Q7Z3K3 (POGZ_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pogo transposable element with ZNF domain

Alternative name(s):
Suppressor of hairy wing homolog 5
Zinc finger protein 280E
Zinc finger protein 635

Gene names

Name:	POGZ
Synonyms:	KIAA0461, SUHW5, ZNF280E, ZNF635
ORF Names:	Nbla00003

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1410 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. Ref.12
Subunit structure	Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1. Ref.5 Ref.9 Ref.11 Ref.12
Subcellular location	Nucleus. Chromosome. Cytoplasm. Note: According to some authors, it is not localized to mitotic chromatin (Ref.9). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). Ref.9 Ref.11 Ref.12
Sequence similarities	Contains 9 C2H2-type zinc fingers. Contains 1 DDE domain. Contains 1 HTH CENPB-type DNA-binding domain.
Sequence caution	The sequence BAE45744.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAI16808.2 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI16810.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Chromosome Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW kinetochore assembly Inferred from mutant phenotype Ref.12. Source: UniProtKB mitotic sister chromatid cohesion Inferred from mutant phenotype Ref.12. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay Ref.12. Source: UniProtKB nuclear chromatin Inferred from direct assay Ref.12. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CBX5	P45973	5	EBI-1389308,EBI-78219
SP1	P08047	2	EBI-1389308,EBI-298336

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z3K3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z3K3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q7Z3K3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     42-94: Missing.
     593-593: Q → QPYFPSYVTQ

Note: No experimental confirmation available.

Isoform 4 (identifier: Q7Z3K3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     360-363: VTSS → GTIT
     364-1410: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q7Z3K3-5)

Also known as: CRA_e;

The sequence of this isoform differs from the canonical sequence as follows:
     96-190: Missing.

Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1410

1410

Pogo transposable element with ZNF domain

PRO_0000047224

Regions

Domain

1015 – 1085

71

HTH CENPB-type

Domain

1117 – 1323

207

DDE

Zinc finger

375 – 397

23

C2H2-type 1; atypical

Zinc finger

494 – 516

23

C2H2-type 2

Zinc finger

530 – 553

24

C2H2-type 3

Zinc finger

560 – 583

24

C2H2-type 4

Zinc finger

590 – 613

24

C2H2-type 5

Zinc finger

619 – 641

23

C2H2-type 6

Zinc finger

647 – 670

24

C2H2-type 7

Zinc finger

771 – 794

24

C2H2-type 8

Zinc finger

815 – 840

26

C2H2-type 9

Region

810 – 850

41

Required for interaction with CBX5

Coiled coil

1340 – 1360

21

Potential

Compositional bias

875 – 931

57

Pro-rich

Amino acid modifications

Modified residue

333

1

Phosphoserine Ref.8

Modified residue

425

1

Phosphoserine Ref.8 Ref.13 Ref.14

Modified residue

439

1

Phosphothreonine Ref.10

Modified residue

445

1

Phosphoserine Ref.10

Modified residue

1338

1

Phosphoserine Ref.8

Natural variations

Alternative sequence

42 – 94

53

Missing in isoform 2 and isoform 3.

VSP_010185

Alternative sequence

96 – 190

95

Missing in isoform 5.

VSP_030150

Alternative sequence

360 – 363

4

VTSS → GTIT in isoform 4.

VSP_010187

Alternative sequence

364 – 1410

1047

Missing in isoform 4.

VSP_010188

Alternative sequence

593

1

Q → QPYFPSYVTQ in isoform 3.

VSP_010186

Natural variant

1365

1

E → D.
Corresponds to variant rs35198305 [ dbSNP | Ensembl ].

VAR_031476

Experimental info

Mutagenesis

817

1

C → A: Diminishes interaction with CBX5 and abolishes interaction with CBX1 and CBX5; when associated with A-820; A-833 and A-840. Ref.12

Mutagenesis

820

1

C → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with when associated with A-817; A-833 and A-840. Ref.12

Mutagenesis

833

1

H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-840. Ref.12

Mutagenesis

840

1

H → A: Abolishes interaction with CBX1, CBX3 and CBX5; when associated with A-817; A-820 and A-833. Ref.12

Sequence conflict

503

1

L → P in BAB87117. Ref.4

Sequence conflict

503

1

L → P in BAE45744. Ref.4

Sequence conflict

788

1

N → T in CAB45136. Ref.5

Sequence conflict

888

1

K → E in BAB87117. Ref.4

Sequence conflict

888

1

K → E in BAE45744. Ref.4

Sequence conflict

933

1

A → V in CAD97850. Ref.1

Sequence conflict

1026

1

E → G in CAD97850. Ref.1

Sequence conflict

1078

1

R → W in BAB87117. Ref.4

Sequence conflict

1078

1

R → W in BAE45744. Ref.4

Sequence conflict

1092 – 1107

16

TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAB87117. Ref.4

Sequence conflict

1092 – 1107

16

TLPKD…LFIDF → PTLLFCLFVFSSPSTL in BAE45744. Ref.4

Sequence conflict

1304

1

W → R in CAD97850. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

1410

Helix Strand Turn

Details...

