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Protein

Solute carrier family 46 member 3

Gene

SLC46A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.1.50.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 46 member 3
Gene namesi
Name:SLC46A3
ORF Names:FKSG16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:27501. SLC46A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 7348ExtracellularSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Topological domaini95 – 1017CytoplasmicSequence analysis
Transmembranei102 – 12423HelicalSequence analysisAdd
BLAST
Topological domaini125 – 1339ExtracellularSequence analysis
Transmembranei134 – 15623HelicalSequence analysisAdd
BLAST
Topological domaini157 – 17014CytoplasmicSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 1976ExtracellularSequence analysis
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 26143CytoplasmicSequence analysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence analysisAdd
BLAST
Topological domaini283 – 29412ExtracellularSequence analysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Topological domaini316 – 3249CytoplasmicSequence analysis
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 3472ExtracellularSequence analysis
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 38214CytoplasmicSequence analysisAdd
BLAST
Transmembranei383 – 40321HelicalSequence analysisAdd
BLAST
Topological domaini404 – 41512ExtracellularSequence analysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Topological domaini437 – 46125CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403791.

Polymorphism and mutation databases

BioMutaiSLC46A3.
DMDMi74723295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 461436Solute carrier family 46 member 3PRO_0000307253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7Z3Q1.
PaxDbiQ7Z3Q1.
PeptideAtlasiQ7Z3Q1.
PRIDEiQ7Z3Q1.

PTM databases

iPTMnetiQ7Z3Q1.
PhosphoSiteiQ7Z3Q1.

Expressioni

Gene expression databases

BgeeiENSG00000139508.
CleanExiHS_SLC46A3.
ExpressionAtlasiQ7Z3Q1. baseline and differential.
GenevisibleiQ7Z3Q1. HS.

Organism-specific databases

HPAiHPA039930.

Interactioni

Protein-protein interaction databases

BioGridi129597. 1 interaction.
STRINGi9606.ENSP00000370192.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3Q1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000074207.
HOVERGENiHBG108453.
InParanoidiQ7Z3Q1.
KOiK14613.
OMAiCLSAFAM.
OrthoDBiEOG091G08MP.
PhylomeDBiQ7Z3Q1.
TreeFamiTF315701.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILFVEPAI FLSAFAMTLT GPLTTQYVYR RIWEETGNYT FSSDSNISEC
60 70 80 90 100
EKNKSSPIFA FQEEVQKKVS RFNLQMDISG LIPGLVSTFI LLSISDHYGR
110 120 130 140 150
KFPMILSSVG ALATSVWLCL LCYFAFPFQL LIASTFIGAF CGNYTTFWGA
160 170 180 190 200
CFAYIVDQCK EHKQKTIRIA IIDFLLGLVT GLTGLSSGYF IRELGFEWSF
210 220 230 240 250
LIIAVSLAVN LIYILFFLGD PVKECSSQNV TMSCSEGFKN LFYRTYMLFK
260 270 280 290 300
NASGKRRFLL CLLLFTVITY FFVVIGIAPI FILYELDSPL CWNEVFIGYG
310 320 330 340 350
SALGSASFLT SFLGIWLFSY CMEDIHMAFI GIFTTMTGMA MTAFASTTLM
360 370 380 390 400
MFLARVPFLF TIVPFSVLRS MLSKVVRSTE QGTLFACIAF LETLGGVTAV
410 420 430 440 450
STFNGIYSAT VAWYPGFTFL LSAGLLLLPA ISLCVVKCTS WNEGSYELLI
460
QEESSEDASD R
Length:461
Mass (Da):51,519
Last modified:October 1, 2003 - v1
Checksum:iCF1227F889055DE5
GO
Isoform 2 (identifier: Q7Z3Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     461-461: R → RAC

Show »
Length:463
Mass (Da):51,694
Checksum:i13C80F1227F88905
GO
Isoform 3 (identifier: Q7Z3Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:386
Mass (Da):42,830
Checksum:i4988E4603352A282
GO

Sequence cautioni

The sequence BAC85896 differs from that shown. Reason: Frameshift at position 353. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091V → I in AAH68556 (PubMed:15489334).Curated
Sequence conflicti126 – 1261F → L in AAL18405 (Ref. 1) Curated
Sequence conflicti140 – 1401F → I in AAL18405 (Ref. 1) Curated
Sequence conflicti159 – 1591C → F in AAH36662 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 3. 1 PublicationVSP_028648Add
BLAST
Alternative sequencei461 – 4611R → RAC in isoform 2. 2 PublicationsVSP_028649

