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Reviewed, UniProtKB/Swiss-Prot Q7Z3E1 (PARPT_HUMAN)

Last modified February 9, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    TCDD-inducible poly [ADP-ribose] polymerase
    EC=2.4.2.30
Alternative name(s):
    Poly [ADP-ribose] polymerase 7
      Short name=PARP-7
Gene names
Name: TIPARP
Synonyms: PARP7
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals By similarity.

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Sequence similarities

Contains 1 C3H1-type zinc finger.

Contains 1 PARP catalytic domain.

Contains 1 WWE domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

XRN2Q9H0D61EBI-373532,EBI-372110

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 657657TCDD-inducible poly [ADP-ribose] polymerase
PRO_0000247835

Regions

Domain332 – 41079WWE
Domain449 – 657209PARP catalytic
Zinc finger237 – 26428C3H1-type

Natural variations

Natural variant4061R → S: dbSNP rs17854621. Ref.2
VAR_027155

Experimental info

Sequence conflict431K → E in CAH18441. Ref.1
Sequence conflict5821G → R in CAH18441. Ref.1
Sequence conflict6331V → A in CAH18441. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7Z3E1-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 1E63E311F1B36CEB

FASTA65776,227
        10         20         30         40         50         60 
MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT GTLRSLRPIL 

        70         80         90        100        110        120 
NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC PPAENNMSVL IPDRTNVGDQ 

       130        140        150        160        170        180 
IPEAHPSTEA PERVVPIQDH SFPSETLSGT VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK 

       190        200        210        220        230        240 
VIDYVPGIFQ ENSFTIQYIL DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI 

       250        260        270        280        290        300 
EICMDFLQGT CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR 

       310        320        330        340        350        360 
MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF CRDHFGWREY 

       370        380        390        400        410        420 
PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK RRPLFRSCFI LLPYLQTLGG 

       430        440        450        460        470        480 
VPTQAPPPLE ATSSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL 

       490        500        510        520        530        540 
FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD 

       550        560        570        580        590        600 
GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS 

       610        620        630        640        650 
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI 

« Hide

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Endometrial tumor and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-406.
Tissue: Brain.
[3]"Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31."
Katoh M., Katoh M.
Int. J. Oncol. 23:541-547(2003) [PubMed: 12851707] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL080156 mRNA. Translation: CAB45747.2.
BX537965 mRNA. Translation: CAD97929.1.
CR749647 mRNA. Translation: CAH18441.1.
BC050350 mRNA. Translation: AAH50350.2.
IPIIPI00384981.
PIRT12540.
RefSeqNP_056323.2.

3D structure databases

SMRQ7Z3E1. Positions 260-403, 460-652.
ModBaseSearch...

Protein-protein interaction databases

IntActQ7Z3E1. 1 interaction.
STRINGQ7Z3E1.

Genome annotation databases

EnsemblENST00000295924; ENSP00000295924; ENSG00000163659; Homo sapiens. [Genome view]
ENST00000461166; ENSP00000420612; ENSG00000163659; Homo sapiens. [Genome view]
ENST00000486483; ENSP00000418757; ENSG00000163659; Homo sapiens. [Genome view]
GeneID25976.
KEGGhsa:25976.
UCSCuc003fav.1. human.

Organism-specific databases

CTD25976.
GeneCardsGC03P157875.
HGNCHGNC:23696. TIPARP.
MIM612480. gene.
PharmGKBPA134885396.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ7Z3E1.
InParanoidQ7Z3E1.
OMADSQEHLE.
OrthoDBEOG9ZKN6F.
PhylomeDBQ7Z3E1.

Enzyme and pathway databases

BRENDA2.4.2.30. 247.

Gene expression databases

ArrayExpressQ7Z3E1.
BgeeQ7Z3E1.
CleanExHS_TIPARP.
GenevestigatorQ7Z3E1.
GermOnlineENSG00000163659. Homo sapiens.

Family and domain databases

InterProIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF00644. PARP. 1 hit.
[Graphical view]
PROSITEPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio47622.
SOURCESearch...

Entry information

Entry namePARPT_HUMAN
AccessionPrimary (citable) accession number: Q7Z3E1
Secondary accession number(s): Q68CY9, Q86VP4, Q9Y4P7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents