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Q7Z3B3

- KANL1_HUMAN

UniProt

Q7Z3B3 - KANL1_HUMAN

Protein

KAT8 regulatory NSL complex subunit 1

Gene

KANSL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (31 May 2011)
      Previous versions | rss
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    Functioni

    As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin organization Source: Reactome
    2. histone H4-K16 acetylation Source: UniProtKB
    3. histone H4-K5 acetylation Source: UniProtKB
    4. histone H4-K8 acetylation Source: UniProtKB

    Keywords - Molecular functioni

    Chromatin regulator

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KAT8 regulatory NSL complex subunit 1
    Alternative name(s):
    MLL1/MLL complex subunit KANSL1
    MSL1 homolog 1
    Short name:
    hMSL1v1
    NSL complex protein NSL1
    Non-specific lethal 1 homolog
    Gene namesi
    Name:KANSL1
    Synonyms:KIAA1267, MSL1V1, NSL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:24565. KANSL1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. histone acetyltransferase complex Source: UniProtKB
    2. MLL1 complex Source: UniProtKB
    3. nucleoplasm Source: Reactome
    4. nucleus Source: LIFEdb

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi852 – 8554RRRR → AAAA: Abolishes KAT8 histone acetyltransferase activity. 1 Publication
    Mutagenesisi856 – 8594GESS → AAAA: Strongly reduces KAT8 histone acetyltransferase activity. 1 Publication
    Mutagenesisi860 – 8634FDIN → AAAA: Strongly reduces KAT8 histone acetyltransferase activity. 1 Publication
    Mutagenesisi864 – 8674NIVI → AAAA: Abolishes KAT8 histone acetyltransferase activity. 1 Publication
    Mutagenesisi868 – 8714PMSV → AAAA: Reduces KAT8 histone acetyltransferase activity. 1 Publication
    Mutagenesisi910 – 9101E → R: Abolishes interaction with KAT8. 2 Publications
    Mutagenesisi917 – 9171F → R: No effect on interaction with KAT8. 2 Publications
    Mutagenesisi921 – 9211H → R: Abolishes interaction with KAT8. 2 Publications

    Organism-specific databases

    Orphaneti363958. 17q21.31 microdeletion syndrome.
    363965. Koolen-De Vries syndrome due to a point mutation.
    PharmGKBiPA142671604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11051105KAT8 regulatory NSL complex subunit 1PRO_0000234565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei104 – 1041N6-acetyllysine1 Publication
    Modified residuei249 – 2491Phosphoserine1 Publication
    Modified residuei268 – 2681Phosphoserine4 Publications
    Modified residuei991 – 9911Phosphoserine2 Publications
    Modified residuei1003 – 10031Phosphothreonine2 Publications
    Modified residuei1045 – 10451Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7Z3B3.
    PaxDbiQ7Z3B3.
    PRIDEiQ7Z3B3.

    PTM databases

    PhosphoSiteiQ7Z3B3.

    Expressioni

    Tissue specificityi

    Expressed in the brain.1 Publication

    Gene expression databases

    ArrayExpressiQ7Z3B3.
    BgeeiQ7Z3B3.
    CleanExiHS_KIAA1267.
    GenevestigatoriQ7Z3B3.

    Organism-specific databases

    HPAiHPA006874.
    HPA007208.

    Interactioni

    Subunit structurei

    Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KAT8; the interaction is direct.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCDC85BQ158342EBI-740244,EBI-739674
    WDR5P619649EBI-740244,EBI-540834

    Protein-protein interaction databases

    BioGridi129744. 24 interactions.
    IntActiQ7Z3B3. 21 interactions.
    MINTiMINT-1183636.
    STRINGi9606.ENSP00000262419.

    Structurei

    Secondary structure

    1
    1105
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi591 – 5933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4CY1X-ray1.50C/D585-598[»]
    4CY2X-ray2.00D585-598[»]
    ProteinModelPortaliQ7Z3B3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni850 – 88233Required for activation of KAT8 histone acetyltransferase activityAdd
    BLAST
    Regioni883 – 1105223Sufficient for interaction with KAT8Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili283 – 31432Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG87566.
    HOVERGENiHBG080054.
    InParanoidiQ7Z3B3.
    OMAiTSANCDL.
    OrthoDBiEOG7VQJF6.
    PhylomeDBiQ7Z3B3.
    TreeFamiTF336511.

