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Protein

Autophagy-related protein 9A

Gene

ATG9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-31313-MONOMER.
ReactomeiR-HSA-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
mATG9
Gene namesi
Name:ATG9A
Synonyms:APG9L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:22408. ATG9A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 66CytoplasmicBy similarityAdd BLAST65
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Topological domaini88 – 131LumenalBy similarityAdd BLAST44
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 289CytoplasmicBy similarityAdd BLAST137
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 371LumenalBy similarityAdd BLAST61
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 400CytoplasmicBy similarity8
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 473LumenalBy similarityAdd BLAST52
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 839CytoplasmicBy similarityAdd BLAST345

GO - Cellular componenti

  • cytoplasmic vesicle Source: UniProtKB-KW
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: MGI
  • late endosome membrane Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • pre-autophagosomal structure Source: MGI
  • recycling endosome Source: MGI
  • trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79065.
OpenTargetsiENSG00000198925.
PharmGKBiPA134931318.

Polymorphism and mutation databases

BioMutaiATG9A.
DMDMi296439428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001198202 – 839Autophagy-related protein 9AAdd BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei16PhosphoserineBy similarity1
Modified residuei18PhosphoserineCombined sources1
Glycosylationi99N-linked (GlcNAc...)1 Publication1
Modified residuei656PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei741PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z3C6.
MaxQBiQ7Z3C6.
PaxDbiQ7Z3C6.
PeptideAtlasiQ7Z3C6.
PRIDEiQ7Z3C6.

PTM databases

iPTMnetiQ7Z3C6.
PhosphoSitePlusiQ7Z3C6.

Expressioni

Gene expression databases

BgeeiENSG00000198925.
CleanExiHS_ATG9A.
ExpressionAtlasiQ7Z3C6. baseline and differential.
GenevisibleiQ7Z3C6. HS.

Organism-specific databases

HPAiHPA059551.

Interactioni

Subunit structurei

Interacts with SUPT20H.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NEM7-28EBI-727146,EBI-7568679
KRT31Q153233EBI-727146,EBI-948001
KRTAP10-8P604103EBI-727146,EBI-10171774
KRTAP4-2Q9BYR53EBI-727146,EBI-10172511
KRTAP5-9P263713EBI-727146,EBI-3958099
LONRF1Q17RB83EBI-727146,EBI-2341787
NOTCH2NLQ7Z3S93EBI-727146,EBI-945833
RELQ048643EBI-727146,EBI-307352
TBK1Q9UHD22EBI-727146,EBI-356402
UBE3AQ05086-23EBI-727146,EBI-10175863

Protein-protein interaction databases

BioGridi122518. 45 interactors.
IntActiQ7Z3C6. 37 interactors.
MINTiMINT-1422125.
STRINGi9606.ENSP00000355173.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2173. Eukaryota.
ENOG410XQBE. LUCA.
GeneTreeiENSGT00390000014839.
HOVERGENiHBG050539.
InParanoidiQ7Z3C6.
KOiK17907.
OMAiSMSELPY.
OrthoDBiEOG091G01WQ.
PhylomeDBiQ7Z3C6.
TreeFamiTF313665.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE
510 520 530 540 550
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT EASVYQQAED
560 570 580 590 600
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP
610 620 630 640 650
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS
660 670 680 690 700
ALRSFSPLQP GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE
710 720 730 740 750
YASTEMSLHA LYMHQLHKQQ AQAEPERHVW HRRESDESGE SAPDEGGEGA
760 770 780 790 800
RAPQSIPRSA SYPCAAPRPG APETTALHGG FQRRYGGITD PGTVPRVPSH
810 820 830
FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV
Length:839
Mass (Da):94,447
Last modified:May 18, 2010 - v3
Checksum:i69BE087CA550DC42
GO
Isoform 2 (identifier: Q7Z3C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:778
Mass (Da):87,379
Checksum:iDBF1B239460D7250
GO
Isoform 3 (identifier: Q7Z3C6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-528: NAHRSQTRDE...CSFAQMDVRQ → VHFGRVAEPH...ADRGLSVPAS
     529-839: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:528
Mass (Da):60,694
Checksum:iFB9BEBBFA794B352
GO

Sequence cautioni

The sequence BAB13882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15246 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55119 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39H → R in CAD97944 (PubMed:17974005).Curated1
Sequence conflicti300L → P in CAD97944 (PubMed:17974005).Curated1
Sequence conflicti381A → T in AAH65534 (PubMed:15489334).Curated1
Sequence conflicti519C → R in CAD98061 (PubMed:17974005).Curated1
Sequence conflicti567W → R in CAD98061 (PubMed:17974005).Curated1
Sequence conflicti669H → N in BAB15246 (PubMed:14702039).Curated1
Sequence conflicti765A → V in CAD97944 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021835592S → G.2 PublicationsCorresponds to variant rs2276635dbSNPEnsembl.1
Natural variantiVAR_055534659Q → H.Corresponds to variant rs2276634dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0133961 – 61Missing in isoform 2. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_013397455 – 528NAHRS…MDVRQ → VHFGRVAEPHCHTPHPHLLP APTGPGDYRLLPKLHRGGRW CGRYLLLCSDGCSPAWSSPV AICWADRGLSVPAS in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_013398529 – 839Missing in isoform 3. 1 PublicationAdd BLAST311