Turn

378 – 380

3

Helix

387 – 397

11

Turn

399 – 401

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 58F672EDCD57CCD8	FASTA	1,410	155,344
	10 20 30 40 50 60 MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS APVPIAAHAS 70 80 90 100 110 120 VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV QQGGQPLILT QNPAPGLGTM 130 140 150 160 170 180 VTQPVLRPVQ VMQNANHVTS SPVASQPIFI TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ 190 200 210 220 230 240 TVRPITLVPA PGTQFVKPTV GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST 250 260 270 280 290 300 VPQSQSQQTK STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS 310 320 330 340 350 360 FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR TSGPESSMKV 370 380 390 400 410 420 TSSIPVFDLQ DGGRKICPRC NAQFRVTEAL RGHMCYCCPE MVEYQKKGKS LDSEPSVPSA 430 440 450 460 470 480 AKPPSPEKTA PVASTPSSTP IPALSPPTKV PEPNENVGDA VQTKLIMLVD DFYYGRDGGK 490 500 510 520 530 540 VAQLTNFPKV ATSFRCPHCT KRLKNNIRFM NHMKHHVELD QQNGEVDGHT ICQHCYRQFS 550 560 570 580 590 600 TPFQLQCHLE NVHSPYESTT KCKICEWAFE SEPLFLQHMK DTHKPGEMPY VCQVCQYRSS 610 620 630 640 650 660 LYSEVDVHFR MIHEDTRHLL CPYCLKVFKN GNAFQQHYMR HQKRNVYHCN KCRLQFLFAK 670 680 690 700 710 720 DKIEHKLQHH KTFRKPKQLE GLKPGTKVTI RASRGQPRTV PVSSNDTPPS ALQEAAPLTS 730 740 750 760 770 780 SMDPLPVFLY PPVQRSIQKR AVRKMSVMGR QTCLECSFEI PDFPNHFPTY VHCSLCRYST 790 800 810 820 830 840 CCSRAYANHM INNHVPRKSP KYLALFKNSV SGIKLACTSC TFVTSVGDAM AKHLVFNPSH 850 860 870 880 890 900 RSSSILPRGL TWIAHSRHGQ TRDRVHDRNV KNMYPPPSFP TNKAATVKSA GATPAEPEEL 910 920 930 940 950 960 LTPLAPALPS PASTATPPPT PTHPQALALP PLATEGAECL NVDDQDEGSP VTQEPELASG 970 980 990 1000 1010 1020 GGGSGGVGKK EQLSVKKLRV VLFALCCNTE QAAEHFRNPQ RRIRRWLRRF QASQGENLEG 1030 1040 1050 1060 1070 1080 KYLSFEAEEK LAEWVLTQRE QQLPVNEETL FQKATKIGRS LEGGFKISYE WAVRFMLRHH 1090 1100 1110 1120 1130 1140 LTPHARRAVA HTLPKDVAEN AGLFIDFVQR QIHNQDLPLS MIVAIDEISL FLDTEVLSSD 1150 1160 1170 1180 1190 1200 DRKENALQTV GTGEPWCDVV LAILADGTVL PTLVFYRGQM DQPANMPDSI LLEAKESGYS 1210 1220 1230 1240 1250 1260 DDEIMELWST RVWQKHTACQ RSKGMLVMDC HRTHLSEEVL AMLSASSTLP AVVPAGCSSK 1270 1280 1290 1300 1310 1320 IQPLDVCIKR TVKNFLHKKW KEQAREMADT ACDSDVLLQL VLVWLGEVLG VIGDCPELVQ 1330 1340 1350 1360 1370 1380 RSFLVASVLP GPDGNINSPT RNADMQEELI ASLEEQLKLS GEHSESSTPR PRSSPEETIE 1390 1400 1410 PESLHQLFEG ESETESFYGF EEADLDLMEI
