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Q7Z3F1

- GP155_HUMAN

UniProt

Q7Z3F1 - GP155_HUMAN

Protein

Integral membrane protein GPR155

Gene

GPR155

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cognition Source: UniProt
    2. intracellular signal transduction Source: InterPro
    3. transmembrane transport Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integral membrane protein GPR155
    Alternative name(s):
    G-protein coupled receptor PGR22
    Gene namesi
    Name:GPR155
    Synonyms:PGR22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:22951. GPR155.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134943679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 870870Integral membrane protein GPR155PRO_0000087551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi612 – 6121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ7Z3F1.
    PRIDEiQ7Z3F1.

    PTM databases

    PhosphoSiteiQ7Z3F1.

    Expressioni

    Gene expression databases

    BgeeiQ7Z3F1.
    CleanExiHS_GPR155.
    GenevestigatoriQ7Z3F1.

    Organism-specific databases

    HPAiHPA036159.

    Interactioni

    Protein-protein interaction databases

    BioGridi127389. 1 interaction.
    MINTiMINT-4726605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z3F1.
    SMRiQ7Z3F1. Positions 765-842.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei347 – 36721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei439 – 45921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei521 – 54121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei661 – 68121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei692 – 71221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini757 – 83579DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi483 – 4864Poly-Ile

    Sequence similaritiesi

    Contains 1 DEP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG85075.
    HOVERGENiHBG057276.
    InParanoidiQ7Z3F1.
    OMAiLYVELQF.
    OrthoDBiEOG7M3HZS.
    PhylomeDBiQ7Z3F1.
    TreeFamiTF324034.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR004776. Auxin_eff.
    IPR000591. DEP_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00610. DEP. 1 hit.
    PF03547. Mem_trans. 2 hits.
    [Graphical view]
    SMARTiSM00049. DEP. 1 hit.
    [Graphical view]
    PROSITEiPS50186. DEP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z3F1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSNLPAENL TIAVNMTKTL PTAVTHGFNS TNDPPSMSIT RLFPALLECF    50
    GIVLCGYIAG RANVITSTQA KGLGNFVSRF ALPALLFKNM VVLNFSNVDW 100
    SFLYSILIAK ASVFFIVCVL TLLVASPDSR FSKAGLFPIF ATQSNDFALG 150
    YPIVEALYQT TYPEYLQYIY LVAPISLMML NPIGFIFCEI QKWKDTQNAS 200
    QNKIKIVGLG LLRVLQNPIV FMVFIGIAFN FILDRKVPVY VENFLDGLGN 250
    SFSGSALFYL GLTMVGKIKR LKKSAFVVLI LLITAKLLVL PLLCREMVEL 300
    LDKGDSVVNH TSLSNYAFLY GVFPVAPGVA IFATQFNMEV EIITSGMVIS 350
    TFVSAPIMYV SAWLLTFPTM DPKPLAYAIQ NVSFDISIVS LISLIWSLAI 400
    LLLSKKYKQL PHMLTTNLLI AQSIVCAGMM IWNFVKEKNF VGQILVFVLL 450
    YSSLYSTYLW TGLLAISLFL LKKRERVQIP VGIIIISGWG IPALLVGVLL 500
    ITGKHNGDSI DSAFFYGKEQ MITTAVTLFC SILIAGISLM CMNQTAQAGS 550
    YEGFDQSQSH KVVEPGNTAF EESPAPVNEP ELFTSSIPET SCCSCSMGNG 600
    ELHCPSIEPI ANTSTSEPVI PSFEKNNHCV SRCNSQSCIL AQEEEQYLQS 650
    GDQQLTRHVL LCLLLIIGLF ANLSSCLWWL FNQEPGRLYV ELQFFCAVFN 700
    FGQGFISFGI FGLDKHLIIL PFKRRLEFLW NNKDTAENRD SPVSEEIKMT 750
    CQQFIHYHRD LCIRNIVKER RCGAKTSAGT FCGCDLVSWL IEVGLASDRG 800
    EAVIYGDRLV QGGVIQHITN EYEFRDEYLF YRFLQKSPEQ SPPAINANTL 850
    QQERYKEIEH SSPPSHSPKT 870
    Length:870
    Mass (Da):96,919
    Last modified:June 21, 2005 - v2
    Checksum:i91A6CFC79B669ACB
    GO

