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Protein

Integral membrane protein GPR155

Gene

GPR155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cognition Source: UniProtKB
  2. intracellular signal transduction Source: InterPro
  3. transmembrane transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR155
Alternative name(s):
G-protein coupled receptor PGR22
Gene namesi
Name:GPR155
Synonyms:PGR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:22951. GPR155.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence AnalysisAdd
BLAST
Transmembranei481 – 50121HelicalSequence AnalysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence AnalysisAdd
BLAST
Transmembranei661 – 68121HelicalSequence AnalysisAdd
BLAST
Transmembranei692 – 71221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943679.

Polymorphism and mutation databases

BioMutaiGPR155.
DMDMi68052330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Integral membrane protein GPR155PRO_0000087551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7Z3F1.
PaxDbiQ7Z3F1.
PRIDEiQ7Z3F1.

PTM databases

PhosphoSiteiQ7Z3F1.

Expressioni

Gene expression databases

BgeeiQ7Z3F1.
CleanExiHS_GPR155.
GenevestigatoriQ7Z3F1.

Organism-specific databases

HPAiHPA036159.

Interactioni

Protein-protein interaction databases

BioGridi127389. 1 interaction.
MINTiMINT-4726605.

Structurei

3D structure databases

SMRiQ7Z3F1. Positions 765-842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini757 – 83579DEPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi483 – 4864Poly-Ile

Sequence similaritiesi

Contains 1 DEP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85075.
GeneTreeiENSGT00390000004153.
HOVERGENiHBG057276.
InParanoidiQ7Z3F1.
OMAiMDSYSDF.
OrthoDBiEOG7M3HZS.
PhylomeDBiQ7Z3F1.
TreeFamiTF324034.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR004776. Auxin_eff.
IPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF
60 70 80 90 100
GIVLCGYIAG RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW
110 120 130 140 150
SFLYSILIAK ASVFFIVCVL TLLVASPDSR FSKAGLFPIF ATQSNDFALG
160 170 180 190 200
YPIVEALYQT TYPEYLQYIY LVAPISLMML NPIGFIFCEI QKWKDTQNAS
210 220 230 240 250
QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY VENFLDGLGN
260 270 280 290 300
SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL
310 320 330 340 350
LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS
360 370 380 390 400
TFVSAPIMYV SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI
410 420 430 440 450
LLLSKKYKQL PHMLTTNLLI AQSIVCAGMM IWNFVKEKNF VGQILVFVLL
460 470 480 490 500
YSSLYSTYLW TGLLAISLFL LKKRERVQIP VGIIIISGWG IPALLVGVLL
510 520 530 540 550
ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM CMNQTAQAGS
560 570 580 590 600
YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG
610 620 630 640 650
ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS
660 670 680 690 700
GDQQLTRHVL LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN
710 720 730 740 750
FGQGFISFGI FGLDKHLIIL PFKRRLEFLW NNKDTAENRD SPVSEEIKMT
760 770 780 790 800
CQQFIHYHRD LCIRNIVKER RCGAKTSAGT FCGCDLVSWL IEVGLASDRG
810 820 830 840 850
EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ SPPAINANTL
860 870
QQERYKEIEH SSPPSHSPKT
Length:870
Mass (Da):96,919
Last modified:June 21, 2005 - v2
Checksum:i91A6CFC79B669ACB
GO