    Family and domain databases

    InterProiIPR026180. NSL1.
    IPR029332. PEHE_dom.
    [Graphical view]
    PANTHERiPTHR22443. PTHR22443. 1 hit.
    PfamiPF15275. PEHE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7Z3B3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAMAPALTD AAAEAHHIRF KLAPPSSTLS PGSAENNGNA NILIAANGTK     50
    RKAIAAEDPS LDFRNNPTKE DLGKLQPLVA SYLCSDVTSV PSKESLKLQG 100
    VFSKQTVLKS HPLLSQSYEL RAELLGRQPV LEFSLENLRT MNTSGQTALP 150
    QAPVNGLAKK LTKSSTHSDH DNSTSLNGGK RALTSSALHG GEMGGSESGD 200
    LKGGMTNCTL PHRSLDVEHT TLYSNNSTAN KSSVNSMEQP ALQGSSRLSP 250
    GTDSSSNLGG VKLEGKKSPL SSILFSALDS DTRITALLRR QADIESRARR 300
    LQKRLQVVQA KQVERHIQHQ LGGFLEKTLS KLPNLESLRP RSQLMLTRKA 350
    EAALRKAASE TTTSEGLSNF LKSNSISEEL ERFTASGIAN LRCSEQAFDS 400
    DVTDSSSGGE SDIEEEELTR ADPEQRHVPL RRRSEWKWAA DRAAIVSRWN 450
    WLQAHVSDLE YRIRQQTDIY KQIRANKGLI VLGEVPPPEH TTDLFLPLSS 500
    EVKTDHGTDK LIESVSQPLE NHGARIIGHI SESLSTKSCG ALRPVNGVIN 550
    TLQPVLADHI PGDSSDAEEQ LHKKQRLNLV SSSSDGTCVA ARTRPVLSCK 600
    KRRLVRPNSI VPLSKKVHRN STIRPGCDVN PSCALCGSGS INTMPPEIHY 650
    EAPLLERLSQ LDSCVHPVLA FPDDVPTSLH FQSMLKSQWQ NKPFDKIKPP 700
    KKLSLKHRAP MPGSLPDSAR KDRHKLVSSF LTTAKLSHHQ TRPDRTHRQH 750
    LDDVGAVPMV ERVTAPKAER LLNPPPPVHD PNHSKMRLRD HSSERSEVLK 800
    HHTDMSSSSY LAATHHPPHS PLVRQLSTSS DSPAPASSSS QVTASTSQQP 850
    VRRRRGESSF DINNIVIPMS VAATTRVEKL QYKEILTPSW REVDLQSLKG 900
    SPDEENEEIE DLSDAAFAAL HAKCEEMERA RWLWTTSVPP QRRGSRSYRS 950
    SDGRTTPQLG SANPSTPQPA SPDVSSSHSL SEYSHGQSPR SPISPELHSA 1000
    PLTPVARDTP RHLASEDTRC STPELGLDEQ SVQPWERRTF PLAHSPQAEC 1050
    EDQLDAQERA ARCTRRTSGS KTGRETEAAP TSPPIVPLKS RHLVAAATAQ 1100
    RPTHR 1105
    Length:1,105
    Mass (Da):121,025
    Last modified:May 31, 2011 - v2
    Checksum:iB69D11BC522B9CAD
    GO
    Isoform 2 (identifier: Q7Z3B3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-669: Missing.
         670-673: AFPD → MFLA

    Note: No experimental confirmation available.

    Show »
    Length:436
    Mass (Da):48,445
    Checksum:iEFA2A4A2BE70F67E
    GO

    Sequence cautioni

    The sequence CAH10565.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti525 – 5251R → P in BAA86581. (PubMed:10574462)Curated
    Sequence conflicti525 – 5251R → P in BAF83948. (PubMed:14702039)Curated
    Sequence conflicti525 – 5251R → P in CAD97958. (PubMed:17974005)Curated
    Sequence conflicti525 – 5251R → P in AAH98376. (PubMed:16625196)Curated
    Sequence conflicti530 – 5301I → F in CAB70694. (PubMed:17974005)Curated
    Sequence conflicti683 – 6831S → G in CAH10565. (PubMed:17974005)Curated
    Sequence conflicti849 – 8491Missing in BAF83948. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041K → T.
    Corresponds to variant rs17585974 [ dbSNP | Ensembl ].
    VAR_049515
    Natural varianti221 – 2211T → I.
    Corresponds to variant rs17662853 [ dbSNP | Ensembl ].
    VAR_049516
    Natural varianti225 – 2251N → D.
    Corresponds to variant rs35643216 [ dbSNP | Ensembl ].
    VAR_049517
    Natural varianti718 – 7181S → P.
    Corresponds to variant rs34043286 [ dbSNP | Ensembl ].
    VAR_049518
    Natural varianti1010 – 10101P → L.4 Publications
    Corresponds to variant rs7220988 [ dbSNP | Ensembl ].
    VAR_026287
    Natural varianti1085 – 10851I → T.
    Corresponds to variant rs34579536 [ dbSNP | Ensembl ].
    VAR_049519

