBI-945833,EBI-448771
EFNA3P527973EBI-945833,EBI-722730
EIF4E2O605733EBI-945833,EBI-398610
EPHB6O15197-23EBI-945833,EBI-10182490
FAAHO005193EBI-945833,EBI-1389829
FAM124BQ9H5Z63EBI-945833,EBI-741626
FAM71CQ8NEG05EBI-945833,EBI-752049
FAM74A6Q5TZK35EBI-945833,EBI-10247271
FARS2O953633EBI-945833,EBI-2513774
FASLGP480233EBI-945833,EBI-495538
FBXL18Q96D163EBI-945833,EBI-744419
FBXW5Q969U65EBI-945833,EBI-741068
FOXB1Q998533EBI-945833,EBI-3916225
FRS3O435595EBI-945833,EBI-725515
GABRDO147643EBI-945833,EBI-744352
GATA2P237693EBI-945833,EBI-2806671
GEMP550403EBI-945833,EBI-744104
GFOD1Q9NXC23EBI-945833,EBI-8799578
GIPP096813EBI-945833,EBI-8588553
GLP1RP432203EBI-945833,EBI-7466542
GLRX3O760033EBI-945833,EBI-374781
GLYATQ6IB773EBI-945833,EBI-715463
GNAI2P048993EBI-945833,EBI-353997
GNEQ9Y2233EBI-945833,EBI-4291090
GSTP1P092115EBI-945833,EBI-353467
GTF3C5Q9Y5Q83EBI-945833,EBI-1045409
HBZP020085EBI-945833,EBI-719843
HCKP086313EBI-945833,EBI-346340
HEL-S-182mPV9HW603EBI-945833,EBI-10180762
HEL-S-90nV9HWJ53EBI-945833,EBI-10330335
HIST1H2AKA4FTV93EBI-945833,EBI-10173457
HOXA1P496395EBI-945833,EBI-740785
HPCAL1P372355EBI-945833,EBI-749311
HSBP1O755063EBI-945833,EBI-748664
HSD3B7Q9H2F33EBI-945833,EBI-3918847
HSPA12BQ96MM65EBI-945833,EBI-10291310
HSPBP1Q9NZL43EBI-945833,EBI-356763
HSPD1P108093EBI-945833,EBI-352528
ICAM4Q14773-35EBI-945833,EBI-10233928
IFI30P132843EBI-945833,EBI-2868897
IL2RGP317853EBI-945833,EBI-80475
INPP5DQ928353EBI-945833,EBI-1380477
ITGB2P051075EBI-945833,EBI-300173
ITGB5L7RT223EBI-945833,EBI-10178729
JOSD1Q150405EBI-945833,EBI-2510602
KCTD15Q96SI13EBI-945833,EBI-715783
KLHL38Q2WGJ65EBI-945833,EBI-6426443
KLK8O602595EBI-945833,EBI-3915857
KRT20P359003EBI-945833,EBI-742094
KRT83P783855EBI-945833,EBI-10221390
KRTAP10-11P604123EBI-945833,EBI-10217483
KRTAP10-5P603705EBI-945833,EBI-10172150
KRTAP10-7P604093EBI-945833,EBI-10172290
KRTAP10-8P604105EBI-945833,EBI-10171774
KRTAP10-9P604115EBI-945833,EBI-10172052
KRTAP12-2P599915EBI-945833,EBI-10176379
KRTAP12-4P603295EBI-945833,EBI-10176396
KRTAP13-3Q3SY465EBI-945833,EBI-10241252
KRTAP26-1Q6PEX35EBI-945833,EBI-3957672
KRTAP3-1Q9BYR83EBI-945833,EBI-9996449
