Q7Z3F1 (GP155_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integral membrane protein GPR155

Alternative name(s):
G-protein coupled receptor PGR22

Gene names

Name:	GPR155
Synonyms:	PGR22

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	870 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Contains 1 DEP domain.
Sequence caution	The sequence BAB71170.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 870	870	Integral membrane protein GPR155		PRO_0000087551
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Transmembrane	214 – 234	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Transmembrane	274 – 294	21	Helical; Potential
	Transmembrane	316 – 336	21	Helical; Potential
	Transmembrane	347 – 367	21	Helical; Potential
	Transmembrane	382 – 402	21	Helical; Potential
	Transmembrane	415 – 435	21	Helical; Potential
	Transmembrane	439 – 459	21	Helical; Potential
	Transmembrane	481 – 501	21	Helical; Potential
	Transmembrane	521 – 541	21	Helical; Potential
	Transmembrane	661 – 681	21	Helical; Potential
	Transmembrane	692 – 712	21	Helical; Potential
	Domain	757 – 835	79	DEP
	Compositional bias	483 – 486	4	Poly-Ile
Amino acid modifications
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	15	1	N-linked (GlcNAc...) Potential
	Glycosylation	29	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Glycosylation	309	1	N-linked (GlcNAc...) Potential
	Glycosylation	381	1	N-linked (GlcNAc...) Potential
	Glycosylation	543	1	N-linked (GlcNAc...) Potential
	Glycosylation	612	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	33	1	D → G in BAC03609. Ref.1
	Sequence conflict	194	1	K → E in AAH28730. Ref.5
	Sequence conflict	260	1	L → H in BAB71170. Ref.1
	Sequence conflict	460	1	W → R in CAD97915. Ref.2
	Sequence conflict	517	1	G → A in CAH10683. Ref.2
	Sequence conflict	550	1	S → G in AAH28730. Ref.5
	Sequence conflict	638	1	C → R in CAD97915. Ref.2
	Sequence conflict	674	1	S → Y in AAH28730. Ref.5
	Sequence conflict	693	1	Q → R in CAH10683. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q7Z3F1 [UniParc]. Last modified June 21, 2005. Version 2. Checksum: 91A6CFC79B669ACB	FASTA	870	96,919
	10 20 30 40 50 60 MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF GIVLCGYIAG 70 80 90 100 110 120 RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW SFLYSILIAK ASVFFIVCVL 130 140 150 160 170 180 TLLVASPDSR FSKAGLFPIF ATQSNDFALG YPIVEALYQT TYPEYLQYIY LVAPISLMML 190 200 210 220 230 240 NPIGFIFCEI QKWKDTQNAS QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY 250 260 270 280 290 300 VENFLDGLGN SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL 310 320 330 340 350 360 LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS TFVSAPIMYV 370 380 390 400 410 420 SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI LLLSKKYKQL PHMLTTNLLI 430 440 450 460 470 480 AQSIVCAGMM IWNFVKEKNF VGQILVFVLL YSSLYSTYLW TGLLAISLFL LKKRERVQIP 490 500 510 520 530 540 VGIIIISGWG IPALLVGVLL ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM 550 560 570 580 590 600 CMNQTAQAGS YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG 610 620 630 640 650 660 ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS GDQQLTRHVL 670 680 690 700 710 720 LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN FGQGFISFGI FGLDKHLIIL 730 740 750 760 770 780 PFKRRLEFLW NNKDTAENRD SPVSEEIKMT CQQFIHYHRD LCIRNIVKER RCGAKTSAGT 790 800 810 820 830 840 FCGCDLVSWL IEVGLASDRG EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ 850 860 870 SPPAINANTL QQERYKEIEH SSPPSHSPKT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue and Trachea.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala and Retina.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-675.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056381 mRNA. Translation: BAB71170.1. Different initiation. AK091200 mRNA. Translation: BAC03609.1. AK096665 mRNA. Translation: BAC04835.1. AK315125 mRNA. Translation: BAG37579.1. BX537947 mRNA. Translation: CAD97915.1. AL834154 mRNA. Translation: CAH10683.1. AC010894 Genomic DNA. Translation: AAY14707.1. AC018470 Genomic DNA. Translation: AAY24218.1. CH471058 Genomic DNA. Translation: EAX11137.1. CH471058 Genomic DNA. Translation: EAX11138.1. CH471058 Genomic DNA. Translation: EAX11139.1. BC028730 mRNA. Translation: AAH28730.1. BC035037 mRNA. Translation: AAH35037.1. AY255528 mRNA. Translation: AAO85040.1.
IPI	IPI00396054.
RefSeq	NP_001028217.1. NM_001033045.3. NP_001253979.1. NM_001267050.1. NP_001253980.1. NM_001267051.1. NP_689742.4. NM_152529.6.
UniGene	Hs.516604. Hs.741466.
3D structure databases
ProteinModelPortal	Q7Z3F1.
ModBase	Search...
PTM databases
PhosphoSite	Q7Z3F1.
Polymorphism databases
DMDM	68052330.
Proteomic databases
PaxDb	Q7Z3F1.
PRIDE	Q7Z3F1.
Protocols and materials databases
DNASU	151556.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000295500; ENSP00000295500; ENSG00000163328. ENST00000392551; ENSP00000376334; ENSG00000163328. ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneID	151556.
KEGG	hsa:151556.
UCSC	uc002uit.3. human.
Organism-specific databases
CTD	151556.
GeneCards	GC02M175296.
HGNC	HGNC:22951. GPR155.
HPA	HPA036159.
neXtProt	NX_Q7Z3F1.
PharmGKB	PA134943679.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85075.
HOVERGEN	HBG057276.
InParanoid	Q7Z3F1.
OMA	IFGLDKH.
OrthoDB	EOG4WWRHW.
PhylomeDB	Q7Z3F1.
Gene expression databases
ArrayExpress	Q7Z3F1.
Bgee	Q7Z3F1.
CleanEx	HS_GPR155.
Genevestigator	Q7Z3F1.
GermOnline	ENSG00000163328. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR004776. Auxin_eff. IPR000591. DEP_dom. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00610. DEP. 1 hit. PF03547. Mem_trans. 2 hits. [Graphical view]
SMART	SM00049. DEP. 1 hit. [Graphical view]
PROSITE	PS50186. DEP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	151556.
NextBio	86726.

Entry information

Entry name

GP155_HUMAN

Accession

Primary (citable) accession number: Q7Z3F1
Secondary accession number(s): B2RCI2 , D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.