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Protein

Coiled-coil domain-containing protein 186

Gene

CCDC186

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 186
Alternative name(s):
CTCL tumor antigen HD-CL-01/L14-2
Gene namesi
Name:CCDC186
Synonyms:C10orf118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24349. CCDC186.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165813.
PharmGKBiPA134904295.

Polymorphism and mutation databases

BioMutaiC10orf118.
DMDMi71152997.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000898232 – 898Coiled-coil domain-containing protein 186Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei740PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7Z3E2.
MaxQBiQ7Z3E2.
PaxDbiQ7Z3E2.
PeptideAtlasiQ7Z3E2.
PRIDEiQ7Z3E2.

PTM databases

iPTMnetiQ7Z3E2.
PhosphoSitePlusiQ7Z3E2.

Expressioni

Gene expression databases

BgeeiENSG00000165813.
CleanExiHS_C10orf118.
ExpressionAtlasiQ7Z3E2. baseline and differential.
GenevisibleiQ7Z3E2. HS.

Organism-specific databases

HPAiHPA014569.
HPA018019.

Interactioni

Protein-protein interaction databases

BioGridi120401. 11 interactors.
DIPiDIP-47298N.
IntActiQ7Z3E2. 11 interactors.
MINTiMINT-1209058.
STRINGi9606.ENSP00000358293.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E2.
SMRiQ7Z3E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili201 – 712Sequence analysisAdd BLAST512
Coiled coili759 – 803Sequence analysisAdd BLAST45
Coiled coili855 – 894Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi710 – 747Ser-richAdd BLAST38

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0992. Eukaryota.
ENOG4110CGV. LUCA.
GeneTreeiENSGT00720000108851.
HOVERGENiHBG081202.
InParanoidiQ7Z3E2.
OMAiCAKTDTG.
OrthoDBiEOG091G05JM.
PhylomeDBiQ7Z3E2.
TreeFamiTF328785.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z3E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD
60 70 80 90 100
KTLCQPNEHN NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN
110 120 130 140 150
FAKHISKTNE TEQKVTQILV ELRSSTFPES ANEKTYSESP YDTDCTKKFI
160 170 180 190 200
SKIKSVSASE DLLEEIESEL LSTEFAEHRV PNGMNKGEHA LVLFEKCVQD
210 220 230 240 250
KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR TETEKQHMNT
260 270 280 290 300
IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK
310 320 330 340 350
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI
360 370 380 390 400
KQLSQEKGRL HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK
410 420 430 440 450
AEMDSHKETK DKLKETTTKL TQAKEEADQI RKNCQDMIKT YQESEEIKSN
460 470 480 490 500
ELDAKLRVTK GELEKQMQEK SDQLEMHHAK IKELEDLKRT FKEGMDELRT
510 520 530 540 550
LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV KTADQLQEQL
560 570 580 590 600
QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA
610 620 630 640 650
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE
660 670 680 690 700
EVQTLQAELA CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ
710 720 730 740 750
ARRKLDQVES GSYDKEVSSM GSRSSSSGSL NARSSAEDRS PENTGSSVAV
760 770 780 790 800
DNFPQVDKAM LIERIVRLQK AHARKNEKIE FMEDHIKQLV EEIRKKTKII
810 820 830 840 850
QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA DNGLTLELSL
860 870 880 890
EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT
Length:898
Mass (Da):103,687
Last modified:July 19, 2005 - v2
Checksum:i47E8A9BD547C82D3
GO

