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Q7Z3K3

- POGZ_HUMAN

UniProt

Q7Z3K3 - POGZ_HUMAN

Protein

Pogo transposable element with ZNF domain

Gene

POGZ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri375 – 39723C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri530 – 55324C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58324C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri590 – 61324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri619 – 64123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri647 – 67024C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri771 – 79424C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri815 – 84026C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. kinetochore assembly Source: UniProtKB
    2. mitotic sister chromatid cohesion Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pogo transposable element with ZNF domain
    Alternative name(s):
    Suppressor of hairy wing homolog 5
    Zinc finger protein 280E
    Zinc finger protein 635
    Gene namesi
    Name:POGZ
    Synonyms:KIAA0461, SUHW5, ZNF280E, ZNF635
    ORF Names:Nbla00003
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18801. POGZ.

    Subcellular locationi

    Nucleus. Chromosome. Cytoplasm
    Note: According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nuclear chromatin Source: UniProtKB
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi817 – 8171C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. 1 Publication
    Mutagenesisi820 – 8201C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. 1 Publication
    Mutagenesisi833 – 8331H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. 1 Publication
    Mutagenesisi840 – 8401H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. 1 Publication

    Organism-specific databases

    PharmGKBiPA38685.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14101410Pogo transposable element with ZNF domainPRO_0000047224Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Phosphoserine1 Publication
    Modified residuei425 – 4251Phosphoserine3 Publications
    Modified residuei439 – 4391Phosphothreonine1 Publication
    Modified residuei445 – 4451Phosphoserine1 Publication
    Modified residuei1338 – 13381Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z3K3.
    PaxDbiQ7Z3K3.
    PRIDEiQ7Z3K3.

    PTM databases

    PhosphoSiteiQ7Z3K3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z3K3.
    BgeeiQ7Z3K3.
    CleanExiHS_POGZ.
    GenevestigatoriQ7Z3K3.

    Organism-specific databases

    HPAiHPA006800.
    HPA008781.

    Interactioni

    Subunit structurei

    Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBX5P459736EBI-1389308,EBI-78219
    SP1P080472EBI-1389308,EBI-298336

    Protein-protein interaction databases

    BioGridi116745. 16 interactions.
    DIPiDIP-38044N.
    IntActiQ7Z3K3. 57 interactions.
    MINTiMINT-144501.

    Structurei

    Secondary structure

    1
    1410
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni378 – 3803
    Helixi387 – 39711
    Turni399 – 4013

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E72NMR-A370-405[»]
    ProteinModelPortaliQ7Z3K3.
    SMRiQ7Z3K3. Positions 374-405, 489-672, 771-798.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7Z3K3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1015 – 108571HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini1117 – 1323207DDEAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni810 – 85041Required for interaction with CBX5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1340 – 136021Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi875 – 93157Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri375 – 39723C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri494 – 51623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri530 – 55324C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri560 – 58324C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri590 – 61324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri619 – 64123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri647 – 67024C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri771 – 79424C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri815 – 84026C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG239493.
    HOVERGENiHBG049435.
    InParanoidiQ7Z3K3.
    OMAiTPTHPQP.
    OrthoDBiEOG7QVM24.
    PhylomeDBiQ7Z3K3.
    TreeFamiTF331707.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z3K3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS     50
    APVPIAAHAS VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV 100
    QQGGQPLILT QNPAPGLGTM VTQPVLRPVQ VMQNANHVTS SPVASQPIFI 150
    TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ TVRPITLVPA PGTQFVKPTV 200
    GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST VPQSQSQQTK 250
    STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS 300
    FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR 350
    TSGPESSMKV TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE 400
    MVEYQKKGKS LDSEPSVPSA AKPPSPEKTA PVASTPSSTP IPALSPPTKV 450
    PEPNENVGDA VQTKLIMLVD DFYYGRDGGK VAQLTNFPKV ATSFRCPHCT 500
    KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS TPFQLQCHLE 550
    NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS 600
    LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN 650
    KCRLQFLFAK DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV 700
    PVSSNDTPPS ALQEAAPLTS SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR 750
    QTCLECSFEI PDFPNHFPTY VHCSLCRYST CCSRAYANHM INNHVPRKSP 800
    KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH RSSSILPRGL 850
    TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL 900
    LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP 950
    VTQEPELASG GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ 1000
    RRIRRWLRRF QASQGENLEG KYLSFEAEEK LAEWVLTQRE QQLPVNEETL 1050
    FQKATKIGRS LEGGFKISYE WAVRFMLRHH LTPHARRAVA HTLPKDVAEN 1100
    AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD DRKENALQTV 1150
    GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS 1200
    DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP 1250
    AVVPAGCSSK IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL 1300
    VLVWLGEVLG VIGDCPELVQ RSFLVASVLP GPDGNINSPT RNADMQEELI 1350
    ASLEEQLKLS GEHSESSTPR PRSSPEETIE PESLHQLFEG ESETESFYGF 1400
    EEADLDLMEI 1410
    Length:1,410
    Mass (Da):155,344
    Last modified:April 3, 2007 - v2
    Checksum:i58F672EDCD57CCD8
    GO
    Isoform 2 (identifier: Q7Z3K3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-94: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,357
    Mass (Da):150,130
    Checksum:i3EC92965C8E95A98
    GO
    Isoform 3 (identifier: Q7Z3K3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-94: Missing.
         593-593: Q → QPYFPSYVTQ

