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Q7Z3E2

- CC186_HUMAN

UniProt

Q7Z3E2 - CC186_HUMAN

Protein

Coiled-coil domain-containing protein 186

Gene

CCDC186

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 186
    Alternative name(s):
    CTCL tumor antigen HD-CL-01/L14-2
    Gene namesi
    Name:CCDC186
    Synonyms:C10orf118
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24349. CCDC186.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134904295.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 898897Coiled-coil domain-containing protein 186PRO_0000089823Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ7Z3E2.
    PaxDbiQ7Z3E2.
    PRIDEiQ7Z3E2.

    PTM databases

    PhosphoSiteiQ7Z3E2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z3E2.
    BgeeiQ7Z3E2.
    CleanExiHS_C10orf118.
    GenevestigatoriQ7Z3E2.

    Organism-specific databases

    HPAiHPA014569.
    HPA018019.

    Interactioni

    Protein-protein interaction databases

    BioGridi120401. 4 interactions.
    DIPiDIP-47298N.
    IntActiQ7Z3E2. 8 interactions.
    MINTiMINT-1209058.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z3E2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili201 – 712512Sequence AnalysisAdd
    BLAST
    Coiled coili759 – 80345Sequence AnalysisAdd
    BLAST
    Coiled coili855 – 89440Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi710 – 74738Ser-richAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG330453.
    HOVERGENiHBG081202.
    InParanoidiQ7Z3E2.
    OMAiFTEAANQ.
    OrthoDBiEOG7VMP4G.
    PhylomeDBiQ7Z3E2.
    TreeFamiTF328785.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7Z3E2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD    50
    KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN 100
    FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI 150
    SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD 200
    KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT 250
    IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK 300
    CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI 350
    KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK 400
    AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN 450
    ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT 500
    LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL 550
    QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA 600
    QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE 650
    EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ 700
    ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV 750
    DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII 800
    QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL 850
    EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT 898
    Length:898
    Mass (Da):103,687
    Last modified:July 19, 2005 - v2
    Checksum:i47E8A9BD547C82D3
    GO

    Sequence cautioni

    The sequence AAH70368.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 212.
    The sequence AAM44457.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 792.
    The sequence BAC03926.1 differs from that shown. Reason: Intron retention.
    The sequence AAM44457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91480.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 763GGG → IRH in AAM44457. (PubMed:14996095)Curated
    Sequence conflicti209 – 2091I → T in AAH70368. (PubMed:15489334)Curated
    Sequence conflicti614 – 6141D → I in BAA91480. (PubMed:14702039)Curated
    Sequence conflicti745 – 7451G → E in CAD39031. (PubMed:17974005)Curated
    Sequence conflicti857 – 8571Q → L in CAD97928. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851T → I.2 Publications
    Corresponds to variant rs1061159 [ dbSNP | Ensembl ].
    VAR_023047
    Natural varianti179 – 1791R → Q.1 Publication
    Corresponds to variant rs12782946 [ dbSNP | Ensembl ].
    VAR_023048
    Natural varianti271 – 2711Q → K.3 Publications
    Corresponds to variant rs7095762 [ dbSNP | Ensembl ].
    VAR_023049

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834368 mRNA. Translation: CAD39031.2.
    BX537964 mRNA. Translation: CAD97928.1.
    BC070368 mRNA. Translation: AAH70368.1. Sequence problems.
    BC103499 mRNA. Translation: AAI03500.1.
    BC105632 mRNA. Translation: AAI05633.1.
    BC152306 mRNA. Translation: AAI52307.1.
    AF273054 mRNA. Translation: AAM44457.1. Sequence problems.
    AK001050 mRNA. Translation: BAA91480.1. Different initiation.
    AK092620 mRNA. Translation: BAC03926.1. Sequence problems.
    BK001329 mRNA. Translation: DAA01463.1.
    CCDSiCCDS7587.1.
    RefSeqiNP_060487.2. NM_018017.2.
    XP_005269994.1. XM_005269937.1.
    UniGeneiHs.159066.
    Hs.603328.

    Genome annotation databases

    EnsembliENST00000369285; ENSP00000358291; ENSG00000165813.
    ENST00000369286; ENSP00000358292; ENSG00000165813.
    ENST00000369287; ENSP00000358293; ENSG00000165813.
    GeneIDi55088.
    KEGGihsa:55088.
    UCSCiuc001lbb.1. human.

    Polymorphism databases

    DMDMi71152997.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL834368 mRNA. Translation: CAD39031.2 .
    BX537964 mRNA. Translation: CAD97928.1 .
    BC070368 mRNA. Translation: AAH70368.1 . Sequence problems.
    BC103499 mRNA. Translation: AAI03500.1 .
    BC105632 mRNA. Translation: AAI05633.1 .
    BC152306 mRNA. Translation: AAI52307.1 .
    AF273054 mRNA. Translation: AAM44457.1 . Sequence problems.
    AK001050 mRNA. Translation: BAA91480.1 . Different initiation.
    AK092620 mRNA. Translation: BAC03926.1 . Sequence problems.
    BK001329 mRNA. Translation: DAA01463.1 .
    CCDSi CCDS7587.1.
    RefSeqi NP_060487.2. NM_018017.2.
    XP_005269994.1. XM_005269937.1.
    UniGenei Hs.159066.
    Hs.603328.

    3D structure databases

    ProteinModelPortali Q7Z3E2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120401. 4 interactions.
    DIPi DIP-47298N.
    IntActi Q7Z3E2. 8 interactions.
    MINTi MINT-1209058.

    PTM databases

    PhosphoSitei Q7Z3E2.

    Polymorphism databases

    DMDMi 71152997.

    Proteomic databases

    MaxQBi Q7Z3E2.
    PaxDbi Q7Z3E2.
    PRIDEi Q7Z3E2.

    Protocols and materials databases

    DNASUi 55088.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369285 ; ENSP00000358291 ; ENSG00000165813 .
    ENST00000369286 ; ENSP00000358292 ; ENSG00000165813 .
    ENST00000369287 ; ENSP00000358293 ; ENSG00000165813 .
    GeneIDi 55088.
    KEGGi hsa:55088.
    UCSCi uc001lbb.1. human.

    Organism-specific databases

    CTDi 55088.
    GeneCardsi GC10M115871.
    HGNCi HGNC:24349. CCDC186.
    HPAi HPA014569.
    HPA018019.
    neXtProti NX_Q7Z3E2.
    PharmGKBi PA134904295.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330453.
    HOVERGENi HBG081202.
    InParanoidi Q7Z3E2.
    OMAi FTEAANQ.
    OrthoDBi EOG7VMP4G.
    PhylomeDBi Q7Z3E2.
    TreeFami TF328785.

    Miscellaneous databases

    GeneWikii C10orf118.
    GenomeRNAii 55088.
    NextBioi 58657.

    Gene expression databases

    ArrayExpressi Q7Z3E2.
    Bgeei Q7Z3E2.
    CleanExi HS_C10orf118.
    Genevestigatori Q7Z3E2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-271.
      Tissue: Endometrial tumor and Melanoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-85 AND LYS-271.
      Tissue: Testis.
    3. "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma."
      Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.
      Br. J. Dermatol. 150:252-258(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-791, VARIANTS ILE-85; GLN-179 AND LYS-271.
      Tissue: Lymphoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 614-898.
      Tissue: Embryo and Prostate.
    5. "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
      Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
      BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCC186_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3E2
    Secondary accession number(s): Q2M2V6
    , Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3