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Protein

Zinc finger protein 572

Gene

ZNF572

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 154C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 572
Gene namesi
Name:ZNF572
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000180938.5.
HGNCiHGNC:26758. ZNF572.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180938.
PharmGKBiPA134924678.

Polymorphism and mutation databases

BioMutaiZNF572.
DMDMi74762429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512231 – 529Zinc finger protein 572Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ7Z3I7.
PaxDbiQ7Z3I7.
PeptideAtlasiQ7Z3I7.
PRIDEiQ7Z3I7.

PTM databases

iPTMnetiQ7Z3I7.
PhosphoSitePlusiQ7Z3I7.

Expressioni

Gene expression databases

BgeeiENSG00000180938.
CleanExiHS_ZNF572.
GenevisibleiQ7Z3I7. HS.

Organism-specific databases

HPAiHPA066838.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126473. 29 interactors.
IntActiQ7Z3I7. 45 interactors.
MINTiMINT-2807992.
STRINGi9606.ENSP00000319305.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3I7.
SMRiQ7Z3I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 154C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri160 – 182C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri188 – 210C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri300 – 322C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri384 – 406C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139326.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7Z3I7.
OMAiCFSRSAY.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7Z3I7.
TreeFamiTF341767.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 12 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.

Sequencei

Sequence statusi: Complete.

Q7Z3I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQEKKLLVS DSNSFMERES LKSPFTGDTS MNNLETVHHN NSKADKLKEK
60 70 80 90 100
PSEWSKRHRP QHYKHEDAKE MPLTWVQDEI WCHDSYESDG KSENWGNFIA
110 120 130 140 150
KEEEKPNHQE WDSGEHTNAC VQQNSSFVDR PYKCSECWKS FSNSSHLRTH
160 170 180 190 200
QRTHSGEKPY KCSECAKCFC NSSHLIQHLR MHTGEKPYQC GECGKSFSNT
210 220 230 240 250
SHLIIHERTH TGEKPYKCPE CGKRFSSSSH LIQHHRSHTG EKPYECSVCG
260 270 280 290 300
KGFSHSYVLI EHQRTHTGEK PYKCPDCGKS FSQSSSLIRH QRTHTGEKPY
310 320 330 340 350
KCLECEKSFG CNSTLIKHQR IHTGEKPYQC PECGKNFSRS SNLITHQKMH
360 370 380 390 400
TGEKSYESSE YEESLGQNCN VIEECRIQLG EKPYRCCECG KSFGLSSHLI
410 420 430 440 450
RHQRTHTGEK PYRCSECWKT FSQSSTLVIH QRTHTGEKPY KCPDCGESFS
460 470 480 490 500
QSFNLIRHRR THIGEKPYKC TSCEKCFSRS AYLSQHRKIH VEKPFESPDV
510 520
GDFPHEWTWK NCSGEMPFIS SFSVSNSSS
Length:529
Mass (Da):61,238
Last modified:October 1, 2003 - v1
Checksum:iFC729DB7BC7FED2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti480S → I in BAC04529 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027664317K → T. Corresponds to variant dbSNP:rs10104558Ensembl.1
Natural variantiVAR_027665380G → E1 PublicationCorresponds to variant dbSNP:rs10105106Ensembl.1
Natural variantiVAR_027666448S → C1 PublicationCorresponds to variant dbSNP:rs10107774Ensembl.1
Natural variantiVAR_027667500V → I. Corresponds to variant dbSNP:rs7825375Ensembl.1
Natural variantiVAR_035591512C → F in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095321 mRNA. Translation: BAC04529.1.
BX537876 mRNA. Translation: CAD97876.1.
BC130515 mRNA. Translation: AAI30516.1.
BC130517 mRNA. Translation: AAI30518.1.
CCDSiCCDS6354.1.
RefSeqiNP_689625.2. NM_152412.2.
UniGeneiHs.175350.
Hs.651593.

Genome annotation databases

EnsembliENST00000319286; ENSP00000319305; ENSG00000180938.
GeneIDi137209.
KEGGihsa:137209.
UCSCiuc003yrr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN572_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3I7
Secondary accession number(s): A1L4E9, A1L4F1, Q8N1Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2003
Last modified: September 27, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families