    Note: No experimental confirmation available.

    Show »
    Length:1,366
    Mass (Da):151,213
    Checksum:iC88635F4469B70AA
    GO
    Isoform 4 (identifier: Q7Z3K3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         360-363: VTSS → GTIT
         364-1410: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:363
    Mass (Da):37,882
    Checksum:iE4CA34C166CC3E78
    GO
    Isoform 5 (identifier: Q7Z3K3-5) [UniParc]FASTAAdd to Basket

    Also known as: CRA_e

    The sequence of this isoform differs from the canonical sequence as follows:
         96-190: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:1,315
    Mass (Da):145,295
    Checksum:i457D70CDC875B81C
    GO
    Isoform 6 (identifier: Q7Z3K3-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         287-295: Missing.

    Show »
    Length:1,401
    Mass (Da):154,492
    Checksum:i99537C2A84842376
    GO
    Isoform 7 (identifier: Q7Z3K3-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-94: Missing.
         287-295: Missing.

    Show »
    Length:1,348
    Mass (Da):149,278
    Checksum:i0016C4CF1C9CB146
    GO

    Sequence cautioni

    The sequence BAE45744.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI16808.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI16810.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti213 – 2131R → G in BAG63781. (PubMed:14702039)Curated
    Sequence conflicti327 – 3271I → F in BAG62060. (PubMed:14702039)Curated
    Sequence conflicti503 – 5031L → P in BAB87117. (PubMed:12880961)Curated
    Sequence conflicti503 – 5031L → P in BAE45744. (PubMed:12880961)Curated
    Sequence conflicti727 – 7271V → A in BAG63781. (PubMed:14702039)Curated
    Sequence conflicti788 – 7881N → T in CAB45136. (PubMed:10976766)Curated
    Sequence conflicti888 – 8881K → E in BAB87117. (PubMed:12880961)Curated
    Sequence conflicti888 – 8881K → E in BAE45744. (PubMed:12880961)Curated
    Sequence conflicti933 – 9331A → V in CAD97850. (PubMed:17974005)Curated
    Sequence conflicti1026 – 10261E → G in CAD97850. (PubMed:17974005)Curated
    Sequence conflicti1078 – 10781R → W in BAB87117. (PubMed:12880961)Curated
    Sequence conflicti1078 – 10781R → W in BAE45744. (PubMed:12880961)Curated
    Sequence conflicti1092 – 110716TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117. (PubMed:12880961)CuratedAdd
    BLAST
    Sequence conflicti1092 – 110716TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744. (PubMed:12880961)CuratedAdd
    BLAST
    Sequence conflicti1248 – 12481T → A in BAG63781. (PubMed:14702039)Curated
    Sequence conflicti1304 – 13041W → R in CAD97850. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1365 – 13651E → D.
    Corresponds to variant rs35198305 [ dbSNP | Ensembl ].
    VAR_031476

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 9453Missing in isoform 2, isoform 3 and isoform 7. 3 PublicationsVSP_010185Add
    BLAST
    Alternative sequencei96 – 19095Missing in isoform 5. CuratedVSP_030150Add
    BLAST
    Alternative sequencei287 – 2959Missing in isoform 6 and isoform 7. 1 PublicationVSP_046785
    Alternative sequencei360 – 3634VTSS → GTIT in isoform 4. 1 PublicationVSP_010187
    Alternative sequencei364 – 14101047Missing in isoform 4. 1 PublicationVSP_010188Add
    BLAST
    Alternative sequencei593 – 5931Q → QPYFPSYVTQ in isoform 3. 1 PublicationVSP_010186