	Isoform 2 [UniParc]. Checksum: 3EC92965C8E95A98	FASTA	1,357	150,130
	10 20 30 40 50 60 MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TAGNPLVQQG GQPLILTQNP 70 80 90 100 110 120 APGLGTMVTQ PVLRPVQVMQ NANHVTSSPV ASQPIFITTQ GFPVRNVRPV QNAMNQVGIV 130 140 150 160 170 180 LNVQQGQTVR PITLVPAPGT QFVKPTVGVP QVFSQMTPVR PGSTMPVRPT TNTFTTVIPA 190 200 210 220 230 240 TLTIRSTVPQ SQSQQTKSTP STSTTPTATQ PTSLGQLAVQ SPGQSNQTTN PKLAPSFPSP 250 260 270 280 290 300 PAVSIASFVT VKRPGVTGEN SNEVAKLVNT LNTIPSLGQS PGPVVVSNNS SAHGSQRTSG 310 320 330 340 350 360 PESSMKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE YQKKGKSLDS 370 380 390 400 410 420 EPSVPSAAKP PSPEKTAPVA STPSSTPIPA LSPPTKVPEP NENVGDAVQT KLIMLVDDFY 430 440 450 460 470 480 YGRDGGKVAQ LTNFPKVATS FRCPHCTKRL KNNIRFMNHM KHHVELDQQN GEVDGHTICQ 490 500 510 520 530 540 HCYRQFSTPF QLQCHLENVH SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ 550 560 570 580 590 600 VCQYRSSLYS EVDVHFRMIH EDTRHLLCPY CLKVFKNGNA FQQHYMRHQK RNVYHCNKCR 610 620 630 640 650 660 LQFLFAKDKI EHKLQHHKTF RKPKQLEGLK PGTKVTIRAS RGQPRTVPVS SNDTPPSALQ 670 680 690 700 710 720 EAAPLTSSMD PLPVFLYPPV QRSIQKRAVR KMSVMGRQTC LECSFEIPDF PNHFPTYVHC 730 740 750 760 770 780 SLCRYSTCCS RAYANHMINN HVPRKSPKYL ALFKNSVSGI KLACTSCTFV TSVGDAMAKH 790 800 810 820 830 840 LVFNPSHRSS SILPRGLTWI AHSRHGQTRD RVHDRNVKNM YPPPSFPTNK AATVKSAGAT 850 860 870 880 890 900 PAEPEELLTP LAPALPSPAS TATPPPTPTH PQALALPPLA TEGAECLNVD DQDEGSPVTQ 910 920 930 940 950 960 EPELASGGGG SGGVGKKEQL SVKKLRVVLF ALCCNTEQAA EHFRNPQRRI RRWLRRFQAS 970 980 990 1000 1010 1020 QGENLEGKYL SFEAEEKLAE WVLTQREQQL PVNEETLFQK ATKIGRSLEG GFKISYEWAV 1030 1040 1050 1060 1070 1080 RFMLRHHLTP HARRAVAHTL PKDVAENAGL FIDFVQRQIH NQDLPLSMIV AIDEISLFLD 1090 1100 1110 1120 1130 1140 TEVLSSDDRK ENALQTVGTG EPWCDVVLAI LADGTVLPTL VFYRGQMDQP ANMPDSILLE 1150 1160 1170 1180 1190 1200 AKESGYSDDE IMELWSTRVW QKHTACQRSK GMLVMDCHRT HLSEEVLAML SASSTLPAVV 1210 1220 1230 1240 1250 1260 PAGCSSKIQP LDVCIKRTVK NFLHKKWKEQ AREMADTACD SDVLLQLVLV WLGEVLGVIG 1270 1280 1290 1300 1310 1320 DCPELVQRSF LVASVLPGPD GNINSPTRNA DMQEELIASL EEQLKLSGEH SESSTPRPRS 1330 1340 1350 SPEETIEPES LHQLFEGESE TESFYGFEEA DLDLMEI
	Isoform 3 [UniParc]. Checksum: C88635F4469B70AA	FASTA	1,366	151,213
