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Q7Z3E2

- CC186_HUMAN

UniProt

Q7Z3E2 - CC186_HUMAN

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Protein
Coiled-coil domain-containing protein 186
Gene
CCDC186, C10orf118
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 186
Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2
Gene namesi
Name:CCDC186
Synonyms:C10orf118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24349. CCDC186.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 898897Coiled-coil domain-containing protein 186
PRO_0000089823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7Z3E2.
PaxDbiQ7Z3E2.
PRIDEiQ7Z3E2.

PTM databases

PhosphoSiteiQ7Z3E2.

Expressioni

Gene expression databases

ArrayExpressiQ7Z3E2.
BgeeiQ7Z3E2.
CleanExiHS_C10orf118.
GenevestigatoriQ7Z3E2.

Organism-specific databases

HPAiHPA014569.
HPA018019.

Interactioni

Protein-protein interaction databases

BioGridi120401. 4 interactions.
DIPiDIP-47298N.
IntActiQ7Z3E2. 7 interactions.
MINTiMINT-1209058.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili201 – 712512 Reviewed prediction
Add
BLAST
Coiled coili759 – 80345 Reviewed prediction
Add
BLAST
Coiled coili855 – 89440 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi710 – 74738Ser-rich
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG330453.
HOVERGENiHBG081202.
InParanoidiQ7Z3E2.
OMAiFTEAANQ.
OrthoDBiEOG7VMP4G.
PhylomeDBiQ7Z3E2.
TreeFamiTF328785.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z3E2-1 [UniParc]FASTAAdd to Basket

« Hide

MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD    50
KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN 100
FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI 150
SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD 200
KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT 250
IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK 300
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI 350
KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK 400
AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN 450
ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT 500
LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL 550
QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA 600
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE 650
EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ 700
ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV 750
DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII 800
QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL 850
EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT 898
Length:898
Mass (Da):103,687
Last modified:July 19, 2005 - v2
Checksum:i47E8A9BD547C82D3
GO

Sequence cautioni

The sequence AAH70368.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 212.
The sequence AAM44457.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 792.
The sequence BAC03926.1 differs from that shown. Reason: Intron retention.
The sequence AAM44457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA91480.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851T → I.2 Publications
Corresponds to variant rs1061159 [ dbSNP | Ensembl ].
VAR_023047
Natural varianti179 – 1791R → Q.1 Publication
Corresponds to variant rs12782946 [ dbSNP | Ensembl ].
VAR_023048
Natural varianti271 – 2711Q → K.3 Publications
Corresponds to variant rs7095762 [ dbSNP | Ensembl ].
VAR_023049

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 763GGG → IRH in AAM44457. 1 Publication
Sequence conflicti209 – 2091I → T in AAH70368. 1 Publication
Sequence conflicti614 – 6141D → I in BAA91480. 1 Publication
Sequence conflicti745 – 7451G → E in CAD39031. 1 Publication
Sequence conflicti857 – 8571Q → L in CAD97928. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834368 mRNA. Translation: CAD39031.2.
BX537964 mRNA. Translation: CAD97928.1.
BC070368 mRNA. Translation: AAH70368.1. Sequence problems.
BC103499 mRNA. Translation: AAI03500.1.
BC105632 mRNA. Translation: AAI05633.1.
BC152306 mRNA. Translation: AAI52307.1.
AF273054 mRNA. Translation: AAM44457.1. Sequence problems.
AK001050 mRNA. Translation: BAA91480.1. Different initiation.
AK092620 mRNA. Translation: BAC03926.1. Sequence problems.
BK001329 mRNA. Translation: DAA01463.1.
CCDSiCCDS7587.1.
RefSeqiNP_060487.2. NM_018017.2.
XP_005269994.1. XM_005269937.1.
UniGeneiHs.159066.
Hs.603328.

Genome annotation databases

EnsembliENST00000369285; ENSP00000358291; ENSG00000165813.
ENST00000369286; ENSP00000358292; ENSG00000165813.
ENST00000369287; ENSP00000358293; ENSG00000165813.
GeneIDi55088.
KEGGihsa:55088.
UCSCiuc001lbb.1. human.

Polymorphism databases

DMDMi71152997.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL834368 mRNA. Translation: CAD39031.2 .
BX537964 mRNA. Translation: CAD97928.1 .
BC070368 mRNA. Translation: AAH70368.1 . Sequence problems.
BC103499 mRNA. Translation: AAI03500.1 .
BC105632 mRNA. Translation: AAI05633.1 .
BC152306 mRNA. Translation: AAI52307.1 .
AF273054 mRNA. Translation: AAM44457.1 . Sequence problems.
AK001050 mRNA. Translation: BAA91480.1 . Different initiation.
AK092620 mRNA. Translation: BAC03926.1 . Sequence problems.
BK001329 mRNA. Translation: DAA01463.1 .
CCDSi CCDS7587.1.
RefSeqi NP_060487.2. NM_018017.2.
XP_005269994.1. XM_005269937.1.
UniGenei Hs.159066.
Hs.603328.

3D structure databases

ProteinModelPortali Q7Z3E2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120401. 4 interactions.
DIPi DIP-47298N.
IntActi Q7Z3E2. 7 interactions.
MINTi MINT-1209058.

PTM databases

PhosphoSitei Q7Z3E2.

Polymorphism databases

DMDMi 71152997.

Proteomic databases

MaxQBi Q7Z3E2.
PaxDbi Q7Z3E2.
PRIDEi Q7Z3E2.

Protocols and materials databases

DNASUi 55088.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369285 ; ENSP00000358291 ; ENSG00000165813 .
ENST00000369286 ; ENSP00000358292 ; ENSG00000165813 .
ENST00000369287 ; ENSP00000358293 ; ENSG00000165813 .
GeneIDi 55088.
KEGGi hsa:55088.
UCSCi uc001lbb.1. human.

Organism-specific databases

CTDi 55088.
GeneCardsi GC10M115871.
HGNCi HGNC:24349. CCDC186.
HPAi HPA014569.
HPA018019.
neXtProti NX_Q7Z3E2.
PharmGKBi PA134904295.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330453.
HOVERGENi HBG081202.
InParanoidi Q7Z3E2.
OMAi FTEAANQ.
OrthoDBi EOG7VMP4G.
PhylomeDBi Q7Z3E2.
TreeFami TF328785.

Miscellaneous databases

GeneWikii C10orf118.
GenomeRNAii 55088.
NextBioi 58657.

Gene expression databases

ArrayExpressi Q7Z3E2.
Bgeei Q7Z3E2.
CleanExi HS_C10orf118.
Genevestigatori Q7Z3E2.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-271.
    Tissue: Endometrial tumor and Melanoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-85 AND LYS-271.
    Tissue: Testis.
  3. "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma."
    Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.
    Br. J. Dermatol. 150:252-258(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-791, VARIANTS ILE-85; GLN-179 AND LYS-271.
    Tissue: Lymphoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 614-898.
    Tissue: Embryo and Prostate.
  5. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
    Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
    BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC186_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6
, Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 3, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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