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX537838 mRNA. Translation: CAD97850.1.
    AK300307 mRNA. Translation: BAG62060.1.
    AK302501 mRNA. Translation: BAG63781.1.
    AL589764 Genomic DNA. Translation: CAI16807.1.
    AL589764 Genomic DNA. Translation: CAI16808.2. Sequence problems.
    AL589764 Genomic DNA. Translation: CAI16809.1.
    AL589764 Genomic DNA. Translation: CAI16810.1. Sequence problems.
    CH471121 Genomic DNA. Translation: EAW53440.1.
    AB037911 mRNA. Translation: BAB87117.1.
    AB075477 mRNA. Translation: BAE45744.1. Different initiation.
    AJ242979 mRNA. Translation: CAB45136.1.
    BC057773 mRNA. Translation: AAH57773.1.
    AB007930 mRNA. Translation: BAA32306.1.
    CCDSiCCDS44222.2. [Q7Z3K3-5]
    CCDS53365.1. [Q7Z3K3-7]
    CCDS53366.1. [Q7Z3K3-6]
    CCDS997.1. [Q7Z3K3-1]
    CCDS998.1. [Q7Z3K3-2]
    PIRiT00075.
    RefSeqiNP_001181866.1. NM_001194937.1. [Q7Z3K3-6]
    NP_001181867.1. NM_001194938.1. [Q7Z3K3-7]
    NP_055915.2. NM_015100.3. [Q7Z3K3-1]
    NP_665739.3. NM_145796.3. [Q7Z3K3-5]
    NP_997054.1. NM_207171.2. [Q7Z3K3-2]
    XP_005245056.1. XM_005244999.1. [Q7Z3K3-1]
    XP_005245057.1. XM_005245000.2. [Q7Z3K3-1]
    XP_005245058.1. XM_005245001.1. [Q7Z3K3-1]
    XP_005245060.1. XM_005245003.1. [Q7Z3K3-6]
    XP_005245061.1. XM_005245004.1. [Q7Z3K3-2]
    XP_005245062.1. XM_005245005.1. [Q7Z3K3-2]
    XP_005245063.1. XM_005245006.2. [Q7Z3K3-2]
    XP_006711300.1. XM_006711237.1. [Q7Z3K3-7]
    UniGeneiHs.489873.

    Genome annotation databases

    EnsembliENST00000271715; ENSP00000271715; ENSG00000143442. [Q7Z3K3-1]
    ENST00000368863; ENSP00000357856; ENSG00000143442. [Q7Z3K3-5]
    ENST00000392723; ENSP00000376484; ENSG00000143442. [Q7Z3K3-2]
    ENST00000409503; ENSP00000386836; ENSG00000143442. [Q7Z3K3-6]
    ENST00000491586; ENSP00000418408; ENSG00000143442. [Q7Z3K3-3]
    ENST00000531094; ENSP00000431259; ENSG00000143442. [Q7Z3K3-7]
    GeneIDi23126.
    KEGGihsa:23126.
    UCSCiuc001eyd.2. human. [Q7Z3K3-1]
    uc001eyf.2. human. [Q7Z3K3-3]
    uc001eyg.2. human. [Q7Z3K3-4]
    uc009wmv.2. human. [Q7Z3K3-5]
    uc021oyq.1. human. [Q7Z3K3-2]

    Polymorphism databases

    DMDMi143811442.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX537838 mRNA. Translation: CAD97850.1 .
    AK300307 mRNA. Translation: BAG62060.1 .
    AK302501 mRNA. Translation: BAG63781.1 .
    AL589764 Genomic DNA. Translation: CAI16807.1 .
    AL589764 Genomic DNA. Translation: CAI16808.2 . Sequence problems.
    AL589764 Genomic DNA. Translation: CAI16809.1 .
    AL589764 Genomic DNA. Translation: CAI16810.1 . Sequence problems.
    CH471121 Genomic DNA. Translation: EAW53440.1 .
    AB037911 mRNA. Translation: BAB87117.1 .
    AB075477 mRNA. Translation: BAE45744.1 . Different initiation.
    AJ242979 mRNA. Translation: CAB45136.1 .
    BC057773 mRNA. Translation: AAH57773.1 .
    AB007930 mRNA. Translation: BAA32306.1 .
    CCDSi CCDS44222.2. [Q7Z3K3-5 ]
    CCDS53365.1. [Q7Z3K3-7 ]
    CCDS53366.1. [Q7Z3K3-6 ]
    CCDS997.1. [Q7Z3K3-1 ]
    CCDS998.1. [Q7Z3K3-2 ]
    PIRi T00075.
    RefSeqi NP_001181866.1. NM_001194937.1. [Q7Z3K3-6 ]
    NP_001181867.1. NM_001194938.1. [Q7Z3K3-7 ]
    NP_055915.2. NM_015100.3. [Q7Z3K3-1 ]
    NP_665739.3. NM_145796.3. [Q7Z3K3-5 ]
    NP_997054.1. NM_207171.2. [Q7Z3K3-2 ]
    XP_005245056.1. XM_005244999.1. [Q7Z3K3-1 ]
    XP_005245057.1. XM_005245000.2. [Q7Z3K3-1 ]
    XP_005245058.1. XM_005245001.1. [Q7Z3K3-1 ]
    XP_005245060.1. XM_005245003.1. [Q7Z3K3-6 ]
    XP_005245061.1. XM_005245004.1. [Q7Z3K3-2 ]
    XP_005245062.1. XM_005245005.1. [Q7Z3K3-2 ]
    XP_005245063.1. XM_005245006.2. [Q7Z3K3-2 ]
    XP_006711300.1. XM_006711237.1. [Q7Z3K3-7 ]
    UniGenei Hs.489873.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E72 NMR - A 370-405 [» ]
    ProteinModelPortali Q7Z3K3.
    SMRi Q7Z3K3. Positions 374-405, 489-672, 771-798.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116745. 16 interactions.
    DIPi DIP-38044N.
    IntActi Q7Z3K3. 57 interactions.
    MINTi MINT-144501.