	10 20 30 40 50 60 MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TAGNPLVQQG GQPLILTQNP 70 80 90 100 110 120 APGLGTMVTQ PVLRPVQVMQ NANHVTSSPV ASQPIFITTQ GFPVRNVRPV QNAMNQVGIV 130 140 150 160 170 180 LNVQQGQTVR PITLVPAPGT QFVKPTVGVP QVFSQMTPVR PGSTMPVRPT TNTFTTVIPA 190 200 210 220 230 240 TLTIRSTVPQ SQSQQTKSTP STSTTPTATQ PTSLGQLAVQ SPGQSNQTTN PKLAPSFPSP 250 260 270 280 290 300 PAVSIASFVT VKRPGVTGEN SNEVAKLVNT LNTIPSLGQS PGPVVVSNNS SAHGSQRTSG 310 320 330 340 350 360 PESSMKVTSS IPVFDLQDGG RKICPRCNAQ FRVTEALRGH MCYCCPEMVE YQKKGKSLDS 370 380 390 400 410 420 EPSVPSAAKP PSPEKTAPVA STPSSTPIPA LSPPTKVPEP NENVGDAVQT KLIMLVDDFY 430 440 450 460 470 480 YGRDGGKVAQ LTNFPKVATS FRCPHCTKRL KNNIRFMNHM KHHVELDQQN GEVDGHTICQ 490 500 510 520 530 540 HCYRQFSTPF QLQCHLENVH SPYESTTKCK ICEWAFESEP LFLQHMKDTH KPGEMPYVCQ 550 560 570 580 590 600 PYFPSYVTQV CQYRSSLYSE VDVHFRMIHE DTRHLLCPYC LKVFKNGNAF QQHYMRHQKR 610 620 630 640 650 660 NVYHCNKCRL QFLFAKDKIE HKLQHHKTFR KPKQLEGLKP GTKVTIRASR GQPRTVPVSS 670 680 690 700 710 720 NDTPPSALQE AAPLTSSMDP LPVFLYPPVQ RSIQKRAVRK MSVMGRQTCL ECSFEIPDFP 730 740 750 760 770 780 NHFPTYVHCS LCRYSTCCSR AYANHMINNH VPRKSPKYLA LFKNSVSGIK LACTSCTFVT 790 800 810 820 830 840 SVGDAMAKHL VFNPSHRSSS ILPRGLTWIA HSRHGQTRDR VHDRNVKNMY PPPSFPTNKA 850 860 870 880 890 900 ATVKSAGATP AEPEELLTPL APALPSPAST ATPPPTPTHP QALALPPLAT EGAECLNVDD 910 920 930 940 950 960 QDEGSPVTQE PELASGGGGS GGVGKKEQLS VKKLRVVLFA LCCNTEQAAE HFRNPQRRIR 970 980 990 1000 1010 1020 RWLRRFQASQ GENLEGKYLS FEAEEKLAEW VLTQREQQLP VNEETLFQKA TKIGRSLEGG 1030 1040 1050 1060 1070 1080 FKISYEWAVR FMLRHHLTPH ARRAVAHTLP KDVAENAGLF IDFVQRQIHN QDLPLSMIVA 1090 1100 1110 1120 1130 1140 IDEISLFLDT EVLSSDDRKE NALQTVGTGE PWCDVVLAIL ADGTVLPTLV FYRGQMDQPA 1150 1160 1170 1180 1190 1200 NMPDSILLEA KESGYSDDEI MELWSTRVWQ KHTACQRSKG MLVMDCHRTH LSEEVLAMLS 1210 1220 1230 1240 1250 1260 ASSTLPAVVP AGCSSKIQPL DVCIKRTVKN FLHKKWKEQA REMADTACDS DVLLQLVLVW 1270 1280 1290 1300 1310 1320 LGEVLGVIGD CPELVQRSFL VASVLPGPDG NINSPTRNAD MQEELIASLE EQLKLSGEHS 1330 1340 1350 1360 ESSTPRPRSS PEETIEPESL HQLFEGESET ESFYGFEEAD LDLMEI
	Isoform 4 [UniParc]. Checksum: E4CA34C166CC3E78	FASTA	363	37,882
	10 20 30 40 50 60 MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS APVPIAAHAS 70 80 90 100 110 120 VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAGNPLV QQGGQPLILT QNPAPGLGTM 130 140 150 160 170 180 VTQPVLRPVQ VMQNANHVTS SPVASQPIFI TTQGFPVRNV RPVQNAMNQV GIVLNVQQGQ 190 200 210 220 230 240 TVRPITLVPA PGTQFVKPTV GVPQVFSQMT PVRPGSTMPV RPTTNTFTTV IPATLTIRST 250 260 270 280 290 300 VPQSQSQQTK STPSTSTTPT ATQPTSLGQL AVQSPGQSNQ TTNPKLAPSF PSPPAVSIAS 310 320 330 340 350 360 FVTVKRPGVT GENSNEVAKL VNTLNTIPSL GQSPGPVVVS NNSSAHGSQR TSGPESSMKG TIT
