##gff-version 3 Q7Z3B3 UniProtKB Chain 1 1105 . . . ID=PRO_0000234565;Note=KAT8 regulatory NSL complex subunit 1 Q7Z3B3 UniProtKB Region 145 211 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Region 225 263 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Region 399 426 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Region 733 857 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Region 850 882 . . . Note=Required for activation of KAT8 histone acetyltransferase activity Q7Z3B3 UniProtKB Region 883 1105 . . . Note=Sufficient for interaction with KAT8 Q7Z3B3 UniProtKB Region 938 1034 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Region 1058 1105 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Coiled coil 283 314 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q7Z3B3 UniProtKB Compositional bias 158 182 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Compositional bias 225 261 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Compositional bias 782 802 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Compositional bias 821 853 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Compositional bias 938 994 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Compositional bias 1058 1072 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q7Z3B3 UniProtKB Modified residue 104 104 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 Q7Z3B3 UniProtKB Modified residue 249 249 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:23186163,PMID:24275569 Q7Z3B3 UniProtKB Modified residue 268 268 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18220336,PMID:18669648,PMID:19690332,PMID:20068231,PMID:23186163 Q7Z3B3 UniProtKB Modified residue 991 991 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18220336,PMID:20068231,PMID:23186163 Q7Z3B3 UniProtKB Modified residue 994 994 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q7Z3B3 UniProtKB Modified residue 1003 1003 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18220336,ECO:0007744|PubMed:20068231;Dbxref=PMID:18220336,PMID:20068231 Q7Z3B3 UniProtKB Modified residue 1045 1045 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q7Z3B3 UniProtKB Cross-link 262 262 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q7Z3B3 UniProtKB Cross-link 331 331 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q7Z3B3 UniProtKB Alternative sequence 1 669 . . . ID=VSP_041132;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q7Z3B3 UniProtKB Alternative sequence 670 673 . . . ID=VSP_041133;Note=In isoform 2 and isoform 3. AFPD->MFLA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q7Z3B3 UniProtKB Alternative sequence 735 798 . . . ID=VSP_058944;Note=In isoform 3. KLSHHQTRPDRTHRQHLDDVGAVPMVERVTAPKAERLLNPPPPVHDPNHSKMRLRDHSSERSEV->M Q7Z3B3 UniProtKB Natural variant 104 104 . . . ID=VAR_049515;Note=K->T;Dbxref=dbSNP:rs17585974 Q7Z3B3 UniProtKB Natural variant 221 221 . . . ID=VAR_049516;Note=T->I;Dbxref=dbSNP:rs17662853 Q7Z3B3 UniProtKB Natural variant 225 225 . . . ID=VAR_049517;Note=N->D;Dbxref=dbSNP:rs35643216 Q7Z3B3 UniProtKB Natural variant 306 1105 . . . ID=VAR_081891;Note=In KDVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22544363;Dbxref=PMID:22544363 Q7Z3B3 UniProtKB Natural variant 348 1105 . . . ID=VAR_081892;Note=In KDVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26424144;Dbxref=PMID:26424144 Q7Z3B3 UniProtKB Natural variant 606 1105 . . . ID=VAR_081893;Note=In KDVS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22544367;Dbxref=PMID:22544367 Q7Z3B3 UniProtKB Natural variant 718 718 . . . ID=VAR_049518;Note=S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs34043286,PMID:14702039 Q7Z3B3 UniProtKB Natural variant 1010 1010 . . . ID=VAR_026287;Note=P->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10574462,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:17974005;Dbxref=dbSNP:rs7220988,PMID:10574462,PMID:14702039,PMID:15489334,PMID:17974005 Q7Z3B3 UniProtKB Natural variant 1085 1085 . . . ID=VAR_049519;Note=I->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14702039;Dbxref=dbSNP:rs34579536,PMID:14702039 Q7Z3B3 UniProtKB Mutagenesis 852 855 . . . Note=Abolishes KAT8 histone acetyltransferase activity. RRRR->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22547026;Dbxref=PMID:22547026 Q7Z3B3 UniProtKB Mutagenesis 856 859 . . . Note=Strongly reduces KAT8 histone acetyltransferase activity. GESS->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22547026;Dbxref=PMID:22547026 Q7Z3B3 UniProtKB Mutagenesis 860 863 . . . Note=Strongly reduces KAT8 histone acetyltransferase activity. FDIN->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22547026;Dbxref=PMID:22547026 Q7Z3B3 UniProtKB Mutagenesis 864 867 . . . Note=Abolishes KAT8 histone acetyltransferase activity. NIVI->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22547026;Dbxref=PMID:22547026 Q7Z3B3 UniProtKB Mutagenesis 868 871 . . . Note=Reduces KAT8 histone acetyltransferase activity. PMSV->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22547026;Dbxref=PMID:22547026 Q7Z3B3 UniProtKB Mutagenesis 910 910 . . . Note=Abolishes interaction with KAT8. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21217699;Dbxref=PMID:21217699 Q7Z3B3 UniProtKB Mutagenesis 917 917 . . . Note=No effect on interaction with KAT8. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21217699;Dbxref=PMID:21217699 Q7Z3B3 UniProtKB Mutagenesis 921 921 . . . Note=Abolishes interaction with KAT8. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21217699;Dbxref=PMID:21217699 Q7Z3B3 UniProtKB Sequence conflict 530 530 . . . Note=I->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q7Z3B3 UniProtKB Sequence conflict 683 683 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q7Z3B3 UniProtKB Sequence conflict 849 849 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q7Z3B3 UniProtKB Helix 591 593 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4CY1