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Reviewed, UniProtKB/Swiss-Prot Q7Z3B4 (NUP54_HUMAN)

Last modified February 9, 2010. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Nucleoporin p54
Alternative name(s):
    54 kDa nucleoporin
Gene names
Name: NUP54
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane By similarity.

Subunit structure

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUPL1 By similarity.

Subcellular location

Nucleus › nuclear pore complex By similarity. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side By similarity. Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter By similarity.

Domain

Contains FG repeats.

Post-translational modification

O-glycosylated By similarity.

Sequence similarities

Belongs to the NUP54 family.

Sequence caution

The sequence BAA91735.1 differs from that shown. Reason: Frameshift at position 479.

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Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
mRNA transport
   Cellular componentMembrane
Nuclear pore complex
Nucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmRNA transport

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Traceable author statement. Source: ProtInc

extrinsic to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

nuclear pore

Traceable author statement. Source: ProtInc

nucleoplasm

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7Z3B4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7Z3B4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-180: Missing.
     353-388: Missing.
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Nucleoporin p54
PRO_0000204874

Regions

Repeat5 – 621
Repeat25 – 2622
Repeat28 – 2923
Repeat53 – 5424
Repeat61 – 6225
Repeat63 – 6426
Repeat67 – 6827
Repeat87 – 8828
Repeat444 – 44529
Region5 – 4454419 X 2 AA repeats of F-G
Compositional bias6 – 8984Gly-rich
Compositional bias30 – 9970Thr-rich
Compositional bias93 – 975Poly-Gln
Compositional bias205 – 2084Poly-Gln

Natural variations

Alternative sequence1 – 180180Missing in isoform 2.
VSP_008740
Alternative sequence353 – 38836Missing in isoform 2.
VSP_008741

Experimental info

Sequence conflict22 – 254AGGF → GWV in AAF67488. Ref.1
Sequence conflict2261N → S in BAA91735. Ref.2
Sequence conflict265 – 27713FEQAN…QLQQL → LNKPYKNTIAAT in AAF67488. Ref.1
Sequence conflict3221L → V in AAF67488. Ref.1
Sequence conflict3631K → T in AAF67488. Ref.1
Sequence conflict4331E → G in AAF67488. Ref.1
Sequence conflict5071S → G in CAD97957. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 31, 2003. Version 2.
Checksum: B5D235E01F1FE467

FASTA50755,435
        10         20         30         40         50         60 
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT GLFGGTQNKG 

        70         80         90        100        110        120 
FGFGTGFGTT TGTSTGLGTG LGTGLGFGGF NTQQQQQTTL GGLFSQPTQA PTQSNQLINT 

       130        140        150        160        170        180 
ASALSAPTLL GDERDAILAK WNQLQAFWGT GKGYFNNNIP PVEFTQENPF CRFKAVGYSC 

       190        200        210        220        230        240 
MPSNKDEDGL VVLVFNKKET EIRSQQQQLV ESLHKVLGGN QTLTVNVEGT KTLPDDQTEV 

       250        260        270        280        290        300 
VIYVVERSPN GTSRRVPATT LYAHFEQANI KTQLQQLGVT LSMTRTELSP AQIKQLLQNP 

       310        320        330        340        350        360 
PAGVDPIIWE QAKVDNPDSE KLIPVPMVGF KELLRRLKVQ DQMTKQHQTR LDIISEDISE 

       370        380        390        400        410        420 
LQKNQTTSVA KIAQYKRKLM DLSHRTLQVL IKQEIQRKSG YAIQADEEQL RVQLDTIQGE 

       430        440        450        460        470        480 
LNAPTQFKGR LNELMSQIRM QNHFGAVRSE ERYYIDADLL REIKQHLKQQ QEGLSHLISI 

       490        500 
IKDDLEDIKL VEHGLNETIH IRGGVFS

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Isoform 2.

Checksum: 442CA17A5CBC6D3E
Show »

FASTA29133,180

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References

[1]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Pituitary.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Teratocarcinoma.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Endometrial tumor.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF157322 mRNA. Translation: AAF67488.1.
AK001517 mRNA. Translation: BAA91735.1. Frameshift.
AK315160 mRNA. Translation: BAG37604.1.
BX538002 mRNA. Translation: CAD97957.1.
CH471057 Genomic DNA. Translation: EAX05777.1.
IPIIPI00386702.
IPI00940095.
RefSeqNP_059122.2.
UniGeneHs.430435

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ7Z3B4. 3 interactions.
STRINGQ7Z3B4.

Proteomic databases

PRIDEQ7Z3B4.

Genome annotation databases

EnsemblENST00000264883; ENSP00000264883; ENSG00000138750; Homo sapiens. [Genome view]
GeneID53371.
KEGGhsa:53371.
UCSCuc003hjs.1. human.
uc003hjt.1. human.

Organism-specific databases

CTD53371.
GeneCardsGC04M077225.
HGNCHGNC:17359. NUP54.
MIM607607. gene.
PharmGKBPA31853.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ7Z3B4.
InParanoidQ7Z3B4.
PhylomeDBQ7Z3B4.

Enzyme and pathway databases

ReactomeREACT_6185. HIV Infection.

Gene expression databases

ArrayExpressQ7Z3B4.
BgeeQ7Z3B4.
CleanExHS_NUP54.
GenevestigatorQ7Z3B4.
GermOnlineENSG00000138750. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio56030.
SOURCESearch...

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Entry information

Entry nameNUP54_HUMAN
AccessionPrimary (citable) accession number: Q7Z3B4
Secondary accession number(s): B2RCK7 expand/collapse secondary AC list , Q96EA7, Q9NVL5, Q9P0I1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: February 9, 2010
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents