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Q7Z3F1 (GP155_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integral membrane protein GPR155
Alternative name(s):
G-protein coupled receptor PGR22
Gene names
Name:GPR155
Synonyms:PGR22
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length870 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Contains 1 DEP domain.

Sequence caution

The sequence BAB71170.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 870870Integral membrane protein GPR155
PRO_0000087551

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane347 – 36721Helical; Potential
Transmembrane382 – 40221Helical; Potential
Transmembrane415 – 43521Helical; Potential
Transmembrane439 – 45921Helical; Potential
Transmembrane481 – 50121Helical; Potential
Transmembrane521 – 54121Helical; Potential
Transmembrane661 – 68121Helical; Potential
Transmembrane692 – 71221Helical; Potential
Domain757 – 83579DEP
Compositional bias483 – 4864Poly-Ile

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation3811N-linked (GlcNAc...) Potential
Glycosylation5431N-linked (GlcNAc...) Potential
Glycosylation6121N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict331D → G in BAC03609. Ref.1
Sequence conflict1941K → E in AAH28730. Ref.5
Sequence conflict2601L → H in BAB71170. Ref.1
Sequence conflict4601W → R in CAD97915. Ref.2
Sequence conflict5171G → A in CAH10683. Ref.2
Sequence conflict5501S → G in AAH28730. Ref.5
Sequence conflict6381C → R in CAD97915. Ref.2
Sequence conflict6741S → Y in AAH28730. Ref.5
Sequence conflict6931Q → R in CAH10683. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7Z3F1 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 91A6CFC79B669ACB

FASTA87096,919
        10         20         30         40         50         60 
MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF GIVLCGYIAG 

        70         80         90        100        110        120 
RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW SFLYSILIAK ASVFFIVCVL 

       130        140        150        160        170        180 
TLLVASPDSR FSKAGLFPIF ATQSNDFALG YPIVEALYQT TYPEYLQYIY LVAPISLMML 

       190        200        210        220        230        240 
NPIGFIFCEI QKWKDTQNAS QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY 

       250        260        270        280        290        300 
VENFLDGLGN SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL 

       310        320        330        340        350        360 
LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS TFVSAPIMYV 

       370        380        390        400        410        420 
SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI LLLSKKYKQL PHMLTTNLLI 

       430        440        450        460        470        480 
AQSIVCAGMM IWNFVKEKNF VGQILVFVLL YSSLYSTYLW TGLLAISLFL LKKRERVQIP 

       490        500        510        520        530        540 
VGIIIISGWG IPALLVGVLL ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM 

       550        560        570        580        590        600 
CMNQTAQAGS YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG 

       610        620        630        640        650        660 
ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS GDQQLTRHVL 

       670        680        690        700        710        720 
LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN FGQGFISFGI FGLDKHLIIL 

       730        740        750        760        770        780 
PFKRRLEFLW NNKDTAENRD SPVSEEIKMT CQQFIHYHRD LCIRNIVKER RCGAKTSAGT 

       790        800        810        820        830        840 
FCGCDLVSWL IEVGLASDRG EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ 

       850        860        870 
SPPAINANTL QQERYKEIEH SSPPSHSPKT 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tongue and Trachea.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala and Retina.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-675.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK056381 mRNA. Translation: BAB71170.1. Different initiation.
AK091200 mRNA. Translation: BAC03609.1.
AK096665 mRNA. Translation: BAC04835.1.
AK315125 mRNA. Translation: BAG37579.1.
BX537947 mRNA. Translation: CAD97915.1.
AL834154 mRNA. Translation: CAH10683.1.
AC010894 Genomic DNA. Translation: AAY14707.1.
AC018470 Genomic DNA. Translation: AAY24218.1.
CH471058 Genomic DNA. Translation: EAX11137.1.
CH471058 Genomic DNA. Translation: EAX11138.1.
CH471058 Genomic DNA. Translation: EAX11139.1.
BC028730 mRNA. Translation: AAH28730.1.
BC035037 mRNA. Translation: AAH35037.1.
AY255528 mRNA. Translation: AAO85040.1.
RefSeqNP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
UniGeneHs.516604.
Hs.741466.

3D structure databases

ProteinModelPortalQ7Z3F1.
SMRQ7Z3F1. Positions 765-842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127389. 1 interaction.
MINTMINT-4726605.

PTM databases

PhosphoSiteQ7Z3F1.

Polymorphism databases

DMDM68052330.

Proteomic databases

PaxDbQ7Z3F1.
PRIDEQ7Z3F1.

Protocols and materials databases

DNASU151556.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295500; ENSP00000295500; ENSG00000163328.
ENST00000392551; ENSP00000376334; ENSG00000163328.
ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneID151556.
KEGGhsa:151556.
UCSCuc002uit.4. human.

Organism-specific databases

CTD151556.
GeneCardsGC02M175296.
HGNCHGNC:22951. GPR155.
HPAHPA036159.
neXtProtNX_Q7Z3F1.
PharmGKBPA134943679.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85075.
HOVERGENHBG057276.
InParanoidQ7Z3F1.
OMALYVELQF.
OrthoDBEOG7M3HZS.
PhylomeDBQ7Z3F1.
TreeFamTF324034.

Gene expression databases

BgeeQ7Z3F1.
CleanExHS_GPR155.
GenevestigatorQ7Z3F1.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR004776. Auxin_eff.
IPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view]
SMARTSM00049. DEP. 1 hit.
[Graphical view]
PROSITEPS50186. DEP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR155.
GenomeRNAi151556.
NextBio86726.
PROQ7Z3F1.

Entry information

Entry nameGP155_HUMAN
AccessionPrimary (citable) accession number: Q7Z3F1
Secondary accession number(s): B2RCI2 expand/collapse secondary AC list , D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM