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Q7Z3C6

- ATG9A_HUMAN

UniProt

Q7Z3C6 - ATG9A_HUMAN

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Protein

Autophagy-related protein 9A

Gene

ATG9A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.1 Publication

GO - Biological processi

  1. autophagic vacuole assembly Source: MGI
  2. late nucleophagy Source: RefGenome
  3. mitochondrion degradation Source: RefGenome
  4. piecemeal microautophagy of nucleus Source: RefGenome
  5. protein localization to pre-autophagosomal structure Source: RefGenome
  6. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9A
Alternative name(s):
APG9-like 1
mATG9
Gene namesi
Name:ATG9A
Synonyms:APG9L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:22408. ATG9A.

Subcellular locationi

Cytoplasmic vesicleautophagosome membrane; Multi-pass membrane protein. Golgi apparatustrans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Note: Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

GO - Cellular componenti

  1. autophagic vacuole Source: RefGenome
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. endosome Source: MGI
  5. integral component of membrane Source: RefGenome
  6. late endosome Source: MGI
  7. membrane Source: UniProtKB
  8. pre-autophagosomal structure Source: MGI
  9. recycling endosome Source: MGI
  10. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 839838Autophagy-related protein 9APRO_0000119820Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei18 – 181Phosphoserine1 Publication
Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
Modified residuei656 – 6561Phosphoserine1 Publication
Modified residuei735 – 7351Phosphoserine1 Publication
Modified residuei738 – 7381Phosphoserine1 Publication
Modified residuei741 – 7411Phosphoserine1 Publication
Modified residuei828 – 8281Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7Z3C6.
PaxDbiQ7Z3C6.
PRIDEiQ7Z3C6.

PTM databases

PhosphoSiteiQ7Z3C6.

Expressioni

Gene expression databases

BgeeiQ7Z3C6.
CleanExiHS_ATG9A.
ExpressionAtlasiQ7Z3C6. baseline and differential.
GenevestigatoriQ7Z3C6.

Organism-specific databases

HPAiHPA059551.

Interactioni

Subunit structurei

Interacts with SUPT20H.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q8NEM7-28EBI-727146,EBI-7568679
TBK1Q9UHD22EBI-727146,EBI-356402

Protein-protein interaction databases

BioGridi122518. 8 interactions.
IntActiQ7Z3C6. 12 interactions.
MINTiMINT-1422125.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3C6.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6665CytoplasmicBy similarityAdd
BLAST
Topological domaini88 – 13144LumenalBy similarityAdd
BLAST
Topological domaini153 – 289137CytoplasmicBy similarityAdd
BLAST
Topological domaini311 – 37161LumenalBy similarityAdd
BLAST
Topological domaini393 – 4008CytoplasmicBy similarity
Topological domaini422 – 47352LumenalBy similarityAdd
BLAST
Topological domaini495 – 839345CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence AnalysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence AnalysisAdd
BLAST
Transmembranei474 – 49421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298729.
GeneTreeiENSGT00390000014839.
HOVERGENiHBG050539.
InParanoidiQ7Z3C6.
KOiK17907.
OMAiEVVFFTR.
OrthoDBiEOG72C4ZM.
PhylomeDBiQ7Z3C6.
TreeFamiTF313665.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7Z3C6) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV
60 70 80 90 100
YNLHQKNGFT CMLIGEIFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH
110 120 130 140 150
SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF
160 170 180 190 200
IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK
210 220 230 240 250
RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEA VFFTRGLKYN
260 270 280 290 300
FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL
310 320 330 340 350
CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL
360 370 380 390 400
QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED
410 420 430 440 450
VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD
460 470 480 490 500
HWQGNAHRSQ TRDEFAQLFQ YKAVFILEEL LSPIVTPLIL IFCLRPRALE
510 520 530 540 550
IIDFFRNFTV EVVGVGDTCS FAQMDVRQHG HPQWLSAGQT EASVYQQAED
560 570 580 590 600
GKTELSLMHF AITNPGWQPP RESTAFLGFL KEQVQRDGAA ASLAQGGLLP
610 620 630 640 650
ENALFTSIQS LQSESEPLSL IANVVAGSSC RGPPLPRDLQ GSRHRAEVAS
660 670 680 690 700
ALRSFSPLQP GQAPTGRAHS TMTGSGVDAR TASSGSSVWE GQLQSLVLSE
710 720 730 740 750
YASTEMSLHA LYMHQLHKQQ AQAEPERHVW HRRESDESGE SAPDEGGEGA
760 770 780 790 800
RAPQSIPRSA SYPCAAPRPG APETTALHGG FQRRYGGITD PGTVPRVPSH
810 820 830
FSRLPLGGWA EDGQSASRHP EPVPEEGSED ELPPQVHKV
Length:839
Mass (Da):94,447
Last modified:May 18, 2010 - v3
Checksum:i69BE087CA550DC42
GO
Isoform 2 (identifier: Q7Z3C6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:778
Mass (Da):87,379
Checksum:iDBF1B239460D7250
GO
Isoform 3 (identifier: Q7Z3C6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-528: NAHRSQTRDE...CSFAQMDVRQ → VHFGRVAEPH...ADRGLSVPAS
     529-839: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:528
Mass (Da):60,694
Checksum:iFB9BEBBFA794B352
GO

