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Q7Z3E5

- ARMC9_HUMAN

UniProt

Q7Z3E5 - ARMC9_HUMAN

Protein

LisH domain-containing protein ARMC9

Gene

ARMC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LisH domain-containing protein ARMC9
    Alternative name(s):
    Melanoma/melanocyte-specific tumor antigen KU-MEL-1
    NS21
    Gene namesi
    Name:ARMC9
    Synonyms:KIAA1868
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20730. ARMC9.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 817817LisH domain-containing protein ARMC9PRO_0000280595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei582 – 5821Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z3E5.
    PaxDbiQ7Z3E5.
    PRIDEiQ7Z3E5.

    PTM databases

    PhosphoSiteiQ7Z3E5.

    Expressioni

    Tissue specificityi

    Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z3E5.
    BgeeiQ7Z3E5.
    CleanExiHS_ARMC9.
    GenevestigatoriQ7Z3E5.

    Organism-specific databases

    HPAiHPA019041.
    HPA026671.

    Interactioni

    Protein-protein interaction databases

    BioGridi123179. 7 interactions.
    STRINGi9606.ENSP00000258417.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z3E5.
    SMRiQ7Z3E5. Positions 375-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 3933LisHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili204 – 23027Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi708 – 7114Poly-Ser

    Sequence similaritiesi

    Contains 1 LisH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG80009.
    HOVERGENiHBG080866.
    InParanoidiQ7Z3E5.
    OMAiKPLCKTV.
    OrthoDBiEOG7DC23S.
    PhylomeDBiQ7Z3E5.
    TreeFamiTF317676.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR006594. LisH_dimerisation.
    [Graphical view]
    SMARTiSM00667. LisH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50896. LISH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z3E5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDILAHESE LLGLVKEYLD FAEFEDTLKT FSKECKIKGK PLCKTVGGSF    50
    RDSKSLTIQK DLVAAFDNGD QKVFFDLWEE HISSSIRDGD SFAQKLEFYL 100
    HIHFAIYLLK YSVGRPDKEE LDEKISYFKT YLETKGAALS QTTEFLPFYA 150
    LPFVPNPMVH PSFKELFQDS WTPELKLKLI KFLALISKAS NTPKLLTIYK 200
    ENGQSNKEIL QQLHQQLVEA ERRSVTYLKR YNKIQADYHN LIGVTAELVD 250
    SLEATVSGKM ITPEYLQSVC VRLFSNQMRQ SLAHSVDFTR PGTASTMLRA 300
    SLAPVKLKDV PLLPSLDYEK LKKDLILGSD RLKAFLLQAL RWRLTTSHPG 350
    EQRETVLQAY ISNDLLDCYS HNQRSVLQLL HSTSDVVRQY MARLINAFAS 400
    LAEGRLYLAQ NTKVLQMLEG RLKEEDKDII TRENVLGALQ KFSLRRPLQT 450
    AMIQDGLIFW LVDVLKDPDC LSDYTLEYSV ALLMNLCLRS TGKNMCAKVA 500
    GLVLKVLSDL LGHENHEIQP YVNGALYSIL SVPSIREEAR AMGMEDILRC 550
    FIKEGNAEMI RQIEFIIKQL NSEELPDGVL ESDDDEDEDD EEDHDIMEAD 600
    LDKDELIQPQ LGELSGEKLL TTEYLGIMTN TGKTRRKGLA NVQWSGDEPL 650
    QRPVTPGGHR NGYPVVEDQH TPPQTAQHAR NGHPQALPAA HEAVYREGKP 700
    STPESCVSSS SAIIAKPGEW LPRGRQEEPR PAPTTPRQPR EAPQDPGNGV 750
    TTRECASAFT CKPRAPCTPE MLDWNPPKAK ASVLAPLFSS CGPQQASRPG 800
    STASSTRGLP SSQSHRK 817
    Length:817
    Mass (Da):91,762
    Last modified:March 20, 2007 - v2
    Checksum:i8FC581F7B3217116
    GO
    Isoform 2 (identifier: Q7Z3E5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         666-817: Missing.

    Show »
    Length:665
    Mass (Da):75,579
    Checksum:i6B59EB1CE6E2CE1F
    GO

    Sequence cautioni

    The sequence BAB14153.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801I → E in AAX22760. (PubMed:11691810)Curated
    Sequence conflicti180 – 1801I → E in AAO63554. 1 PublicationCurated
    Sequence conflicti180 – 1801I → E in CAD97923. (PubMed:17974005)Curated
    Sequence conflicti180 – 1801I → E in AAH04514. (PubMed:15489334)Curated
    Sequence conflicti180 – 1801I → E in AAH65271. (PubMed:15489334)Curated
    Sequence conflicti180 – 1801I → E in BAB14153. (PubMed:14702039)Curated
    Sequence conflicti436 – 4361L → P in AAO63554. 1 PublicationCurated
    Sequence conflicti734 – 7341T → TG in BAB47497. (PubMed:11347906)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081L → F.1 Publication
    Corresponds to variant rs11558175 [ dbSNP | Ensembl ].
    VAR_031170
    Natural varianti180 – 1801I → V.
    Corresponds to variant rs1626450 [ dbSNP | Ensembl ].
    VAR_056739
    Natural varianti209 – 2091I → T.
    Corresponds to variant rs16827883 [ dbSNP | Ensembl ].
    VAR_031171
    Natural varianti222 – 2221R → H.
    Corresponds to variant rs3752780 [ dbSNP | Ensembl ].
    VAR_031172
    Natural varianti330 – 3301D → N.1 Publication
    VAR_069411

