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Protein

D-glutamate cyclase, mitochondrial

Gene

DGLUCY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.By similarity

Catalytic activityi

D-glutamate = 5-oxo-D-proline + H2O.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
D-glutamate cyclase, mitochondrialCurated (EC:4.2.1.48By similarity)
Gene namesi
Name:DGLUCYImported
Synonyms:C14orf159Imported
ORF Names:UNQ2439/PRO50001 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000133943.20
HGNCiHGNC:20498 DGLUCY
neXtProtiNX_Q7Z3D6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133943
PharmGKBiPA134952868

Polymorphism and mutation databases

BioMutaiC14orf159
DMDMi48428039

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000003629229 – 616D-glutamate cyclase, mitochondrialAdd BLAST588

Proteomic databases

MaxQBiQ7Z3D6
PaxDbiQ7Z3D6
PeptideAtlasiQ7Z3D6
PRIDEiQ7Z3D6
ProteomicsDBi69032
69033 [Q7Z3D6-2]
69034 [Q7Z3D6-3]
69035 [Q7Z3D6-4]
69036 [Q7Z3D6-5]
69037 [Q7Z3D6-6]

PTM databases

iPTMnetiQ7Z3D6
PhosphoSitePlusiQ7Z3D6

Expressioni

Gene expression databases

BgeeiENSG00000133943
CleanExiHS_C14orf159
ExpressionAtlasiQ7Z3D6 baseline and differential
GenevisibleiQ7Z3D6 HS

Organism-specific databases

HPAiHPA041423
HPA052932

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-2807872,EBI-348380

Protein-protein interaction databases

BioGridi123071, 8 interactors
IntActiQ7Z3D6, 2 interactors
STRINGi9606.ENSP00000256324

Structurei

3D structure databases

ProteinModelPortaliQ7Z3D6
SMRiQ7Z3D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the D-glutamate cyclase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IGIV Eukaryota
COG4336 LUCA
GeneTreeiENSGT00390000002237
HOVERGENiHBG051034
InParanoidiQ7Z3D6
KOiK22210
OMAiGIGHLLC
OrthoDBiEOG091G02WW
PhylomeDBiQ7Z3D6
TreeFamiTF300254

Family and domain databases

InterProiView protein in InterPro
IPR009906 D-Glu_cyclase
IPR017135 D-Glu_cyclase_mito
IPR025504 DUF4392
IPR038021 Putative_hydro-lyase
PfamiView protein in Pfam
PF07286 DUF1445, 1 hit
PF14336 DUF4392, 1 hit
PIRSFiPIRSF037204 UCP037204, 1 hit
SUPFAMiSSF160920 SSF160920, 1 hit

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3D6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFTLHLRSR LPSAIRSLIL QKKPNIRNTS SMAGELRPAS LVVLPRSLAP
60 70 80 90 100
AFERFCQVNT GPLPLLGQSE PEKWMLPPQG AISETRMGHP QFWKYEFGAC
110 120 130 140 150
TGSLASLEQY SEQLKDMVAF FLGCSFSLEE ALEKAGLPRR DPAGHSQTTV
160 170 180 190 200
PCVTHAGFCC PLVVTMRPIP KDKLEGLVRA CCSLGGEQGQ PVHMGDPELL
210 220 230 240 250
GIKELSKPAY GDAMVCPPGE VPVFWPSPLT SLGAVSSCET PLAFASIPGC
260 270 280 290 300
TVMTDLKDAK APPGCLTPER IPEVHHISQD PLHYSIASVS ASQKIRELES
310 320 330 340 350
MIGIDPGNRG IGHLLCKDEL LKASLSLSHA RSVLITTGFP THFNHEPPEE
360 370 380 390 400
TDGPPGAVAL VAFLQALEKE VAIIVDQRAW NLHQKIVEDA VEQGVLKTQI
410 420 430 440 450
PILTYQGGSV EAAQAFLCKN GDPQTPRFDH LVAIERAGRA ADGNYYNARK
460 470 480 490 500
MNIKHLVDPI DDLFLAAKKI PGISSTGVGD GGNELGMGKV KEAVRRHIRH
510 520 530 540 550
GDVIACDVEA DFAVIAGVSN WGGYALACAL YILYSCAVHS QYLRKAVGPS
560 570 580 590 600
RAPGDQAWTQ ALPSVIKEEK MLGILVQHKV RSGVSGIVGM EVDGLPFHNT
610
HAEMIQKLVD VTTAQV
Length:616
Mass (Da):66,437
Last modified:June 7, 2004 - v2
Checksum:iC33884FA33D4D1AC
GO
Isoform 2 (identifier: Q7Z3D6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Q → QAGAYK

Show »
Length:621
Mass (Da):66,927
Checksum:i83EF9BEBBD38AE37
GO
Isoform 3 (identifier: Q7Z3D6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Q → QAGAYK
     477-516: Missing.

Note: No experimental confirmation available.
Show »
Length:581
Mass (Da):62,782
Checksum:i3DD939B5DF4DC6E1
GO
Isoform 4 (identifier: Q7Z3D6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     147-147: Q → QAGAYK
     569-574: EKMLGI → SKGRKL
     575-616: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:579
Mass (Da):62,401
Checksum:i957E67F7EB24BC50
GO
Isoform 5 (identifier: Q7Z3D6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-197: Missing.
     477-516: Missing.