	Isoform 5 (CRA_e) [UniParc]. Checksum: 457D70CDC875B81C	FASTA	1,315	145,295
	10 20 30 40 50 60 MADTDLFMEC EEEELEPWQK ISDVIEDSVV EDYNSVDKTT TVSVSQQPVS APVPIAAHAS 70 80 90 100 110 120 VAGHLSTSTT VSSSGAQNSD STKKTLVTLI ANNNAPGTQF VKPTVGVPQV FSQMTPVRPG 130 140 150 160 170 180 STMPVRPTTN TFTTVIPATL TIRSTVPQSQ SQQTKSTPST STTPTATQPT SLGQLAVQSP 190 200 210 220 230 240 GQSNQTTNPK LAPSFPSPPA VSIASFVTVK RPGVTGENSN EVAKLVNTLN TIPSLGQSPG 250 260 270 280 290 300 PVVVSNNSSA HGSQRTSGPE SSMKVTSSIP VFDLQDGGRK ICPRCNAQFR VTEALRGHMC 310 320 330 340 350 360 YCCPEMVEYQ KKGKSLDSEP SVPSAAKPPS PEKTAPVAST PSSTPIPALS PPTKVPEPNE 370 380 390 400 410 420 NVGDAVQTKL IMLVDDFYYG RDGGKVAQLT NFPKVATSFR CPHCTKRLKN NIRFMNHMKH 430 440 450 460 470 480 HVELDQQNGE VDGHTICQHC YRQFSTPFQL QCHLENVHSP YESTTKCKIC EWAFESEPLF 490 500 510 520 530 540 LQHMKDTHKP GEMPYVCQVC QYRSSLYSEV DVHFRMIHED TRHLLCPYCL KVFKNGNAFQ 550 560 570 580 590 600 QHYMRHQKRN VYHCNKCRLQ FLFAKDKIEH KLQHHKTFRK PKQLEGLKPG TKVTIRASRG 610 620 630 640 650 660 QPRTVPVSSN DTPPSALQEA APLTSSMDPL PVFLYPPVQR SIQKRAVRKM SVMGRQTCLE 670 680 690 700 710 720 CSFEIPDFPN HFPTYVHCSL CRYSTCCSRA YANHMINNHV PRKSPKYLAL FKNSVSGIKL 730 740 750 760 770 780 ACTSCTFVTS VGDAMAKHLV FNPSHRSSSI LPRGLTWIAH SRHGQTRDRV HDRNVKNMYP 790 800 810 820 830 840 PPSFPTNKAA TVKSAGATPA EPEELLTPLA PALPSPASTA TPPPTPTHPQ ALALPPLATE 850 860 870 880 890 900 GAECLNVDDQ DEGSPVTQEP ELASGGGGSG GVGKKEQLSV KKLRVVLFAL CCNTEQAAEH 910 920 930 940 950 960 FRNPQRRIRR WLRRFQASQG ENLEGKYLSF EAEEKLAEWV LTQREQQLPV NEETLFQKAT 970 980 990 1000 1010 1020 KIGRSLEGGF KISYEWAVRF MLRHHLTPHA RRAVAHTLPK DVAENAGLFI DFVQRQIHNQ 1030 1040 1050 1060 1070 1080 DLPLSMIVAI DEISLFLDTE VLSSDDRKEN ALQTVGTGEP WCDVVLAILA DGTVLPTLVF 1090 1100 1110 1120 1130 1140 YRGQMDQPAN MPDSILLEAK ESGYSDDEIM ELWSTRVWQK HTACQRSKGM LVMDCHRTHL 1150 1160 1170 1180 1190 1200 SEEVLAMLSA SSTLPAVVPA GCSSKIQPLD VCIKRTVKNF LHKKWKEQAR EMADTACDSD 1210 1220 1230 1240 1250 1260 VLLQLVLVWL GEVLGVIGDC PELVQRSFLV ASVLPGPDGN INSPTRNADM QEELIASLEE 1270 1280 1290 1300 1310 QLKLSGEHSE SSTPRPRSSP EETIEPESLH QLFEGESETE SFYGFEEADL DLMEI

