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Protein

LysM and putative peptidoglycan-binding domain-containing protein 3

Gene

LYSMD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
LysM and putative peptidoglycan-binding domain-containing protein 3
Gene namesi
Name:LYSMD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000176018.12.
HGNCiHGNC:26969. LYSMD3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 217ExtracellularSequence analysisAdd BLAST217
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 306CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi116068.
OpenTargetsiENSG00000176018.
PharmGKBiPA142671495.

Polymorphism and mutation databases

BioMutaiLYSMD3.
DMDMi114150022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002480071 – 306LysM and putative peptidoglycan-binding domain-containing protein 3Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z3D4.
MaxQBiQ7Z3D4.
PaxDbiQ7Z3D4.
PeptideAtlasiQ7Z3D4.
PRIDEiQ7Z3D4.

PTM databases

iPTMnetiQ7Z3D4.
PhosphoSitePlusiQ7Z3D4.

Expressioni

Gene expression databases

BgeeiENSG00000176018.
CleanExiHS_LYSMD3.
ExpressionAtlasiQ7Z3D4. baseline and differential.
GenevisibleiQ7Z3D4. HS.

Organism-specific databases

HPAiHPA018024.

Interactioni

Protein-protein interaction databases

BioGridi125469. 2 interactors.
IntActiQ7Z3D4. 2 interactors.
MINTiMINT-4722119.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3D4.
SMRiQ7Z3D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 109LysMPROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2850. Eukaryota.
ENOG4112BYV. LUCA.
GeneTreeiENSGT00530000063803.
HOGENOMiHOG000237338.
HOVERGENiHBG081944.
InParanoidiQ7Z3D4.
OMAiPYYGADW.
OrthoDBiEOG091G0Q9I.
PhylomeDBiQ7Z3D4.
TreeFamiTF326271.

Family and domain databases

CDDicd00118. LysM. 1 hit.
Gene3Di3.10.350.10. 1 hit.
InterProiView protein in InterPro
IPR018392. LysM_dom.
IPR036779. LysM_dom_sf.
PfamiView protein in Pfam
PF01476. LysM. 1 hit.
SMARTiView protein in SMART
SM00257. LysM. 1 hit.
SUPFAMiSSF54106. SSF54106. 1 hit.
PROSITEiView protein in PROSITE
PS51782. LYSM. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3D4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRHQNRSF PLPGVQSSGQ VHAFGNCSDS DILEEDAEVY ELRSRGKEKV
60 70 80 90 100
RRSTSRDRLD DIIVLTKDIQ EGDTLNAIAL QYCCTVADIK RVNNLISDQD
110 120 130 140 150
FFALRSIKIP VKKFSSLTET LCPPKGRQTS RHSSVQYSSE QQEILPANDS
160 170 180 190 200
LAYSDSAGSF LKEVDRDIEQ IVKCTDNKRE NLNEVVSALT AQQMRFEPDN
210 220 230 240 250
KNTQRKDPYY GADWGIGWWT AVVIMLIVGI ITPVFYLLYY EILAKVDVSH
260 270 280 290 300
HSTVDSSHLH SKITPPSQQR EMENGIVPTK GIHFSQQDDH KLYSQDSQSP

AAQQET
Length:306
Mass (Da):34,538
Last modified:September 5, 2006 - v2
Checksum:iDBCEAF17C2ADC42D
GO
Isoform 2 (identifier: Q7Z3D4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-127: ADIKRVNNLI...TETLCPPKGR → YQNSSKKVQF...LFRTTGNFAS
     128-306: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,332
Checksum:i4456DA8A8860BD20
GO
Isoform 3 (identifier: Q7Z3D4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-150: VADIKRVNNL...QQEILPANDS → LRWMLVIIQQ...HLLLNRKHSN
     151-306: Missing.

Note: No experimental confirmation available.
Show »
Length:150
Mass (Da):17,482
Checksum:i7B15B60DE19239A8
GO

Sequence cautioni

The sequence CAD97936 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02012586 – 150VADIK…PANDS → LRWMLVIIQQWTLHIYIQKS HPHHSREKWKMELCQLKEYI SANKMIINCIVKILSHLLLN RKHSN in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_02012687 – 127ADIKR…PPKGR → YQNSSKKVQFLDRNTLSSKR KTDFTSFICSILFRTTGNFA S in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_020127128 – 306Missing in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_020128151 – 306Missing in isoform 3. 1 PublicationAdd BLAST156

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137315 mRNA. Translation: CAB70692.1.
BX537972 mRNA. Translation: CAD97936.1. Different initiation.
CR933624 mRNA. Translation: CAI45934.1.
BC058027 mRNA. Translation: AAH58027.1.
CCDSiCCDS43338.1. [Q7Z3D4-1]
CCDS68911.1. [Q7Z3D4-2]
PIRiT46287.
RefSeqiNP_001273741.1. NM_001286812.1. [Q7Z3D4-2]
NP_938014.1. NM_198273.2. [Q7Z3D4-1]
XP_005248478.1. XM_005248421.4. [Q7Z3D4-1]
UniGeneiHs.136235.

Genome annotation databases

EnsembliENST00000315948; ENSP00000314518; ENSG00000176018. [Q7Z3D4-1]
ENST00000500869; ENSP00000427020; ENSG00000176018. [Q7Z3D4-3]
ENST00000509384; ENSP00000427683; ENSG00000176018. [Q7Z3D4-2]
GeneIDi116068.
KEGGihsa:116068.
UCSCiuc003kjr.5. human. [Q7Z3D4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLYSM3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3D4
Secondary accession number(s): Q5H9U0, Q6PEK0, Q9NTE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 25, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM