Q7Z3E2 (CJ118_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C10orf118

Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2

Gene names

Name:

C10orf118

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	898 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence caution

The sequence AAH70368.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 212. The sequence AAM44457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAM44457.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 792. The sequence BAA91480.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC03926.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 898	898	Uncharacterized protein C10orf118		PRO_0000089823
Regions
	Coiled coil	201 – 712	512	Potential
	Coiled coil	759 – 803	45	Potential
	Coiled coil	855 – 894	40	Potential
	Compositional bias	710 – 747	38	Ser-rich
Natural variations
	Natural variant	85	1	T → I. Ref.2 Ref.3 Corresponds to variant rs1061159 [ dbSNP | Ensembl ].		VAR_023047
	Natural variant	179	1	R → Q. Ref.3 Corresponds to variant rs12782946 [ dbSNP | Ensembl ].		VAR_023048
	Natural variant	271	1	Q → K. Ref.1 Ref.2 Ref.3 Corresponds to variant rs7095762 [ dbSNP | Ensembl ].		VAR_023049
Experimental info
	Sequence conflict	74 – 76	3	GGG → IRH in AAM44457. Ref.3
	Sequence conflict	209	1	I → T in AAH70368. Ref.2
	Sequence conflict	614	1	D → I in BAA91480. Ref.4
	Sequence conflict	745	1	G → E in CAD39031. Ref.1
	Sequence conflict	857	1	Q → L in CAD97928. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z3E2 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 47E8A9BD547C82D3	FASTA	898	103,687
	10 20 30 40 50 60 MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD KTLCQPNEHN 70 80 90 100 110 120 NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN FAKHISKTNE TEQKVTQILV 130 140 150 160 170 180 ELRSSTFPES ANEKTYSESP YDTDCTKKFI SKIKSVSASE DLLEEIESEL LSTEFAEHRV 190 200 210 220 230 240 PNGMNKGEHA LVLFEKCVQD KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR 250 260 270 280 290 300 TETEKQHMNT IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK 310 320 330 340 350 360 CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI KQLSQEKGRL 370 380 390 400 410 420 HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK AEMDSHKETK DKLKETTTKL 430 440 450 460 470 480 TQAKEEADQI RKNCQDMIKT YQESEEIKSN ELDAKLRVTK GELEKQMQEK SDQLEMHHAK 490 500 510 520 530 540 IKELEDLKRT FKEGMDELRT LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV 550 560 570 580 590 600 KTADQLQEQL QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA 610 620 630 640 650 660 QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE EVQTLQAELA 670 680 690 700 710 720 CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ ARRKLDQVES GSYDKEVSSM 730 740 750 760 770 780 GSRSSSSGSL NARSSAEDRS PENTGSSVAV DNFPQVDKAM LIERIVRLQK AHARKNEKIE 790 800 810 820 830 840 FMEDHIKQLV EEIRKKTKII QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA 850 860 870 880 890 DNGLTLELSL EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-271. Tissue: Endometrial tumor and Melanoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-85 AND LYS-271. Tissue: Testis.
[3]	"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma." Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S. Br. J. Dermatol. 150:252-258(2004) [PubMed: 14996095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-791, VARIANTS ILE-85; GLN-179 AND LYS-271. Tissue: Lymphoma.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 614-898. Tissue: Embryo and Prostate.
[5]	"Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs." Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C. BMC Genomics 4:22-22(2003) [PubMed: 12783626] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL834368 mRNA. Translation: CAD39031.2. BX537964 mRNA. Translation: CAD97928.1. BC070368 mRNA. Translation: AAH70368.1. Sequence problems. BC103499 mRNA. Translation: AAI03500.1. BC105632 mRNA. Translation: AAI05633.1. BC152306 mRNA. Translation: AAI52307.1. AF273054 mRNA. Translation: AAM44457.1. Sequence problems. AK001050 mRNA. Translation: BAA91480.1. Different initiation. AK092620 mRNA. Translation: BAC03926.1. Sequence problems. BK001329 mRNA. Translation: DAA01463.1.
IPI	IPI00947080.
RefSeq	NP_060487.2. NM_018017.2.
UniGene	Hs.159066. Hs.603328.
3D structure databases
ProteinModelPortal	Q7Z3E2.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-47298N.
IntAct	Q7Z3E2. 6 interactions.
MINT	MINT-1209058.
PTM databases
PhosphoSite	Q7Z3E2.
Polymorphism databases
DMDM	71152997.
Proteomic databases
PRIDE	Q7Z3E2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369287; ENSP00000358293; ENSG00000165813.
GeneID	55088.
KEGG	hsa:55088.
UCSC	uc001lbb.1. human. uc001lbd.2. human.
Organism-specific databases
CTD	55088.
GeneCards	GC10M115871.
HGNC	HGNC:24349. C10orf118.
HPA	HPA014569. HPA018019.
neXtProt	NX_Q7Z3E2.
PharmGKB	PA134904295.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000010528.
HOVERGEN	HBG081202.
InParanoid	Q7Z3E2.
OMA	QEHTIKK.
OrthoDB	EOG4P8FHJ.
PhylomeDB	Q7Z3E2.
Gene expression databases
ArrayExpress	Q7Z3E2.
Bgee	Q7Z3E2.
CleanEx	HS_C10orf118.
Genevestigator	Q7Z3E2.
GermOnline	ENSG00000165813. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	58657.

Entry information

Entry name

CJ118_HUMAN

Accession

Primary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6 , Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.