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 669669Missing in isoform 2. 1 PublicationVSP_041132Add
    BLAST
    Alternative sequencei670 – 6734AFPD → MFLA in isoform 2. 1 PublicationVSP_041133

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033093 mRNA. Translation: BAA86581.1.
    AK291259 mRNA. Translation: BAF83948.1.
    AL117476 mRNA. Translation: CAB55949.1.
    AL137317 mRNA. Translation: CAB70694.1.
    BX538006 mRNA. Translation: CAD97958.1.
    BX648760 mRNA. Translation: CAH10565.1. Different initiation.
    AC217773 Genomic DNA. No translation available.
    CR936218 Genomic DNA. No translation available.
    BC035892 mRNA. Translation: AAH35892.1.
    BC098376 mRNA. Translation: AAH98376.1.
    CCDSiCCDS11503.1. [Q7Z3B3-1]
    PIRiT17259.
    T46385.
    RefSeqiNP_001180394.1. NM_001193465.1.
    NP_001180395.1. NM_001193466.1.
    NP_056258.1. NM_015443.3.
    XP_005257289.2. XM_005257232.2.
    XP_005257290.2. XM_005257233.2.
    XP_006721886.1. XM_006721823.1.
    XP_006721887.1. XM_006721824.1.
    UniGeneiHs.648744.

    Genome annotation databases

    EnsembliENST00000262419; ENSP00000262419; ENSG00000120071. [Q7Z3B3-1]
    ENST00000432791; ENSP00000387393; ENSG00000120071. [Q7Z3B3-1]
    ENST00000572904; ENSP00000461484; ENSG00000120071. [Q7Z3B3-1]
    ENST00000574590; ENSP00000461812; ENSG00000120071. [Q7Z3B3-1]
    GeneIDi284058.
    KEGGihsa:284058.
    UCSCiuc002ikc.3. human. [Q7Z3B3-1]
    uc010wkb.2. human. [Q7Z3B3-2]

    Polymorphism databases

    DMDMi334302834.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB033093 mRNA. Translation: BAA86581.1 .
    AK291259 mRNA. Translation: BAF83948.1 .
    AL117476 mRNA. Translation: CAB55949.1 .
    AL137317 mRNA. Translation: CAB70694.1 .
    BX538006 mRNA. Translation: CAD97958.1 .
    BX648760 mRNA. Translation: CAH10565.1 . Different initiation.
    AC217773 Genomic DNA. No translation available.
    CR936218 Genomic DNA. No translation available.
    BC035892 mRNA. Translation: AAH35892.1 .
    BC098376 mRNA. Translation: AAH98376.1 .
    CCDSi CCDS11503.1. [Q7Z3B3-1 ]
    PIRi T17259.
    T46385.
    RefSeqi NP_001180394.1. NM_001193465.1.
    NP_001180395.1. NM_001193466.1.
    NP_056258.1. NM_015443.3.
    XP_005257289.2. XM_005257232.2.
    XP_005257290.2. XM_005257233.2.
    XP_006721886.1. XM_006721823.1.
    XP_006721887.1. XM_006721824.1.
    UniGenei Hs.648744.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4CY1 X-ray 1.50 C/D 585-598 [» ]
    4CY2 X-ray 2.00 D 585-598 [» ]
    ProteinModelPortali Q7Z3B3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129744. 24 interactions.
    IntActi Q7Z3B3. 21 interactions.
    MINTi MINT-1183636.
    STRINGi 9606.ENSP00000262419.

    PTM databases

    PhosphoSitei Q7Z3B3.

    Polymorphism databases

    DMDMi 334302834.

    Proteomic databases

    MaxQBi Q7Z3B3.
    PaxDbi Q7Z3B3.
    PRIDEi Q7Z3B3.