Sequence cautioni

The sequence BAB13882.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB15246.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB55119.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391H → R in CAD97944. (PubMed:17974005)Curated
Sequence conflicti300 – 3001L → P in CAD97944. (PubMed:17974005)Curated
Sequence conflicti381 – 3811A → T in AAH65534. (PubMed:15489334)Curated
Sequence conflicti519 – 5191C → R in CAD98061. (PubMed:17974005)Curated
Sequence conflicti567 – 5671W → R in CAD98061. (PubMed:17974005)Curated
Sequence conflicti669 – 6691H → N in BAB15246. (PubMed:14702039)Curated
Sequence conflicti765 – 7651A → V in CAD97944. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti592 – 5921S → G.2 Publications
Corresponds to variant rs2276635 [ dbSNP | Ensembl ].
VAR_021835
Natural varianti659 – 6591Q → H.
Corresponds to variant rs2276634 [ dbSNP | Ensembl ].
VAR_055534

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161Missing in isoform 2. 1 PublicationVSP_013396Add
BLAST
Alternative sequencei455 – 52874NAHRS…MDVRQ → VHFGRVAEPHCHTPHPHLLP APTGPGDYRLLPKLHRGGRW CGRYLLLCSDGCSPAWSSPV AICWADRGLSVPAS in isoform 3. 1 PublicationVSP_013397Add
BLAST
Alternative sequencei529 – 839311Missing in isoform 3. 1 PublicationVSP_013398Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833865 mRNA. Translation: CAD38723.1.
BX537984 mRNA. Translation: CAD97944.1.
BX538192 mRNA. Translation: CAD98061.1.
BX538198 mRNA. Translation: CAD98064.1.
AC068946 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70706.1.
BC001098 mRNA. Translation: AAH01098.2.
BC021202 mRNA. Translation: AAH21202.2.
BC065534 mRNA. Translation: AAH65534.1.
AK021732 mRNA. Translation: BAB13882.1. Different initiation.
AK027448 mRNA. Translation: BAB55119.1. Different initiation.
AK025822 mRNA. Translation: BAB15246.1. Different initiation.
BK004018 mRNA. Translation: DAA05199.1.
CCDSiCCDS42820.1. [Q7Z3C6-1]
RefSeqiNP_001070666.1. NM_001077198.2. [Q7Z3C6-1]
NP_076990.4. NM_024085.4. [Q7Z3C6-1]
UniGeneiHs.323363.

Genome annotation databases

EnsembliENST00000361242; ENSP00000355173; ENSG00000198925. [Q7Z3C6-1]
ENST00000396761; ENSP00000379983; ENSG00000198925. [Q7Z3C6-1]
ENST00000409033; ENSP00000386482; ENSG00000198925. [Q7Z3C6-3]
ENST00000409422; ENSP00000386535; ENSG00000198925. [Q7Z3C6-2]
ENST00000409618; ENSP00000386710; ENSG00000198925. [Q7Z3C6-1]
GeneIDi79065.
KEGGihsa:79065.
UCSCiuc002vke.1. human. [Q7Z3C6-1]

Polymorphism databases

DMDMi296439428.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL833865 mRNA. Translation: CAD38723.1 .
BX537984 mRNA. Translation: CAD97944.1 .
BX538192 mRNA. Translation: CAD98061.1 .
BX538198 mRNA. Translation: CAD98064.1 .
AC068946 Genomic DNA. No translation available.
CH471063 Genomic DNA. Translation: EAW70706.1 .
BC001098 mRNA. Translation: AAH01098.2 .
BC021202 mRNA. Translation: AAH21202.2 .
BC065534 mRNA. Translation: AAH65534.1 .
AK021732 mRNA. Translation: BAB13882.1 . Different initiation.
AK027448 mRNA. Translation: BAB55119.1 . Different initiation.
AK025822 mRNA. Translation: BAB15246.1 . Different initiation.
BK004018 mRNA. Translation: DAA05199.1 .
CCDSi CCDS42820.1. [Q7Z3C6-1 ]
RefSeqi NP_001070666.1. NM_001077198.2. [Q7Z3C6-1 ]
NP_076990.4. NM_024085.4. [Q7Z3C6-1 ]
UniGenei Hs.323363.

