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Protein

Zinc finger protein 572

Gene

ZNF572

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri132 – 15423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 572
Gene namesi
Name:ZNF572
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26758. ZNF572.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924678.

Polymorphism and mutation databases

BioMutaiZNF572.
DMDMi74762429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Zinc finger protein 572PRO_0000251223Add
BLAST

Proteomic databases

PaxDbiQ7Z3I7.
PeptideAtlasiQ7Z3I7.
PRIDEiQ7Z3I7.

PTM databases

iPTMnetiQ7Z3I7.
PhosphoSiteiQ7Z3I7.

Expressioni

Gene expression databases

BgeeiENSG00000180938.
CleanExiHS_ZNF572.
GenevisibleiQ7Z3I7. HS.

Organism-specific databases

HPAiHPA066838.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CADPSQ9ULU8-43EBI-10257016,EBI-10180690
CARD9Q9H2573EBI-10257016,EBI-751319
CCDC102BA1A4H13EBI-10257016,EBI-10171570
CCDC130P139943EBI-10257016,EBI-716093
CCDC136Q96JN2-23EBI-10257016,EBI-10171416
CCDC67E9PJR53EBI-10257016,EBI-10177066
CCDC67Q05D603EBI-10257016,EBI-748597
CEP70Q8NHQ13EBI-10257016,EBI-739624
FSD2A1L4K14EBI-10257016,EBI-5661036
GOLGA2Q083793EBI-10257016,EBI-618309
GPR50Q135853EBI-10257016,EBI-8550965
KIFC3Q9BVG83EBI-10257016,EBI-2125614
KLC3Q6P5973EBI-10257016,EBI-1643885
KRT31Q153233EBI-10257016,EBI-948001
KRTAP10-5P603703EBI-10257016,EBI-10172150
KRTAP10-7P604093EBI-10257016,EBI-10172290
KRTAP10-8P604103EBI-10257016,EBI-10171774
KRTAP10-9P604113EBI-10257016,EBI-10172052
LZTS2Q9BRK43EBI-10257016,EBI-741037
MEOX2A4D1273EBI-10257016,EBI-10172134
MTUS2Q5JR593EBI-10257016,EBI-742948
NDEL1Q9GZM83EBI-10257016,EBI-928842
RELQ048643EBI-10257016,EBI-307352
TRAF1Q130773EBI-10257016,EBI-359224
TRIM27P143733EBI-10257016,EBI-719493
TRIM54Q9BYV23EBI-10257016,EBI-2130429

Protein-protein interaction databases

BioGridi126473. 29 interactions.
IntActiQ7Z3I7. 26 interactions.
MINTiMINT-2807992.
STRINGi9606.ENSP00000319305.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3I7.
SMRiQ7Z3I7. Positions 87-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri132 – 15423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri160 – 18223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri188 – 21023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri468 – 49023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z3I7.
OMAiIQHLRMH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z3I7.
TreeFamiTF341767.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQEKKLLVS DSNSFMERES LKSPFTGDTS MNNLETVHHN NSKADKLKEK
60 70 80 90 100
PSEWSKRHRP QHYKHEDAKE MPLTWVQDEI WCHDSYESDG KSENWGNFIA
110 120 130 140 150
KEEEKPNHQE WDSGEHTNAC VQQNSSFVDR PYKCSECWKS FSNSSHLRTH
160 170 180 190 200
QRTHSGEKPY KCSECAKCFC NSSHLIQHLR MHTGEKPYQC GECGKSFSNT
210 220 230 240 250
SHLIIHERTH TGEKPYKCPE CGKRFSSSSH LIQHHRSHTG EKPYECSVCG
260 270 280 290 300
KGFSHSYVLI EHQRTHTGEK PYKCPDCGKS FSQSSSLIRH QRTHTGEKPY
310 320 330 340 350
KCLECEKSFG CNSTLIKHQR IHTGEKPYQC PECGKNFSRS SNLITHQKMH
360 370 380 390 400
TGEKSYESSE YEESLGQNCN VIEECRIQLG EKPYRCCECG KSFGLSSHLI
410 420 430 440 450
RHQRTHTGEK PYRCSECWKT FSQSSTLVIH QRTHTGEKPY KCPDCGESFS
460 470 480 490 500
QSFNLIRHRR THIGEKPYKC TSCEKCFSRS AYLSQHRKIH VEKPFESPDV
510 520
GDFPHEWTWK NCSGEMPFIS SFSVSNSSS
Length:529
Mass (Da):61,238
Last modified:October 1, 2003 - v1
Checksum:iFC729DB7BC7FED2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti480 – 4801S → I in BAC04529 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti317 – 3171K → T.
Corresponds to variant rs10104558 [ dbSNP | Ensembl ].
VAR_027664
Natural varianti380 – 3801G → E.
Corresponds to variant rs10105106 [ dbSNP | Ensembl ].
VAR_027665
Natural varianti448 – 4481S → C.
Corresponds to variant rs10107774 [ dbSNP | Ensembl ].
VAR_027666
Natural varianti500 – 5001V → I.
Corresponds to variant rs7825375 [ dbSNP | Ensembl ].
VAR_027667
Natural varianti512 – 5121C → F in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095321 mRNA. Translation: BAC04529.1.
BX537876 mRNA. Translation: CAD97876.1.
BC130517 mRNA. Translation: AAI30518.1.
CCDSiCCDS6354.1.
RefSeqiNP_689625.2. NM_152412.2.
UniGeneiHs.175350.
Hs.651593.

Genome annotation databases

EnsembliENST00000319286; ENSP00000319305; ENSG00000180938.
GeneIDi137209.
KEGGihsa:137209.
UCSCiuc003yrr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095321 mRNA. Translation: BAC04529.1.
BX537876 mRNA. Translation: CAD97876.1.
BC130517 mRNA. Translation: AAI30518.1.
CCDSiCCDS6354.1.
RefSeqiNP_689625.2. NM_152412.2.
UniGeneiHs.175350.
Hs.651593.

3D structure databases

ProteinModelPortaliQ7Z3I7.
SMRiQ7Z3I7. Positions 87-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126473. 29 interactions.
IntActiQ7Z3I7. 26 interactions.
MINTiMINT-2807992.
STRINGi9606.ENSP00000319305.

PTM databases

iPTMnetiQ7Z3I7.
PhosphoSiteiQ7Z3I7.

Polymorphism and mutation databases

BioMutaiZNF572.
DMDMi74762429.

Proteomic databases

PaxDbiQ7Z3I7.
PeptideAtlasiQ7Z3I7.
PRIDEiQ7Z3I7.

Protocols and materials databases

DNASUi137209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319286; ENSP00000319305; ENSG00000180938.
GeneIDi137209.
KEGGihsa:137209.
UCSCiuc003yrr.4. human.

Organism-specific databases

CTDi137209.
GeneCardsiZNF572.
HGNCiHGNC:26758. ZNF572.
HPAiHPA066838.
neXtProtiNX_Q7Z3I7.
PharmGKBiPA134924678.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129696.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z3I7.
OMAiIQHLRMH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z3I7.
TreeFamiTF341767.

Miscellaneous databases

GenomeRNAii137209.
PROiQ7Z3I7.

Gene expression databases

BgeeiENSG00000180938.
CleanExiHS_ZNF572.
GenevisibleiQ7Z3I7. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN572_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3I7
Secondary accession number(s): A1L4F1, Q8N1Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.