    PTM databases

    PhosphoSitei Q7Z3K3.

    Polymorphism databases

    DMDMi 143811442.

    Proteomic databases

    MaxQBi Q7Z3K3.
    PaxDbi Q7Z3K3.
    PRIDEi Q7Z3K3.

    Protocols and materials databases

    DNASUi 23126.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271715 ; ENSP00000271715 ; ENSG00000143442 . [Q7Z3K3-1 ]
    ENST00000368863 ; ENSP00000357856 ; ENSG00000143442 . [Q7Z3K3-5 ]
    ENST00000392723 ; ENSP00000376484 ; ENSG00000143442 . [Q7Z3K3-2 ]
    ENST00000409503 ; ENSP00000386836 ; ENSG00000143442 . [Q7Z3K3-6 ]
    ENST00000491586 ; ENSP00000418408 ; ENSG00000143442 . [Q7Z3K3-3 ]
    ENST00000531094 ; ENSP00000431259 ; ENSG00000143442 . [Q7Z3K3-7 ]
    GeneIDi 23126.
    KEGGi hsa:23126.
    UCSCi uc001eyd.2. human. [Q7Z3K3-1 ]
    uc001eyf.2. human. [Q7Z3K3-3 ]
    uc001eyg.2. human. [Q7Z3K3-4 ]
    uc009wmv.2. human. [Q7Z3K3-5 ]
    uc021oyq.1. human. [Q7Z3K3-2 ]

    Organism-specific databases

    CTDi 23126.
    GeneCardsi GC01M151375.
    HGNCi HGNC:18801. POGZ.
    HPAi HPA006800.
    HPA008781.
    MIMi 614787. gene.
    neXtProti NX_Q7Z3K3.
    PharmGKBi PA38685.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239493.
    HOVERGENi HBG049435.
    InParanoidi Q7Z3K3.
    OMAi TPTHPQP.
    OrthoDBi EOG7QVM24.
    PhylomeDBi Q7Z3K3.
    TreeFami TF331707.

    Miscellaneous databases

    EvolutionaryTracei Q7Z3K3.
    GeneWikii POGZ.
    GenomeRNAii 23126.
    NextBioi 44359.
    PROi Q7Z3K3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z3K3.
    Bgeei Q7Z3K3.
    CleanExi HS_POGZ.
    Genevestigatori Q7Z3K3.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7).
      Tissue: Placenta and Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
      Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
      Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1107 (ISOFORM 3).
      Tissue: Neuroblastoma.
    6. "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening."
      Gunther M., Laithier M., Brison O.
      Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-788 (ISOFORM 1), INTERACTION WITH SP1.
      Tissue: Colon.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-363 (ISOFORM 4).
      Tissue: Placenta.
    8. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
      DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1410 (ISOFORM 2).
      Tissue: Brain.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-425 AND SER-1338, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ."
      Bartholomeeusen K., Christ F., Hendrix J., Rain J.C., Emiliani S., Benarous R., Debyser Z., Gijsbers R., De Rijck J.
      J. Biol. Chem. 284:11467-11477(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PSIP1.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-439 AND SER-445, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."
      Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S., Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G., Mann M.
      Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CHAMP1; MAD2L2; CBX1; CBX3 AND CBX5.
    14. "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation."
      Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C.
      Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CBX1; CBX3 AND CBX5, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-817; CYS-820; HIS-833 AND HIS-840.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Solution structure of the zinc finger domain of human KIAA0461."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUL-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 352-405.

    Entry informationi

    Entry nameiPOGZ_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3K3
    Secondary accession number(s): B4DTP8
    , B4DYL9, B7ZBY5, E9PM80, O75049, Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q8TDZ7, Q9Y4X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3