Q7Z3E5 (ARMC9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LisH domain-containing protein ARMC9

Alternative name(s):
Melanoma/melanocyte-specific tumor antigen KU-MEL-1
NS21

Gene names

Name:	ARMC9
Synonyms:	KIAA1868

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	817 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis. Ref.1
Sequence similarities	Contains 1 LisH domain.
Sequence caution	The sequence BAB14153.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7Z3E5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7Z3E5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     666-817: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 817	817	LisH domain-containing protein ARMC9		PRO_0000280595
Regions
	Domain	7 – 39	33	LisH
	Coiled coil	204 – 230	27	Potential
	Compositional bias	708 – 711	4	Poly-Ser
Amino acid modifications
	Modified residue	582	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	666 – 817	152	Missing in isoform 2.		VSP_023804
	Natural variant	108	1	L → F. Ref.5 Corresponds to variant rs11558175 [ dbSNP | Ensembl ].		VAR_031170
	Natural variant	180	1	I → V. Corresponds to variant rs1626450 [ dbSNP | Ensembl ].		VAR_056739
	Natural variant	209	1	I → T. Corresponds to variant rs16827883 [ dbSNP | Ensembl ].		VAR_031171
	Natural variant	222	1	R → H. Corresponds to variant rs3752780 [ dbSNP | Ensembl ].		VAR_031172
Experimental info
	Sequence conflict	180	1	I → E in AAX22760. Ref.1
	Sequence conflict	180	1	I → E in AAO63554. Ref.2
	Sequence conflict	180	1	I → E in CAD97923. Ref.3
	Sequence conflict	180	1	I → E in AAH04514. Ref.5
	Sequence conflict	180	1	I → E in AAH65271. Ref.5
	Sequence conflict	180	1	I → E in BAB14153. Ref.6
	Sequence conflict	436	1	L → P in AAO63554. Ref.2
	Sequence conflict	734	1	T → TG in BAB47497. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 8FC581F7B3217116	FASTA	817	91,762
	10 20 30 40 50 60 MGDILAHESE LLGLVKEYLD FAEFEDTLKT FSKECKIKGK PLCKTVGGSF RDSKSLTIQK 70 80 90 100 110 120 DLVAAFDNGD QKVFFDLWEE HISSSIRDGD SFAQKLEFYL HIHFAIYLLK YSVGRPDKEE 130 140 150 160 170 180 LDEKISYFKT YLETKGAALS QTTEFLPFYA LPFVPNPMVH PSFKELFQDS WTPELKLKLI 190 200 210 220 230 240 KFLALISKAS NTPKLLTIYK ENGQSNKEIL QQLHQQLVEA ERRSVTYLKR YNKIQADYHN 250 260 270 280 290 300 LIGVTAELVD SLEATVSGKM ITPEYLQSVC VRLFSNQMRQ SLAHSVDFTR PGTASTMLRA 310 320 330 340 350 360 SLAPVKLKDV PLLPSLDYEK LKKDLILGSD RLKAFLLQAL RWRLTTSHPG EQRETVLQAY 370 380 390 400 410 420 ISNDLLDCYS HNQRSVLQLL HSTSDVVRQY MARLINAFAS LAEGRLYLAQ NTKVLQMLEG 430 440 450 460 470 480 RLKEEDKDII TRENVLGALQ KFSLRRPLQT AMIQDGLIFW LVDVLKDPDC LSDYTLEYSV 490 500 510 520 530 540 ALLMNLCLRS TGKNMCAKVA GLVLKVLSDL LGHENHEIQP YVNGALYSIL SVPSIREEAR 550 560 570 580 590 600 AMGMEDILRC FIKEGNAEMI RQIEFIIKQL NSEELPDGVL ESDDDEDEDD EEDHDIMEAD 610 620 630 640 650 660 LDKDELIQPQ LGELSGEKLL TTEYLGIMTN TGKTRRKGLA NVQWSGDEPL QRPVTPGGHR 670 680 690 700 710 720 NGYPVVEDQH TPPQTAQHAR NGHPQALPAA HEAVYREGKP STPESCVSSS SAIIAKPGEW 730 740 750 760 770 780 LPRGRQEEPR PAPTTPRQPR EAPQDPGNGV TTRECASAFT CKPRAPCTPE MLDWNPPKAK 790 800 810 ASVLAPLFSS CGPQQASRPG STASSTRGLP SSQSHRK
	Isoform 2 [UniParc]. Checksum: 6B59EB1CE6E2CE1F	FASTA	665	75,579