Sequence cautioni

The sequence AAH70368 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 212.Curated
The sequence AAM44457 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 792.Curated
The sequence AAM44457 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91480 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03926 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74 – 76GGG → IRH in AAM44457 (PubMed:14996095).Curated3
Sequence conflicti209I → T in AAH70368 (PubMed:15489334).Curated1
Sequence conflicti614D → I in BAA91480 (PubMed:14702039).Curated1
Sequence conflicti745G → E in CAD39031 (PubMed:17974005).Curated1
Sequence conflicti857Q → L in CAD97928 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02304785T → I.2 PublicationsCorresponds to variant rs1061159dbSNPEnsembl.1
Natural variantiVAR_023048179R → Q.1 PublicationCorresponds to variant rs12782946dbSNPEnsembl.1
Natural variantiVAR_023049271Q → K.3 PublicationsCorresponds to variant rs7095762dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834368 mRNA. Translation: CAD39031.2.
BX537964 mRNA. Translation: CAD97928.1.
BC070368 mRNA. Translation: AAH70368.1. Sequence problems.
BC103499 mRNA. Translation: AAI03500.1.
BC105632 mRNA. Translation: AAI05633.1.
BC152306 mRNA. Translation: AAI52307.1.
AF273054 mRNA. Translation: AAM44457.1. Sequence problems.
AK001050 mRNA. Translation: BAA91480.1. Different initiation.
AK092620 mRNA. Translation: BAC03926.1. Sequence problems.
BK001329 mRNA. Translation: DAA01463.1.
CCDSiCCDS7587.1.
RefSeqiNP_001308758.1. NM_001321829.1.
NP_060487.2. NM_018017.3.
NP_694981.1. NM_153249.1.
UniGeneiHs.159066.
Hs.603328.
Hs.732218.

Genome annotation databases

EnsembliENST00000369287; ENSP00000358293; ENSG00000165813.
GeneIDi55088.
KEGGihsa:55088.
UCSCiuc001lbb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834368 mRNA. Translation: CAD39031.2.
BX537964 mRNA. Translation: CAD97928.1.
BC070368 mRNA. Translation: AAH70368.1. Sequence problems.
BC103499 mRNA. Translation: AAI03500.1.
BC105632 mRNA. Translation: AAI05633.1.
BC152306 mRNA. Translation: AAI52307.1.
AF273054 mRNA. Translation: AAM44457.1. Sequence problems.
AK001050 mRNA. Translation: BAA91480.1. Different initiation.
AK092620 mRNA. Translation: BAC03926.1. Sequence problems.
BK001329 mRNA. Translation: DAA01463.1.
CCDSiCCDS7587.1.
RefSeqiNP_001308758.1. NM_001321829.1.
NP_060487.2. NM_018017.3.
NP_694981.1. NM_153249.1.
UniGeneiHs.159066.
Hs.603328.
Hs.732218.

3D structure databases

ProteinModelPortaliQ7Z3E2.
SMRiQ7Z3E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120401. 11 interactors.
DIPiDIP-47298N.
IntActiQ7Z3E2. 11 interactors.
MINTiMINT-1209058.
STRINGi9606.ENSP00000358293.

PTM databases

iPTMnetiQ7Z3E2.
PhosphoSitePlusiQ7Z3E2.

Polymorphism and mutation databases

BioMutaiC10orf118.
DMDMi71152997.

Proteomic databases

EPDiQ7Z3E2.
MaxQBiQ7Z3E2.
PaxDbiQ7Z3E2.
PeptideAtlasiQ7Z3E2.
PRIDEiQ7Z3E2.

Protocols and materials databases

DNASUi55088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369287; ENSP00000358293; ENSG00000165813.
GeneIDi55088.
KEGGihsa:55088.
UCSCiuc001lbb.2. human.

Organism-specific databases

CTDi55088.
GeneCardsiCCDC186.
HGNCiHGNC:24349. CCDC186.
HPAiHPA014569.
HPA018019.
neXtProtiNX_Q7Z3E2.
OpenTargetsiENSG00000165813.
PharmGKBiPA134904295.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0992. Eukaryota.
ENOG4110CGV. LUCA.
GeneTreeiENSGT00720000108851.
HOVERGENiHBG081202.
InParanoidiQ7Z3E2.
OMAiCAKTDTG.
OrthoDBiEOG091G05JM.
PhylomeDBiQ7Z3E2.
TreeFamiTF328785.

Miscellaneous databases

ChiTaRSiC10orf118. human.
GeneWikiiC10orf118.
GenomeRNAii55088.
PROiQ7Z3E2.

Gene expression databases

BgeeiENSG00000165813.
CleanExiHS_C10orf118.
ExpressionAtlasiQ7Z3E2. baseline and differential.
GenevisibleiQ7Z3E2. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC186_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E2
Secondary accession number(s): Q2M2V6
, Q3ZB81, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.