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Q7Z3K3

- POGZ_HUMAN

UniProt

Q7Z3K3 - POGZ_HUMAN

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Protein

Pogo transposable element with ZNF domain

Gene

POGZ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri375 – 39723C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 67024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri771 – 79424C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri815 – 84026C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. kinetochore assembly Source: UniProtKB
  2. mitotic sister chromatid cohesion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Pogo transposable element with ZNF domain
Alternative name(s):
Suppressor of hairy wing homolog 5
Zinc finger protein 280E
Zinc finger protein 635
Gene namesi
Name:POGZ
Synonyms:KIAA0461, SUHW5, ZNF280E, ZNF635
ORF Names:Nbla00003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18801. POGZ.

Subcellular locationi

Nucleus. Chromosome. Cytoplasm
Note: According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear chromatin Source: UniProtKB
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi817 – 8171C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. 1 Publication
Mutagenesisi820 – 8201C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. 1 Publication
Mutagenesisi833 – 8331H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. 1 Publication
Mutagenesisi840 – 8401H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. 1 Publication

Organism-specific databases

PharmGKBiPA38685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14101410Pogo transposable element with ZNF domainPRO_0000047224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Phosphoserine1 Publication
Modified residuei425 – 4251Phosphoserine3 Publications
Modified residuei439 – 4391Phosphothreonine1 Publication
Modified residuei445 – 4451Phosphoserine1 Publication
Modified residuei1338 – 13381Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z3K3.
PaxDbiQ7Z3K3.
PRIDEiQ7Z3K3.

PTM databases

PhosphoSiteiQ7Z3K3.

Expressioni

Gene expression databases

BgeeiQ7Z3K3.
CleanExiHS_POGZ.
ExpressionAtlasiQ7Z3K3. baseline and differential.
GenevestigatoriQ7Z3K3.

Organism-specific databases

HPAiHPA006800.
HPA008781.

Interactioni

Subunit structurei

Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX5P459736EBI-1389308,EBI-78219
SP1P080472EBI-1389308,EBI-298336

Protein-protein interaction databases

BioGridi116745. 17 interactions.
DIPiDIP-38044N.
IntActiQ7Z3K3. 57 interactions.
MINTiMINT-144501.

Structurei

Secondary structure

1
1410
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni378 – 3803
Helixi387 – 39711
Turni399 – 4013

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E72NMR-A370-405[»]
ProteinModelPortaliQ7Z3K3.
SMRiQ7Z3K3. Positions 374-405, 489-669, 771-798, 814-840.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z3K3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1015 – 108571HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini1117 – 1323207DDEAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni810 – 85041Required for interaction with CBX5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1340 – 136021Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi875 – 93157Pro-richAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri375 – 39723C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri530 – 55324C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri560 – 58324C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61324C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri619 – 64123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri647 – 67024C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri771 – 79424C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri815 – 84026C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG239493.
GeneTreeiENSGT00530000063300.
HOVERGENiHBG049435.
InParanoidiQ7Z3K3.
OMAiTPTHPQP.
OrthoDBiEOG7QVM24.
PhylomeDBiQ7Z3K3.
TreeFamiTF331707.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z3K3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS
60 70 80 90 100
APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV
110 120 130 140 150
QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI
160 170 180 190 200
TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV
210 220 230 240 250
GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK
260 270 280 290 300
STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS
310 320 330 340 350
FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR
360 370 380 390 400
TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE
410 420 430 440 450
MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV
460 470 480 490 500
PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT
510 520 530 540 550
KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE
560 570 580 590 600
NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS
610 620 630 640 650
LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN
660 670 680 690 700
KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV
710 720 730 740 750
PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR
760 770 780 790 800
QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP
810 820 830 840 850
KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL
860 870 880 890 900
TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL
910 920 930 940 950
LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP
960 970 980 990 1000
VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ
1010 1020 1030 1040 1050
RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL
1060 1070 1080 1090 1100
FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN
1110 1120 1130 1140 1150
AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV
1160 1170 1180 1190 1200
GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS
1210 1220 1230 1240 1250
DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP
1260 1270 1280 1290 1300
AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL
1310 1320 1330 1340 1350
VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI
1360 1370 1380 1390 1400
ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF
1410
EEADLDLMEI
Length:1,410
Mass (Da):155,344
Last modified:April 3, 2007 - v2
Checksum:i58F672EDCD57CCD8
GO
Isoform 2 (identifier: Q7Z3K3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.

