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Q7Z3C6

- ATG9A_HUMAN

UniProt

Q7Z3C6 - ATG9A_HUMAN

Protein

Autophagy-related protein 9A

Gene

ATG9A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. autophagic vacuole assembly Source: MGI
    2. innate immune response Source: Ensembl
    3. late nucleophagy Source: RefGenome
    4. mitochondrion degradation Source: RefGenome
    5. piecemeal microautophagy of nucleus Source: RefGenome
    6. protein localization to Golgi apparatus Source: Ensembl
    7. protein localization to pre-autophagosomal structure Source: RefGenome
    8. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 9A
    Alternative name(s):
    APG9-like 1
    mATG9
    Gene namesi
    Name:ATG9A
    Synonyms:APG9L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:22408. ATG9A.

    Subcellular locationi

    Cytoplasmic vesicleautophagosome membrane; Multi-pass membrane protein. Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
    Note: Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

    GO - Cellular componenti

    1. autophagic vacuole Source: RefGenome
    2. autophagic vacuole membrane Source: UniProtKB-SubCell
    3. cytoplasmic vesicle Source: UniProtKB-KW
    4. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    5. endosome Source: MGI
    6. integral component of membrane Source: RefGenome
    7. late endosome membrane Source: UniProtKB-SubCell
    8. membrane Source: UniProtKB
    9. pre-autophagosomal structure Source: RefGenome
    10. trans-Golgi network Source: MGI

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134931318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 839838Autophagy-related protein 9APRO_0000119820Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications
    Modified residuei18 – 181Phosphoserine1 Publication
    Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
    Modified residuei656 – 6561Phosphoserine1 Publication
    Modified residuei735 – 7351Phosphoserine1 Publication
    Modified residuei738 – 7381Phosphoserine1 Publication
    Modified residuei741 – 7411Phosphoserine1 Publication
    Modified residuei828 – 8281Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z3C6.
    PaxDbiQ7Z3C6.
    PRIDEiQ7Z3C6.

    PTM databases

    PhosphoSiteiQ7Z3C6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7Z3C6.
    BgeeiQ7Z3C6.
    CleanExiHS_ATG9A.
    GenevestigatoriQ7Z3C6.

    Organism-specific databases

    HPAiHPA059551.

    Interactioni

    Subunit structurei

    Interacts with SUPT20H.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q8NEM7-28EBI-727146,EBI-7568679
    TBK1Q9UHD22EBI-727146,EBI-356402

    Protein-protein interaction databases

    BioGridi122518. 3 interactions.
    IntActiQ7Z3C6. 12 interactions.
    MINTiMINT-1422125.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7Z3C6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 6665CytoplasmicBy similarityAdd
    BLAST
    Topological domaini88 – 13144LumenalBy similarityAdd
    BLAST
    Topological domaini153 – 289137CytoplasmicBy similarityAdd
    BLAST
    Topological domaini311 – 37161LumenalBy similarityAdd
    BLAST
    Topological domaini393 – 4008CytoplasmicBy similarity
    Topological domaini422 – 47352LumenalBy similarityAdd
    BLAST
    Topological domaini495 – 839345CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei372 – 39221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei474 – 49421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG9 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG298729.
    HOVERGENiHBG050539.
    InParanoidiQ7Z3C6.
    KOiK17907.
    OMAiEVVFFTR.
    OrthoDBiEOG72C4ZM.
    PhylomeDBiQ7Z3C6.
    TreeFamiTF313665.

    Family and domain databases

    InterProiIPR007241. Autophagy-rel_prot_9.
    [Graphical view]
    PANTHERiPTHR13038. PTHR13038. 1 hit.
    PfamiPF04109. APG9. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z3C6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV    50
    YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH 100
    SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF 150
    IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK 200
    RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA VFFTRGLKYN 250
    FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL 300
    CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL 350
    QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED 400
    VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD 450
    HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE 500
    IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT EASVYQQAED 550
    GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP 600
    ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS 650
    ALRSFSPLQP GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE 700
    YASTEMSLHA LYMHQLHKQQ AQAEPERHVW HRRESDESGE SAPDEGGEGA 750
    RAPQSIPRSA SYPCAAPRPG APETTALHGG FQRRYGGITD PGTVPRVPSH 800
    FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV 839
    Length:839
    Mass (Da):94,447
    Last modified:May 18, 2010 - v3
    Checksum:i69BE087CA550DC42
    GO
    Isoform 2 (identifier: Q7Z3C6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: Missing.

