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Q7Z3E5

- ARMC9_HUMAN

UniProt

Q7Z3E5 - ARMC9_HUMAN

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Protein

LisH domain-containing protein ARMC9

Gene

ARMC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LisH domain-containing protein ARMC9
Alternative name(s):
Melanoma/melanocyte-specific tumor antigen KU-MEL-1
NS21
Gene namesi
Name:ARMC9
Synonyms:KIAA1868
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20730. ARMC9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817LisH domain-containing protein ARMC9PRO_0000280595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei582 – 5821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z3E5.
PaxDbiQ7Z3E5.
PRIDEiQ7Z3E5.

PTM databases

PhosphoSiteiQ7Z3E5.

Expressioni

Tissue specificityi

Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis.1 Publication

Gene expression databases

BgeeiQ7Z3E5.
CleanExiHS_ARMC9.
ExpressionAtlasiQ7Z3E5. baseline and differential.
GenevestigatoriQ7Z3E5.

Organism-specific databases

HPAiHPA019041.
HPA026671.

Interactioni

Protein-protein interaction databases

BioGridi123179. 7 interactions.
STRINGi9606.ENSP00000258417.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E5.
SMRiQ7Z3E5. Positions 375-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 3933LisHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili204 – 23027Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi708 – 7114Poly-Ser

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG80009.
GeneTreeiENSGT00390000018026.
HOVERGENiHBG080866.
InParanoidiQ7Z3E5.
OMAiKPLCKTV.
OrthoDBiEOG7DC23S.
PhylomeDBiQ7Z3E5.
TreeFamiTF317676.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006594. LisH_dimerisation.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z3E5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDILAHESE LLGLVKEYLD FAEFEDTLKT FSKECKIKGK PLCKTVGGSF
60 70 80 90 100
RDSKSLTIQK DLVAAFDNGD QKVFFDLWEE HISSSIRDGD SFAQKLEFYL
110 120 130 140 150
HIHFAIYLLK YSVGRPDKEE LDEKISYFKT YLETKGAALS QTTEFLPFYA
160 170 180 190 200
LPFVPNPMVH PSFKELFQDS WTPELKLKLI KFLALISKAS NTPKLLTIYK
210 220 230 240 250
ENGQSNKEIL QQLHQQLVEA ERRSVTYLKR YNKIQADYHN LIGVTAELVD
260 270 280 290 300
SLEATVSGKM ITPEYLQSVC VRLFSNQMRQ SLAHSVDFTR PGTASTMLRA
310 320 330 340 350
SLAPVKLKDV PLLPSLDYEK LKKDLILGSD RLKAFLLQAL RWRLTTSHPG
360 370 380 390 400
EQRETVLQAY ISNDLLDCYS HNQRSVLQLL HSTSDVVRQY MARLINAFAS
410 420 430 440 450
LAEGRLYLAQ NTKVLQMLEG RLKEEDKDII TRENVLGALQ KFSLRRPLQT
460 470 480 490 500
AMIQDGLIFW LVDVLKDPDC LSDYTLEYSV ALLMNLCLRS TGKNMCAKVA
510 520 530 540 550
GLVLKVLSDL LGHENHEIQP YVNGALYSIL SVPSIREEAR AMGMEDILRC
560 570 580 590 600
FIKEGNAEMI RQIEFIIKQL NSEELPDGVL ESDDDEDEDD EEDHDIMEAD
610 620 630 640 650
LDKDELIQPQ LGELSGEKLL TTEYLGIMTN TGKTRRKGLA NVQWSGDEPL
660 670 680 690 700
QRPVTPGGHR NGYPVVEDQH TPPQTAQHAR NGHPQALPAA HEAVYREGKP
710 720 730 740 750
STPESCVSSS SAIIAKPGEW LPRGRQEEPR PAPTTPRQPR EAPQDPGNGV
760 770 780 790 800
TTRECASAFT CKPRAPCTPE MLDWNPPKAK ASVLAPLFSS CGPQQASRPG
810
STASSTRGLP SSQSHRK
Length:817
Mass (Da):91,762
Last modified:March 20, 2007 - v2
Checksum:i8FC581F7B3217116
GO
Isoform 2 (identifier: Q7Z3E5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     666-817: Missing.

Show »
Length:665
Mass (Da):75,579
Checksum:i6B59EB1CE6E2CE1F
GO

Sequence cautioni

The sequence BAB14153.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801I → E in AAX22760. (PubMed:11691810)Curated
Sequence conflicti180 – 1801I → E in AAO63554. 1 PublicationCurated
Sequence conflicti180 – 1801I → E in CAD97923. (PubMed:17974005)Curated
Sequence conflicti180 – 1801I → E in AAH04514. (PubMed:15489334)Curated
Sequence conflicti180 – 1801I → E in AAH65271. (PubMed:15489334)Curated
Sequence conflicti180 – 1801I → E in BAB14153. (PubMed:14702039)Curated
Sequence conflicti436 – 4361L → P in AAO63554. 1 PublicationCurated
Sequence conflicti734 – 7341T → TG in BAB47497. (PubMed:11347906)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081L → F.1 Publication
Corresponds to variant rs11558175 [ dbSNP | Ensembl ].
VAR_031170
Natural varianti180 – 1801I → V.
Corresponds to variant rs1626450 [ dbSNP | Ensembl ].
VAR_056739
Natural varianti209 – 2091I → T.
Corresponds to variant rs16827883 [ dbSNP | Ensembl ].
VAR_031171
Natural varianti222 – 2221R → H.
Corresponds to variant rs3752780 [ dbSNP | Ensembl ].
VAR_031172
Natural varianti330 – 3301D → N.1 Publication
VAR_069411