    Protocols and materials databases

    DNASUi 284058.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262419 ; ENSP00000262419 ; ENSG00000120071 . [Q7Z3B3-1 ]
    ENST00000432791 ; ENSP00000387393 ; ENSG00000120071 . [Q7Z3B3-1 ]
    ENST00000572904 ; ENSP00000461484 ; ENSG00000120071 . [Q7Z3B3-1 ]
    ENST00000574590 ; ENSP00000461812 ; ENSG00000120071 . [Q7Z3B3-1 ]
    GeneIDi 284058.
    KEGGi hsa:284058.
    UCSCi uc002ikc.3. human. [Q7Z3B3-1 ]
    uc010wkb.2. human. [Q7Z3B3-2 ]

    Organism-specific databases

    CTDi 284058.
    GeneCardsi GC17M044108.
    GeneReviewsi KANSL1.
    HGNCi HGNC:24565. KANSL1.
    HPAi HPA006874.
    HPA007208.
    MIMi 612452. gene.
    neXtProti NX_Q7Z3B3.
    Orphaneti 363958. 17q21.31 microdeletion syndrome.
    363965. Koolen-De Vries syndrome due to a point mutation.
    PharmGKBi PA142671604.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87566.
    HOVERGENi HBG080054.
    InParanoidi Q7Z3B3.
    OMAi TSANCDL.
    OrthoDBi EOG7VQJF6.
    PhylomeDBi Q7Z3B3.
    TreeFami TF336511.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.

    Miscellaneous databases

    GeneWikii KIAA1267.
    GenomeRNAii 284058.
    NextBioi 94492.
    PROi Q7Z3B3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7Z3B3.
    Bgeei Q7Z3B3.
    CleanExi HS_KIAA1267.
    Genevestigatori Q7Z3B3.

    Family and domain databases

    InterProi IPR026180. NSL1.
    IPR029332. PEHE_dom.
    [Graphical view ]
    PANTHERi PTHR22443. PTHR22443. 1 hit.
    Pfami PF15275. PEHE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-1010.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-1010.
      Tissue: Teratocarcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-1010.
      Tissue: Fetal kidney, Mammary cancer and Testis.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-1010.
      Tissue: Leukocyte and PNS.
    6. "A genomic sequence analysis of the mouse and human microtubule-associated protein tau."
      Poorkaj P., Kas A., D'Souza I., Zhou Y., Pham Q., Stone M., Olson M.V., Schellenberg G.D.
      Mamm. Genome 12:700-712(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
      Dou Y., Milne T.A., Tackett A.J., Smith E.R., Fukuda A., Wysocka J., Allis C.D., Chait B.T., Hess J.L., Roeder R.G.
      Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX.
    8. "A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16."
      Smith E.R., Cayrou C., Huang R., Lane W.S., Cote J., Lucchesi J.C.
      Mol. Cell. Biol. 25:9175-9188(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A MULTIPROTEIN COMPLEX.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila."
      Mendjan S., Taipale M., Kind J., Holz H., Gebhardt P., Schelder M., Vermeulen M., Buscaino A., Duncan K., Mueller J., Wilm M., Stunnenberg H.G., Saumweber H., Akhtar A.
      Mol. Cell 21:811-823(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NSL COMPLEX, INTERACTION WITH KAT8.
    11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-991 AND THR-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249; SER-268 AND SER-1045, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-104, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."
      Cai Y., Jin J., Swanson S.K., Cole M.D., Choi S.H., Florens L., Washburn M.P., Conaway J.W., Conaway R.C.
      J. Biol. Chem. 285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN HISTONE H4 ACETYLATION, IDENTIFICATION IN NSL COMPLEX, SUBCELLULAR LOCATION.
    16. "The nonspecific lethal complex is a transcriptional regulator in Drosophila."
      Raja S.J., Charapitsa I., Conrad T., Vaquerizas J.M., Gebhardt P., Holz H., Kadlec J., Fraterman S., Luscombe N.M., Akhtar A.
      Mol. Cell 38:827-841(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KAT8.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-991 AND THR-1003, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1."
      Kadlec J., Hallacli E., Lipp M., Holz H., Sanchez-Weatherby J., Cusack S., Akhtar A.
      Nat. Struct. Mol. Biol. 18:142-149(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KAT8, MUTAGENESIS OF GLU-910; PHE-917 AND HIS-921.
    19. "Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex."
      Huang J., Wan B., Wu L., Yang Y., Dou Y., Lei M.
      Cell Res. 22:1078-1081(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NSL COMPLEX, INTERACTION WITH KAT8, MUTAGENESIS OF 852-ARG--ARG-855; 856-GLY--SER-859; 860-PHE--ASN-863; 864-ASN--ILE-867 AND 868-PRO--VAL-871.

    Entry informationi

    Entry nameiKANL1_HUMAN
    AccessioniPrimary (citable) accession number: Q7Z3B3
    Secondary accession number(s): A8K5E4
    , Q6AW85, Q8IYH1, Q9BRH0, Q9NTE7, Q9UFT0, Q9ULF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3