    Show »
    Length:778
    Mass (Da):87,379
    Checksum:iDBF1B239460D7250
    GO
    Isoform 3 (identifier: Q7Z3C6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         455-528: NAHRSQTRDE...CSFAQMDVRQ → VHFGRVAEPH...ADRGLSVPAS
         529-839: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:528
    Mass (Da):60,694
    Checksum:iFB9BEBBFA794B352
    GO

    Sequence cautioni

    The sequence BAB13882.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB15246.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB55119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391H → R in CAD97944. (PubMed:17974005)Curated
    Sequence conflicti300 – 3001L → P in CAD97944. (PubMed:17974005)Curated
    Sequence conflicti381 – 3811A → T in AAH65534. (PubMed:15489334)Curated
    Sequence conflicti519 – 5191C → R in CAD98061. (PubMed:17974005)Curated
    Sequence conflicti567 – 5671W → R in CAD98061. (PubMed:17974005)Curated
    Sequence conflicti669 – 6691H → N in BAB15246. (PubMed:14702039)Curated
    Sequence conflicti765 – 7651A → V in CAD97944. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti592 – 5921S → G.2 Publications
    Corresponds to variant rs2276635 [ dbSNP | Ensembl ].
    VAR_021835
    Natural varianti659 – 6591Q → H.
    Corresponds to variant rs2276634 [ dbSNP | Ensembl ].
    VAR_055534

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161Missing in isoform 2. 1 PublicationVSP_013396Add
    BLAST
    Alternative sequencei455 – 52874NAHRS…MDVRQ → VHFGRVAEPHCHTPHPHLLP APTGPGDYRLLPKLHRGGRW CGRYLLLCSDGCSPAWSSPV AICWADRGLSVPAS in isoform 3. 1 PublicationVSP_013397Add
    BLAST
    Alternative sequencei529 – 839311Missing in isoform 3. 1 PublicationVSP_013398Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833865 mRNA. Translation: CAD38723.1.
    BX537984 mRNA. Translation: CAD97944.1.
    BX538192 mRNA. Translation: CAD98061.1.
    BX538198 mRNA. Translation: CAD98064.1.
    AC068946 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70706.1.
    BC001098 mRNA. Translation: AAH01098.2.
    BC021202 mRNA. Translation: AAH21202.2.
    BC065534 mRNA. Translation: AAH65534.1.
    AK021732 mRNA. Translation: BAB13882.1. Different initiation.
    AK027448 mRNA. Translation: BAB55119.1. Different initiation.
    AK025822 mRNA. Translation: BAB15246.1. Different initiation.
    BK004018 mRNA. Translation: DAA05199.1.
    CCDSiCCDS42820.1. [Q7Z3C6-1]
    RefSeqiNP_001070666.1. NM_001077198.2. [Q7Z3C6-1]
    NP_076990.4. NM_024085.4. [Q7Z3C6-1]
    UniGeneiHs.323363.

    Genome annotation databases

    EnsembliENST00000361242; ENSP00000355173; ENSG00000198925. [Q7Z3C6-1]
    ENST00000396761; ENSP00000379983; ENSG00000198925. [Q7Z3C6-1]
    ENST00000409033; ENSP00000386482; ENSG00000198925. [Q7Z3C6-3]
    ENST00000409422; ENSP00000386535; ENSG00000198925. [Q7Z3C6-2]
    ENST00000409618; ENSP00000386710; ENSG00000198925. [Q7Z3C6-1]
    GeneIDi79065.
    KEGGihsa:79065.
    UCSCiuc002vke.1. human. [Q7Z3C6-1]

    Polymorphism databases

    DMDMi296439428.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL833865 mRNA. Translation: CAD38723.1 .
    BX537984 mRNA. Translation: CAD97944.1 .
    BX538192 mRNA. Translation: CAD98061.1 .
    BX538198 mRNA. Translation: CAD98064.1 .
    AC068946 Genomic DNA. No translation available.
    CH471063 Genomic DNA. Translation: EAW70706.1 .
    BC001098 mRNA. Translation: AAH01098.2 .
    BC021202 mRNA. Translation: AAH21202.2 .
    BC065534 mRNA. Translation: AAH65534.1 .
    AK021732 mRNA. Translation: BAB13882.1 . Different initiation.
    AK027448 mRNA. Translation: BAB55119.1 . Different initiation.
    AK025822 mRNA. Translation: BAB15246.1 . Different initiation.
    BK004018 mRNA. Translation: DAA05199.1 .
    CCDSi CCDS42820.1. [Q7Z3C6-1 ]
    RefSeqi NP_001070666.1. NM_001077198.2. [Q7Z3C6-1 ]
    NP_076990.4. NM_024085.4. [Q7Z3C6-1 ]
    UniGenei Hs.323363.

