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Protein

TCDD-inducible poly [ADP-ribose] polymerase

Gene

TIPARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity).By similarity

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 264C3H1-typePROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

  • enhancer binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • NAD+ ADP-ribosyltransferase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS15095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TCDD-inducible poly [ADP-ribose] polymerase (EC:2.4.2.30)
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 14
Short name:
ARTD14
Poly [ADP-ribose] polymerase 7
Short name:
PARP-7
Gene namesi
Name:TIPARP
Synonyms:PARP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23696. TIPARP.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi25976.
OpenTargetsiENSG00000163659.
PharmGKBiPA134885396.

Chemistry databases

ChEMBLiCHEMBL2380188.

Polymorphism and mutation databases

BioMutaiTIPARP.
DMDMi74723283.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478351 – 657TCDD-inducible poly [ADP-ribose] polymeraseAdd BLAST657

Proteomic databases

EPDiQ7Z3E1.
PaxDbiQ7Z3E1.
PRIDEiQ7Z3E1.

PTM databases

iPTMnetiQ7Z3E1.
PhosphoSitePlusiQ7Z3E1.

Expressioni

Gene expression databases

BgeeiENSG00000163659.
CleanExiHS_TIPARP.
ExpressionAtlasiQ7Z3E1. baseline and differential.
GenevisibleiQ7Z3E1. HS.

Organism-specific databases

HPAiHPA036796.
HPA049230.

Interactioni

Protein-protein interaction databases

BioGridi117460. 1 interactor.
IntActiQ7Z3E1. 1 interactor.
MINTiMINT-4719567.
STRINGi9606.ENSP00000295924.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3E1.
SMRiQ7Z3E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini332 – 410WWEPROSITE-ProRule annotationAdd BLAST79
Domaini449 – 657PARP catalyticPROSITE-ProRule annotationAdd BLAST209

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
Contains 1 WWE domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 264C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IIZH. Eukaryota.
ENOG410YI58. LUCA.
GeneTreeiENSGT00760000119084.
HOVERGENiHBG082109.
InParanoidiQ7Z3E1.
KOiK15259.
OMAiLNQLQYH.
OrthoDBiEOG091G14UY.
PhylomeDBiQ7Z3E1.
TreeFamiTF328965.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7Z3E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT
60 70 80 90 100
GTLRSLRPIL NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC
110 120 130 140 150
PPAENNMSVL IPDRTNVGDQ IPEAHPSTEA PERVVPIQDH SFPSETLSGT
160 170 180 190 200
VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK VIDYVPGIFQ ENSFTIQYIL
210 220 230 240 250
DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI EICMDFLQGT
260 270 280 290 300
CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR
310 320 330 340 350
MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF
360 370 380 390 400
CRDHFGWREY PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK
410 420 430 440 450
RRPLFRSCFI LLPYLQTLGG VPTQAPPPLE ATSSSQIICP DGVTSANFYP
460 470 480 490 500
ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN
510 520 530 540 550
QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD GICKHNFDPR
560 570 580 590 600
VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS
610 620 630 640 650
HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE

VSNTVSI
Length:657
Mass (Da):76,227
Last modified:October 1, 2003 - v1
Checksum:i1E63E311F1B36CEB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43K → E in CAH18441 (PubMed:17974005).Curated1
Sequence conflicti582G → R in CAH18441 (PubMed:17974005).Curated1
Sequence conflicti633V → A in CAH18441 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027155406R → S.1 PublicationCorresponds to variant rs17854621dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA. Translation: CAB45747.2.
BX537965 mRNA. Translation: CAD97929.1.
CR749647 mRNA. Translation: CAH18441.1.
CH471052 Genomic DNA. Translation: EAW78725.1.
CH471052 Genomic DNA. Translation: EAW78728.1.
BC050350 mRNA. Translation: AAH50350.2.
CCDSiCCDS3177.1.
PIRiT12540.
RefSeqiNP_001171646.1. NM_001184717.1.
NP_001171647.1. NM_001184718.1.
NP_056323.2. NM_015508.4.
UniGeneiHs.744050.

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659.
ENST00000461166; ENSP00000420612; ENSG00000163659.
ENST00000486483; ENSP00000418757; ENSG00000163659.
ENST00000542783; ENSP00000438345; ENSG00000163659.
GeneIDi25976.
KEGGihsa:25976.
UCSCiuc003fav.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080156 mRNA. Translation: CAB45747.2.
BX537965 mRNA. Translation: CAD97929.1.
CR749647 mRNA. Translation: CAH18441.1.
CH471052 Genomic DNA. Translation: EAW78725.1.
CH471052 Genomic DNA. Translation: EAW78728.1.
BC050350 mRNA. Translation: AAH50350.2.
CCDSiCCDS3177.1.
PIRiT12540.
RefSeqiNP_001171646.1. NM_001184717.1.
NP_001171647.1. NM_001184718.1.
NP_056323.2. NM_015508.4.
UniGeneiHs.744050.

3D structure databases

ProteinModelPortaliQ7Z3E1.
SMRiQ7Z3E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117460. 1 interactor.
IntActiQ7Z3E1. 1 interactor.
MINTiMINT-4719567.
STRINGi9606.ENSP00000295924.

Chemistry databases

ChEMBLiCHEMBL2380188.

PTM databases

iPTMnetiQ7Z3E1.
PhosphoSitePlusiQ7Z3E1.

Polymorphism and mutation databases

BioMutaiTIPARP.
DMDMi74723283.

Proteomic databases

EPDiQ7Z3E1.
PaxDbiQ7Z3E1.
PRIDEiQ7Z3E1.

Protocols and materials databases

DNASUi25976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295924; ENSP00000295924; ENSG00000163659.
ENST00000461166; ENSP00000420612; ENSG00000163659.
ENST00000486483; ENSP00000418757; ENSG00000163659.
ENST00000542783; ENSP00000438345; ENSG00000163659.
GeneIDi25976.
KEGGihsa:25976.
UCSCiuc003fav.4. human.

Organism-specific databases

CTDi25976.
DisGeNETi25976.
GeneCardsiTIPARP.
HGNCiHGNC:23696. TIPARP.
HPAiHPA036796.
HPA049230.
MIMi612480. gene.
neXtProtiNX_Q7Z3E1.
OpenTargetsiENSG00000163659.
PharmGKBiPA134885396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZH. Eukaryota.
ENOG410YI58. LUCA.
GeneTreeiENSGT00760000119084.
HOVERGENiHBG082109.
InParanoidiQ7Z3E1.
KOiK15259.
OMAiLNQLQYH.
OrthoDBiEOG091G14UY.
PhylomeDBiQ7Z3E1.
TreeFamiTF328965.

Enzyme and pathway databases

BioCyciZFISH:HS15095-MONOMER.

Miscellaneous databases

GeneWikiiTIPARP.
GenomeRNAii25976.
PROiQ7Z3E1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163659.
CleanExiHS_TIPARP.
ExpressionAtlasiQ7Z3E1. baseline and differential.
GenevisibleiQ7Z3E1. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004170. WWE-dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
PS50918. WWE. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARPT_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3E1
Secondary accession number(s): D3DNK6
, Q68CY9, Q86VP4, Q9Y4P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.