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Q7Z3F1

- GP155_HUMAN

UniProt

Q7Z3F1 - GP155_HUMAN

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Protein

Integral membrane protein GPR155

Gene
GPR155, PGR22
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cognition Source: UniProt
  2. intracellular signal transduction Source: InterPro
  3. transmembrane transport Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR155
Alternative name(s):
G-protein coupled receptor PGR22
Gene namesi
Name:GPR155
Synonyms:PGR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:22951. GPR155.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Reviewed predictionAdd
BLAST
Transmembranei105 – 12521Helical; Reviewed predictionAdd
BLAST
Transmembranei134 – 15421Helical; Reviewed predictionAdd
BLAST
Transmembranei168 – 18821Helical; Reviewed predictionAdd
BLAST
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Transmembranei244 – 26421Helical; Reviewed predictionAdd
BLAST
Transmembranei274 – 29421Helical; Reviewed predictionAdd
BLAST
Transmembranei316 – 33621Helical; Reviewed predictionAdd
BLAST
Transmembranei347 – 36721Helical; Reviewed predictionAdd
BLAST
Transmembranei382 – 40221Helical; Reviewed predictionAdd
BLAST
Transmembranei415 – 43521Helical; Reviewed predictionAdd
BLAST
Transmembranei439 – 45921Helical; Reviewed predictionAdd
BLAST
Transmembranei481 – 50121Helical; Reviewed predictionAdd
BLAST
Transmembranei521 – 54121Helical; Reviewed predictionAdd
BLAST
Transmembranei661 – 68121Helical; Reviewed predictionAdd
BLAST
Transmembranei692 – 71221Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 870870Integral membrane protein GPR155PRO_0000087551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi543 – 5431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi612 – 6121N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7Z3F1.
PRIDEiQ7Z3F1.

PTM databases

PhosphoSiteiQ7Z3F1.

Expressioni

Gene expression databases

BgeeiQ7Z3F1.
CleanExiHS_GPR155.
GenevestigatoriQ7Z3F1.

Organism-specific databases

HPAiHPA036159.

Interactioni

Protein-protein interaction databases

BioGridi127389. 1 interaction.
MINTiMINT-4726605.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3F1.
SMRiQ7Z3F1. Positions 765-842.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini757 – 83579DEPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi483 – 4864Poly-Ile

Sequence similaritiesi

Contains 1 DEP domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG85075.
HOVERGENiHBG057276.
InParanoidiQ7Z3F1.
OMAiLYVELQF.
OrthoDBiEOG7M3HZS.
PhylomeDBiQ7Z3F1.
TreeFamiTF324034.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR004776. Auxin_eff.
IPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view]
SMARTiSM00049. DEP. 1 hit.
[Graphical view]
PROSITEiPS50186. DEP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3F1-1 [UniParc]FASTAAdd to Basket

« Hide

MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF    50
GIVLCGYIAG RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW 100
SFLYSILIAK ASVFFIVCVL TLLVASPDSR FSKAGLFPIF ATQSNDFALG 150
YPIVEALYQT TYPEYLQYIY LVAPISLMML NPIGFIFCEI QKWKDTQNAS 200
QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY VENFLDGLGN 250
SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL 300
LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS 350
TFVSAPIMYV SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI 400
LLLSKKYKQL PHMLTTNLLI AQSIVCAGMM IWNFVKEKNF VGQILVFVLL 450
YSSLYSTYLW TGLLAISLFL LKKRERVQIP VGIIIISGWG IPALLVGVLL 500
ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM CMNQTAQAGS 550
YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG 600
ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS 650
GDQQLTRHVL LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN 700
FGQGFISFGI FGLDKHLIIL PFKRRLEFLW NNKDTAENRD SPVSEEIKMT 750
CQQFIHYHRD LCIRNIVKER RCGAKTSAGT FCGCDLVSWL IEVGLASDRG 800
EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ SPPAINANTL 850
QQERYKEIEH SSPPSHSPKT 870
Length:870
Mass (Da):96,919
Last modified:June 21, 2005 - v2
Checksum:i91A6CFC79B669ACB
GO

