Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Autophagy-related protein 9A

Gene

ATG9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
mATG9
Gene namesi
Name:ATG9A
Synonyms:APG9L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:22408. ATG9A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6665CytoplasmicBy similarityAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 13144LumenalBy similarityAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Topological domaini153 – 289137CytoplasmicBy similarityAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Topological domaini311 – 37161LumenalBy similarityAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Topological domaini393 – 4008CytoplasmicBy similarity
Transmembranei401 – 42121HelicalSequence AnalysisAdd
BLAST
Topological domaini422 – 47352LumenalBy similarityAdd
BLAST
Transmembranei474 – 49421HelicalSequence AnalysisAdd
BLAST
Topological domaini495 – 839345CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • autophagosome Source: GO_Central
  • cytoplasmic vesicle Source: UniProtKB-KW
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: MGI
  • late endosome membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • pre-autophagosomal structure Source: MGI
  • recycling endosome Source: MGI
  • trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931318.

Polymorphism and mutation databases

BioMutaiATG9A.
DMDMi296439428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 839838Autophagy-related protein 9APRO_0000119820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei18 – 181Phosphoserine1 Publication
Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
Modified residuei656 – 6561Phosphoserine1 Publication
Modified residuei735 – 7351Phosphoserine2 Publications
Modified residuei738 – 7381Phosphoserine1 Publication
Modified residuei741 – 7411Phosphoserine1 Publication
Modified residuei828 – 8281Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7Z3C6.
PaxDbiQ7Z3C6.
PRIDEiQ7Z3C6.

PTM databases

PhosphoSiteiQ7Z3C6.

Expressioni

Gene expression databases

BgeeiQ7Z3C6.
CleanExiHS_ATG9A.
ExpressionAtlasiQ7Z3C6. baseline and differential.
GenevisibleiQ7Z3C6. HS.

Organism-specific databases

HPAiHPA059551.

Interactioni

Subunit structurei

Interacts with SUPT20H.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NEM7-28EBI-727146,EBI-7568679
KRT31Q153233EBI-727146,EBI-948001
KRTAP10-8P604103EBI-727146,EBI-10171774
KRTAP4-2Q9BYR53EBI-727146,EBI-10172511
KRTAP5-9P263713EBI-727146,EBI-3958099
LONRF1Q17RB83EBI-727146,EBI-2341787
NOTCH2NLQ7Z3S93EBI-727146,EBI-945833
RELQ048643EBI-727146,EBI-307352
TBK1Q9UHD22EBI-727146,EBI-356402
UBE3AQ05086-23EBI-727146,EBI-10175863

Protein-protein interaction databases

BioGridi122518. 32 interactions.
IntActiQ7Z3C6. 26 interactions.
MINTiMINT-1422125.
STRINGi9606.ENSP00000355173.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298729.
GeneTreeiENSGT00390000014839.
HOVERGENiHBG050539.
InParanoidiQ7Z3C6.
KOiK17907.
OMAiQLHVYNL.
OrthoDBiEOG72C4ZM.
PhylomeDBiQ7Z3C6.
TreeFamiTF313665.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE
510 520 530 540 550
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT EASVYQQAED
560 570 580 590 600
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP
610 620 630 640 650
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS
660 670 680 690 700
ALRSFSPLQP GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE
710 720 730 740 750
YASTEMSLHA LYMHQLHKQQ AQAEPERHVW HRRESDESGE SAPDEGGEGA
760 770 780 790 800
RAPQSIPRSA SYPCAAPRPG APETTALHGG FQRRYGGITD PGTVPRVPSH
810 820 830
FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV
Length:839
Mass (Da):94,447
Last modified:May 18, 2010 - v3
Checksum:i69BE087CA550DC42
GO
Isoform 2 (identifier: Q7Z3C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:778
Mass (Da):87,379
Checksum:iDBF1B239460D7250
GO
Isoform 3 (identifier: Q7Z3C6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-528: NAHRSQTRDE...CSFAQMDVRQ → VHFGRVAEPH...ADRGLSVPAS
     529-839: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:528
Mass (Da):60,694
Checksum:iFB9BEBBFA794B352
GO

Sequence cautioni

The sequence BAB13882.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15246.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391H → R in CAD97944 (PubMed:17974005).Curated
Sequence conflicti300 – 3001L → P in CAD97944 (PubMed:17974005).Curated
Sequence conflicti381 – 3811A → T in AAH65534 (PubMed:15489334).Curated
Sequence conflicti519 – 5191C → R in CAD98061 (PubMed:17974005).Curated
Sequence conflicti567 – 5671W → R in CAD98061 (PubMed:17974005).Curated
Sequence conflicti669 – 6691H → N in BAB15246 (PubMed:14702039).Curated
Sequence conflicti765 – 7651A → V in CAD97944 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti592 – 5921S → G.2 Publications
Corresponds to variant rs2276635 [ dbSNP | Ensembl ].
VAR_021835
Natural varianti659 – 6591Q → H.
Corresponds to variant rs2276634 [ dbSNP | Ensembl ].
VAR_055534

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161Missing in isoform 2. 1 PublicationVSP_013396Add
BLAST
Alternative sequencei455 – 52874NAHRS…MDVRQ → VHFGRVAEPHCHTPHPHLLP APTGPGDYRLLPKLHRGGRW CGRYLLLCSDGCSPAWSSPV AICWADRGLSVPAS in isoform 3. 1 PublicationVSP_013397Add
BLAST
Alternative sequencei529 – 839311Missing in isoform 3. 1 PublicationVSP_013398Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833865 mRNA. Translation: CAD38723.1.
BX537984 mRNA. Translation: CAD97944.1.
BX538192 mRNA. Translation: CAD98061.1.
BX538198 mRNA. Translation: CAD98064.1.
AC068946 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70706.1.
BC001098 mRNA. Translation: AAH01098.2.
BC021202 mRNA. Translation: AAH21202.2.
BC065534 mRNA. Translation: AAH65534.1.
AK021732 mRNA. Translation: BAB13882.1. Different initiation.
AK027448 mRNA. Translation: BAB55119.1. Different initiation.
AK025822 mRNA. Translation: BAB15246.1. Different initiation.
BK004018 mRNA. Translation: DAA05199.1.
CCDSiCCDS42820.1. [Q7Z3C6-1]
RefSeqiNP_001070666.1. NM_001077198.2. [Q7Z3C6-1]
NP_076990.4. NM_024085.4. [Q7Z3C6-1]
UniGeneiHs.323363.

