Reviewed, UniProtKB/Swiss-Prot Q7Z3E1 (PARPT_HUMAN)

Names and origin

Protein names

Recommended name:
    TCDD-inducible poly [ADP-ribose] polymerase
    EC=2.4.2.30
Alternative name(s):
    Poly [ADP-ribose] polymerase 7
      Short name=PARP-7

Gene names

Name:	TIPARP
Synonyms:	PARP7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals By similarity.
Catalytic activity	NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Sequence similarities	Contains 1 C3H1-type zinc finger. Contains 1 PARP catalytic domain. Contains 1 WWE domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Zinc-finger
Ligand	Metal-binding NAD Zinc
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	NAD+ ADP-ribosyltransferase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
XRN2	Q9H0D6	1	EBI-373532,EBI-372110

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	TCDD-inducible poly [ADP-ribose] polymerase		PRO_0000247835
Regions
	Domain	332 – 410	79	WWE
	Domain	449 – 657	209	PARP catalytic
	Zinc finger	237 – 264	28	C3H1-type
Natural variations
	Natural variant	406	1	R → S: dbSNP rs17854621. Ref.2		VAR_027155
Experimental info
	Sequence conflict	43	1	K → E in CAH18441. Ref.1
	Sequence conflict	582	1	G → R in CAH18441. Ref.1
	Sequence conflict	633	1	V → A in CAH18441. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q7Z3E1-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 1E63E311F1B36CEB	FASTA	657	76,227
	10 20 30 40 50 60 MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT GTLRSLRPIL 70 80 90 100 110 120 NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC PPAENNMSVL IPDRTNVGDQ 130 140 150 160 170 180 IPEAHPSTEA PERVVPIQDH SFPSETLSGT VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK 190 200 210 220 230 240 VIDYVPGIFQ ENSFTIQYIL DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI 250 260 270 280 290 300 EICMDFLQGT CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR 310 320 330 340 350 360 MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF CRDHFGWREY 370 380 390 400 410 420 PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK RRPLFRSCFI LLPYLQTLGG 430 440 450 460 470 480 VPTQAPPPLE ATSSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL 490 500 510 520 530 540 FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD 550 560 570 580 590 600 GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS 610 620 630 640 650 HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Endometrial tumor and Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-406. Tissue: Brain.
[3]	"Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31." Katoh M., Katoh M. Int. J. Oncol. 23:541-547(2003) [PubMed: 12851707] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL080156 mRNA. Translation: CAB45747.2. BX537965 mRNA. Translation: CAD97929.1. CR749647 mRNA. Translation: CAH18441.1. BC050350 mRNA. Translation: AAH50350.2.
IPI	IPI00384981.
PIR	T12540.
RefSeq	NP_056323.2.
3D structure databases
SMR	Q7Z3E1. Positions 260-403, 460-652.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7Z3E1. 1 interaction.
STRING	Q7Z3E1.
Genome annotation databases
Ensembl	ENST00000295924; ENSP00000295924; ENSG00000163659; Homo sapiens. [Genome view] ENST00000461166; ENSP00000420612; ENSG00000163659; Homo sapiens. [Genome view] ENST00000486483; ENSP00000418757; ENSG00000163659; Homo sapiens. [Genome view]
GeneID	25976.
KEGG	hsa:25976.
UCSC	uc003fav.1. human.
Organism-specific databases
CTD	25976.
GeneCards	GC03P157875.
HGNC	HGNC:23696. TIPARP.
MIM	612480. gene.
PharmGKB	PA134885396.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7Z3E1.
InParanoid	Q7Z3E1.
OMA	DSQEHLE.
OrthoDB	EOG9ZKN6F.
PhylomeDB	Q7Z3E1.
Enzyme and pathway databases
BRENDA	2.4.2.30. 247.
Gene expression databases
ArrayExpress	Q7Z3E1.
Bgee	Q7Z3E1.
CleanEx	HS_TIPARP.
Genevestigator	Q7Z3E1.
GermOnline	ENSG00000163659. Homo sapiens.
Family and domain databases
InterPro	IPR012317. Poly(ADP-ribose)pol_cat_dom. IPR004170. WWE-dom. IPR000571. Znf_CCCH. [Graphical view]
Pfam	PF00644. PARP. 1 hit. [Graphical view]
PROSITE	PS51059. PARP_CATALYTIC. 1 hit. PS50918. WWE. 1 hit. PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47622.
SOURCE	Search...

Entry information

Entry name

PARPT_HUMAN

Accession

Primary (citable) accession number: Q7Z3E1
Secondary accession number(s): Q68CY9, Q86VP4, Q9Y4P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	October 1, 2003
Last modified:	February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.