Sequence cautioni

The sequence BAB71170.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331D → G in BAC03609. 1 Publication
Sequence conflicti194 – 1941K → E in AAH28730. 1 Publication
Sequence conflicti260 – 2601L → H in BAB71170. 1 Publication
Sequence conflicti460 – 4601W → R in CAD97915. 1 Publication
Sequence conflicti517 – 5171G → A in CAH10683. 1 Publication
Sequence conflicti550 – 5501S → G in AAH28730. 1 Publication
Sequence conflicti638 – 6381C → R in CAD97915. 1 Publication
Sequence conflicti674 – 6741S → Y in AAH28730. 1 Publication
Sequence conflicti693 – 6931Q → R in CAH10683. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056381 mRNA. Translation: BAB71170.1. Different initiation.
AK091200 mRNA. Translation: BAC03609.1.
AK096665 mRNA. Translation: BAC04835.1.
AK315125 mRNA. Translation: BAG37579.1.
BX537947 mRNA. Translation: CAD97915.1.
AL834154 mRNA. Translation: CAH10683.1.
AC010894 Genomic DNA. Translation: AAY14707.1.
AC018470 Genomic DNA. Translation: AAY24218.1.
CH471058 Genomic DNA. Translation: EAX11137.1.
CH471058 Genomic DNA. Translation: EAX11138.1.
CH471058 Genomic DNA. Translation: EAX11139.1.
BC028730 mRNA. Translation: AAH28730.1.
BC035037 mRNA. Translation: AAH35037.1.
AY255528 mRNA. Translation: AAO85040.1.
CCDSiCCDS2259.1.
RefSeqiNP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
UniGeneiHs.516604.
Hs.741466.

Genome annotation databases

EnsembliENST00000295500; ENSP00000295500; ENSG00000163328.
ENST00000392551; ENSP00000376334; ENSG00000163328.
ENST00000392552; ENSP00000376335; ENSG00000163328.
GeneIDi151556.
KEGGihsa:151556.
UCSCiuc002uit.4. human.

Polymorphism databases

DMDMi68052330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK056381 mRNA. Translation: BAB71170.1 . Different initiation.
AK091200 mRNA. Translation: BAC03609.1 .
AK096665 mRNA. Translation: BAC04835.1 .
AK315125 mRNA. Translation: BAG37579.1 .
BX537947 mRNA. Translation: CAD97915.1 .
AL834154 mRNA. Translation: CAH10683.1 .
AC010894 Genomic DNA. Translation: AAY14707.1 .
AC018470 Genomic DNA. Translation: AAY24218.1 .
CH471058 Genomic DNA. Translation: EAX11137.1 .
CH471058 Genomic DNA. Translation: EAX11138.1 .
CH471058 Genomic DNA. Translation: EAX11139.1 .
BC028730 mRNA. Translation: AAH28730.1 .
BC035037 mRNA. Translation: AAH35037.1 .
AY255528 mRNA. Translation: AAO85040.1 .
CCDSi CCDS2259.1.
RefSeqi NP_001028217.1. NM_001033045.3.
NP_001253979.1. NM_001267050.1.
NP_001253980.1. NM_001267051.1.
NP_689742.4. NM_152529.6.
UniGenei Hs.516604.
Hs.741466.

3D structure databases

ProteinModelPortali Q7Z3F1.
SMRi Q7Z3F1. Positions 765-842.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127389. 1 interaction.
MINTi MINT-4726605.

PTM databases

PhosphoSitei Q7Z3F1.

Polymorphism databases

DMDMi 68052330.

Proteomic databases

PaxDbi Q7Z3F1.
PRIDEi Q7Z3F1.

Protocols and materials databases

DNASUi 151556.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295500 ; ENSP00000295500 ; ENSG00000163328 .
ENST00000392551 ; ENSP00000376334 ; ENSG00000163328 .
ENST00000392552 ; ENSP00000376335 ; ENSG00000163328 .
GeneIDi 151556.
KEGGi hsa:151556.
UCSCi uc002uit.4. human.

Organism-specific databases

CTDi 151556.
GeneCardsi GC02M175296.
HGNCi HGNC:22951. GPR155.
HPAi HPA036159.
neXtProti NX_Q7Z3F1.
PharmGKBi PA134943679.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85075.
HOVERGENi HBG057276.
InParanoidi Q7Z3F1.
OMAi LYVELQF.
OrthoDBi EOG7M3HZS.
PhylomeDBi Q7Z3F1.
TreeFami TF324034.

Miscellaneous databases

GeneWikii GPR155.
GenomeRNAii 151556.
NextBioi 86726.
PROi Q7Z3F1.

Gene expression databases

Bgeei Q7Z3F1.
CleanExi HS_GPR155.
Genevestigatori Q7Z3F1.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR004776. Auxin_eff.
IPR000591. DEP_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00610. DEP. 1 hit.
PF03547. Mem_trans. 2 hits.
[Graphical view ]
SMARTi SM00049. DEP. 1 hit.
[Graphical view ]
PROSITEi PS50186. DEP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue and Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Retina.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-675.

Entry informationi

Entry nameiGP155_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3F1
Secondary accession number(s): B2RCI2
, D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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