Note: No experimental confirmation available.

Show »
Length:1,357
Mass (Da):150,130
Checksum:i3EC92965C8E95A98
GO
Isoform 3 (identifier: Q7Z3K3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     593-593: Q → QPYFPSYVTQ

Note: No experimental confirmation available.

Show »
Length:1,366
Mass (Da):151,213
Checksum:iC88635F4469B70AA
GO
Isoform 4 (identifier: Q7Z3K3-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-363: VTSS → GTIT
     364-1410: Missing.

Note: No experimental confirmation available.

Show »
Length:363
Mass (Da):37,882
Checksum:iE4CA34C166CC3E78
GO
Isoform 5 (identifier: Q7Z3K3-5) [UniParc]FASTAAdd to Basket

Also known as: CRA_e

The sequence of this isoform differs from the canonical sequence as follows:
     96-190: Missing.

Note: Gene prediction based on EST data.

Show »
Length:1,315
Mass (Da):145,295
Checksum:i457D70CDC875B81C
GO
Isoform 6 (identifier: Q7Z3K3-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-295: Missing.

Show »
Length:1,401
Mass (Da):154,492
Checksum:i99537C2A84842376
GO
Isoform 7 (identifier: Q7Z3K3-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     287-295: Missing.

Show »
Length:1,348
Mass (Da):149,278
Checksum:i0016C4CF1C9CB146
GO

Sequence cautioni

The sequence BAE45744.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAI16808.2 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI16810.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131R → G in BAG63781. (PubMed:14702039)Curated
Sequence conflicti327 – 3271I → F in BAG62060. (PubMed:14702039)Curated
Sequence conflicti503 – 5031L → P in BAB87117. (PubMed:12880961)Curated
Sequence conflicti503 – 5031L → P in BAE45744. (PubMed:12880961)Curated
Sequence conflicti727 – 7271V → A in BAG63781. (PubMed:14702039)Curated
Sequence conflicti788 – 7881N → T in CAB45136. (PubMed:10976766)Curated
Sequence conflicti888 – 8881K → E in BAB87117. (PubMed:12880961)Curated
Sequence conflicti888 – 8881K → E in BAE45744. (PubMed:12880961)Curated
Sequence conflicti933 – 9331A → V in CAD97850. (PubMed:17974005)Curated
Sequence conflicti1026 – 10261E → G in CAD97850. (PubMed:17974005)Curated
Sequence conflicti1078 – 10781R → W in BAB87117. (PubMed:12880961)Curated
Sequence conflicti1078 – 10781R → W in BAE45744. (PubMed:12880961)Curated
Sequence conflicti1092 – 110716TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117. (PubMed:12880961)CuratedAdd
BLAST
Sequence conflicti1092 – 110716TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744. (PubMed:12880961)CuratedAdd
BLAST
Sequence conflicti1248 – 12481T → A in BAG63781. (PubMed:14702039)Curated
Sequence conflicti1304 – 13041W → R in CAD97850. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1365 – 13651E → D.
Corresponds to variant rs35198305 [ dbSNP | Ensembl ].
VAR_031476

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 9453Missing in isoform 2, isoform 3 and isoform 7. 3 PublicationsVSP_010185Add
BLAST
Alternative sequencei96 – 19095Missing in isoform 5. CuratedVSP_030150Add
BLAST
Alternative sequencei287 – 2959Missing in isoform 6 and isoform 7. 1 PublicationVSP_046785
Alternative sequencei360 – 3634VTSS → GTIT in isoform 4. 1 PublicationVSP_010187
Alternative sequencei364 – 14101047Missing in isoform 4. 1 PublicationVSP_010188Add
BLAST
Alternative sequencei593 – 5931Q → QPYFPSYVTQ in isoform 3. 1 PublicationVSP_010186