    3D structure databases

    ProteinModelPortali Q7Z3C6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122518. 3 interactions.
    IntActi Q7Z3C6. 12 interactions.
    MINTi MINT-1422125.

    PTM databases

    PhosphoSitei Q7Z3C6.

    Polymorphism databases

    DMDMi 296439428.

    Proteomic databases

    MaxQBi Q7Z3C6.
    PaxDbi Q7Z3C6.
    PRIDEi Q7Z3C6.

    Protocols and materials databases

    DNASUi 79065.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361242 ; ENSP00000355173 ; ENSG00000198925 . [Q7Z3C6-1 ]
    ENST00000396761 ; ENSP00000379983 ; ENSG00000198925 . [Q7Z3C6-1 ]
    ENST00000409033 ; ENSP00000386482 ; ENSG00000198925 . [Q7Z3C6-3 ]
    ENST00000409422 ; ENSP00000386535 ; ENSG00000198925 . [Q7Z3C6-2 ]
    ENST00000409618 ; ENSP00000386710 ; ENSG00000198925 . [Q7Z3C6-1 ]
    GeneIDi 79065.
    KEGGi hsa:79065.
    UCSCi uc002vke.1. human. [Q7Z3C6-1 ]

    Organism-specific databases

    CTDi 79065.
    GeneCardsi GC02M220074.
    H-InvDB HIX0002853.
    HIX0077803.
    HGNCi HGNC:22408. ATG9A.
    HPAi HPA059551.
    MIMi 612204. gene.
    neXtProti NX_Q7Z3C6.
    PharmGKBi PA134931318.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298729.
    HOVERGENi HBG050539.
    InParanoidi Q7Z3C6.
    KOi K17907.
    OMAi EVVFFTR.
    OrthoDBi EOG72C4ZM.
    PhylomeDBi Q7Z3C6.
    TreeFami TF313665.

    Miscellaneous databases

    GeneWikii ATG9A.
    GenomeRNAii 79065.
    NextBioi 67835.
    PROi Q7Z3C6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z3C6.
    Bgeei Q7Z3C6.
    CleanExi HS_ATG9A.
    Genevestigatori Q7Z3C6.

    Family and domain databases

    InterProi IPR007241. Autophagy-rel_prot_9.
    [Graphical view ]
    PANTHERi PTHR13038. PTHR13038. 1 hit.
    Pfami PF04109. APG9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-592.
      Tissue: Fetal brain, Lung endothelial cell, Rectum tumor and Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain and Lymph.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-839, VARIANT GLY-592.
      Tissue: Embryo.
    6. "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast."
      Yamada T., Carson A.R., Caniggia I., Umebayashi K., Yoshimori T., Nakabayashi K., Scherer S.W.
      J. Biol. Chem. 280:18283-18290(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes."
      Young A.R., Chan E.Y., Hu X.W., Kochl R., Crawshaw S.G., High S., Hailey D.W., Lippincott-Schwartz J., Tooze S.A.
      J. Cell Sci. 119:3888-3900(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION AT ASN-99.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-656, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism."
      Chan E.Y.W., Longatti A., McKnight N.C., Tooze S.A.
      Mol. Cell. Biol. 29:157-171(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."
      Webber J.L., Tooze S.A.
      EMBO J. 29:27-40(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SUPT20H.
    12. "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment."
      Gao W., Kang J.H., Liao Y., Ding W.X., Gambotto A.A., Watkins S.C., Liu Y.J., Stolz D.B., Yin X.M.
      J. Biol. Chem. 285:1371-1383(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    13. "Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains."
      Tamura H., Shibata M., Koike M., Sasaki M., Uchiyama Y.
      J. Histochem. Cytochem. 58:443-453(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy."
      Takahashi Y., Meyerkord C.L., Hori T., Runkle K., Fox T.E., Kester M., Loughran T.P., Wang H.G.
      Autophagy 7:61-73(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TRAFFICKING.
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735; SER-738 AND SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATG9A_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3C6
    Secondary accession number(s): Q3ZAQ6
    , Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3