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Protein

Neuronal growth regulator 1

Gene

NEGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal growth regulator 1
Alternative name(s):
IgLON family member 4
Gene namesi
Name:NEGR1
Synonyms:IGLON4
ORF Names:UNQ2433/PRO4993
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17302. NEGR1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi257194.
OpenTargetsiENSG00000172260.
PharmGKBiPA134862452.

Polymorphism and mutation databases

BioMutaiNEGR1.
DMDMi88984537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37By similarityAdd BLAST37
ChainiPRO_000001503738 – 324Neuronal growth regulator 1Add BLAST287
PropeptideiPRO_0000015038325 – 354Removed in mature formCuratedAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 118PROSITE-ProRule annotation
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi155N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160 ↔ 203PROSITE-ProRule annotation
Modified residuei187PhosphotyrosineBy similarity1
Disulfide bondi245 ↔ 297PROSITE-ProRule annotation
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Lipidationi324GPI-anchor amidated glycine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ7Z3B1.
MaxQBiQ7Z3B1.
PaxDbiQ7Z3B1.
PeptideAtlasiQ7Z3B1.
PRIDEiQ7Z3B1.

PTM databases

iPTMnetiQ7Z3B1.
PhosphoSitePlusiQ7Z3B1.

Expressioni

Gene expression databases

BgeeiENSG00000172260.
CleanExiHS_NEGR1.
GenevisibleiQ7Z3B1. HS.

Organism-specific databases

HPAiHPA011894.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSAMPQ134492EBI-4314838,EBI-4314821
NTMQ9P1212EBI-4314838,EBI-4315078

Protein-protein interaction databases

BioGridi129205. 4 interactors.
IntActiQ7Z3B1. 3 interactors.
STRINGi9606.ENSP00000350364.

Structurei

3D structure databases

ProteinModelPortaliQ7Z3B1.
SMRiQ7Z3B1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 134Ig-like C2-type 1Add BLAST97
Domaini139 – 221Ig-like C2-type 2Add BLAST83
Domaini225 – 313Ig-like C2-type 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJE. Eukaryota.
ENOG4110TBP. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ7Z3B1.
KOiK06775.
OMAiYDISTDM.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ7Z3B1.
TreeFamiTF351104.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z3B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMMLLVQGA CCSNQWLAAV LLSLCCLLPS CLPAGQSVDF PWAAVDNMMV
60 70 80 90 100
RKGDTAVLRC YLEDGASKGA WLNRSSIIFA GGDKWSVDPR VSISTLNKRD
110 120 130 140 150
YSLQIQNVDV TDDGPYTCSV QTQHTPRTMQ VHLTVQVPPK IYDISNDMTV
160 170 180 190 200
NEGTNVTLTC LATGKPEPSI SWRHISPSAK PFENGQYLDI YGITRDQAGE
210 220 230 240 250
YECSAENDVS FPDVRKVKVV VNFAPTIQEI KSGTVTPGRS GLIRCEGAGV
260 270 280 290 300
PPPAFEWYKG EKKLFNGQQG IIIQNFSTRS ILTVTNVTQE HFGNYTCVAA
310 320 330 340 350
NKLGTTNASL PLNPPSTAQY GITGSADVLF SCWYLVLTLS SFTSIFYLKN

AILQ
Length:354
Mass (Da):38,719
Last modified:February 21, 2006 - v3
Checksum:i41B05D00224CF34A
GO
Isoform 2 (identifier: Q7Z3B1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):24,733
Checksum:i61EBC9E93977B520
GO