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX537838 mRNA. Translation: CAD97850.1.
AK300307 mRNA. Translation: BAG62060.1.
AK302501 mRNA. Translation: BAG63781.1.
AL589764 Genomic DNA. Translation: CAI16807.1.
AL589764 Genomic DNA. Translation: CAI16808.2. Sequence problems.
AL589764 Genomic DNA. Translation: CAI16809.1.
AL589764 Genomic DNA. Translation: CAI16810.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53440.1.
AB037911 mRNA. Translation: BAB87117.1.
AB075477 mRNA. Translation: BAE45744.1. Different initiation.
AJ242979 mRNA. Translation: CAB45136.1.
BC057773 mRNA. Translation: AAH57773.1.
AB007930 mRNA. Translation: BAA32306.1.
CCDSiCCDS44222.2. [Q7Z3K3-5]
CCDS53365.1. [Q7Z3K3-7]
CCDS53366.1. [Q7Z3K3-6]
CCDS997.1. [Q7Z3K3-1]
CCDS998.1. [Q7Z3K3-2]
PIRiT00075.
RefSeqiNP_001181866.1. NM_001194937.1. [Q7Z3K3-6]
NP_001181867.1. NM_001194938.1. [Q7Z3K3-7]
NP_055915.2. NM_015100.3. [Q7Z3K3-1]
NP_665739.3. NM_145796.3. [Q7Z3K3-5]
NP_997054.1. NM_207171.2. [Q7Z3K3-2]
XP_005245056.1. XM_005244999.1. [Q7Z3K3-1]
XP_005245057.1. XM_005245000.2. [Q7Z3K3-1]
XP_005245058.1. XM_005245001.1. [Q7Z3K3-1]
XP_005245060.1. XM_005245003.1. [Q7Z3K3-6]
XP_005245061.1. XM_005245004.1. [Q7Z3K3-2]
XP_005245062.1. XM_005245005.1. [Q7Z3K3-2]
XP_005245063.1. XM_005245006.2. [Q7Z3K3-2]
XP_006711300.1. XM_006711237.1. [Q7Z3K3-7]
UniGeneiHs.489873.

Genome annotation databases

EnsembliENST00000271715; ENSP00000271715; ENSG00000143442. [Q7Z3K3-1]
ENST00000368863; ENSP00000357856; ENSG00000143442. [Q7Z3K3-5]
ENST00000392723; ENSP00000376484; ENSG00000143442. [Q7Z3K3-2]
ENST00000409503; ENSP00000386836; ENSG00000143442. [Q7Z3K3-6]
ENST00000491586; ENSP00000418408; ENSG00000143442. [Q7Z3K3-3]
ENST00000531094; ENSP00000431259; ENSG00000143442. [Q7Z3K3-7]
GeneIDi23126.
KEGGihsa:23126.
UCSCiuc001eyd.2. human. [Q7Z3K3-1]
uc001eyf.2. human. [Q7Z3K3-3]
uc001eyg.2. human. [Q7Z3K3-4]
uc009wmv.2. human. [Q7Z3K3-5]
uc021oyq.1. human. [Q7Z3K3-2]

Polymorphism databases

DMDMi143811442.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX537838 mRNA. Translation: CAD97850.1 .
AK300307 mRNA. Translation: BAG62060.1 .
AK302501 mRNA. Translation: BAG63781.1 .
AL589764 Genomic DNA. Translation: CAI16807.1 .
AL589764 Genomic DNA. Translation: CAI16808.2 . Sequence problems.
AL589764 Genomic DNA. Translation: CAI16809.1 .
AL589764 Genomic DNA. Translation: CAI16810.1 . Sequence problems.
CH471121 Genomic DNA. Translation: EAW53440.1 .
AB037911 mRNA. Translation: BAB87117.1 .
AB075477 mRNA. Translation: BAE45744.1 . Different initiation.
AJ242979 mRNA. Translation: CAB45136.1 .
BC057773 mRNA. Translation: AAH57773.1 .
AB007930 mRNA. Translation: BAA32306.1 .
CCDSi CCDS44222.2. [Q7Z3K3-5 ]
CCDS53365.1. [Q7Z3K3-7 ]
CCDS53366.1. [Q7Z3K3-6 ]
CCDS997.1. [Q7Z3K3-1 ]
CCDS998.1. [Q7Z3K3-2 ]
PIRi T00075.
RefSeqi NP_001181866.1. NM_001194937.1. [Q7Z3K3-6 ]
NP_001181867.1. NM_001194938.1. [Q7Z3K3-7 ]
NP_055915.2. NM_015100.3. [Q7Z3K3-1 ]
NP_665739.3. NM_145796.3. [Q7Z3K3-5 ]
NP_997054.1. NM_207171.2. [Q7Z3K3-2 ]
XP_005245056.1. XM_005244999.1. [Q7Z3K3-1 ]
XP_005245057.1. XM_005245000.2. [Q7Z3K3-1 ]
XP_005245058.1. XM_005245001.1. [Q7Z3K3-1 ]
XP_005245060.1. XM_005245003.1. [Q7Z3K3-6 ]
XP_005245061.1. XM_005245004.1. [Q7Z3K3-2 ]
XP_005245062.1. XM_005245005.1. [Q7Z3K3-2 ]
XP_005245063.1. XM_005245006.2. [Q7Z3K3-2 ]
XP_006711300.1. XM_006711237.1. [Q7Z3K3-7 ]
UniGenei Hs.489873.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E72 NMR - A 370-405 [» ]
ProteinModelPortali Q7Z3K3.
SMRi Q7Z3K3. Positions 374-405, 489-669, 771-798, 814-840.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116745. 17 interactions.
DIPi DIP-38044N.
IntActi Q7Z3K3. 57 interactions.
MINTi MINT-144501.