KRTAP4-11Q9BYQ65EBI-945833,EBI-10302392
KRTAP4-12Q9BQ663EBI-945833,EBI-739863
KRTAP4-2Q9BYR55EBI-945833,EBI-10172511
KRTAP4-7Q9BYR03EBI-945833,EBI-10302547
KRTAP5-6Q6L8G95EBI-945833,EBI-10250562
KRTAP5-9P263715EBI-945833,EBI-3958099
KRTAP9-2Q9BYQ45EBI-945833,EBI-1044640
KRTAP9-4Q9BYQ23EBI-945833,EBI-10185730
LCE1BQ5T7P35EBI-945833,EBI-10245913
LCE2DQ5TA825EBI-945833,EBI-10246750
LCE3CQ5T5A85EBI-945833,EBI-10245291
LCE3EQ5T5B05EBI-945833,EBI-10245456
LIMS2Q7Z4I7-53EBI-945833,EBI-10257651
LIN7AO149103EBI-945833,EBI-2513988
LINC00526Q96FQ75EBI-945833,EBI-10286106
LMO2P257913EBI-945833,EBI-739696
LNX1Q8TBB15EBI-945833,EBI-739832
LOC200261Q17RD93EBI-945833,EBI-10239007
LONRF3Q496Y03EBI-945833,EBI-2690768
LRCH4O754273EBI-945833,EBI-718707
LRFN4Q6PJG95EBI-945833,EBI-7910762
MAPKBP1O603365EBI-945833,EBI-947402
MARK4Q6IPE93EBI-945833,EBI-10250211
MATN3O152323EBI-945833,EBI-6262458
MELTFP08582-25EBI-945833,EBI-10195914
MGC13033Q4ZG743EBI-945833,EBI-10241963
MRGBPQ9NV565EBI-945833,EBI-399076
MRPL40Q9NQ505EBI-945833,EBI-1053902
MTA1Q133303EBI-945833,EBI-714236
MXD3Q9BW115EBI-945833,EBI-741574
MXI1P50539-33EBI-945833,EBI-10211940
NAB2Q157423EBI-945833,EBI-8641936
NAXDQ8IW453EBI-945833,EBI-8650724
NECTIN2Q926923EBI-945833,EBI-718419
NECTIN3Q9NQS33EBI-945833,EBI-2826725
NEU2Q9Y3R43EBI-945833,EBI-10327976
NMUP486455EBI-945833,EBI-10210351
NPBWR2P481463EBI-945833,EBI-10210114
NPDC1Q9NQX55EBI-945833,EBI-748927
NPPBP168603EBI-945833,EBI-747044
NR1D2Q6NSM05EBI-945833,EBI-10250949
NUBP2Q9Y5Y23EBI-945833,EBI-1048886
P2RX4Q995715EBI-945833,EBI-2828248
PCED1AQ9H1Q73EBI-945833,EBI-748452
PCED1BQ96HM73EBI-945833,EBI-1222622
PCSK5Q928243EBI-945833,EBI-751290
PDE9AO760833EBI-945833,EBI-742764
PID1Q7Z2X43EBI-945833,EBI-10256685
PIGSQ96S525EBI-945833,EBI-2908273
PLPP2O436883EBI-945833,EBI-722017
PLSCR4Q9NRQ23EBI-945833,EBI-769257
POMGNT2Q8NAT13EBI-945833,EBI-10269044
PRKAA2P546463EBI-945833,EBI-1383852
PRPF31F1T0A53EBI-945833,EBI-10177194
PRPS2P119083EBI-945833,EBI-4290895
PSMA1P257865EBI-945833,EBI-359352
PSMG2Q969U73EBI-945833,EBI-723276
PTGER3Q147X83EBI-945833,EBI-10234038
PTPMT1Q8WUK05EBI-945833,EBI-7199479