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei666 – 817152Missing in isoform 2. 5 PublicationsVSP_023804Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY929062 mRNA. Translation: AAX22760.1.
    AY219922 mRNA. Translation: AAO63554.1.
    BX537956 mRNA. Translation: CAD97923.1.
    AC009407 Genomic DNA. Translation: AAX93129.1.
    AC018738 Genomic DNA. No translation available.
    BC004514 mRNA. Translation: AAH04514.2.
    BC065271 mRNA. Translation: AAH65271.1.
    AK022646 mRNA. Translation: BAB14153.1. Different initiation.
    AB058771 mRNA. Translation: BAB47497.1.
    CCDSiCCDS2484.1. [Q7Z3E5-2]
    RefSeqiNP_001258395.1. NM_001271466.2.
    NP_001278585.1. NM_001291656.1.
    NP_079415.3. NM_025139.5.
    UniGeneiHs.471610.
    Hs.744341.

    Genome annotation databases

    EnsembliENST00000349938; ENSP00000258417; ENSG00000135931. [Q7Z3E5-2]
    GeneIDi80210.
    KEGGihsa:80210.
    UCSCiuc002vrp.5. human. [Q7Z3E5-1]

    Polymorphism databases

    DMDMi134035387.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY929062 mRNA. Translation: AAX22760.1 .
    AY219922 mRNA. Translation: AAO63554.1 .
    BX537956 mRNA. Translation: CAD97923.1 .
    AC009407 Genomic DNA. Translation: AAX93129.1 .
    AC018738 Genomic DNA. No translation available.
    BC004514 mRNA. Translation: AAH04514.2 .
    BC065271 mRNA. Translation: AAH65271.1 .
    AK022646 mRNA. Translation: BAB14153.1 . Different initiation.
    AB058771 mRNA. Translation: BAB47497.1 .
    CCDSi CCDS2484.1. [Q7Z3E5-2 ]
    RefSeqi NP_001258395.1. NM_001271466.2.
    NP_001278585.1. NM_001291656.1.
    NP_079415.3. NM_025139.5.
    UniGenei Hs.471610.
    Hs.744341.

    3D structure databases

    ProteinModelPortali Q7Z3E5.
    SMRi Q7Z3E5. Positions 375-521.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123179. 7 interactions.
    STRINGi 9606.ENSP00000258417.

    PTM databases

    PhosphoSitei Q7Z3E5.

    Polymorphism databases

    DMDMi 134035387.

    Proteomic databases

    MaxQBi Q7Z3E5.
    PaxDbi Q7Z3E5.
    PRIDEi Q7Z3E5.

    Protocols and materials databases

    DNASUi 80210.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349938 ; ENSP00000258417 ; ENSG00000135931 . [Q7Z3E5-2 ]
    GeneIDi 80210.
    KEGGi hsa:80210.
    UCSCi uc002vrp.5. human. [Q7Z3E5-1 ]

    Organism-specific databases

    CTDi 80210.
    GeneCardsi GC02P232064.
    H-InvDB HIX0002915.
    HGNCi HGNC:20730. ARMC9.
    HPAi HPA019041.
    HPA026671.
    neXtProti NX_Q7Z3E5.
    PharmGKBi PA142672581.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG80009.
    HOVERGENi HBG080866.
    InParanoidi Q7Z3E5.
    OMAi KPLCKTV.
    OrthoDBi EOG7DC23S.
    PhylomeDBi Q7Z3E5.
    TreeFami TF317676.

    Miscellaneous databases

    GeneWikii ARMC9.
    GenomeRNAii 80210.
    NextBioi 70600.
    PROi Q7Z3E5.

    Gene expression databases

    ArrayExpressi Q7Z3E5.
    Bgeei Q7Z3E5.
    CleanExi HS_ARMC9.
    Genevestigatori Q7Z3E5.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR006594. LisH_dimerisation.
    [Graphical view ]
    SMARTi SM00667. LisH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tumor antigens isolated from a patient with vitiligo and T-cell-infiltrated melanoma."
      Kiniwa Y., Fujita T., Akada M., Ito K., Shofuda T., Suzuki Y., Yamamoto A., Saida T., Kawakami Y.
      Cancer Res. 61:7900-7907(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Cloning and characterization of a novel ARM protein."
      Chen J., Lu Y., Xie Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Esophageal carcinoma.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-108.
      Tissue: Ovary and Skin.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-817 (ISOFORM 2).
    7. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 356-817 (ISOFORM 1).
      Tissue: Brain.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: VARIANT ASN-330.

    Entry informationi

    Entry nameiARMC9_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3E5
    Secondary accession number(s): Q53TI3
    , Q6P162, Q7L594, Q86WG2, Q96JF9, Q9H9R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3