	10 20 30 40 50 60 MGDILAHESE LLGLVKEYLD FAEFEDTLKT FSKECKIKGK PLCKTVGGSF RDSKSLTIQK 70 80 90 100 110 120 DLVAAFDNGD QKVFFDLWEE HISSSIRDGD SFAQKLEFYL HIHFAIYLLK YSVGRPDKEE 130 140 150 160 170 180 LDEKISYFKT YLETKGAALS QTTEFLPFYA LPFVPNPMVH PSFKELFQDS WTPELKLKLI 190 200 210 220 230 240 KFLALISKAS NTPKLLTIYK ENGQSNKEIL QQLHQQLVEA ERRSVTYLKR YNKIQADYHN 250 260 270 280 290 300 LIGVTAELVD SLEATVSGKM ITPEYLQSVC VRLFSNQMRQ SLAHSVDFTR PGTASTMLRA 310 320 330 340 350 360 SLAPVKLKDV PLLPSLDYEK LKKDLILGSD RLKAFLLQAL RWRLTTSHPG EQRETVLQAY 370 380 390 400 410 420 ISNDLLDCYS HNQRSVLQLL HSTSDVVRQY MARLINAFAS LAEGRLYLAQ NTKVLQMLEG 430 440 450 460 470 480 RLKEEDKDII TRENVLGALQ KFSLRRPLQT AMIQDGLIFW LVDVLKDPDC LSDYTLEYSV 490 500 510 520 530 540 ALLMNLCLRS TGKNMCAKVA GLVLKVLSDL LGHENHEIQP YVNGALYSIL SVPSIREEAR 550 560 570 580 590 600 AMGMEDILRC FIKEGNAEMI RQIEFIIKQL NSEELPDGVL ESDDDEDEDD EEDHDIMEAD 610 620 630 640 650 660 LDKDELIQPQ LGELSGEKLL TTEYLGIMTN TGKTRRKGLA NVQWSGDEPL QRPVTPGGHR NGYPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tumor antigens isolated from a patient with vitiligo and T-cell-infiltrated melanoma." Kiniwa Y., Fujita T., Akada M., Ito K., Shofuda T., Suzuki Y., Yamamoto A., Saida T., Kawakami Y. Cancer Res. 61:7900-7907(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"Cloning and characterization of a novel ARM protein." Chen J., Lu Y., Xie Y. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Esophageal carcinoma.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-108. Tissue: Ovary and Skin.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-817 (ISOFORM 2).
[7]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-817 (ISOFORM 1). Tissue: Brain.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY929062 mRNA. Translation: AAX22760.1. AY219922 mRNA. Translation: AAO63554.1. BX537956 mRNA. Translation: CAD97923.1. AC009407 Genomic DNA. Translation: AAX93129.1. AC018738 Genomic DNA. No translation available. BC004514 mRNA. Translation: AAH04514.2. BC065271 mRNA. Translation: AAH65271.1. AK022646 mRNA. Translation: BAB14153.1. Different initiation. AB058771 mRNA. Translation: BAB47497.1.
IPI	IPI00216484. IPI00829927.
RefSeq	NP_001258395.1. NM_001271466.1. NP_079415.3. NM_025139.4.
UniGene	Hs.471610.
3D structure databases
ProteinModelPortal	Q7Z3E5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000258417.
PTM databases
PhosphoSite	Q7Z3E5.
Polymorphism databases
DMDM	134035387.
Proteomic databases
PaxDb	Q7Z3E5.
PRIDE	Q7Z3E5.
Protocols and materials databases
DNASU	80210.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349938; ENSP00000258417; ENSG00000135931.
GeneID	80210.
KEGG	hsa:80210.
UCSC	uc002vrp.4. human.
Organism-specific databases
CTD	80210.
GeneCards	GC02P232064.
H-InvDB	HIX0002915.
HGNC	HGNC:20730. ARMC9.
HPA	HPA019041. HPA026671.
neXtProt	NX_Q7Z3E5.
PharmGKB	PA142672581.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG80009.
HOVERGEN	HBG080866.
InParanoid	Q7Z3E5.
Gene expression databases
ArrayExpress	Q7Z3E5.
Bgee	Q7Z3E5.
CleanEx	HS_ARMC9.
Genevestigator	Q7Z3E5.
Family and domain databases
Gene3D	1.25.10.10. 3 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR006594. LisH_dimerisation. [Graphical view]
SMART	SM00667. LisH. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50896. LISH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80210.
NextBio	70600.

Entry information

Entry name

ARMC9_HUMAN

Accession

Primary (citable) accession number: Q7Z3E5
Secondary accession number(s): Q53TI3 , Q6P162, Q7L594, Q86WG2, Q96JF9, Q9H9R8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.