Reviewed, UniProtKB/Swiss-Prot Q7Z3J2 (CP062_HUMAN)

Names and origin

Protein names

Recommended name:
    UPF0505 protein C16orf62
Alternative name(s):
    Esophageal cancer-associated protein

Gene names

Name:	C16orf62
ORF Names:	101F10.2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	963 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane proteinPotential.
Sequence similarities	Belongs to the UPF0505 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z3J2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z3J2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     123-144: EILARYTTTEKLSINLFMGSEK → MPPLGVLVHEKSHLCDVNSFCL
     214-243: CSKLLSDTSVIQFYPSKFVLITDILDTFGK → EE

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 963	963	UPF0505 protein C16orf62		PRO_0000311352
Regions
	Transmembrane	703 – 719	17	Potential
	Compositional bias	53 – 71	19	Ser-rich
Amino acid modifications
	Modified residue	58	1	Phosphoserine
Natural variations
	Alternative sequence	1 – 122	122	Missing in isoform 2.		VSP_029536
	Alternative sequence	123 – 144	22	EILAR…MGSEK → MPPLGVLVHEKSHLCDVNSF CL in isoform 2.		VSP_029537
	Alternative sequence	214 – 243	30	CSKLL…DTFGK → EE in isoform 2.		VSP_029538
	Natural variant	32	1	Y → C: dbSNP rs17854969.		VAR_037230
	Natural variant	186	1	N → I: dbSNP rs7206637.		VAR_037231
	Natural variant	506	1	A → V: dbSNP rs17854970.		VAR_037232
Experimental info
	Sequence conflict	168	1	F → S in CAH10399. Ref.2
	Sequence conflict	340	1	C → G in AAL67806. Ref.1
	Sequence conflict	675	1	I → V in CAD97869. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: 5500471390F85683	FASTA	963	109,563
	10 20 30 40 50 60 MAVFPWHSRN RNYKAEFASC RLEAVPLEFG DYHPLKPITV TESKTKKVNR KGSTSSTSSS 70 80 90 100 110 120 SSSSVVDPLS SVLDGTDPLS MFAATADPAA LAAAMDSSRR KRDRDDNSVV GSDFEPWTNK 130 140 150 160 170 180 RGEILARYTT TEKLSINLFM GSEKGKAGTA TLAMSEKVRT RLEELDDFEE GSQKELLNLT 190 200 210 220 230 240 QQDYVNRIEE LNQSLKDAWA SDQKVKALKI VIQCSKLLSD TSVIQFYPSK FVLITDILDT 250 260 270 280 290 300 FGKLVYERIF SMCVDSRSVL PDHFSPENAN DTAKETCLNW FFKIASIREL IPRFYVEASI 310 320 330 340 350 360 LKCNKFLSKT GISECLPRLT CMIRGIGDPL VSVYARAYLC RVGMEVAPHL KETLNKNFFD 370 380 390 400 410 420 FLLTFKQIHG DTVQNQLVVQ GVELPSYLPL YPPAMDWIFQ CISYHAPEAL LTEMMERCKK 430 440 450 460 470 480 LGNNALLLNS VMSAFRAEFI ATRSMDFIGM IKECDESGFP KHLLFRSLGL NLALADPPES 490 500 510 520 530 540 DRLQILNEAW KVITKLKNPQ DYINCAEVWV EYTCKHFTKR EVNTVLADVI KHMTPDRAFE 550 560 570 580 590 600 DSYPQLQLII KKVIAHFHDF SVLFSVEKFL PFLDMFQKES VRVEVCKCIM DAFIKHQQEP 610 620 630 640 650 660 TKDPVILNAL LHVCKTMHDS VNALTLEDEK RMLSYLINGF IKMVSFGRDF EQQLSFYVES 670 680 690 700 710 720 RSMFCNLEPV LVQLIHSVNR LAMETRKVMK GNHSRKTAAF VRACVAYCFI TIPSLAGIFT 730 740 750 760 770 780 RLNLYLHSGQ VALANQCLSQ ADAFFKAAIS LVPEVPKMIN IDGKMRPSES FLLEFLCNFF 790 800 810 820 830 840 STLLIVPDHP EHGVLFLVRE LLNVIQDYTW EDNSDEKIRI YTCVLHLLSA MSQETYLYHI 850 860 870 880 890 900 DKVDSNDSLY GGDSKFLAEN NKLCETVMAQ ILEHLKTLAK DEALKRQSSL GLSFFNSILA 910 920 930 940 950 960 HGDLRNNKLN QLSVNLWHLA QRHGCADTRT MVKTLEYIKK QSKQPDMTHL TELALRLPLQ TRT
	Isoform 2 [UniParc]. Checksum: D5D3817BDA5B0129		813	93,086
