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Protein

Integral membrane protein GPR155

Gene

GPR155

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cognition Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • transmembrane transport Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR155
Alternative name(s):
G-protein coupled receptor PGR22
Gene namesi
Name:GPR155
Synonyms:PGR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163328.13
HGNCiHGNC:22951 GPR155
neXtProtiNX_Q7Z3F1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei661 – 681HelicalSequence analysisAdd BLAST21
Transmembranei692 – 712HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi151556
OpenTargetsiENSG00000163328
PharmGKBiPA134943679

Polymorphism and mutation databases

BioMutaiGPR155
DMDMi68052330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875511 – 870Integral membrane protein GPR155Add BLAST870

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7Z3F1
PaxDbiQ7Z3F1
PeptideAtlasiQ7Z3F1
PRIDEiQ7Z3F1

PTM databases

iPTMnetiQ7Z3F1
PhosphoSitePlusiQ7Z3F1

Expressioni

Gene expression databases

BgeeiENSG00000163328
CleanExiHS_GPR155
ExpressionAtlasiQ7Z3F1 baseline and differential
GenevisibleiQ7Z3F1 HS

Organism-specific databases

HPAiHPA036159
HPA057384

Interactioni

Protein-protein interaction databases

BioGridi127389, 1 interactor
STRINGi9606.ENSP00000295500

Structurei

3D structure databases

ProteinModelPortaliQ7Z3F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini757 – 835DEPPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi483 – 486Poly-Ile4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWV Eukaryota
ENOG410XQEU LUCA
GeneTreeiENSGT00390000004153
HOVERGENiHBG057276
InParanoidiQ7Z3F1
OMAiLYVELQF
OrthoDBiEOG091G046L
PhylomeDBiQ7Z3F1
TreeFamiTF324034

Family and domain databases

CDDicd04443 DEP_GPR155, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR037368 GPR155_DEP
IPR004776 Mem_trans
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF03547 Mem_trans, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z3F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF
60 70 80 90 100
GIVLCGYIAG RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW
110 120 130 140 150
SFLYSILIAK ASVFFIVCVL TLLVASPDSR FSKAGLFPIF ATQSNDFALG
160 170 180 190 200
YPIVEALYQT TYPEYLQYIY LVAPISLMML NPIGFIFCEI QKWKDTQNAS
210 220 230 240 250
QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY VENFLDGLGN
260 270 280 290 300
SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL
310 320 330 340 350
LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS
360 370 380 390 400
TFVSAPIMYV SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI
410 420 430 440 450
LLLSKKYKQL PHMLTTNLLI AQSIVCAGMM IWNFVKEKNF VGQILVFVLL
460 470 480 490 500
YSSLYSTYLW TGLLAISLFL LKKRERVQIP VGIIIISGWG IPALLVGVLL
510 520 530 540 550
ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM CMNQTAQAGS
560 570 580 590 600
YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG
610 620 630 640 650
ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS
660 670 680 690 700
GDQQLTRHVL LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN
710 720 730 740 750
FGQGFISFGI FGLDKHLIIL PFKRRLEFLW NNKDTAENRD SPVSEEIKMT
760 770 780 790 800
CQQFIHYHRD LCIRNIVKER RCGAKTSAGT FCGCDLVSWL IEVGLASDRG
810 820 830 840 850
EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ SPPAINANTL
860 870
QQERYKEIEH SSPPSHSPKT
Length:870
Mass (Da):96,919
Last modified:June 21, 2005 - v2
Checksum:i91A6CFC79B669ACB
GO

Sequence cautioni

The sequence BAB71170 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33D → G in BAC03609 (PubMed:14702039).Curated1
Sequence conflicti194K → E in AAH28730 (PubMed:15489334).Curated1
Sequence conflicti260L → H in BAB71170 (PubMed:14702039).Curated1
Sequence conflicti460W → R in CAD97915 (PubMed:17974005).Curated1
Sequence conflicti517G → A in CAH10683 (PubMed:17974005).Curated1
Sequence conflicti550S → G in AAH28730 (PubMed:15489334).Curated1
Sequence conflicti638C → R in CAD97915 (PubMed:17974005).Curated1
Sequence conflicti674S → Y in AAH28730 (PubMed:15489334).Curated1
Sequence conflicti693Q → R in CAH10683 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056381 mRNA Translation: BAB71170.1 Different initiation.
AK091200 mRNA Translation: BAC03609.1
AK096665 mRNA Translation: BAC04835.1
AK315125 mRNA Translation: BAG37579.1
BX537947 mRNA Translation: CAD97915.1
AL834154 mRNA Translation: CAH10683.1
AC010894 Genomic DNA Translation: AAY14707.1
AC018470 Genomic DNA Translation: AAY24218.1
CH471058 Genomic DNA Translation: EAX11137.1
CH471058 Genomic DNA Translation: EAX11138.1
CH471058 Genomic DNA Translation: EAX11139.1
BC028730 mRNA Translation: AAH28730.1
BC035037 mRNA Translation: AAH35037.1
AY255528 mRNA Translation: AAO85040.1
CCDSiCCDS2259.1
RefSeqiNP_001028217.1, NM_001033045.3
NP_001253979.1, NM_001267050.1
NP_001253980.1, NM_001267051.1
NP_689742.4, NM_152529.6
XP_016858974.1, XM_017003485.1
XP_016858975.1, XM_017003486.1
XP_016858976.1, XM_017003487.1
UniGeneiHs.516604
Hs.741466

Genome annotation databases

EnsembliENST00000295500; ENSP00000295500; ENSG00000163328
ENST00000392551; ENSP00000376334; ENSG00000163328
ENST00000392552; ENSP00000376335; ENSG00000163328
GeneIDi151556
KEGGihsa:151556
UCSCiuc002uit.5 human

Similar proteinsi

Entry informationi

Entry nameiGP155_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3F1
Secondary accession number(s): B2RCI2
, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: April 25, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

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