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833865 mRNA. Translation: CAD38723.1.
BX537984 mRNA. Translation: CAD97944.1.
BX538192 mRNA. Translation: CAD98061.1.
BX538198 mRNA. Translation: CAD98064.1.
AC068946 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70706.1.
BC001098 mRNA. Translation: AAH01098.2.
BC021202 mRNA. Translation: AAH21202.2.
BC065534 mRNA. Translation: AAH65534.1.
AK021732 mRNA. Translation: BAB13882.1. Different initiation.
AK027448 mRNA. Translation: BAB55119.1. Different initiation.
AK025822 mRNA. Translation: BAB15246.1. Different initiation.
BK004018 mRNA. Translation: DAA05199.1.
CCDSiCCDS42820.1. [Q7Z3C6-1]
RefSeqiNP_001070666.1. NM_001077198.2. [Q7Z3C6-1]
NP_076990.4. NM_024085.4. [Q7Z3C6-1]
UniGeneiHs.323363.

Genome annotation databases

EnsembliENST00000361242; ENSP00000355173; ENSG00000198925. [Q7Z3C6-1]
ENST00000396761; ENSP00000379983; ENSG00000198925. [Q7Z3C6-1]
ENST00000409033; ENSP00000386482; ENSG00000198925. [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925. [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925. [Q7Z3C6-1]
GeneIDi79065.
KEGGihsa:79065.
UCSCiuc002vke.3. human. [Q7Z3C6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833865 mRNA. Translation: CAD38723.1.
BX537984 mRNA. Translation: CAD97944.1.
BX538192 mRNA. Translation: CAD98061.1.
BX538198 mRNA. Translation: CAD98064.1.
AC068946 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70706.1.
BC001098 mRNA. Translation: AAH01098.2.
BC021202 mRNA. Translation: AAH21202.2.
BC065534 mRNA. Translation: AAH65534.1.
AK021732 mRNA. Translation: BAB13882.1. Different initiation.
AK027448 mRNA. Translation: BAB55119.1. Different initiation.
AK025822 mRNA. Translation: BAB15246.1. Different initiation.
BK004018 mRNA. Translation: DAA05199.1.
CCDSiCCDS42820.1. [Q7Z3C6-1]
RefSeqiNP_001070666.1. NM_001077198.2. [Q7Z3C6-1]
NP_076990.4. NM_024085.4. [Q7Z3C6-1]
UniGeneiHs.323363.

3D structure databases

ProteinModelPortaliQ7Z3C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122518. 45 interactors.
IntActiQ7Z3C6. 37 interactors.
MINTiMINT-1422125.
STRINGi9606.ENSP00000355173.

PTM databases

iPTMnetiQ7Z3C6.
PhosphoSitePlusiQ7Z3C6.

Polymorphism and mutation databases

BioMutaiATG9A.
DMDMi296439428.

Proteomic databases

EPDiQ7Z3C6.
MaxQBiQ7Z3C6.
PaxDbiQ7Z3C6.
PeptideAtlasiQ7Z3C6.
PRIDEiQ7Z3C6.

Protocols and materials databases

DNASUi79065.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361242; ENSP00000355173; ENSG00000198925. [Q7Z3C6-1]
ENST00000396761; ENSP00000379983; ENSG00000198925. [Q7Z3C6-1]
ENST00000409033; ENSP00000386482; ENSG00000198925. [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925. [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925. [Q7Z3C6-1]
GeneIDi79065.
KEGGihsa:79065.
UCSCiuc002vke.3. human. [Q7Z3C6-1]

Organism-specific databases

CTDi79065.
DisGeNETi79065.
GeneCardsiATG9A.
H-InvDBHIX0002853.
HIX0077803.
HGNCiHGNC:22408. ATG9A.
HPAiHPA059551.
MIMi612204. gene.
neXtProtiNX_Q7Z3C6.
OpenTargetsiENSG00000198925.
PharmGKBiPA134931318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2173. Eukaryota.
ENOG410XQBE. LUCA.
GeneTreeiENSGT00390000014839.
HOVERGENiHBG050539.
InParanoidiQ7Z3C6.
KOiK17907.
OMAiSMSELPY.
OrthoDBiEOG091G01WQ.
PhylomeDBiQ7Z3C6.
TreeFamiTF313665.

Enzyme and pathway databases

BioCyciZFISH:G66-31313-MONOMER.
ReactomeiR-HSA-1632852. Macroautophagy.

Miscellaneous databases

ChiTaRSiATG9A. human.
GeneWikiiATG9A.
GenomeRNAii79065.
PROiQ7Z3C6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198925.
CleanExiHS_ATG9A.
ExpressionAtlasiQ7Z3C6. baseline and differential.
GenevisibleiQ7Z3C6. HS.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG9A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3C6
Secondary accession number(s): Q3ZAQ6
, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.