PTPN23Q9H3S73EBI-945833,EBI-724478
PVRP151513EBI-945833,EBI-3919694
R3HDM2Q9Y2K5-23EBI-945833,EBI-10326419
RAB3IL1Q8TBN05EBI-945833,EBI-743796
RAMP3O608965EBI-945833,EBI-720447
RCHY1Q96PM53EBI-945833,EBI-947779
RECKQ6P9E25EBI-945833,EBI-10253121
RETP079493EBI-945833,EBI-2480756
RGL2O152113EBI-945833,EBI-712355
RPS28P628573EBI-945833,EBI-353027
RTN4RL1Q86UN25EBI-945833,EBI-10258951
RYDENQ9NUL53EBI-945833,EBI-10313866
SCNM1Q9BWG65EBI-945833,EBI-748391
SDCBPO005603EBI-945833,EBI-727004
SELMQ8WWX93EBI-945833,EBI-10277687
SEMA4CQ9C0C45EBI-945833,EBI-10303490
SLC22A23A1A5C73EBI-945833,EBI-10171756
SLC23A1Q9UHI73EBI-945833,EBI-1759386
SLC25A10Q9UBX33EBI-945833,EBI-750394
SLC25A6P122363EBI-945833,EBI-356254
SLC6A20Q9NP915EBI-945833,EBI-10311198
SMARCE1Q969G33EBI-945833,EBI-455078
SMCPP499015EBI-945833,EBI-750494
SMOC1Q9H4F83EBI-945833,EBI-2801103
SNAI1O958633EBI-945833,EBI-1045459
SPATA8Q6RVD65EBI-945833,EBI-8635958
SPG7Q9UQ905EBI-945833,EBI-717201
SPINK2P201553EBI-945833,EBI-10200479
SPRY1O436095EBI-945833,EBI-3866665
STK16O757165EBI-945833,EBI-749295
TBC1D10CQ8IV043EBI-945833,EBI-10261452
THAP7Q9BT495EBI-945833,EBI-741350
THEMIS2Q5TEJ83EBI-945833,EBI-2806032
TINAGL1Q9GZM7-33EBI-945833,EBI-10303636
TMEM150AQ86TG15EBI-945833,EBI-2799342
TMEM231Q9H6L23EBI-945833,EBI-10307654
TMEM41AQ96HV53EBI-945833,EBI-10288884
TNIP3Q96KP63EBI-945833,EBI-2509913
TNK2Q079123EBI-945833,EBI-603457
TNP2Q4VB563EBI-945833,EBI-10241829
TRIM27P143733EBI-945833,EBI-719493
TRIM42A1L4B63EBI-945833,EBI-10172216
TRIM42Q8IWZ55EBI-945833,EBI-5235829
TRPV6Q9Y2603EBI-945833,EBI-750052
TSPAN4O148175EBI-945833,EBI-8652667
TXNDC5Q86UY05EBI-945833,EBI-2825190
UTP23Q9BRU95EBI-945833,EBI-5457544
UXTQ9UBK95EBI-945833,EBI-357355
WDR25Q64LD23EBI-945833,EBI-744560
WT1-ASQ062505EBI-945833,EBI-10223946
XCL2Q9UBD33EBI-945833,EBI-10319095
YIPF3Q9GZM53EBI-945833,EBI-743787
ZFYVE21Q9BQ243EBI-945833,EBI-2849569
ZNF32P170413EBI-945833,EBI-1965483
ZNF417Q8TAU35EBI-945833,EBI-740727
ZNF439Q8NDP43EBI-945833,EBI-747580
ZNF440Q8IYI85EBI-945833,EBI-726439
ZNF446Q96AF53EBI-945833,EBI-740232
ZNF581Q9P0T45EBI-945833,EBI-745520
ZNF587Q96SQ55EBI-945833,EBI-6427977