    Sequence cautioni

    The sequence BAB71170.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331D → G in BAC03609. (PubMed:14702039)Curated
    Sequence conflicti194 – 1941K → E in AAH28730. (PubMed:15489334)Curated
    Sequence conflicti260 – 2601L → H in BAB71170. (PubMed:14702039)Curated
    Sequence conflicti460 – 4601W → R in CAD97915. (PubMed:17974005)Curated
    Sequence conflicti517 – 5171G → A in CAH10683. (PubMed:17974005)Curated
    Sequence conflicti550 – 5501S → G in AAH28730. (PubMed:15489334)Curated
    Sequence conflicti638 – 6381C → R in CAD97915. (PubMed:17974005)Curated
    Sequence conflicti674 – 6741S → Y in AAH28730. (PubMed:15489334)Curated
    Sequence conflicti693 – 6931Q → R in CAH10683. (PubMed:17974005)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056381 mRNA. Translation: BAB71170.1. Different initiation.
    AK091200 mRNA. Translation: BAC03609.1.
    AK096665 mRNA. Translation: BAC04835.1.
    AK315125 mRNA. Translation: BAG37579.1.
    BX537947 mRNA. Translation: CAD97915.1.
    AL834154 mRNA. Translation: CAH10683.1.
    AC010894 Genomic DNA. Translation: AAY14707.1.
    AC018470 Genomic DNA. Translation: AAY24218.1.
    CH471058 Genomic DNA. Translation: EAX11137.1.
    CH471058 Genomic DNA. Translation: EAX11138.1.
    CH471058 Genomic DNA. Translation: EAX11139.1.
    BC028730 mRNA. Translation: AAH28730.1.
    BC035037 mRNA. Translation: AAH35037.1.
    AY255528 mRNA. Translation: AAO85040.1.
    CCDSiCCDS2259.1.
    RefSeqiNP_001028217.1. NM_001033045.3.
    NP_001253979.1. NM_001267050.1.
    NP_001253980.1. NM_001267051.1.
    NP_689742.4. NM_152529.6.
    UniGeneiHs.516604.
    Hs.741466.

    Genome annotation databases

    EnsembliENST00000295500; ENSP00000295500; ENSG00000163328.
    ENST00000392551; ENSP00000376334; ENSG00000163328.
    ENST00000392552; ENSP00000376335; ENSG00000163328.
    GeneIDi151556.
    KEGGihsa:151556.
    UCSCiuc002uit.4. human.

    Polymorphism databases

    DMDMi68052330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK056381 mRNA. Translation: BAB71170.1 . Different initiation.
    AK091200 mRNA. Translation: BAC03609.1 .
    AK096665 mRNA. Translation: BAC04835.1 .
    AK315125 mRNA. Translation: BAG37579.1 .
    BX537947 mRNA. Translation: CAD97915.1 .
    AL834154 mRNA. Translation: CAH10683.1 .
    AC010894 Genomic DNA. Translation: AAY14707.1 .
    AC018470 Genomic DNA. Translation: AAY24218.1 .
    CH471058 Genomic DNA. Translation: EAX11137.1 .
    CH471058 Genomic DNA. Translation: EAX11138.1 .
    CH471058 Genomic DNA. Translation: EAX11139.1 .
    BC028730 mRNA. Translation: AAH28730.1 .
    BC035037 mRNA. Translation: AAH35037.1 .
    AY255528 mRNA. Translation: AAO85040.1 .
    CCDSi CCDS2259.1.
    RefSeqi NP_001028217.1. NM_001033045.3.
    NP_001253979.1. NM_001267050.1.
    NP_001253980.1. NM_001267051.1.
    NP_689742.4. NM_152529.6.
    UniGenei Hs.516604.
    Hs.741466.

    3D structure databases

    ProteinModelPortali Q7Z3F1.
    SMRi Q7Z3F1. Positions 765-842.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127389. 1 interaction.
    MINTi MINT-4726605.

    PTM databases

    PhosphoSitei Q7Z3F1.

    Polymorphism databases

    DMDMi 68052330.

    Proteomic databases

    PaxDbi Q7Z3F1.
    PRIDEi Q7Z3F1.

    Protocols and materials databases

    DNASUi 151556.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295500 ; ENSP00000295500 ; ENSG00000163328 .
    ENST00000392551 ; ENSP00000376334 ; ENSG00000163328 .
    ENST00000392552 ; ENSP00000376335 ; ENSG00000163328 .
    GeneIDi 151556.
    KEGGi hsa:151556.
    UCSCi uc002uit.4. human.

    Organism-specific databases

    CTDi 151556.
    GeneCardsi GC02M175296.
    HGNCi HGNC:22951. GPR155.
    HPAi HPA036159.
    neXtProti NX_Q7Z3F1.
    PharmGKBi PA134943679.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85075.
    HOVERGENi HBG057276.
    InParanoidi Q7Z3F1.
    OMAi LYVELQF.
    OrthoDBi EOG7M3HZS.
    PhylomeDBi Q7Z3F1.
    TreeFami TF324034.

    Miscellaneous databases

    GeneWikii GPR155.
    GenomeRNAii 151556.
    NextBioi 86726.
    PROi Q7Z3F1.

    Gene expression databases

    Bgeei Q7Z3F1.
    CleanExi HS_GPR155.
    Genevestigatori Q7Z3F1.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR004776. Auxin_eff.
    IPR000591. DEP_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00610. DEP. 1 hit.
    PF03547. Mem_trans. 2 hits.
    [Graphical view ]
    SMARTi SM00049. DEP. 1 hit.
    [Graphical view ]
    PROSITEi PS50186. DEP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue and Trachea.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala and Retina.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-675.

    Entry informationi

    Entry nameiGP155_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3F1
    Secondary accession number(s): B2RCI2
    , D3DPE2, Q4G0Y6, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3