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Q7Z3E2

- CC186_HUMAN

UniProt

Q7Z3E2 - CC186_HUMAN

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Protein

Coiled-coil domain-containing protein 186

Gene

CCDC186

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 186
Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2
Gene namesi
Name:CCDC186
Synonyms:C10orf118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24349. CCDC186.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 898897Coiled-coil domain-containing protein 186PRO_0000089823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7Z3E2.
PaxDbiQ7Z3E2.
PRIDEiQ7Z3E2.

PTM databases

PhosphoSiteiQ7Z3E2.

Expressioni

Gene expression databases

BgeeiQ7Z3E2.
CleanExiHS_C10orf118.
ExpressionAtlasiQ7Z3E2. baseline and differential.
GenevestigatoriQ7Z3E2.

Organism-specific databases

HPAiHPA014569.
HPA018019.

Interactioni

Protein-protein interaction databases

BioGridi120401. 4 interactions.
DIPiDIP-47298N.
IntActiQ7Z3E2. 8 interactions.
MINTiMINT-1209058.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili201 – 712512Sequence AnalysisAdd
BLAST
Coiled coili759 – 80345Sequence AnalysisAdd
BLAST
Coiled coili855 – 89440Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi710 – 74738Ser-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG330453.
GeneTreeiENSGT00720000108851.
HOVERGENiHBG081202.
InParanoidiQ7Z3E2.
OMAiFTEAANQ.
OrthoDBiEOG7VMP4G.
PhylomeDBiQ7Z3E2.
TreeFamiTF328785.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z3E2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD
60 70 80 90 100
KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN
110 120 130 140 150
FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI
160 170 180 190 200
SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD
210 220 230 240 250
KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT
260 270 280 290 300
IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK
310 320 330 340 350
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI
360 370 380 390 400
KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK
410 420 430 440 450
AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN
460 470 480 490 500
ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT
510 520 530 540 550
LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL
560 570 580 590 600
QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA
610 620 630 640 650
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE
660 670 680 690 700
EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ
710 720 730 740 750
ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV
760 770 780 790 800
DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII
810 820 830 840 850
QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL
860 870 880 890
EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT
Length:898
Mass (Da):103,687
Last modified:July 19, 2005 - v2
Checksum:i47E8A9BD547C82D3
GO

Sequence cautioni

The sequence AAH70368.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 212.
The sequence AAM44457.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 792.
The sequence BAC03926.1 differs from that shown. Reason: Intron retention.
The sequence AAM44457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91480.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 763GGG → IRH in AAM44457. (PubMed:14996095)Curated
Sequence conflicti209 – 2091I → T in AAH70368. (PubMed:15489334)Curated
Sequence conflicti614 – 6141D → I in BAA91480. (PubMed:14702039)Curated
Sequence conflicti745 – 7451G → E in CAD39031. (PubMed:17974005)Curated
Sequence conflicti857 – 8571Q → L in CAD97928. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851T → I.2 Publications
Corresponds to variant rs1061159 [ dbSNP | Ensembl ].
VAR_023047
Natural varianti179 – 1791R → Q.1 Publication
Corresponds to variant rs12782946 [ dbSNP | Ensembl ].
VAR_023048
Natural varianti271 – 2711Q → K.3 Publications
Corresponds to variant rs7095762 [ dbSNP | Ensembl ].
VAR_023049

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834368 mRNA. Translation: CAD39031.2.
BX537964 mRNA. Translation: CAD97928.1.
BC070368 mRNA. Translation: AAH70368.1. Sequence problems.
BC103499 mRNA. Translation: AAI03500.1.
BC105632 mRNA. Translation: AAI05633.1.
BC152306 mRNA. Translation: AAI52307.1.
AF273054 mRNA. Translation: AAM44457.1. Sequence problems.
AK001050 mRNA. Translation: BAA91480.1. Different initiation.
AK092620 mRNA. Translation: BAC03926.1. Sequence problems.
BK001329 mRNA. Translation: DAA01463.1.
CCDSiCCDS7587.1.
RefSeqiNP_060487.2. NM_018017.2.
XP_005269994.1. XM_005269937.1.
UniGeneiHs.159066.
Hs.603328.

Genome annotation databases

EnsembliENST00000369285; ENSP00000358291; ENSG00000165813.
ENST00000369286; ENSP00000358292; ENSG00000165813.
ENST00000369287; ENSP00000358293; ENSG00000165813.
GeneIDi55088.
KEGGihsa:55088.
UCSCiuc001lbb.1. human.

Polymorphism databases

DMDMi71152997.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834368 mRNA. Translation: CAD39031.2 .
BX537964 mRNA. Translation: CAD97928.1 .
BC070368 mRNA. Translation: AAH70368.1 . Sequence problems.
BC103499 mRNA. Translation: AAI03500.1 .
BC105632 mRNA. Translation: AAI05633.1 .
BC152306 mRNA. Translation: AAI52307.1 .
AF273054 mRNA. Translation: AAM44457.1 . Sequence problems.
AK001050 mRNA. Translation: BAA91480.1 . Different initiation.
AK092620 mRNA. Translation: BAC03926.1 . Sequence problems.
BK001329 mRNA. Translation: DAA01463.1 .
CCDSi CCDS7587.1.
RefSeqi NP_060487.2. NM_018017.2.
XP_005269994.1. XM_005269937.1.
UniGenei Hs.159066.
Hs.603328.

3D structure databases

ProteinModelPortali Q7Z3E2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120401. 4 interactions.
DIPi DIP-47298N.
IntActi Q7Z3E2. 8 interactions.
MINTi MINT-1209058.

PTM databases

PhosphoSitei Q7Z3E2.

Polymorphism databases

DMDMi 71152997.

Proteomic databases

MaxQBi Q7Z3E2.
PaxDbi Q7Z3E2.
PRIDEi Q7Z3E2.

Protocols and materials databases

DNASUi 55088.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369285 ; ENSP00000358291 ; ENSG00000165813 .
ENST00000369286 ; ENSP00000358292 ; ENSG00000165813 .
ENST00000369287 ; ENSP00000358293 ; ENSG00000165813 .
GeneIDi 55088.
KEGGi hsa:55088.
UCSCi uc001lbb.1. human.

Organism-specific databases

CTDi 55088.
GeneCardsi GC10M115871.
HGNCi HGNC:24349. CCDC186.
HPAi HPA014569.
HPA018019.
neXtProti NX_Q7Z3E2.
PharmGKBi PA134904295.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330453.
GeneTreei ENSGT00720000108851.
HOVERGENi HBG081202.
InParanoidi Q7Z3E2.
OMAi FTEAANQ.
OrthoDBi EOG7VMP4G.
PhylomeDBi Q7Z3E2.
TreeFami TF328785.

Miscellaneous databases

GeneWikii C10orf118.
GenomeRNAii 55088.
NextBioi 58657.

Gene expression databases

Bgeei Q7Z3E2.
CleanExi HS_C10orf118.
ExpressionAtlasi Q7Z3E2. baseline and differential.
Genevestigatori Q7Z3E2.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-271.
    Tissue: Endometrial tumor and Melanoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-85 AND LYS-271.
    Tissue: Testis.
  3. "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma."
    Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.
    Br. J. Dermatol. 150:252-258(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-791, VARIANTS ILE-85; GLN-179 AND LYS-271.
    Tissue: Lymphoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 614-898.
    Tissue: Embryo and Prostate.
  5. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
    Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
    BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC186_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6
, Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3