Sequence cautioni

The sequence BAB71170.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331D → G in BAC03609 (PubMed:14702039).Curated
Sequence conflicti194 – 1941K → E in AAH28730 (PubMed:15489334).Curated
Sequence conflicti260 – 2601L → H in BAB71170 (PubMed:14702039).Curated
Sequence conflicti460 – 4601W → R in CAD97915 (PubMed:17974005).Curated
Sequence conflicti517 – 5171G → A in CAH10683 (PubMed:17974005).Curated
Sequence conflicti550 – 5501S → G in AAH28730 (PubMed:15489334).Curated
Sequence conflicti638 – 6381C → R in CAD97915 (PubMed:17974005).Curated
Sequence conflicti674 – 6741S → Y in AAH28730 (PubMed:15489334).Curated
Sequence conflicti693 – 6931Q → R in CAH10683 (PubMed:17974005).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056381 mRNA. Translation: BAB71170.1. Different initiation.
AK091200 mRNA. Translation: BAC03609.1.
AK096665 mRNA. Translation: BAC04835.1.
AK315125 mRNA. Translation: BAG37579.1.
BX537947 mRNA. Translation: CAD97915.1.
AL834154 mRNA. Translation: CAH10683.1.
AC010894 Genomic DNA. Translation: AAY14707.1.
AC018470 Genomic DNA. Translation: AAY24218.1.
CH471058 Genomic DNA. Translation: EAX11137.1.
CH471058 Genomic DNA. Translation: EAX11138.1.
CH471058 Genomic DNA. Translation: EAX11139.1.
BC028730 mRNA. Translation: AAH28730.1.
BC035037 mRNA. Translation: AAH35037.1.
AY255528 mRNA. Translation: AAO85040.1.
CCDSiCCDS2259.1.
RefSeqiNP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
UniGeneiHs.516604.
Hs.741466.

Genome annotation databases

EnsembliENST00000295500; ENSP00000295500; ENSG00000163328.
ENST00000392551; ENSP00000376334; ENSG00000163328.
ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneIDi151556.
KEGGihsa:151556.
UCSCiuc002uit.4. human.

Polymorphism and mutation databases

BioMutaiGPR155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056381 mRNA. Translation: BAB71170.1. Different initiation.
AK091200 mRNA. Translation: BAC03609.1.
AK096665 mRNA. Translation: BAC04835.1.
AK315125 mRNA. Translation: BAG37579.1.
BX537947 mRNA. Translation: CAD97915.1.
AL834154 mRNA. Translation: CAH10683.1.
AC010894 Genomic DNA. Translation: AAY14707.1.
AC018470 Genomic DNA. Translation: AAY24218.1.
CH471058 Genomic DNA. Translation: EAX11137.1.
CH471058 Genomic DNA. Translation: EAX11138.1.
CH471058 Genomic DNA. Translation: EAX11139.1.
BC028730 mRNA. Translation: AAH28730.1.
BC035037 mRNA. Translation: AAH35037.1.
AY255528 mRNA. Translation: AAO85040.1.
CCDSiCCDS2259.1.
RefSeqiNP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
UniGeneiHs.516604.
Hs.741466.

3D structure databases

SMRiQ7Z3F1. Positions 765-842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127389. 1 interaction.
MINTiMINT-4726605.

PTM databases

PhosphoSiteiQ7Z3F1.

Polymorphism and mutation databases

BioMutaiGPR155.
DMDMi68052330.

Proteomic databases

MaxQBiQ7Z3F1.
PaxDbiQ7Z3F1.
PRIDEiQ7Z3F1.

Protocols and materials databases

DNASUi151556.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295500; ENSP00000295500; ENSG00000163328.
ENST00000392551; ENSP00000376334; ENSG00000163328.
ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneIDi151556.
KEGGihsa:151556.
UCSCiuc002uit.4. human.

Organism-specific databases

CTDi151556.
GeneCardsiGC02M175296.
HGNCiHGNC:22951. GPR155.
HPAiHPA036159.
neXtProtiNX_Q7Z3F1.
PharmGKBiPA134943679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85075.
GeneTreeiENSGT00390000004153.
HOVERGENiHBG057276.
InParanoidiQ7Z3F1.
OMAiMDSYSDF.
OrthoDBiEOG7M3HZS.
PhylomeDBiQ7Z3F1.
TreeFamiTF324034.

Miscellaneous databases

GeneWikiiGPR155.
GenomeRNAii151556.
NextBioi86726.
PROiQ7Z3F1.

Gene expression databases

BgeeiQ7Z3F1.
CleanExiHS_GPR155.
GenevestigatoriQ7Z3F1.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR004776. Auxin_eff.
IPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue and Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Retina.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-675.

Entry informationi

Entry nameiGP155_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3F1
Secondary accession number(s): B2RCI2
, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: April 29, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.