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Protein

Mitogen-activated protein kinase

Gene

DKFZp686O0215

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: InterPro

GO - Biological processi

  1. cartilage development Source: Ensembl
  2. cellular response to DNA damage stimulus Source: Ensembl
  3. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  4. negative regulation of apolipoprotein binding Source: Ensembl
  5. organ morphogenesis Source: Ensembl
  6. regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  7. response to exogenous dsRNA Source: Ensembl
  8. sensory perception of pain Source: Ensembl
  9. transcription, DNA-templated Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ7Z3H5.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinaseSAAS annotation (EC:2.7.11.24SAAS annotation)
Gene namesi
Name:DKFZp686O0215Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. nucleus Source: Ensembl
  3. pseudopodium Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ7Z3H5.

Expressioni

Gene expression databases

BgeeiQ7Z3H5.
ExpressionAtlasiQ7Z3H5. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ7Z3H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG014652.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q7Z3H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SSAYDHVRKT RVAIKKISPF EHQTYCQRTL REIQILLRFR HENVIGIRDI
60 70 80 90 100
LRASTLEAMR DVYIVQDLME TDLYKLLKSQ QLSNDHICYF LYQILRGLKY
110 120 130 140 150
IHSANVLHRD LKPSNLLINT TCDLKICDFG LARIADPEHD HTGFLTEYVA
160 170 180 190 200
TRWYRAPEIM LNSKGYTKSI DIWSVGCILA EMLSNRPIFP GKHYLDQLNH
210 220 230 240 250
ILGILGSPSQ EDLNCIINMK ARNYLQSLPS KTKVAWAKLF PKSDSKALDL
260 270 280 290 300
LDRMLTFNPN KRITVEEALA HPYLEQYYDP TDEPVAEEPF TFAMELDDLP
310 320
KERLKELIFQ ETARFQPGVL EAP
Length:323
Mass (Da):37,501
Last modified:October 1, 2003 - v1
Checksum:i53D4EF00913948C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537897 mRNA. Translation: CAD97888.1.
UniGeneiHs.861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537897 mRNA. Translation: CAD97888.1.
UniGeneiHs.861.

3D structure databases

ProteinModelPortaliQ7Z3H5.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ7Z3H5.

Proteomic databases

PRIDEiQ7Z3H5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG014652.

Enzyme and pathway databases

SignaLinkiQ7Z3H5.

Gene expression databases

BgeeiQ7Z3H5.
ExpressionAtlasiQ7Z3H5. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008349. MAPK_ERK1/2.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01770. ERK1ERK2MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Koehrer K., Beyer A., Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Human cervixImported.

Entry informationi

Entry nameiQ7Z3H5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3H5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.