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315594 mRNA. Translation: AAL18405.1.
AK124604 mRNA. Translation: BAC85896.1. Frameshift.
BX537565 mRNA. Translation: CAD97783.1.
AL359454 Genomic DNA. Translation: CAI17158.1.
AL359454 Genomic DNA. Translation: CAM24029.1.
CH471075 Genomic DNA. Translation: EAX08436.1.
CH471075 Genomic DNA. Translation: EAX08438.1.
BC036662 mRNA. Translation: AAH36662.1.
BC060850 mRNA. Translation: AAH60850.1.
BC068556 mRNA. Translation: AAH68556.1.
CCDSiCCDS45021.1. [Q7Z3Q1-2]
CCDS9332.1. [Q7Z3Q1-1]
RefSeqiNP_001129391.1. NM_001135919.1. [Q7Z3Q1-2]
NP_861450.1. NM_181785.3. [Q7Z3Q1-1]
XP_005266418.1. XM_005266361.2. [Q7Z3Q1-2]
UniGeneiHs.117167.

Genome annotation databases

EnsembliENST00000266943; ENSP00000266943; ENSG00000139508. [Q7Z3Q1-1]
ENST00000380814; ENSP00000370192; ENSG00000139508. [Q7Z3Q1-2]
GeneIDi283537.
KEGGihsa:283537.
UCSCiuc001ush.4. human. [Q7Z3Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315594 mRNA. Translation: AAL18405.1.
AK124604 mRNA. Translation: BAC85896.1. Frameshift.
BX537565 mRNA. Translation: CAD97783.1.
AL359454 Genomic DNA. Translation: CAI17158.1.
AL359454 Genomic DNA. Translation: CAM24029.1.
CH471075 Genomic DNA. Translation: EAX08436.1.
CH471075 Genomic DNA. Translation: EAX08438.1.
BC036662 mRNA. Translation: AAH36662.1.
BC060850 mRNA. Translation: AAH60850.1.
BC068556 mRNA. Translation: AAH68556.1.
CCDSiCCDS45021.1. [Q7Z3Q1-2]
CCDS9332.1. [Q7Z3Q1-1]
RefSeqiNP_001129391.1. NM_001135919.1. [Q7Z3Q1-2]
NP_861450.1. NM_181785.3. [Q7Z3Q1-1]
XP_005266418.1. XM_005266361.2. [Q7Z3Q1-2]
UniGeneiHs.117167.

3D structure databases

ProteinModelPortaliQ7Z3Q1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129597. 1 interaction.
STRINGi9606.ENSP00000370192.

Protein family/group databases

TCDBi2.A.1.50.3. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ7Z3Q1.
PhosphoSiteiQ7Z3Q1.

Polymorphism and mutation databases

BioMutaiSLC46A3.
DMDMi74723295.

Proteomic databases

MaxQBiQ7Z3Q1.
PaxDbiQ7Z3Q1.
PeptideAtlasiQ7Z3Q1.
PRIDEiQ7Z3Q1.

Protocols and materials databases

DNASUi283537.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266943; ENSP00000266943; ENSG00000139508. [Q7Z3Q1-1]
ENST00000380814; ENSP00000370192; ENSG00000139508. [Q7Z3Q1-2]
GeneIDi283537.
KEGGihsa:283537.
UCSCiuc001ush.4. human. [Q7Z3Q1-1]

Organism-specific databases

CTDi283537.
GeneCardsiSLC46A3.
HGNCiHGNC:27501. SLC46A3.
HPAiHPA039930.
neXtProtiNX_Q7Z3Q1.
PharmGKBiPA162403791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2816. Eukaryota.
ENOG410ZVCA. LUCA.
GeneTreeiENSGT00530000063076.
HOGENOMiHOG000074207.
HOVERGENiHBG108453.
InParanoidiQ7Z3Q1.
KOiK14613.
OMAiCLSAFAM.
OrthoDBiEOG091G08MP.
PhylomeDBiQ7Z3Q1.
TreeFamiTF315701.

Miscellaneous databases

GenomeRNAii283537.
PROiQ7Z3Q1.

Gene expression databases

BgeeiENSG00000139508.
CleanExiHS_SLC46A3.
ExpressionAtlasiQ7Z3Q1. baseline and differential.
GenevisibleiQ7Z3Q1. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS46A3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3Q1
Secondary accession number(s): Q3ZCV8
, Q6NUK5, Q6P9B3, Q6ZVG5, Q96QA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.