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei666 – 817152Missing in isoform 2. 5 PublicationsVSP_023804Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929062 mRNA. Translation: AAX22760.1.
AY219922 mRNA. Translation: AAO63554.1.
BX537956 mRNA. Translation: CAD97923.1.
AC009407 Genomic DNA. Translation: AAX93129.1.
AC018738 Genomic DNA. No translation available.
BC004514 mRNA. Translation: AAH04514.2.
BC065271 mRNA. Translation: AAH65271.1.
AK022646 mRNA. Translation: BAB14153.1. Different initiation.
AB058771 mRNA. Translation: BAB47497.1.
CCDSiCCDS2484.1. [Q7Z3E5-2]
RefSeqiNP_001258395.1. NM_001271466.2.
NP_001278585.1. NM_001291656.1.
NP_079415.3. NM_025139.5.
UniGeneiHs.471610.
Hs.744341.

Genome annotation databases

EnsembliENST00000349938; ENSP00000258417; ENSG00000135931. [Q7Z3E5-2]
GeneIDi80210.
KEGGihsa:80210.
UCSCiuc002vrp.5. human. [Q7Z3E5-1]

Polymorphism databases

DMDMi134035387.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY929062 mRNA. Translation: AAX22760.1 .
AY219922 mRNA. Translation: AAO63554.1 .
BX537956 mRNA. Translation: CAD97923.1 .
AC009407 Genomic DNA. Translation: AAX93129.1 .
AC018738 Genomic DNA. No translation available.
BC004514 mRNA. Translation: AAH04514.2 .
BC065271 mRNA. Translation: AAH65271.1 .
AK022646 mRNA. Translation: BAB14153.1 . Different initiation.
AB058771 mRNA. Translation: BAB47497.1 .
CCDSi CCDS2484.1. [Q7Z3E5-2 ]
RefSeqi NP_001258395.1. NM_001271466.2.
NP_001278585.1. NM_001291656.1.
NP_079415.3. NM_025139.5.
UniGenei Hs.471610.
Hs.744341.

3D structure databases

ProteinModelPortali Q7Z3E5.
SMRi Q7Z3E5. Positions 375-532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123179. 7 interactions.
STRINGi 9606.ENSP00000258417.

PTM databases

PhosphoSitei Q7Z3E5.

Polymorphism databases

DMDMi 134035387.

Proteomic databases

MaxQBi Q7Z3E5.
PaxDbi Q7Z3E5.
PRIDEi Q7Z3E5.

Protocols and materials databases

DNASUi 80210.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000349938 ; ENSP00000258417 ; ENSG00000135931 . [Q7Z3E5-2 ]
GeneIDi 80210.
KEGGi hsa:80210.
UCSCi uc002vrp.5. human. [Q7Z3E5-1 ]

Organism-specific databases

CTDi 80210.
GeneCardsi GC02P232064.
H-InvDB HIX0002915.
HGNCi HGNC:20730. ARMC9.
HPAi HPA019041.
HPA026671.
neXtProti NX_Q7Z3E5.
PharmGKBi PA142672581.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG80009.
GeneTreei ENSGT00390000018026.
HOVERGENi HBG080866.
InParanoidi Q7Z3E5.
OMAi KPLCKTV.
OrthoDBi EOG7DC23S.
PhylomeDBi Q7Z3E5.
TreeFami TF317676.

Miscellaneous databases

ChiTaRSi ARMC9. human.
GeneWikii ARMC9.
GenomeRNAii 80210.
NextBioi 70600.
PROi Q7Z3E5.

Gene expression databases

Bgeei Q7Z3E5.
CleanExi HS_ARMC9.
ExpressionAtlasi Q7Z3E5. baseline and differential.
Genevestigatori Q7Z3E5.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR006594. LisH_dimerisation.
[Graphical view ]
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tumor antigens isolated from a patient with vitiligo and T-cell-infiltrated melanoma."
    Kiniwa Y., Fujita T., Akada M., Ito K., Shofuda T., Suzuki Y., Yamamoto A., Saida T., Kawakami Y.
    Cancer Res. 61:7900-7907(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Cloning and characterization of a novel ARM protein."
    Chen J., Lu Y., Xie Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Esophageal carcinoma.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-108.
    Tissue: Ovary and Skin.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-817 (ISOFORM 2).
  7. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-817 (ISOFORM 1).
    Tissue: Brain.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANT ASN-330.

Entry informationi

Entry nameiARMC9_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E5
Secondary accession number(s): Q53TI3
, Q6P162, Q7L594, Q86WG2, Q96JF9, Q9H9R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 26, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3