References

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[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma." Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A. Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1107 (ISOFORM 3). Tissue: Neuroblastoma.
[5]	"A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening." Gunther M., Laithier M., Brison O. Mol. Cell. Biochem. 210:131-142(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-788 (ISOFORM 1), INTERACTION WITH SP1. Tissue: Colon.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-363 (ISOFORM 4). Tissue: Placenta.
[7]	"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1410 (ISOFORM 2). Tissue: Brain.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333; SER-425 AND SER-1338, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ." Bartholomeeusen K., Christ F., Hendrix J., Rain J.C., Emiliani S., Benarous R., Debyser Z., Gijsbers R., De Rijck J. J. Biol. Chem. 284:11467-11477(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PSIP1.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-439 AND SER-445, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers." Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S., Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G., Mann M. Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CHAMP1; MAD2L2; CBX1; CBX3 AND CBX5.
[12]	"Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation." Nozawa R.S., Nagao K., Masuda H.T., Iwasaki O., Hirota T., Nozaki N., Kimura H., Obuse C. Nat. Cell Biol. 12:719-727(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CBX1; CBX3 AND CBX5, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-817; CYS-820; HIS-833 AND HIS-840.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, MASS SPECTROMETRY.
[15]	"Solution structure of the zinc finger domain of human KIAA0461." RIKEN structural genomics initiative (RSGI) Submitted (JUL-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 352-405.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BX537838 mRNA. Translation: CAD97850.1.
AL589764 Genomic DNA. Translation: CAI16807.1.
AL589764 Genomic DNA. Translation: CAI16808.2. Sequence problems.
AL589764 Genomic DNA. Translation: CAI16809.1.
AL589764 Genomic DNA. Translation: CAI16810.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53440.1.
AB037911 mRNA. Translation: BAB87117.1.
AB075477 mRNA. Translation: BAE45744.1. Different initiation.
AJ242979 mRNA. Translation: CAB45136.1.
BC057773 mRNA. Translation: AAH57773.1.
AB007930 mRNA. Translation: BAA32306.1.

IPI

IPI00410717.
IPI00410719.
IPI00514078.
IPI00514439.
IPI00982239.

PIR

T00075.

RefSeq

NP_001181866.1. NM_001194937.1.
NP_001181867.1. NM_001194938.1.
NP_055915.2. NM_015100.3.
NP_665739.3. NM_145796.3.
NP_997054.1. NM_207171.2.

UniGene

Hs.489873.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2E72	NMR	-	A	370-405	[»]

ProteinModelPortal

Q7Z3K3.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-38044N.

IntAct

Q7Z3K3. 54 interactions.

PTM databases

PhosphoSite

Q7Z3K3.

Polymorphism databases

DMDM

143811442.

Proteomic databases

PaxDb

Q7Z3K3.

PRIDE

Q7Z3K3.

Protocols and materials databases

DNASU

23126.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000271715; ENSP00000271715; ENSG00000143442.
ENST00000361398; ENSP00000354467; ENSG00000143442.
ENST00000368863; ENSP00000357856; ENSG00000143442.
ENST00000392723; ENSP00000376484; ENSG00000143442.
ENST00000491586; ENSP00000418408; ENSG00000143442.

GeneID

23126.

KEGG

hsa:23126.

UCSC

uc001eyd.2. human.
uc001eyf.2. human.
uc001eyg.2. human.
uc009wmv.2. human.
uc021oyq.1. human.

Organism-specific databases

CTD

23126.

GeneCards

GC01M151375.

HGNC

HGNC:18801. POGZ.

HPA

HPA006800.
HPA008781.

MIM

614787. gene.

neXtProt

NX_Q7Z3K3.

PharmGKB

PA38685.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG239493.

HOVERGEN

HBG049435.

InParanoid

Q7Z3K3.

OMA

GPMVVSN.

OrthoDB

EOG4SXNBN.

PhylomeDB

Q7Z3K3.

Gene expression databases

ArrayExpress

Q7Z3K3.

Bgee

Q7Z3K3.

CleanEx

HS_POGZ.

Genevestigator

Q7Z3K3.

GermOnline

ENSG00000143442. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.60. 1 hit.

InterPro

IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]

Pfam

PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]

SMART

SM00674. CENPB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS51253. HTH_CENPB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q7Z3K3.

GenomeRNAi

23126.

NextBio

44359.

SOURCE

Search...

Entry information

Entry name

POGZ_HUMAN

Accession

Primary (citable) accession number: Q7Z3K3
Secondary accession number(s): O75049 , Q3LIC4, Q5SZS1, Q5SZS2, Q5SZS3, Q5SZS4, Q8TDZ7, Q9Y4X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.