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Protein

Integral membrane protein GPR155

Gene

GPR155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cognition Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • transmembrane transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR155
Alternative name(s):
G-protein coupled receptor PGR22
Gene namesi
Name:GPR155
Synonyms:PGR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:22951. GPR155.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei661 – 681HelicalSequence analysisAdd BLAST21
Transmembranei692 – 712HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi151556.
OpenTargetsiENSG00000163328.
PharmGKBiPA134943679.

Polymorphism and mutation databases

BioMutaiGPR155.
DMDMi68052330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875511 – 870Integral membrane protein GPR155Add BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Glycosylationi15N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Glycosylationi612N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7Z3F1.
PaxDbiQ7Z3F1.
PeptideAtlasiQ7Z3F1.
PRIDEiQ7Z3F1.

PTM databases

iPTMnetiQ7Z3F1.
PhosphoSitePlusiQ7Z3F1.

Expressioni

Gene expression databases

BgeeiENSG00000163328.
CleanExiHS_GPR155.
ExpressionAtlasiQ7Z3F1. baseline and differential.
GenevisibleiQ7Z3F1. HS.

Organism-specific databases

HPAiHPA036159.

Interactioni

Protein-protein interaction databases

BioGridi127389. 1 interactor.
MINTiMINT-4726605.
STRINGi9606.ENSP00000295500.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3F1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini757 – 835DEPPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi483 – 486Poly-Ile4

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWV. Eukaryota.
ENOG410XQEU. LUCA.
GeneTreeiENSGT00390000004153.
HOVERGENiHBG057276.
InParanoidiQ7Z3F1.
OMAiPARINEP.
OrthoDBiEOG091G046L.
PhylomeDBiQ7Z3F1.
TreeFamiTF324034.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR004776. Mem_trans.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF
60 70 80 90 100
GIVLCGYIAG RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW
110 120 130 140 150
SFLYSILIAK ASVFFIVCVL TLLVASPDSR FSKAGLFPIF ATQSNDFALG
160 170 180 190 200
YPIVEALYQT TYPEYLQYIY LVAPISLMML NPIGFIFCEI QKWKDTQNAS
210 220 230 240 250
QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY VENFLDGLGN
260 270 280 290 300
SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL
310 320 330 340 350
LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS
360 370 380 390 400
TFVSAPIMYV SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI
410 420 430 440 450
LLLSKKYKQL PHMLTTNLLI AQSIVCAGMM IWNFVKEKNF VGQILVFVLL
460 470 480 490 500
YSSLYSTYLW TGLLAISLFL LKKRERVQIP VGIIIISGWG IPALLVGVLL
510 520 530 540 550
ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM CMNQTAQAGS
560 570 580 590 600
YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG
610 620 630 640 650
ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS
660 670 680 690 700
GDQQLTRHVL LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN
710 720 730 740 750
FGQGFISFGI FGLDKHLIIL PFKRRLEFLW NNKDTAENRD SPVSEEIKMT
760 770 780 790 800
CQQFIHYHRD LCIRNIVKER RCGAKTSAGT FCGCDLVSWL IEVGLASDRG
810 820 830 840 850
EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ SPPAINANTL
860 870
QQERYKEIEH SSPPSHSPKT
Length:870
Mass (Da):96,919
Last modified:June 21, 2005 - v2
Checksum:i91A6CFC79B669ACB
GO