Genome annotation databases

EnsembliENST00000361242; ENSP00000355173; ENSG00000198925.
ENST00000396761; ENSP00000379983; ENSG00000198925.
ENST00000409033; ENSP00000386482; ENSG00000198925. [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925. [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925.
GeneIDi79065.
KEGGihsa:79065.
UCSCiuc002vke.1. human. [Q7Z3C6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833865 mRNA. Translation: CAD38723.1.
BX537984 mRNA. Translation: CAD97944.1.
BX538192 mRNA. Translation: CAD98061.1.
BX538198 mRNA. Translation: CAD98064.1.
AC068946 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70706.1.
BC001098 mRNA. Translation: AAH01098.2.
BC021202 mRNA. Translation: AAH21202.2.
BC065534 mRNA. Translation: AAH65534.1.
AK021732 mRNA. Translation: BAB13882.1. Different initiation.
AK027448 mRNA. Translation: BAB55119.1. Different initiation.
AK025822 mRNA. Translation: BAB15246.1. Different initiation.
BK004018 mRNA. Translation: DAA05199.1.
CCDSiCCDS42820.1. [Q7Z3C6-1]
RefSeqiNP_001070666.1. NM_001077198.2. [Q7Z3C6-1]
NP_076990.4. NM_024085.4. [Q7Z3C6-1]
UniGeneiHs.323363.

3D structure databases

ProteinModelPortaliQ7Z3C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122518. 32 interactions.
IntActiQ7Z3C6. 26 interactions.
MINTiMINT-1422125.
STRINGi9606.ENSP00000355173.

PTM databases

PhosphoSiteiQ7Z3C6.

Polymorphism and mutation databases

BioMutaiATG9A.
DMDMi296439428.

Proteomic databases

MaxQBiQ7Z3C6.
PaxDbiQ7Z3C6.
PRIDEiQ7Z3C6.

Protocols and materials databases

DNASUi79065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361242; ENSP00000355173; ENSG00000198925.
ENST00000396761; ENSP00000379983; ENSG00000198925.
ENST00000409033; ENSP00000386482; ENSG00000198925. [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925. [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925.
GeneIDi79065.
KEGGihsa:79065.
UCSCiuc002vke.1. human. [Q7Z3C6-1]

Organism-specific databases

CTDi79065.
GeneCardsiGC02M220074.
H-InvDBHIX0002853.
HIX0077803.
HGNCiHGNC:22408. ATG9A.
HPAiHPA059551.
MIMi612204. gene.
neXtProtiNX_Q7Z3C6.
PharmGKBiPA134931318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG298729.
GeneTreeiENSGT00390000014839.
HOVERGENiHBG050539.
InParanoidiQ7Z3C6.
KOiK17907.
OMAiQLHVYNL.
OrthoDBiEOG72C4ZM.
PhylomeDBiQ7Z3C6.
TreeFamiTF313665.

Miscellaneous databases

ChiTaRSiATG9A. human.
GeneWikiiATG9A.
GenomeRNAii79065.
NextBioi67835.
PROiQ7Z3C6.
SOURCEiSearch...

Gene expression databases

BgeeiQ7Z3C6.
CleanExiHS_ATG9A.
ExpressionAtlasiQ7Z3C6. baseline and differential.
GenevisibleiQ7Z3C6. HS.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-592.
    Tissue: Fetal brain, Lung endothelial cell, Rectum tumor and Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain and Lymph.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-839, VARIANT GLY-592.
    Tissue: Embryo.
  6. "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast."
    Yamada T., Carson A.R., Caniggia I., Umebayashi K., Yoshimori T., Nakabayashi K., Scherer S.W.
    J. Biol. Chem. 280:18283-18290(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes."
    Young A.R., Chan E.Y., Hu X.W., Kochl R., Crawshaw S.G., High S., Hailey D.W., Lippincott-Schwartz J., Tooze S.A.
    J. Cell Sci. 119:3888-3900(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION AT ASN-99.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-656, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism."
    Chan E.Y.W., Longatti A., McKnight N.C., Tooze S.A.
    Mol. Cell. Biol. 29:157-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."
    Webber J.L., Tooze S.A.
    EMBO J. 29:27-40(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SUPT20H.
  12. "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment."
    Gao W., Kang J.H., Liao Y., Ding W.X., Gambotto A.A., Watkins S.C., Liu Y.J., Stolz D.B., Yin X.M.
    J. Biol. Chem. 285:1371-1383(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains."
    Tamura H., Shibata M., Koike M., Sasaki M., Uchiyama Y.
    J. Histochem. Cytochem. 58:443-453(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy."
    Takahashi Y., Meyerkord C.L., Hori T., Runkle K., Fox T.E., Kester M., Loughran T.P., Wang H.G.
    Autophagy 7:61-73(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TRAFFICKING.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735; SER-738 AND SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735 AND SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiATG9A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3C6
Secondary accession number(s): Q3ZAQ6
, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 18, 2010
Last modified: July 22, 2015
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.