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Protein

TCDD-inducible poly [ADP-ribose] polymerase

Gene

TIPARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 26428C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • enhancer binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
TCDD-inducible poly [ADP-ribose] polymerase (EC:2.4.2.30)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 14
Short name:
ARTD14
Poly [ADP-ribose] polymerase 7
Short name:
PARP-7
Gene namesi
Name:TIPARP
Synonyms:PARP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23696. TIPARP.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885396.

Polymorphism and mutation databases

BioMutaiTIPARP.
DMDMi74723283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657TCDD-inducible poly [ADP-ribose] polymerasePRO_0000247835Add
BLAST

Proteomic databases

PaxDbiQ7Z3E1.
PRIDEiQ7Z3E1.

PTM databases

PhosphoSiteiQ7Z3E1.

Expressioni

Gene expression databases

BgeeiQ7Z3E1.
CleanExiHS_TIPARP.
ExpressionAtlasiQ7Z3E1. baseline and differential.
GenevisibleiQ7Z3E1. HS.

Organism-specific databases

HPAiHPA036796.
HPA049230.

Interactioni

Protein-protein interaction databases

BioGridi117460. 1 interaction.
IntActiQ7Z3E1. 1 interaction.
MINTiMINT-4719567.
STRINGi9606.ENSP00000295924.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E1.
SMRiQ7Z3E1. Positions 462-648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini332 – 41079WWEPROSITE-ProRule annotationAdd
BLAST
Domaini449 – 657209PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 1 WWE domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 26428C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG27203.
GeneTreeiENSGT00760000119084.
HOVERGENiHBG082109.
InParanoidiQ7Z3E1.
KOiK15259.
OMAiLNQLQYH.
OrthoDBiEOG7P5T0J.
PhylomeDBiQ7Z3E1.
TreeFamiTF328965.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT
60 70 80 90 100
GTLRSLRPIL NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC
110 120 130 140 150
PPAENNMSVL IPDRTNVGDQ IPEAHPSTEA PERVVPIQDH SFPSETLSGT
160 170 180 190 200
VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK VIDYVPGIFQ ENSFTIQYIL
210 220 230 240 250
DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI EICMDFLQGT
260 270 280 290 300
CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR
310 320 330 340 350
MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF
360 370 380 390 400
CRDHFGWREY PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK
410 420 430 440 450
RRPLFRSCFI LLPYLQTLGG VPTQAPPPLE ATSSSQIICP DGVTSANFYP
460 470 480 490 500
ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN
510 520 530 540 550
QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD GICKHNFDPR
560 570 580 590 600
VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS
610 620 630 640 650
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE

VSNTVSI
Length:657
Mass (Da):76,227
Last modified:October 1, 2003 - v1
Checksum:i1E63E311F1B36CEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431K → E in CAH18441 (PubMed:17974005).Curated
Sequence conflicti582 – 5821G → R in CAH18441 (PubMed:17974005).Curated
Sequence conflicti633 – 6331V → A in CAH18441 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti406 – 4061R → S.1 Publication
Corresponds to variant rs17854621 [ dbSNP | Ensembl ].
VAR_027155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA. Translation: CAB45747.2.
BX537965 mRNA. Translation: CAD97929.1.
CR749647 mRNA. Translation: CAH18441.1.
CH471052 Genomic DNA. Translation: EAW78725.1.
CH471052 Genomic DNA. Translation: EAW78728.1.
BC050350 mRNA. Translation: AAH50350.2.
CCDSiCCDS3177.1.
PIRiT12540.
RefSeqiNP_001171646.1. NM_001184717.1.
NP_001171647.1. NM_001184718.1.
NP_056323.2. NM_015508.4.
XP_011510970.1. XM_011512668.1.
UniGeneiHs.744050.

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659.
ENST00000461166; ENSP00000420612; ENSG00000163659.
ENST00000486483; ENSP00000418757; ENSG00000163659.
ENST00000542783; ENSP00000438345; ENSG00000163659.
GeneIDi25976.
KEGGihsa:25976.
UCSCiuc003fav.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA. Translation: CAB45747.2.
BX537965 mRNA. Translation: CAD97929.1.
CR749647 mRNA. Translation: CAH18441.1.
CH471052 Genomic DNA. Translation: EAW78725.1.
CH471052 Genomic DNA. Translation: EAW78728.1.
BC050350 mRNA. Translation: AAH50350.2.
CCDSiCCDS3177.1.
PIRiT12540.
RefSeqiNP_001171646.1. NM_001184717.1.
NP_001171647.1. NM_001184718.1.
NP_056323.2. NM_015508.4.
XP_011510970.1. XM_011512668.1.
UniGeneiHs.744050.

3D structure databases

ProteinModelPortaliQ7Z3E1.
SMRiQ7Z3E1. Positions 462-648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117460. 1 interaction.
IntActiQ7Z3E1. 1 interaction.
MINTiMINT-4719567.
STRINGi9606.ENSP00000295924.

Chemistry

ChEMBLiCHEMBL2380188.

PTM databases

PhosphoSiteiQ7Z3E1.

Polymorphism and mutation databases

BioMutaiTIPARP.
DMDMi74723283.

Proteomic databases

PaxDbiQ7Z3E1.
PRIDEiQ7Z3E1.

Protocols and materials databases

DNASUi25976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659.
ENST00000461166; ENSP00000420612; ENSG00000163659.
ENST00000486483; ENSP00000418757; ENSG00000163659.
ENST00000542783; ENSP00000438345; ENSG00000163659.
GeneIDi25976.
KEGGihsa:25976.
UCSCiuc003fav.3. human.

Organism-specific databases

CTDi25976.
GeneCardsiGC03P156391.
HGNCiHGNC:23696. TIPARP.
HPAiHPA036796.
HPA049230.
MIMi612480. gene.
neXtProtiNX_Q7Z3E1.
PharmGKBiPA134885396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG27203.
GeneTreeiENSGT00760000119084.
HOVERGENiHBG082109.
InParanoidiQ7Z3E1.
KOiK15259.
OMAiLNQLQYH.
OrthoDBiEOG7P5T0J.
PhylomeDBiQ7Z3E1.
TreeFamiTF328965.

Miscellaneous databases

GeneWikiiTIPARP.
GenomeRNAii25976.
NextBioi47622.
PROiQ7Z3E1.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z3E1.
CleanExiHS_TIPARP.
ExpressionAtlasiQ7Z3E1. baseline and differential.
GenevisibleiQ7Z3E1. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrial tumor and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-406.
    Tissue: Brain.
  4. "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31."
    Katoh M., Katoh M.
    Int. J. Oncol. 23:541-547(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
    Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
    Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiPARPT_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E1
Secondary accession number(s): D3DNK6
, Q68CY9, Q86VP4, Q9Y4P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.