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Q7Z3E2 (CJ118_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C10orf118
Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2
Gene names
Name:C10orf118
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length898 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence AAH70368.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 212.

The sequence AAM44457.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAM44457.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence starting in position 792.

The sequence BAA91480.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC03926.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 898897Uncharacterized protein C10orf118
PRO_0000089823

Regions

Coiled coil201 – 712512 Potential
Coiled coil759 – 80345 Potential
Coiled coil855 – 89440 Potential
Compositional bias710 – 74738Ser-rich

Amino acid modifications

Modified residue21N-acetylserine Ref.6

Natural variations

Natural variant851T → I. Ref.2 Ref.3
Corresponds to variant rs1061159 [ dbSNP | Ensembl ].
VAR_023047
Natural variant1791R → Q. Ref.3
Corresponds to variant rs12782946 [ dbSNP | Ensembl ].
VAR_023048
Natural variant2711Q → K. Ref.1 Ref.2 Ref.3
Corresponds to variant rs7095762 [ dbSNP | Ensembl ].
VAR_023049

Experimental info

Sequence conflict74 – 763GGG → IRH in AAM44457. Ref.3
Sequence conflict2091I → T in AAH70368. Ref.2
Sequence conflict6141D → I in BAA91480. Ref.4
Sequence conflict7451G → E in CAD39031. Ref.1
Sequence conflict8571Q → L in CAD97928. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z3E2 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: 47E8A9BD547C82D3

FASTA898103,687
        10         20         30         40         50         60 
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD KTLCQPNEHN 

        70         80         90        100        110        120 
NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN FAKHISKTNE TEQKVTQILV 

       130        140        150        160        170        180 
ELRSSTFPES ANEKTYSESP YDTDCTKKFI SKIKSVSASE DLLEEIESEL LSTEFAEHRV 

       190        200        210        220        230        240 
PNGMNKGEHA LVLFEKCVQD KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR 

       250        260        270        280        290        300 
TETEKQHMNT IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK 

       310        320        330        340        350        360 
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI KQLSQEKGRL 

       370        380        390        400        410        420 
HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK AEMDSHKETK DKLKETTTKL 

       430        440        450        460        470        480 
TQAKEEADQI RKNCQDMIKT YQESEEIKSN ELDAKLRVTK GELEKQMQEK SDQLEMHHAK 

       490        500        510        520        530        540 
IKELEDLKRT FKEGMDELRT LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV 

       550        560        570        580        590        600 
KTADQLQEQL QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA 

       610        620        630        640        650        660 
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE EVQTLQAELA 

       670        680        690        700        710        720 
CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ ARRKLDQVES GSYDKEVSSM 

       730        740        750        760        770        780 
GSRSSSSGSL NARSSAEDRS PENTGSSVAV DNFPQVDKAM LIERIVRLQK AHARKNEKIE 

       790        800        810        820        830        840 
FMEDHIKQLV EEIRKKTKII QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA 

       850        860        870        880        890 
DNGLTLELSL EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT 

« Hide

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-271.
Tissue: Endometrial tumor and Melanoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ILE-85 AND LYS-271.
Tissue: Testis.
[3]"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma."
Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.
Br. J. Dermatol. 150:252-258(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-791, VARIANTS ILE-85; GLN-179 AND LYS-271.
Tissue: Lymphoma.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 614-898.
Tissue: Embryo and Prostate.
[5]"Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs."
Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.
BMC Genomics 4:22-22(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL834368 mRNA. Translation: CAD39031.2.
BX537964 mRNA. Translation: CAD97928.1.
BC070368 mRNA. Translation: AAH70368.1. Sequence problems.
BC103499 mRNA. Translation: AAI03500.1.
BC105632 mRNA. Translation: AAI05633.1.
BC152306 mRNA. Translation: AAI52307.1.
AF273054 mRNA. Translation: AAM44457.1. Sequence problems.
AK001050 mRNA. Translation: BAA91480.1. Different initiation.
AK092620 mRNA. Translation: BAC03926.1. Sequence problems.
BK001329 mRNA. Translation: DAA01463.1.
CCDSCCDS7587.1.
RefSeqNP_060487.2. NM_018017.2.
XP_005269994.1. XM_005269937.1.
UniGeneHs.159066.
Hs.603328.

3D structure databases

ProteinModelPortalQ7Z3E2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120401. 4 interactions.
DIPDIP-47298N.
IntActQ7Z3E2. 7 interactions.
MINTMINT-1209058.

PTM databases

PhosphoSiteQ7Z3E2.

Polymorphism databases

DMDM71152997.

Proteomic databases

MaxQBQ7Z3E2.
PaxDbQ7Z3E2.
PRIDEQ7Z3E2.

Protocols and materials databases

DNASU55088.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369285; ENSP00000358291; ENSG00000165813.
ENST00000369286; ENSP00000358292; ENSG00000165813.
ENST00000369287; ENSP00000358293; ENSG00000165813.
GeneID55088.
KEGGhsa:55088.
UCSCuc001lbb.1. human.

Organism-specific databases

CTD55088.
GeneCardsGC10M115871.
HGNCHGNC:24349. C10orf118.
HPAHPA014569.
HPA018019.
neXtProtNX_Q7Z3E2.
PharmGKBPA134904295.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330453.
HOVERGENHBG081202.
InParanoidQ7Z3E2.
OMAFTEAANQ.
OrthoDBEOG7VMP4G.
PhylomeDBQ7Z3E2.
TreeFamTF328785.

Gene expression databases

ArrayExpressQ7Z3E2.
BgeeQ7Z3E2.
CleanExHS_C10orf118.
GenevestigatorQ7Z3E2.

Family and domain databases

ProtoNetSearch...

Other

GeneWikiC10orf118.
GenomeRNAi55088.
NextBio58657.

Entry information

Entry nameCJ118_HUMAN
AccessionPrimary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6 expand/collapse secondary AC list , Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM