Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 550

Gene

ZNF550

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 550
Gene namesi
Name:ZNF550
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28643. ZNF550.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937679.

Polymorphism and mutation databases

DMDMi97219074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Zinc finger protein 550PRO_0000234585Add
BLAST

Proteomic databases

EPDiQ7Z398.
PeptideAtlasiQ7Z398.
PRIDEiQ7Z398.

PTM databases

iPTMnetiQ7Z398.
PhosphoSiteiQ7Z398.

Expressioni

Gene expression databases

CleanExiHS_ZNF550.
ExpressionAtlasiQ7Z398. baseline and differential.
GenevisibleiQ7Z398. HS.

Organism-specific databases

HPAiHPA003251.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10256834,EBI-307352

Protein-protein interaction databases

BioGridi127836. 32 interactions.
IntActiQ7Z398. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7Z398.
SMRiQ7Z398. Positions 197-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri203 – 22523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri231 – 25323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00750000117699.
HOVERGENiHBG018163.
InParanoidiQ7Z398.
KOiK09228.
OMAiHECDSQQ.
PhylomeDBiQ7Z398.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z398-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETKDAAQM LVTFKDVAVT FTREEWRQLD LAQRTLYREV MLETCGLLVS
60 70 80 90 100
LGHRVPKPEL VHLLEHGQEL WIVKRGLSHA TCAGDRAQVH TREPTTYPPV
110 120 130 140 150
LSERAFLRGS LTLESSTSSD SRLGRARDEE GLLEMQKGKV TPETDLHKET
160 170 180 190 200
HLGKVSLEGE GLGTDDGLHS RALQEWLSAD VLHECDSQQP GKDALIHAGT
210 220 230 240 250
NPYKCKQCGK GFNRKWYLVR HQRVHTGMKP YECNACGKAF SQSSTLIRHY
260 270 280 290 300
LIHTGEKPYK CLECGKAFKR RSYLMQHHPI HTGEKPYECS QCRKAFTHRS
310 320 330 340 350
TFIRHNRTHT GEKPFECKEC EKAFSNRAHL IQHYIIHTGE KPYDCMACGK
360 370 380 390 400
AFRCSSELIQ HQRIHTGEKP YECTQCGKAF HRSTYLIQHS VIHTGEMPYK
410 420
CIECGKAFKR RSHLLQHQRV HT
Length:422
Mass (Da):48,381
Last modified:May 16, 2006 - v2
Checksum:i16217CD2FB9357B2
GO
Isoform 2 (identifier: Q7Z398-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-84: Missing.

Note: No experimental confirmation available.
Show »
Length:390
Mass (Da):44,787
Checksum:i08A256A3CF6784B3
GO

Sequence cautioni

The sequence AAH34810.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH53858.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti329 – 3291H → R in AAH34810 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti359 – 3591I → T.3 Publications
Corresponds to variant rs1548476 [ dbSNP | Ensembl ].
VAR_026294

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 8432Missing in isoform 2. CuratedVSP_018380Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122867 mRNA. Translation: BAG53768.1.
BX538032 mRNA. Translation: CAD97977.1.
AC003682 Genomic DNA. Translation: AAC24606.1.
BC034810 mRNA. Translation: AAH34810.1. Different initiation.
BC053858 mRNA. Translation: AAH53858.1. Different initiation.
CCDSiCCDS35500.2. [Q7Z398-1]
RefSeqiNP_001264019.1. NM_001277090.1. [Q7Z398-1]
NP_001264020.1. NM_001277091.1. [Q7Z398-1]
NP_001264021.1. NM_001277092.1. [Q7Z398-1]
NP_001264022.1. NM_001277093.1.
XP_011524869.1. XM_011526567.1. [Q7Z398-1]
XP_011524870.1. XM_011526568.1.
UniGeneiHs.180257.

Genome annotation databases

EnsembliENST00000325134; ENSP00000446224; ENSG00000251369. [Q7Z398-1]
ENST00000376230; ENSP00000469537; ENSG00000251369. [Q7Z398-1]
ENST00000447310; ENSP00000469580; ENSG00000251369. [Q7Z398-1]
ENST00000457177; ENSP00000469679; ENSG00000251369. [Q7Z398-1]
GeneIDi162972.
KEGGihsa:162972.
UCSCiuc002qpc.5. human. [Q7Z398-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122867 mRNA. Translation: BAG53768.1.
BX538032 mRNA. Translation: CAD97977.1.
AC003682 Genomic DNA. Translation: AAC24606.1.
BC034810 mRNA. Translation: AAH34810.1. Different initiation.
BC053858 mRNA. Translation: AAH53858.1. Different initiation.
CCDSiCCDS35500.2. [Q7Z398-1]
RefSeqiNP_001264019.1. NM_001277090.1. [Q7Z398-1]
NP_001264020.1. NM_001277091.1. [Q7Z398-1]
NP_001264021.1. NM_001277092.1. [Q7Z398-1]
NP_001264022.1. NM_001277093.1.
XP_011524869.1. XM_011526567.1. [Q7Z398-1]
XP_011524870.1. XM_011526568.1.
UniGeneiHs.180257.

3D structure databases

ProteinModelPortaliQ7Z398.
SMRiQ7Z398. Positions 197-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127836. 32 interactions.
IntActiQ7Z398. 1 interaction.

PTM databases

iPTMnetiQ7Z398.
PhosphoSiteiQ7Z398.

Polymorphism and mutation databases

DMDMi97219074.

Proteomic databases

EPDiQ7Z398.
PeptideAtlasiQ7Z398.
PRIDEiQ7Z398.

Protocols and materials databases

DNASUi162972.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325134; ENSP00000446224; ENSG00000251369. [Q7Z398-1]
ENST00000376230; ENSP00000469537; ENSG00000251369. [Q7Z398-1]
ENST00000447310; ENSP00000469580; ENSG00000251369. [Q7Z398-1]
ENST00000457177; ENSP00000469679; ENSG00000251369. [Q7Z398-1]
GeneIDi162972.
KEGGihsa:162972.
UCSCiuc002qpc.5. human. [Q7Z398-1]

Organism-specific databases

CTDi162972.
GeneCardsiZNF550.
HGNCiHGNC:28643. ZNF550.
HPAiHPA003251.
neXtProtiNX_Q7Z398.
PharmGKBiPA134937679.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00750000117699.
HOVERGENiHBG018163.
InParanoidiQ7Z398.
KOiK09228.
OMAiHECDSQQ.
PhylomeDBiQ7Z398.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF550. human.
GenomeRNAii162972.
PROiQ7Z398.

Gene expression databases

CleanExiHS_ZNF550.
ExpressionAtlasiQ7Z398. baseline and differential.
GenevisibleiQ7Z398. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-359.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-359.
    Tissue: Endometrial tumor.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-359.
    Tissue: Testis.

Entry informationi

Entry nameiZN550_HUMAN
AccessioniPrimary (citable) accession number: Q7Z398
Secondary accession number(s): B3KVF6
, O43337, Q7Z6D7, Q8NE45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-10 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.