3D structure databases

ProteinModelPortali Q7Z3C6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122518. 8 interactions.
IntActi Q7Z3C6. 12 interactions.
MINTi MINT-1422125.

PTM databases

PhosphoSitei Q7Z3C6.

Polymorphism databases

DMDMi 296439428.

Proteomic databases

MaxQBi Q7Z3C6.
PaxDbi Q7Z3C6.
PRIDEi Q7Z3C6.

Protocols and materials databases

DNASUi 79065.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361242 ; ENSP00000355173 ; ENSG00000198925 . [Q7Z3C6-1 ]
ENST00000396761 ; ENSP00000379983 ; ENSG00000198925 . [Q7Z3C6-1 ]
ENST00000409033 ; ENSP00000386482 ; ENSG00000198925 . [Q7Z3C6-3 ]
ENST00000409422 ; ENSP00000386535 ; ENSG00000198925 . [Q7Z3C6-2 ]
ENST00000409618 ; ENSP00000386710 ; ENSG00000198925 . [Q7Z3C6-1 ]
GeneIDi 79065.
KEGGi hsa:79065.
UCSCi uc002vke.1. human. [Q7Z3C6-1 ]

Organism-specific databases

CTDi 79065.
GeneCardsi GC02M220074.
H-InvDB HIX0002853.
HIX0077803.
HGNCi HGNC:22408. ATG9A.
HPAi HPA059551.
MIMi 612204. gene.
neXtProti NX_Q7Z3C6.
PharmGKBi PA134931318.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG298729.
GeneTreei ENSGT00390000014839.
HOVERGENi HBG050539.
InParanoidi Q7Z3C6.
KOi K17907.
OMAi EVVFFTR.
OrthoDBi EOG72C4ZM.
PhylomeDBi Q7Z3C6.
TreeFami TF313665.

Miscellaneous databases

GeneWikii ATG9A.
GenomeRNAii 79065.
NextBioi 67835.
PROi Q7Z3C6.
SOURCEi Search...

Gene expression databases

Bgeei Q7Z3C6.
CleanExi HS_ATG9A.
ExpressionAtlasi Q7Z3C6. baseline and differential.
Genevestigatori Q7Z3C6.

Family and domain databases

InterProi IPR007241. Autophagy-rel_prot_9.
[Graphical view ]
PANTHERi PTHR13038. PTHR13038. 1 hit.
Pfami PF04109. APG9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-592.
    Tissue: Fetal brain, Lung endothelial cell, Rectum tumor and Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain and Lymph.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 156-839, VARIANT GLY-592.
    Tissue: Embryo.
  6. "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast."
    Yamada T., Carson A.R., Caniggia I., Umebayashi K., Yoshimori T., Nakabayashi K., Scherer S.W.
    J. Biol. Chem. 280:18283-18290(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes."
    Young A.R., Chan E.Y., Hu X.W., Kochl R., Crawshaw S.G., High S., Hailey D.W., Lippincott-Schwartz J., Tooze S.A.
    J. Cell Sci. 119:3888-3900(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION AT ASN-99.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-656, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism."
    Chan E.Y.W., Longatti A., McKnight N.C., Tooze S.A.
    Mol. Cell. Biol. 29:157-171(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP."
    Webber J.L., Tooze S.A.
    EMBO J. 29:27-40(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SUPT20H.
  12. "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment."
    Gao W., Kang J.H., Liao Y., Ding W.X., Gambotto A.A., Watkins S.C., Liu Y.J., Stolz D.B., Yin X.M.
    J. Biol. Chem. 285:1371-1383(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains."
    Tamura H., Shibata M., Koike M., Sasaki M., Uchiyama Y.
    J. Histochem. Cytochem. 58:443-453(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-828, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy."
    Takahashi Y., Meyerkord C.L., Hori T., Runkle K., Fox T.E., Kester M., Loughran T.P., Wang H.G.
    Autophagy 7:61-73(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TRAFFICKING.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-735; SER-738 AND SER-741, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATG9A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3C6
Secondary accession number(s): Q3ZAQ6
, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3