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):61,059
Checksum:i6A36A72C24467686
GO
Isoform 6 (identifier: Q7Z3D6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-159: RMGHPQFWKY...VPCVTHAGFC → SLRDLHSAWH...AQARNPPVQD
     160-616: Missing.

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):17,705
Checksum:iA2E225F80B94267B
GO

Sequence cautioni

The sequence BAB14932 differs from that shown. Reason: Frameshift at positions 436 and 582.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32M → V in CAD97934 (PubMed:17974005).Curated1
Sequence conflicti147Q → P in AAQ88880 (PubMed:12975309).Curated1
Sequence conflicti165T → M in CAD97934 (PubMed:17974005).Curated1
Sequence conflicti349E → V in BAB14932 (PubMed:14702039).Curated1
Sequence conflicti368E → G in CAD97934 (PubMed:17974005).Curated1
Sequence conflicti497H → R in BAB14932 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01873810R → C. Corresponds to variant dbSNP:rs10142502Ensembl.1
Natural variantiVAR_052599237S → N. Corresponds to variant dbSNP:rs34302825Ensembl.1
Natural variantiVAR_052600372A → T. Corresponds to variant dbSNP:rs12895348Ensembl.1
Natural variantiVAR_018739502D → N. Corresponds to variant dbSNP:rs2295524Ensembl.1
Natural variantiVAR_052601507D → N. Corresponds to variant dbSNP:rs34523602Ensembl.1
Natural variantiVAR_052602583G → D. Corresponds to variant dbSNP:rs34748911Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01050586 – 159RMGHP…HAGFC → SLRDLHSAWHRTSLMTVAQE RAALPTVLTPSPITWRLSWL RSLRSWRKSSPGEIPLALPS VHSIAQARNPPVQD in isoform 6. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_010506147Q → QAGAYK in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_010507160 – 616Missing in isoform 6. 1 PublicationAdd BLAST457
Alternative sequenceiVSP_010508186 – 197Missing in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_010509477 – 516Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_010510569 – 574EKMLGI → SKGRKL in isoform 4. 1 Publication6
Alternative sequenceiVSP_010511575 – 616Missing in isoform 4. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358516 mRNA Translation: AAQ88880.1
AK022564 mRNA Translation: BAB14102.1
AK023200 mRNA Translation: BAB14458.1
AK024603 mRNA Translation: BAB14932.1 Sequence problems.
AK097294 mRNA Translation: BAG53449.1
BX161393 mRNA Translation: CAD61880.1
BX247989 mRNA Translation: CAD62323.1
BX248060 mRNA Translation: CAD62356.1
BX248294 mRNA Translation: CAD62622.1
BX248782 mRNA Translation: CAD66589.1
BX537970 mRNA Translation: CAD97934.1
BC009182 mRNA Translation: AAH09182.1
BC010614 mRNA Translation: AAH10614.1
BC065558 mRNA Translation: AAH65558.1
CCDSiCCDS32141.1 [Q7Z3D6-1]
CCDS41979.1 [Q7Z3D6-2]
CCDS45150.1 [Q7Z3D6-5]
CCDS66693.1 [Q7Z3D6-3]
CCDS73677.1 [Q7Z3D6-6]
RefSeqiNP_001095836.1, NM_001102366.2 [Q7Z3D6-1]
NP_001095837.1, NM_001102367.2 [Q7Z3D6-1]
NP_001095838.1, NM_001102368.2 [Q7Z3D6-2]
NP_001095839.1, NM_001102369.2 [Q7Z3D6-5]
NP_001273399.1, NM_001286470.1 [Q7Z3D6-2]
NP_001273400.1, NM_001286471.1 [Q7Z3D6-1]
NP_001273401.1, NM_001286472.1 [Q7Z3D6-3]
NP_001273402.1, NM_001286473.1 [Q7Z3D6-6]
NP_079228.4, NM_024952.7 [Q7Z3D6-1]
UniGeneiHs.309849

Genome annotation databases

EnsembliENST00000256324; ENSP00000256324; ENSG00000133943 [Q7Z3D6-2]
ENST00000298858; ENSP00000298858; ENSG00000133943 [Q7Z3D6-6]
ENST00000412671; ENSP00000404196; ENSG00000133943 [Q7Z3D6-2]
ENST00000428926; ENSP00000404343; ENSG00000133943 [Q7Z3D6-1]
ENST00000518665; ENSP00000429098; ENSG00000133943 [Q7Z3D6-6]
ENST00000518868; ENSP00000428263; ENSG00000133943 [Q7Z3D6-2]
ENST00000520328; ENSP00000429453; ENSG00000133943 [Q7Z3D6-5]
ENST00000521077; ENSP00000430137; ENSG00000133943 [Q7Z3D6-3]
ENST00000522322; ENSP00000427953; ENSG00000133943 [Q7Z3D6-1]
ENST00000523771; ENSP00000429655; ENSG00000133943 [Q7Z3D6-1]
ENST00000523816; ENSP00000428974; ENSG00000133943 [Q7Z3D6-1]
ENST00000525393; ENSP00000435459; ENSG00000133943 [Q7Z3D6-3]
GeneIDi80017
KEGGihsa:80017
UCSCiuc001xyv.4 human [Q7Z3D6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGLUCM_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3D6
Secondary accession number(s): B3KUI7
, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 20, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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