Sequence cautioni

The sequence BAB71170 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33D → G in BAC03609 (PubMed:14702039).Curated1
Sequence conflicti194K → E in AAH28730 (PubMed:15489334).Curated1
Sequence conflicti260L → H in BAB71170 (PubMed:14702039).Curated1
Sequence conflicti460W → R in CAD97915 (PubMed:17974005).Curated1
Sequence conflicti517G → A in CAH10683 (PubMed:17974005).Curated1
Sequence conflicti550S → G in AAH28730 (PubMed:15489334).Curated1
Sequence conflicti638C → R in CAD97915 (PubMed:17974005).Curated1
Sequence conflicti674S → Y in AAH28730 (PubMed:15489334).Curated1
Sequence conflicti693Q → R in CAH10683 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056381 mRNA. Translation: BAB71170.1. Different initiation.
AK091200 mRNA. Translation: BAC03609.1.
AK096665 mRNA. Translation: BAC04835.1.
AK315125 mRNA. Translation: BAG37579.1.
BX537947 mRNA. Translation: CAD97915.1.
AL834154 mRNA. Translation: CAH10683.1.
AC010894 Genomic DNA. Translation: AAY14707.1.
AC018470 Genomic DNA. Translation: AAY24218.1.
CH471058 Genomic DNA. Translation: EAX11137.1.
CH471058 Genomic DNA. Translation: EAX11138.1.
CH471058 Genomic DNA. Translation: EAX11139.1.
BC028730 mRNA. Translation: AAH28730.1.
BC035037 mRNA. Translation: AAH35037.1.
AY255528 mRNA. Translation: AAO85040.1.
CCDSiCCDS2259.1.
RefSeqiNP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
XP_016858974.1. XM_017003485.1.
XP_016858975.1. XM_017003486.1.
XP_016858976.1. XM_017003487.1.
UniGeneiHs.516604.
Hs.741466.

Genome annotation databases

EnsembliENST00000295500; ENSP00000295500; ENSG00000163328.
ENST00000392551; ENSP00000376334; ENSG00000163328.
ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneIDi151556.
KEGGihsa:151556.
UCSCiuc002uit.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056381 mRNA. Translation: BAB71170.1. Different initiation.
AK091200 mRNA. Translation: BAC03609.1.
AK096665 mRNA. Translation: BAC04835.1.
AK315125 mRNA. Translation: BAG37579.1.
BX537947 mRNA. Translation: CAD97915.1.
AL834154 mRNA. Translation: CAH10683.1.
AC010894 Genomic DNA. Translation: AAY14707.1.
AC018470 Genomic DNA. Translation: AAY24218.1.
CH471058 Genomic DNA. Translation: EAX11137.1.
CH471058 Genomic DNA. Translation: EAX11138.1.
CH471058 Genomic DNA. Translation: EAX11139.1.
BC028730 mRNA. Translation: AAH28730.1.
BC035037 mRNA. Translation: AAH35037.1.
AY255528 mRNA. Translation: AAO85040.1.
CCDSiCCDS2259.1.
RefSeqiNP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
XP_016858974.1. XM_017003485.1.
XP_016858975.1. XM_017003486.1.
XP_016858976.1. XM_017003487.1.
UniGeneiHs.516604.
Hs.741466.

3D structure databases

ProteinModelPortaliQ7Z3F1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127389. 1 interactor.
MINTiMINT-4726605.
STRINGi9606.ENSP00000295500.

PTM databases

iPTMnetiQ7Z3F1.
PhosphoSitePlusiQ7Z3F1.

Polymorphism and mutation databases

BioMutaiGPR155.
DMDMi68052330.

Proteomic databases

MaxQBiQ7Z3F1.
PaxDbiQ7Z3F1.
PeptideAtlasiQ7Z3F1.
PRIDEiQ7Z3F1.

Protocols and materials databases

DNASUi151556.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295500; ENSP00000295500; ENSG00000163328.
ENST00000392551; ENSP00000376334; ENSG00000163328.
ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneIDi151556.
KEGGihsa:151556.
UCSCiuc002uit.5. human.

Organism-specific databases

CTDi151556.
DisGeNETi151556.
GeneCardsiGPR155.
HGNCiHGNC:22951. GPR155.
HPAiHPA036159.
neXtProtiNX_Q7Z3F1.
OpenTargetsiENSG00000163328.
PharmGKBiPA134943679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEWV. Eukaryota.
ENOG410XQEU. LUCA.
GeneTreeiENSGT00390000004153.
HOVERGENiHBG057276.
InParanoidiQ7Z3F1.
OMAiPARINEP.
OrthoDBiEOG091G046L.
PhylomeDBiQ7Z3F1.
TreeFamiTF324034.

Miscellaneous databases

GeneWikiiGPR155.
GenomeRNAii151556.
PROiQ7Z3F1.

Gene expression databases

BgeeiENSG00000163328.
CleanExiHS_GPR155.
ExpressionAtlasiQ7Z3F1. baseline and differential.
GenevisibleiQ7Z3F1. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR004776. Mem_trans.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP155_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3F1
Secondary accession number(s): B2RCI2
, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.