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Q7Z3E1

- PARPT_HUMAN

UniProt

Q7Z3E1 - PARPT_HUMAN

Protein

TCDD-inducible poly [ADP-ribose] polymerase

Gene

TIPARP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals By similarity.By similarity

    Catalytic activityi

    NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri237 – 26428C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. enhancer binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. NAD+ ADP-ribosyltransferase activity Source: MGI

    GO - Biological processi

    1. androgen metabolic process Source: Ensembl
    2. cellular response to organic cyclic compound Source: MGI
    3. estrogen metabolic process Source: Ensembl
    4. face morphogenesis Source: Ensembl
    5. female gonad development Source: Ensembl
    6. hemopoiesis Source: Ensembl
    7. kidney development Source: Ensembl
    8. multicellular organismal metabolic process Source: Ensembl
    9. negative regulation of gene expression Source: MGI
    10. nitrogen compound metabolic process Source: Ensembl
    11. palate development Source: Ensembl
    12. platelet-derived growth factor receptor signaling pathway Source: Ensembl
    13. positive regulation of protein catabolic process Source: MGI
    14. post-embryonic development Source: Ensembl
    15. protein ADP-ribosylation Source: Ensembl
    16. skeletal system morphogenesis Source: Ensembl
    17. smooth muscle tissue development Source: Ensembl
    18. vasculogenesis Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TCDD-inducible poly [ADP-ribose] polymerase (EC:2.4.2.30)
    Alternative name(s):
    ADP-ribosyltransferase diphtheria toxin-like 14
    Short name:
    ARTD14
    Poly [ADP-ribose] polymerase 7
    Short name:
    PARP-7
    Gene namesi
    Name:TIPARP
    Synonyms:PARP7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:23696. TIPARP.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134885396.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 657657TCDD-inducible poly [ADP-ribose] polymerasePRO_0000247835Add
    BLAST

    Proteomic databases

    PaxDbiQ7Z3E1.
    PRIDEiQ7Z3E1.

    PTM databases

    PhosphoSiteiQ7Z3E1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z3E1.
    BgeeiQ7Z3E1.
    CleanExiHS_TIPARP.
    GenevestigatoriQ7Z3E1.

    Organism-specific databases

    HPAiHPA036796.
    HPA049230.

    Interactioni

    Protein-protein interaction databases

    BioGridi117460. 3 interactions.
    IntActiQ7Z3E1. 1 interaction.
    MINTiMINT-4719567.
    STRINGi9606.ENSP00000295924.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z3E1.
    SMRiQ7Z3E1. Positions 462-648.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini332 – 41079WWEPROSITE-ProRule annotationAdd
    BLAST
    Domaini449 – 657209PARP catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PARP catalytic domain.PROSITE-ProRule annotation
    Contains 1 WWE domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri237 – 26428C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG27203.
    HOVERGENiHBG082109.
    InParanoidiQ7Z3E1.
    KOiK15259.
    OMAiDSQEHLE.
    OrthoDBiEOG7P5T0J.
    PhylomeDBiQ7Z3E1.
    TreeFamiTF328965.

    Family and domain databases

    Gene3Di3.90.228.10. 1 hit.
    InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR004170. WWE-dom.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00644. PARP. 1 hit.
    [Graphical view]
    PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
    PS50918. WWE. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7Z3E1-1 [UniParc]FASTAAdd to Basket

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    MEMETTEPEP DCVVQPPSPP DDFSCQMRLS EKITPLKTCF KKKDQKRLGT    50
    GTLRSLRPIL NTLLESGSLD GVFRSRNQST DENSLHEPMM KKAMEINSSC 100
    PPAENNMSVL IPDRTNVGDQ IPEAHPSTEA PERVVPIQDH SFPSETLSGT 150
    VADSTPAHFQ TDLLHPVSSD VPTSPDCLDK VIDYVPGIFQ ENSFTIQYIL 200
    DTSDKLSTEL FQDKSEEASL DLVFELVNQL QYHTHQENGI EICMDFLQGT 250
    CIYGRDCLKH HTVLPYHWQI KRTTTQKWQS VFNDSQEHLE RFYCNPENDR 300
    MRMKYGGQEF WADLNAMNVY ETTEFDQLRR LSTPPSSNVN SIYHTVWKFF 350
    CRDHFGWREY PESVIRLIEE ANSRGLKEVR FMMWNNHYIL HNSFFRREIK 400
    RRPLFRSCFI LLPYLQTLGG VPTQAPPPLE ATSSSQIICP DGVTSANFYP 450
    ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN 500
    QFLWEKYKRK KEYMNRKMFG RDRIINERHL FHGTSQDVVD GICKHNFDPR 550
    VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS 600
    HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE 650
    VSNTVSI 657
    Length:657
    Mass (Da):76,227
    Last modified:October 1, 2003 - v1
    Checksum:i1E63E311F1B36CEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431K → E in CAH18441. (PubMed:17974005)Curated
    Sequence conflicti582 – 5821G → R in CAH18441. (PubMed:17974005)Curated
    Sequence conflicti633 – 6331V → A in CAH18441. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti406 – 4061R → S.1 Publication
    Corresponds to variant rs17854621 [ dbSNP | Ensembl ].
    VAR_027155