Protein-protein interaction databases

BioGridi132802. 244 interactors.
DIPiDIP-47315N.
IntActiQ7Z3S9. 345 interactors.
MINTiMINT-2879553.
STRINGi9606.ENSP00000354929.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3S9.
SMRiQ7Z3S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 24EGF-like 1PROSITE-ProRule annotationAdd BLAST24
Domaini25 – 63EGF-like 2PROSITE-ProRule annotationAdd BLAST39
Domaini66 – 104EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini105 – 141EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini143 – 180EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini182 – 219EGF-like 6PROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the NOTCH family.Curated
Contains 6 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00420000029746.
ENSGT00840000129708.
HOVERGENiHBG104750.
InParanoidiQ7Z3S9.
OMAiITIRRIR.
OrthoDBiEOG091G0F6Z.
PhylomeDBiQ7Z3S9.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF07645. EGF_CA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT
60 70 80 90 100
CRCASGFTGE DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG
110 120 130 140 150
KECQWTDACL SHPCANGSTC TTVANQFSCK CLTGFTGQKC ETDVNECDIP
160 170 180 190 200
GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD SLYVPCAPSP CVNGGTCRQT
210 220 230
GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
Length:236
Mass (Da):25,835
Last modified:October 1, 2003 - v1
Checksum:i2DF01880A22814C9
GO
Isoform 2 (identifier: Q7Z3S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-236: ETVRRGTELWERDREVWNGKEHDEN → ATWPIFPKLLSLQEKESYC

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):24,947
Checksum:i20FEA84A26A5D539
GO
Isoform 3 (identifier: Q7Z3S9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCRDGYEPCVNEGM

Show »
Length:249
Mass (Da):27,289
Checksum:i960F7D405055C9FC
GO

Sequence cautioni

The sequence AAH84572 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11381 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19L → S in BAC11381 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04360167S → P.Corresponds to variant rs10910779dbSNPEnsembl.1
Natural variantiVAR_043602158T → I.1 PublicationCorresponds to variant rs8002dbSNPEnsembl.1
Natural variantiVAR_043603196T → S.Corresponds to variant rs4649852dbSNPEnsembl.1
Natural variantiVAR_043604226E → Q.Corresponds to variant rs1053710dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0338951M → MCRDGYEPCVNEGM in isoform 3. 1 Publication1
Alternative sequenceiVSP_033896212 – 236ETVRR…EHDEN → ATWPIFPKLLSLQEKESYC in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075065 mRNA. Translation: BAC11381.1. Different initiation.
BX537434 mRNA. Translation: CAD97676.1.
AL592307 Genomic DNA. Translation: CAH73993.1.
AL592307 Genomic DNA. Translation: CAH73994.1.
BC010154 mRNA. Translation: AAH10154.3.
BC019835 mRNA. Translation: AAH19835.1.
BC065219 mRNA. Translation: AAH65219.2.
BC084572 mRNA. Translation: AAH84572.1. Different initiation.
BC090943 mRNA. Translation: AAH90943.1.
CCDSiCCDS72880.1. [Q7Z3S9-1]
RefSeqiNP_982283.2. NM_203458.4. [Q7Z3S9-1]
XP_006711766.1. XM_006711703.3.
XP_006726418.1. XM_006726355.3.
XP_016855384.1. XM_016999895.1. [Q7Z3S9-1]
XP_016855385.1. XM_016999896.1. [Q7Z3S9-1]
XP_016855386.1. XM_016999897.1. [Q7Z3S9-1]
XP_016855387.1. XM_016999898.1. [Q7Z3S9-1]
XP_016858537.1. XM_017003048.1. [Q7Z3S9-1]
XP_016858538.1. XM_017003049.1. [Q7Z3S9-1]
XP_016858539.1. XM_017003050.1. [Q7Z3S9-1]
XP_016858540.1. XM_017003051.1. [Q7Z3S9-1]
UniGeneiHs.655156.
Hs.683989.
Hs.728902.