Sequence cautioni

The sequence AAQ88499 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169S → F in BAC03858 (PubMed:14702039).Curated1
Sequence conflicti208D → A (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563131 – 128Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538014 mRNA. Translation: CAD97961.1.
AY358132 mRNA. Translation: AAQ88499.1. Different initiation.
AK092307 mRNA. Translation: BAC03858.1.
AL359821
, AL645724, AL627317, AL356600, AL354949 Genomic DNA. Translation: CAH70913.1.
AL627317
, AL354949, AL356600, AL645724, AL359821 Genomic DNA. Translation: CAH72391.1.
AL354949
, AL356600, AL359821, AL645724, AL627317 Genomic DNA. Translation: CAI16869.1.
AL645724
, AL359821, AL356600, AL354949, AL627317 Genomic DNA. Translation: CAI21858.1.
AL356600
, AL645724, AL627317, AL359821, AL354949 Genomic DNA. Translation: CAI23492.1.
AL355590 Genomic DNA. No translation available.
AL365362 Genomic DNA. No translation available.
AL391239 Genomic DNA. No translation available.
AL513349 Genomic DNA. No translation available.
AL645767 Genomic DNA. No translation available.
BC036771 mRNA. Translation: AAH36771.1.
CCDSiCCDS661.1. [Q7Z3B1-1]
RefSeqiNP_776169.2. NM_173808.2. [Q7Z3B1-1]
UniGeneiHs.146542.

Genome annotation databases

EnsembliENST00000306821; ENSP00000305938; ENSG00000172260. [Q7Z3B1-2]
ENST00000357731; ENSP00000350364; ENSG00000172260. [Q7Z3B1-1]
GeneIDi257194.
KEGGihsa:257194.
UCSCiuc001dfv.4. human. [Q7Z3B1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538014 mRNA. Translation: CAD97961.1.
AY358132 mRNA. Translation: AAQ88499.1. Different initiation.
AK092307 mRNA. Translation: BAC03858.1.
AL359821
, AL645724, AL627317, AL356600, AL354949 Genomic DNA. Translation: CAH70913.1.
AL627317
, AL354949, AL356600, AL645724, AL359821 Genomic DNA. Translation: CAH72391.1.
AL354949
, AL356600, AL359821, AL645724, AL627317 Genomic DNA. Translation: CAI16869.1.
AL645724
, AL359821, AL356600, AL354949, AL627317 Genomic DNA. Translation: CAI21858.1.
AL356600
, AL645724, AL627317, AL359821, AL354949 Genomic DNA. Translation: CAI23492.1.
AL355590 Genomic DNA. No translation available.
AL365362 Genomic DNA. No translation available.
AL391239 Genomic DNA. No translation available.
AL513349 Genomic DNA. No translation available.
AL645767 Genomic DNA. No translation available.
BC036771 mRNA. Translation: AAH36771.1.
CCDSiCCDS661.1. [Q7Z3B1-1]
RefSeqiNP_776169.2. NM_173808.2. [Q7Z3B1-1]
UniGeneiHs.146542.

3D structure databases

ProteinModelPortaliQ7Z3B1.
SMRiQ7Z3B1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129205. 4 interactors.
IntActiQ7Z3B1. 3 interactors.
STRINGi9606.ENSP00000350364.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ7Z3B1.
PhosphoSitePlusiQ7Z3B1.

Polymorphism and mutation databases

BioMutaiNEGR1.
DMDMi88984537.

Proteomic databases

EPDiQ7Z3B1.
MaxQBiQ7Z3B1.
PaxDbiQ7Z3B1.
PeptideAtlasiQ7Z3B1.
PRIDEiQ7Z3B1.

Protocols and materials databases

DNASUi257194.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306821; ENSP00000305938; ENSG00000172260. [Q7Z3B1-2]
ENST00000357731; ENSP00000350364; ENSG00000172260. [Q7Z3B1-1]
GeneIDi257194.
KEGGihsa:257194.
UCSCiuc001dfv.4. human. [Q7Z3B1-1]

Organism-specific databases

CTDi257194.
DisGeNETi257194.
GeneCardsiNEGR1.
HGNCiHGNC:17302. NEGR1.
HPAiHPA011894.
MIMi613173. gene.
neXtProtiNX_Q7Z3B1.
OpenTargetsiENSG00000172260.
PharmGKBiPA134862452.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJE. Eukaryota.
ENOG4110TBP. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ7Z3B1.
KOiK06775.
OMAiYDISTDM.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ7Z3B1.
TreeFamiTF351104.

Miscellaneous databases

ChiTaRSiNEGR1. human.
GeneWikiiNEGR1.
GenomeRNAii257194.
PROiQ7Z3B1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172260.
CleanExiHS_NEGR1.
GenevisibleiQ7Z3B1. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEGR1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z3B1
Secondary accession number(s): Q5VT21
, Q6UY06, Q8N440, Q8NAQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: February 21, 2006
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.