PTM databases

PhosphoSitei Q7Z3K3.

Polymorphism databases

DMDMi 143811442.

Proteomic databases

MaxQBi Q7Z3K3.
PaxDbi Q7Z3K3.
PRIDEi Q7Z3K3.

Protocols and materials databases

DNASUi 23126.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271715 ; ENSP00000271715 ; ENSG00000143442 . [Q7Z3K3-1 ]
ENST00000368863 ; ENSP00000357856 ; ENSG00000143442 . [Q7Z3K3-5 ]
ENST00000392723 ; ENSP00000376484 ; ENSG00000143442 . [Q7Z3K3-2 ]
ENST00000409503 ; ENSP00000386836 ; ENSG00000143442 . [Q7Z3K3-6 ]
ENST00000491586 ; ENSP00000418408 ; ENSG00000143442 . [Q7Z3K3-3 ]
ENST00000531094 ; ENSP00000431259 ; ENSG00000143442 . [Q7Z3K3-7 ]
GeneIDi 23126.
KEGGi hsa:23126.
UCSCi uc001eyd.2. human. [Q7Z3K3-1 ]
uc001eyf.2. human. [Q7Z3K3-3 ]
uc001eyg.2. human. [Q7Z3K3-4 ]
uc009wmv.2. human. [Q7Z3K3-5 ]
uc021oyq.1. human. [Q7Z3K3-2 ]

Organism-specific databases

CTDi 23126.
GeneCardsi GC01M151375.
HGNCi HGNC:18801. POGZ.
HPAi HPA006800.
HPA008781.
MIMi 614787. gene.
neXtProti NX_Q7Z3K3.
PharmGKBi PA38685.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239493.
GeneTreei ENSGT00530000063300.
HOVERGENi HBG049435.
InParanoidi Q7Z3K3.
OMAi TPTHPQP.
OrthoDBi EOG7QVM24.
PhylomeDBi Q7Z3K3.
TreeFami TF331707.

Miscellaneous databases

EvolutionaryTracei Q7Z3K3.
GeneWikii POGZ.
GenomeRNAii 23126.
NextBioi 44359.
PROi Q7Z3K3.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z3K3.
CleanExi HS_POGZ.
ExpressionAtlasi Q7Z3K3. baseline and differential.
Genevestigatori Q7Z3K3.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
Pfami PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7).
    Tissue: Placenta and Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1107 (ISOFORM 3).
    Tissue: Neuroblastoma.
  6. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
    Gunther M., Laithier M., Brison O.
    Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-788 (ISOFORM 1), INTERACTION WITH SP1.
    Tissue: Colon.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-363 (ISOFORM 4).
    Tissue: Placenta.
  8. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1410 (ISOFORM 2).
    Tissue: Brain.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-425 AND SER-1338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ."
    Bartholomeeusen K., Christ F., Hendrix J., Rain J.C., Emiliani S., Benarous R., Debyser Z., Gijsbers R., De Rijck J.
    J. Biol. Chem. 284:11467-11477(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PSIP1.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-439 AND SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."
    Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S., Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G., Mann M.
    Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CHAMP1; MAD2L2; CBX1; CBX3 AND CBX5.
  14. "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."
    Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C.
    Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CBX1; CBX3 AND CBX5, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-817; CYS-820; HIS-833 AND HIS-840.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Solution structure of the zinc finger domain of human KIAA0461."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 352-405.

Entry informationi

Entry nameiPOGZ_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3K3
Secondary accession number(s): B4DTP8
, B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q8TDZ7, Q9Y4X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3