	10 20 30 40 50 60 MPPLGVLVHE KSHLCDVNSF CLGKAGTATL AMSEKVRTRL EELDDFEEGS QKELLNLTQQ 70 80 90 100 110 120 DYVNRIEELN QSLKDAWASD QKVKALKIVI QEELVYERIF SMCVDSRSVL PDHFSPENAN 130 140 150 160 170 180 DTAKETCLNW FFKIASIREL IPRFYVEASI LKCNKFLSKT GISECLPRLT CMIRGIGDPL 190 200 210 220 230 240 VSVYARAYLC RVGMEVAPHL KETLNKNFFD FLLTFKQIHG DTVQNQLVVQ GVELPSYLPL 250 260 270 280 290 300 YPPAMDWIFQ CISYHAPEAL LTEMMERCKK LGNNALLLNS VMSAFRAEFI ATRSMDFIGM 310 320 330 340 350 360 IKECDESGFP KHLLFRSLGL NLALADPPES DRLQILNEAW KVITKLKNPQ DYINCAEVWV 370 380 390 400 410 420 EYTCKHFTKR EVNTVLADVI KHMTPDRAFE DSYPQLQLII KKVIAHFHDF SVLFSVEKFL 430 440 450 460 470 480 PFLDMFQKES VRVEVCKCIM DAFIKHQQEP TKDPVILNAL LHVCKTMHDS VNALTLEDEK 490 500 510 520 530 540 RMLSYLINGF IKMVSFGRDF EQQLSFYVES RSMFCNLEPV LVQLIHSVNR LAMETRKVMK 550 560 570 580 590 600 GNHSRKTAAF VRACVAYCFI TIPSLAGIFT RLNLYLHSGQ VALANQCLSQ ADAFFKAAIS 610 620 630 640 650 660 LVPEVPKMIN IDGKMRPSES FLLEFLCNFF STLLIVPDHP EHGVLFLVRE LLNVIQDYTW 670 680 690 700 710 720 EDNSDEKIRI YTCVLHLLSA MSQETYLYHI DKVDSNDSLY GGDSKFLAEN NKLCETVMAQ 730 740 750 760 770 780 ILEHLKTLAK DEALKRQSSL GLSFFNSILA HGDLRNNKLN QLSVNLWHLA QRHGCADTRT 790 800 810 MVKTLEYIKK QSKQPDMTHL TELALRLPLQ TRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Lu J., Liu Z., Hu G., Wu M., Wang X. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	The German cDNA consortium Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Heart.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS CYS-32 AND VAL-506. Tissue: Pancreas and Uterus.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-963.
[5]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-963 (ISOFORM 1). Tissue: Testis.
[6]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed: 10493829] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 758-963 (ISOFORM 1).
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF461052 mRNA. Translation: AAL67806.2. BX537867 mRNA. Translation: CAD97869.1. Different initiation. AL833428 mRNA. Translation: CAH10399.1. BC014900 mRNA. Translation: AAH14900.2. Different initiation. BC050464 mRNA. Translation: AAH50464.1. BC058845 mRNA. Translation: AAH58845.1. AK024693 mRNA. Translation: BAB14965.1. AL136744 mRNA. Translation: CAB66678.1. AC002550 Genomic DNA. Translation: AAC05806.1.
RefSeq	NP_064710.3.
UniGene	Hs.654964
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q7Z3J2.
Genome annotation databases
Ensembl	ENSG00000103544. Homo sapiens. [Contig view]
GeneID	57020.
KEGG	hsa:57020.
Organism-specific databases
HGNC	HGNC:24641. C16orf62.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q7Z3J2.
HOVERGEN	Q7Z3J2.
Gene expression databases
ArrayExpress	Q7Z3J2.
CleanEx	HS_C16orf62.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	62774.

Entry information

Entry name

CP062_HUMAN

Accession

Primary (citable) accession number: Q7Z3J2
Secondary accession number(s): O43329 , Q69YI1, Q6PDA0, Q7L371, Q86W66, Q8WXA5, Q9H0L7, Q9H7C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	November 4, 2008
This is version 23 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)