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL080156 mRNA. Translation: CAB45747.2.
    BX537965 mRNA. Translation: CAD97929.1.
    CR749647 mRNA. Translation: CAH18441.1.
    CH471052 Genomic DNA. Translation: EAW78725.1.
    CH471052 Genomic DNA. Translation: EAW78728.1.
    BC050350 mRNA. Translation: AAH50350.2.
    CCDSiCCDS3177.1.
    PIRiT12540.
    RefSeqiNP_001171646.1. NM_001184717.1.
    NP_001171647.1. NM_001184718.1.
    NP_056323.2. NM_015508.4.
    UniGeneiHs.744050.

    Genome annotation databases

    EnsembliENST00000295924; ENSP00000295924; ENSG00000163659.
    ENST00000461166; ENSP00000420612; ENSG00000163659.
    ENST00000486483; ENSP00000418757; ENSG00000163659.
    ENST00000542783; ENSP00000438345; ENSG00000163659.
    GeneIDi25976.
    KEGGihsa:25976.
    UCSCiuc003fav.3. human.

    Polymorphism databases

    DMDMi74723283.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL080156 mRNA. Translation: CAB45747.2 .
    BX537965 mRNA. Translation: CAD97929.1 .
    CR749647 mRNA. Translation: CAH18441.1 .
    CH471052 Genomic DNA. Translation: EAW78725.1 .
    CH471052 Genomic DNA. Translation: EAW78728.1 .
    BC050350 mRNA. Translation: AAH50350.2 .
    CCDSi CCDS3177.1.
    PIRi T12540.
    RefSeqi NP_001171646.1. NM_001184717.1.
    NP_001171647.1. NM_001184718.1.
    NP_056323.2. NM_015508.4.
    UniGenei Hs.744050.

    3D structure databases

    ProteinModelPortali Q7Z3E1.
    SMRi Q7Z3E1. Positions 462-648.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117460. 3 interactions.
    IntActi Q7Z3E1. 1 interaction.
    MINTi MINT-4719567.
    STRINGi 9606.ENSP00000295924.

    Chemistry

    ChEMBLi CHEMBL2380188.

    PTM databases

    PhosphoSitei Q7Z3E1.

    Polymorphism databases

    DMDMi 74723283.

    Proteomic databases

    PaxDbi Q7Z3E1.
    PRIDEi Q7Z3E1.

    Protocols and materials databases

    DNASUi 25976.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295924 ; ENSP00000295924 ; ENSG00000163659 .
    ENST00000461166 ; ENSP00000420612 ; ENSG00000163659 .
    ENST00000486483 ; ENSP00000418757 ; ENSG00000163659 .
    ENST00000542783 ; ENSP00000438345 ; ENSG00000163659 .
    GeneIDi 25976.
    KEGGi hsa:25976.
    UCSCi uc003fav.3. human.

    Organism-specific databases

    CTDi 25976.
    GeneCardsi GC03P156391.
    HGNCi HGNC:23696. TIPARP.
    HPAi HPA036796.
    HPA049230.
    MIMi 612480. gene.
    neXtProti NX_Q7Z3E1.
    PharmGKBi PA134885396.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27203.
    HOVERGENi HBG082109.
    InParanoidi Q7Z3E1.
    KOi K15259.
    OMAi DSQEHLE.
    OrthoDBi EOG7P5T0J.
    PhylomeDBi Q7Z3E1.
    TreeFami TF328965.

    Miscellaneous databases

    GeneWikii TIPARP.
    GenomeRNAii 25976.
    NextBioi 47622.
    PROi Q7Z3E1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z3E1.
    Bgeei Q7Z3E1.
    CleanExi HS_TIPARP.
    Genevestigatori Q7Z3E1.

    Family and domain databases

    Gene3Di 3.90.228.10. 1 hit.
    InterProi IPR012317. Poly(ADP-ribose)pol_cat_dom.
    IPR004170. WWE-dom.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00644. PARP. 1 hit.
    [Graphical view ]
    PROSITEi PS51059. PARP_CATALYTIC. 1 hit.
    PS50918. WWE. 1 hit.
    PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Endometrial tumor and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-406.
      Tissue: Brain.
    4. "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31."
      Katoh M., Katoh M.
      Int. J. Oncol. 23:541-547(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
      Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
      Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiPARPT_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3E1
    Secondary accession number(s): D3DNK6
    , Q68CY9, Q86VP4, Q9Y4P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3