Genome annotation databases

EnsembliENST00000362074; ENSP00000354929; ENSG00000264343. [Q7Z3S9-1]
ENST00000578207; ENSP00000464060; ENSG00000264343. [Q7Z3S9-1]
ENST00000579793; ENSP00000476330; ENSG00000264343. [Q7Z3S9-2]
GeneIDi100996717.
100996763.
388677.
KEGGihsa:100996763.
hsa:388677.
UCSCiuc031utx.2. human. [Q7Z3S9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075065 mRNA. Translation: BAC11381.1. Different initiation.
BX537434 mRNA. Translation: CAD97676.1.
AL592307 Genomic DNA. Translation: CAH73993.1.
AL592307 Genomic DNA. Translation: CAH73994.1.
BC010154 mRNA. Translation: AAH10154.3.
BC019835 mRNA. Translation: AAH19835.1.
BC065219 mRNA. Translation: AAH65219.2.
BC084572 mRNA. Translation: AAH84572.1. Different initiation.
BC090943 mRNA. Translation: AAH90943.1.
CCDSiCCDS72880.1. [Q7Z3S9-1]
RefSeqiNP_982283.2. NM_203458.4. [Q7Z3S9-1]
XP_006711766.1. XM_006711703.3.
XP_006726418.1. XM_006726355.3.
XP_016855384.1. XM_016999895.1. [Q7Z3S9-1]
XP_016855385.1. XM_016999896.1. [Q7Z3S9-1]
XP_016855386.1. XM_016999897.1. [Q7Z3S9-1]
XP_016855387.1. XM_016999898.1. [Q7Z3S9-1]
XP_016858537.1. XM_017003048.1. [Q7Z3S9-1]
XP_016858538.1. XM_017003049.1. [Q7Z3S9-1]
XP_016858539.1. XM_017003050.1. [Q7Z3S9-1]
XP_016858540.1. XM_017003051.1. [Q7Z3S9-1]
UniGeneiHs.655156.
Hs.683989.
Hs.728902.

3D structure databases

ProteinModelPortaliQ7Z3S9.
SMRiQ7Z3S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132802. 244 interactors.
DIPiDIP-47315N.
IntActiQ7Z3S9. 345 interactors.
MINTiMINT-2879553.
STRINGi9606.ENSP00000354929.

Polymorphism and mutation databases

DMDMi74750065.

Proteomic databases

MaxQBiQ7Z3S9.
PaxDbiQ7Z3S9.
PeptideAtlasiQ7Z3S9.
PRIDEiQ7Z3S9.
TopDownProteomicsiQ7Z3S9-3. [Q7Z3S9-3]

Protocols and materials databases

DNASUi388677.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362074; ENSP00000354929; ENSG00000264343. [Q7Z3S9-1]
ENST00000578207; ENSP00000464060; ENSG00000264343. [Q7Z3S9-1]
ENST00000579793; ENSP00000476330; ENSG00000264343. [Q7Z3S9-2]
GeneIDi100996717.
100996763.
388677.
KEGGihsa:100996763.
hsa:388677.
UCSCiuc031utx.2. human. [Q7Z3S9-1]

Organism-specific databases

CTDi388677.
GeneCardsiNOTCH2NL.
HGNCiHGNC:31862. NOTCH2NL.
HPAiCAB004669.
HPA046392.
neXtProtiNX_Q7Z3S9.
OpenTargetsiENSG00000264343.
ENSG00000271383.
PharmGKBiPA134983899.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00420000029746.
ENSGT00840000129708.
HOVERGENiHBG104750.
InParanoidiQ7Z3S9.
OMAiITIRRIR.
OrthoDBiEOG091G0F6Z.
PhylomeDBiQ7Z3S9.

Enzyme and pathway databases

BioCyciZFISH:G66-31048-MONOMER.

Miscellaneous databases

PMAP-CutDBQ7Z3S9.
PROiQ7Z3S9.

Gene expression databases

BgeeiENSG00000213240.
CleanExiHS_NOTCH2NL.
GenevisibleiQ7Z3S9. HS.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
[Graphical view]
PfamiPF00008. EGF. 3 hits.
PF07645. EGF_CA. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNT2NL_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3S9
Secondary accession number(s): Q5BKT8
, Q5VTG9, Q5XG84, Q6P192, Q8NC23, Q8WUQ9, Q96FY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.